Family Medicine

Research Output 1996 2019

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15 Citations (Scopus)

Differential response to low-dose dopamine or low-dose nesiritide in acute heart failure with reduced or preserved ejection fraction

Wan, S. H., Stevens, S. R., Borlaug, B. A., Anstrom, K. J., Deswal, A., Felker, G. M., Givertz, M. M., Bart, B. A., Tang, W. H. W., Redfield, M. M. & Chen, H. H., Aug 1 2016, In : Circulation: Heart Failure. 9, 8, e002593.

Research output: Contribution to journalArticle

Brain Natriuretic Peptide
Dopamine
Heart Failure
Placebos
Urine
8 Citations (Scopus)
Heart Failure
Kidney
Natriuretic Peptides
Glomerular Filtration Rate
omega-N-Methylarginine
856 Citations (Scopus)

Diuretic strategies in patients with acute decompensated heart failure

Felker, G. M., Lee, K. L., Bull, D. A., Redfield, M. M., Stevenson, L. W., Goldsmith, S. R., LeWinter, M. M., Deswal, A., Rouleau, J. L., Ofili, E. O., Anstrom, K. J., Hernandez, A. F., McNulty, S. E., Velazquez, E. J., Kfoury, A. G., Chen, H. H., Givertz, M. M., Semigran, M. J., Bart, B. A., Mascette, A. M. & 2 others, Braunwald, E. & O'Connor, C. M., Mar 3 2011, In : New England Journal of Medicine. 364, 9, p. 797-805 9 p.

Research output: Contribution to journalArticle

Diuretics
Heart Failure
Symptom Assessment
Area Under Curve
Creatinine
3 Citations (Scopus)
Natriuretic Agents
Brain Natriuretic Peptide
Kidney Diseases
Vasodilator Agents
Dopamine
55 Citations (Scopus)

Effect of brinzolamide and dorzolamide on aqueous humor flow in human eyes

Ingram, C. & Brubaker, R. F., Sep 1 1999, In : American journal of ophthalmology. 128, 3, p. 292-296 5 p.

Research output: Contribution to journalArticle

dorzolamide
Aqueous Humor
Intraocular Pressure
Fluorophotometry
Carbonic Anhydrase Inhibitors
23 Citations (Scopus)

Effect of Inorganic Nitrite vs Placebo on Exercise Capacity among Patients with Heart Failure with Preserved Ejection Fraction: The INDIE-HFpEF Randomized Clinical Trial

Borlaug, B. A., Anstrom, K. J., Lewis, G. D., Shah, S. J., Levine, J. A., Koepp, G. A., Givertz, M. M., Felker, G. M., Lewinter, M. M., Mann, D. L., Margulies, K. B., Smith, A. L., Tang, W. H. W., Whellan, D. J., Chen, H. H., Davila-Roman, V. G., McNulty, S., Desvigne-Nickens, P., Hernandez, A. F., Braunwald, E. & 1 others, Redfield, M. M., Nov 6 2018, In : JAMA - Journal of the American Medical Association. 320, 17, p. 1764-1773 10 p.

Research output: Contribution to journalArticle

Nitrites
Randomized Controlled Trials
Heart Failure
Placebos
Exercise
615 Citations (Scopus)

Effect of phosphodiesterase-5 inhibition on exercise capacity and clinical status in heart failure with preserved ejection fraction: A randomized clinical trial

Redfield, M. M., Chen, H. H., Borlaug, B. A., Semigran, M. J., Lee, K. L., Lewis, G., LeWinter, M. M., Rouleau, J. L., Bull, D. A., Mann, D. L., Deswal, A., Stevenson, L. W., Givertz Elizabeth O Ofili, M. M., O'Connor, C. M., Felker, G. M., Goldsmith, S. R., Bart, B. A., McNulty, S. E., Ibarra, J. C., Lin, G. D. & 9 others, Oh, J. K., Patel, M. R., Kim, R. J., Tracy, R. P., Velazquez, E. J., Anstrom, K. J., Hernandez, A. F., Mascette, A. M. & Braunwald, E., Mar 27 2013, In : JAMA - Journal of the American Medical Association. 309, 12, p. 1268-1277 10 p.

