Cardiovascular Medicine

Research Output 1962 2020

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2018

Usefulness of Heart Rate Control in Atrial Fibrillation Patients With Obstructive Sleep Apnea

Konecny, T., Brady, P. A., Park, J. Y., Reddy, P. K., Ruzek, L., Mach, L., Caples, S. M. & Somers, V., Jan 1 2018, (Accepted/In press) In : American Journal of Cardiology.

Research output: Contribution to journalArticle

Obstructive Sleep Apnea
Atrial Fibrillation
Heart Rate
Ambulatory Electrocardiography
Polysomnography
1 Citation (Scopus)
Thromboembolism
Atrial Fibrillation
Kidney
Mortality
Confidence Intervals
2 Citations (Scopus)

Use of echocardiography in outpatients with chest pain and normal resting electrocardiograms referred to Mayo Clinic Rochester

Gibbons, R. J., Carryer, D., Liu, H. D., Brady, P. A., Askew, J. W., Hodge, D., Ammash, N., Ebbert, J. O. & Roger, V. L., Feb 1 2018, In : American Heart Journal. 196, p. 49-55 7 p.

Research output: Contribution to journalArticle

Chest Pain
Echocardiography
Electrocardiography
Outpatients
Referral and Consultation
4 Citations (Scopus)
Graft Rejection
Stroke Volume
Echocardiography
Transplants
Biopsy
1 Citation (Scopus)

Use of supplemental oxygen in patients with pulmonary arterial hypertension in REVEAL

Farber, H. W., Badesch, D. B., Benza, R. L., Elliott, C. G., Frantz, R., McGoon, M. D., Selej, M., Zhao, C. & Frost, A. E., Jan 1 2018, (Accepted/In press) In : Journal of Heart and Lung Transplantation.

Research output: Contribution to journalArticle

Pulmonary Hypertension
Lung Volume Measurements
Carbon Monoxide
Oxygen
Observational Studies
8 Citations (Scopus)

Using the genome aggregation database, computational pathogenicity prediction tools, and patch clamp heterologous expression studies to demote previously published long QT syndrome type 1 mutations from pathogenic to benign

Clemens, D. J., Lentino, A. R., Kapplinger, J. D., Ye, D., Zhou, W., Tester, D. J. & Ackerman, M. J., Jan 1 2018, (Accepted/In press) In : Heart Rhythm.

Research output: Contribution to journalArticle

Romano-Ward Syndrome
Virulence
Genome
Databases