Research output: Contribution to journalArticle

Type 5 Cyclic Nucleotide Phosphodiesterases
Randomized Controlled Trials
Heart Failure
Placebos
Exercise
5 Citations (Scopus)
Sleep Apnea Syndromes
Meta-Analysis
Confidence Intervals
Quality of Health Care
Arousal
2 Citations (Scopus)
Patient Acceptance of Health Care
Central Sleep Apnea
Mortality
Population
Hospital Emergency Service
39 Citations (Scopus)

Effects of Sildenafil on Ventricular and Vascular Function in Heart Failure with Preserved Ejection Fraction

Borlaug, B. A., Lewis, G. D., McNulty, S. E., Semigran, M. J., Lewinter, M., Chen, H. H., Lin, G. D., Deswal, A., Margulies, K. B. & Redfield, M. M., May 4 2015, In : Circulation: Heart Failure. 8, 3, p. 533-541 9 p.

Research output: Contribution to journalArticle

Ventricular Function
Blood Vessels
Heart Failure
Phosphodiesterase 5 Inhibitors
Placebos
47 Citations (Scopus)

Endogenous natriuretic peptides participate in renal and humoral actions of acute vasopeptidase inhibition in experimental mild heart failure

Chen, H. H., Lainchbury, J. G., Matsuda, Y., Harty, G. J. & Burnett, J. C. J., 2001, In : Hypertension. 38, 2, p. 187-191 5 p.

Research output: Contribution to journalArticle

Natriuretic Peptides
Atrial Natriuretic Factor
Brain Natriuretic Peptide
Heart Failure
Kidney
26 Citations (Scopus)

Endothelin A Receptor Antagonism in Experimental Congestive Heart Failure Results in Augmentation of the Renin-Angiotensin System and Sustained Sodium Retention

Schirger, J. A., Chen, H. H., Jougasaki, M., Lisy, O., Boerrigter, G., Cataliotti, A. & Burnett, J. C. J., Jan 20 2004, In : Circulation. 109, 2, p. 249-254 6 p.

Research output: Contribution to journalArticle

Endothelin A Receptors
Renin-Angiotensin System
Heart Failure
Sodium
Endothelin-1
33 Citations (Scopus)
Brain Natriuretic Peptide
Atrial Natriuretic Factor
Heart Failure
Kidney
Natriuretic Peptides
1 Citation (Scopus)

Estimated Glomerular Filtration Rate, Activation of Cardiac Biomarkers and Long-Term Cardiovascular Outcomes: A Population-Based Cohort

Vinnakota, S., Scott, C. G., Rodeheffer, R. J. & Chen, H. H., Nov 2019, In : Mayo Clinic proceedings. 94, 11, p. 2189-2198 10 p.

Research output: Contribution to journalArticle

Glomerular Filtration Rate
Chronic Renal Insufficiency
Biomarkers
Myocardial Infarction
Brain Natriuretic Peptide
6 Citations (Scopus)

Evaluation of a provocative dyspnea severity score in acute heart failure

Abou Ezzeddine, O., Lala, A., Khazanie, P. P., Shah, R., Ho, J. E., Chen, H. H., Pang, P. S., McNulty, S. E., Anstrom, K. J., Hernandez, A. F. & Redfield, M. M., Feb 1 2016, In : American Heart Journal. 172, p. 34-41 8 p.

Research output: Contribution to journalArticle

Dyspnea
Heart Failure
Visual Analog Scale
Exercise
Oxygen
3 Citations (Scopus)

Evolving treatment strategies for management of cardiorenal syndrome

Dandamudi, S. & Chen, H. H., Dec 2011, In : Current Treatment Options in Cardiovascular Medicine. 13, 6, p. 556-569 14 p.

Research output: Contribution to journalArticle

Cardio-Renal Syndrome
Kidney
Heart Failure
Brain Natriuretic Peptide
Ultrafiltration

Excessive sleepiness and associated symptoms in the U.S. adult population: prevalence, correlates, and comorbidity

Kolla, B. P., He, J. P., Mansukhani, M. P., Frye, M. A. & Merikangas, K., Jan 1 2019, (Accepted/In press) In : Sleep Health.

Research output: Contribution to journalArticle

Diagnostic and Statistical Manual of Mental Disorders
Comorbidity
Sleep
Odds Ratio
Sleep Initiation and Maintenance Disorders
12 Citations (Scopus)
Natriuretic Peptides
Brain Natriuretic Peptide
Coronary Artery Disease
Exercise
Atrial Natriuretic Factor
50 Citations (Scopus)

Experimental mild renal insufficiency mediates early cardiac apoptosis, fibrosis, and diastolic dysfunction: A kidney-heart connection

Martin, F. L., McKie, P., Cataliotti, A., Sangaralingham, S. J., Korinek, J., Huntley, B. K., Oehler, E. A., Harders, G. E., Ichiki, T., Mangiafico, S., Nath, K. A., Redfield, M. M., Chen, H. H. & Burnett, J. C. J., Jan 2012, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 302, 2

Research output: Contribution to journalArticle

Renal Insufficiency
Fibrosis
Apoptosis
Kidney
Brain Natriuretic Peptide
20 Citations (Scopus)

Formative evaluation of the accuracy of a clinical decision support system for cervical cancer screening

Wagholikar Dr., K. B., Mac Laughlin, K., Kastner, T. M., Casey, P. M., Henry, M., Greenes, R. A., Liu, H. D. & Chaudhry, R., 2013, In : Journal of the American Medical Informatics Association. 20, 4, p. 749-757 9 p.

Research output: Contribution to journalArticle

Clinical Decision Support Systems
Early Detection of Cancer
Uterine Cervical Neoplasms
Crowdsourcing
Guidelines
20 Citations (Scopus)

Functional aerobic capacity in patients with sleep-disordered breathing

Mansukhani, M., Allison, T. G., Lopez-Jimenez, F., Somers, V. & Caples, S. M., Jun 1 2013, In : American Journal of Cardiology. 111, 11, p. 1650-1654 5 p.

Research output: Contribution to journalArticle

Sleep Apnea Syndromes
Apnea
Body Mass Index
Exercise
Heart Rate
43 Citations (Scopus)

Galectin-3 in heart failure with preservedejection fraction. A RELAX trial substudy (phosphodiesterase-5 inhibition to improve clinical status and exercise capacity in diastolic heartfailure).

Abou Ezzeddine, O., Haines, P., Stevens, S., Nativi-Nicolau, J., Felker, G. M., Borlaug, B. A., Chen, H. H., Tracy, R. P., Braunwald, E. & Redfield, M. M., Mar 1 2015, In : JACC: Heart Failure. 3, 3, p. 245-252 8 p.

Research output: Contribution to journalArticle

Type 5 Cyclic Nucleotide Phosphodiesterases
Galectin 3
Heart Failure
Exercise
Fibrosis
57 Citations (Scopus)

Heart Failure. A State of Brain Natriuretic Peptide Deficiency or Resistance or Both!

Chen, H. H., Mar 13 2007, In : Journal of the American College of Cardiology. 49, 10, p. 1089-1091 3 p.

Research output: Contribution to journalArticle

Animal Disease Models
Phosphodiesterase Inhibitors
Brain Natriuretic Peptide
Cardiac Output
Reference Values
3 Citations (Scopus)

Hormones therapy for management of menopausal breast cancer risk

Files, J. A., Allen, S. & Pruthi, S., Jun 2012, In : Minerva Ginecologica. 64, 3, p. 223-230 8 p.

Research output: Contribution to journalArticle

Hormones
Breast Neoplasms
Therapeutics
Survivors
Women's Health
49 Citations (Scopus)

Human hypertension is characterized by a lack of activation of the antihypertensive cardiac hormones ANP and BNP

MacHeret, F., Heublein, D., Costello-Boerrigter, L. C., Boerrigter, G., McKie, P., Bellavia, D., Mangiafico, S., Ikeda, Y. H., Bailey, K. R., Scott, C. G., Sandberg, S., Chen, H. H., Malatino, L., Redfield, M. M., Rodeheffer, R., Burnett, J. C. J. & Cataliotti, A., Oct 16 2012, In : Journal of the American College of Cardiology. 60, 16, p. 1558-1565 8 p.

Research output: Contribution to journalArticle

Brain Natriuretic Peptide
Atrial Natriuretic Factor
Antihypertensive Agents
Hormones
Hypertension

Immediate impact of positive airway pressure on atrial fibrillation

Saeidifard, F., Kolla, B. P., Foroughi, M. & Mansukhani, M., Nov 1 2017, In : Sleep Medicine. 39, p. 84-86 3 p.

Research output: Contribution to journalArticle

Continuous Positive Airway Pressure
Obstructive Sleep Apnea
Atrial Fibrillation
Cardiac Arrhythmias
Pressure
97 Citations (Scopus)

Immune-mediated tumor regression induced by CpG-containing oligodeoxynucleotides

Baines, J. & Celis, E., Jul 1 2003, In : Clinical Cancer Research. 9, 7, p. 2693-2700 8 p.

Research output: Contribution to journalArticle

Oligodeoxyribonucleotides
T-Lymphocytes
Neoplasms
Carcinoma
Histocompatibility Antigens Class I
15 Citations (Scopus)

Impact of Contraception on Female Sexual Function

Casey, P. M., Mac Laughlin, K. & Faubion, S. S., Mar 1 2017, In : Journal of Women's Health. 26, 3, p. 207-213 7 p.

Research output: Contribution to journalArticle

Contraception
Lubricants
Pelvic Floor
Reproductive Health
Women's Health
22 Citations (Scopus)

Impact of dopamine agonists on compulsive behaviors: A case series of pramipexole-induced pathological gambling

Kolla, B. P., Mansukhani, M., Barraza, R. & Bostwick, J. M., Jan 1 2010, In : Psychosomatics. 51, 3, p. 271-273 3 p.

Research output: Contribution to journalArticle

Compulsive Behavior
Gambling
Dopamine Agonists
Reward
Restless Legs Syndrome
2 Citations (Scopus)

Impact of Patient Reminders on Papanicolaou Test Completion for High-Risk Patients Identified by a Clinical Decision Support System

Mac Laughlin, K., Kessler, M. E., Komandur Elayavilli, R., Hickey, B. C., Scheitel, M. R., Wagholikar, K. B., Liu, H. D., Kremers, W. K. & Chaudhry, R., May 1 2018, In : Journal of Women's Health. 27, 5, p. 569-574 6 p.

Research output: Contribution to journalArticle

Clinical Decision Support Systems
Papanicolaou Test
Uterine Cervical Neoplasms
Early Detection of Cancer
Guideline Adherence
3 Citations (Scopus)

Impact of symptom remission on outpatient visits in depressed primary care patients treated with collaborative care management and usual care

Meunier, M. R., Angstman, K. B., Mac Laughlin, K., Oberhelman, S. S., Rohrer, J. E., Katzelnick, D. J. & Matthews, M. R., Jun 1 2014, In : Population Health Management. 17, 3, p. 180-184 5 p.

Research output: Contribution to journalArticle

Primary Health Care
Outpatients
Odds Ratio
Confidence Intervals
Patient Acceptance of Health Care
46 Citations (Scopus)

Impaired natriuretic and renal endocrine response to acute volume expansion in pre-clinical systolic and diastolic dysfunction

McKie, P., Schirger, J. A., Costello-Boerrigter, L. C., Benike, S. L., Harstad, L. K., Bailey, K. R., Hodge, D. O., Redfield, M. M., Simari, R. D., Burnett, J. C. J. & Chen, H. H., Nov 8 2011, In : Journal of the American College of Cardiology. 58, 20, p. 2095-2103 9 p.

Research output: Contribution to journalArticle

Natriuresis
Cyclic GMP
Brain Natriuretic Peptide
Kidney
Healthy Volunteers
7 Citations (Scopus)

Implications of using different definitions on outcomes in worsening heart failure

Kelly, J. P., Cooper, L. B., Gallup, D., Anstrom, K. J., Chen, H. H., Redfield, M. M., O'Connor, C. M., Mentz, R. J., Hernanadez, A. F. & Felker, G. M., Aug 1 2016, In : Circulation: Heart Failure. 9, 8, e003048.

Research output: Contribution to journalArticle

Heart Failure
Diuretics
Confidence Intervals
Kidney
National Institutes of Health (U.S.)
1 Citation (Scopus)

Improving the Accuracy of a Clinical Decision Support System for Cervical Cancer Screening and Surveillance

Ravikumar, K. E., Mac Laughlin, K., Scheitel, M. R., Kessler, M., Wagholikar, K. B., Liu, H. D. & Chaudhry, R., Jan 1 2018, In : Applied Clinical Informatics. 9, 1, p. 62-71 10 p.

Research output: Contribution to journalArticle

Clinical Decision Support Systems
Decision support systems
Early Detection of Cancer
Uterine Cervical Neoplasms
Screening
1 Citation (Scopus)

Increased adherence to prenatal group B streptococcal screening guidelines through a paired electronic reminder and education intervention

MacLaughlin, K. L., Garrison, G. M., Matthews, M. R., O'Brien, M. L., Westby, E. & Targonski, P. V., Jan 2014, In : Maternal and Child Health Journal. 18, 1, p. 16-21 6 p.

Research output: Contribution to journalArticle

Centers for Disease Control and Prevention (U.S.)
Guidelines
Education
Pregnant Women
Multivariate Analysis
9 Citations (Scopus)

Increased Anxiety and Length of Treatment Associated With Depressed Patients Who are Readmitted to Collaborative Care

Angstman, K. B., Mac Laughlin, K., Williams, M. D., Rasmussen, N. H. & Dejesus, R. S., 2011, In : Journal of primary care & community health. 2, 2, p. 82-86 5 p.

Research output: Contribution to journalArticle

Anxiety
Depression
Comorbidity
Mental Health
Therapeutics
15 Citations (Scopus)

Insulin-Like Growth Factor–Binding Protein-7 as a Biomarker of Diastolic Dysfunction and Functional Capacity in Heart Failure With Preserved Ejection Fraction: Results From the RELAX Trial

Gandhi, P. U., Gaggin, H. K., Redfield, M. M., Chen, H. H., Stevens, S. R., Anstrom, K. J., Semigran, M. J., Liu, P. & Januzzi, J. L., Nov 1 2016, In : JACC: Heart Failure. 4, 11, p. 860-869 10 p.

Research output: Contribution to journalArticle

Biomarkers
Insulin
Growth
Heart Failure
Proteins
16 Citations (Scopus)
Heart Failure
Dogs
Peptides
Second Messenger Systems
Hemodynamics
21 Citations (Scopus)

Intensification of Medication Therapy for Cardiorenal Syndrome in Acute Decompensated Heart Failure

Grodin, J. L., Stevens, S. R., de las Fuentes, L., Kiernan, M., Birati, E. Y., Gupta, D., Bart, B. A., Felker, G. M., Chen, H. H., Butler, J., Dávila-Román, V. G., Margulies, K. B., Hernandez, A. F., Anstrom, K. J. & Tang, W. H. W., Apr 5 2015, (Accepted/In press) In : Journal of Cardiac Failure.

Research output: Contribution to journalArticle

Cardio-Renal Syndrome
Heart Failure
Kidney
Diuretics
Weight Loss
5 Citations (Scopus)
Odds Ratio
Remission
Interrelationship
Enrollment
Predictors
3 Citations (Scopus)

In vitro evaluation of cenderitide-eluting stent I - An antirestenosis and proendothelization approach

Ng, X. W., Huang, Y., Liu, K. L., Lim, S. G., Chen, H. H., Burnett, J. C. J., Boey, Y. C. F. & Venkatraman, S. S., Sep 15 2014, In : Journal of Pharmaceutical Sciences. 103, 11, p. 3631-3640 10 p.

Research output: Contribution to journalArticle

Stents
Cell Proliferation
Smooth Muscle Myocytes
Drug-Eluting Stents
Human Umbilical Vein Endothelial Cells
2 Citations (Scopus)

In-Vivo Evaluation of an In Situ Polymer Precipitation Delivery System for a Novel Natriuretic Peptide

Lim, S. G., Venkatraman, S. S., Burnett, J. C. J. & Chen, H. H., Feb 18 2013, In : PLoS One. 8, 2, e52484.

Research output: Contribution to journalArticle

natriuretic peptides
guanosine
Natriuretic Peptides
Cyclic GMP
polymers
4 Citations (Scopus)

In vivo Evaluation of Cenderitide-Eluting Stent (CES) II

Huang, Y., Ng, X. W., Lim, S. G., Chen, H. H., Burnett, J. C. J., Boey, Y. C. F. & Venkatraman, S. S., Feb 1 2016, In : Annals of Biomedical Engineering. 44, 2, p. 432-441 10 p.

Research output: Contribution to journalArticle

Stents
Struts
Plasmas
Endothelial cells
Peptides
5 Citations (Scopus)

Is cystatin C an important prognostic marker independent of renal function?

Chen, H. H., Nov 30 2010, In : Journal of the American College of Cardiology. 56, 23, p. 1937-1938 2 p.

Research output: Contribution to journalArticle

Cystatin C
Nutrition Surveys
Kidney Diseases
Survival Analysis
Glomerular Filtration Rate
197 Citations (Scopus)

Isosorbide mononitrate in heart failure with preserved ejection fraction

Redfield, M. M., Anstrom, K. J., Levine, J. A., Koepp, G. A., Borlaug, B. A., Chen, H. H., LeWinter, M. M., Joseph, S. M., Shah, S. J., Semigran, M. J., Felker, G. M., Cole, R. T., Reeves, G. R., Tedford, R. J., Tang, W. H. W., McNulty, S. E., Velazquez, E. J., Shah, M. R. & Braunwald, E., Dec 10 2015, In : New England Journal of Medicine. 373, 24, p. 2314-2324 11 p.

Research output: Contribution to journalArticle

isosorbide-5-mononitrate
Heart Failure
Placebos
Brain Natriuretic Peptide
Quality of Life
1 Citation (Scopus)

Is there still a role for low-dose dopamine use in acute heart failure?

Torres-Courchoud, I. & Chen, H. H., 2014, In : Current Opinion in Critical Care. 20, 5, p. 467-471 5 p.

Research output: Contribution to journalArticle

Dopamine
Heart Failure
Placebos
Kidney
Cystatin C
1 Citation (Scopus)

I’m Still Me: Inspiration and Instruction from Individuals with Brain Cancer

Piderman, K. M., Egginton, J. S., Ingram, C., Dose, A. M., Yoder, T. J., Lovejoy, L. A., Swanson, S. W., Hogg, J. T., Lapid, M. I., Jatoi, A., Remtema, M. S., Tata, B. S. & Radecki Breitkopf, C., Jul 10 2016, (Accepted/In press) In : Journal of Health Care Chaplaincy. p. 1-19 19 p.

Research output: Contribution to journalArticle

Brain Neoplasms
Clergy
brain
cancer
instruction
42 Citations (Scopus)

Lack of activation of molecular forms of the BNP system in human grade 1 hypertension and relationship to cardiac hypertrophy

Belluardo, P., Cataliotti, A., Bonaiuto, L., Giuffré, E., Maugeri, E., Noto, P., Orlando, G., Raspa, G., Piazza, B., Babuin, L., Chen, H. H., Martin, F. L., McKie, P., Heublein, D. M., Burnett, J. C. J. & Malatino, L. S., 2006, In : American Journal of Physiology - Heart and Circulatory Physiology. 291, 4

Research output: Contribution to journalArticle

Cardiomegaly
Hypertension
pro-brain natriuretic peptide (1-76)
Brain Natriuretic Peptide
Left Ventricular Hypertrophy
15 Citations (Scopus)

Leukemia inhibitory factor is augmented in the heart in experimental heart failure

Jougasaki, M., Leskinen, H., Larsen, A. M., Cataliotti, A., Chen, H. H. & Burnett, J. C. J., Mar 2003, In : European Journal of Heart Failure. 5, 2, p. 137-145 9 p.

Research output: Contribution to journalArticle

Leukemia Inhibitory Factor
Heart Failure
Messenger RNA
Heart Atria
Canidae
18 Citations (Scopus)

Local Renal Delivery of a Natriuretic Peptide. A Renal-Enhancing Strategy for B-Type Natriuretic Peptide in Overt Experimental Heart Failure

Chen, H. H., Cataliotti, A., Schirger, J. A., Martin, F. L., Harstad, L. K. & Burnett, J. C. J., Apr 14 2009, In : Journal of the American College of Cardiology. 53, 15, p. 1302-1308 7 p.

Research output: Contribution to journalArticle

Natriuretic Peptides
Brain Natriuretic Peptide
Heart Failure
Kidney
Glomerular Filtration Rate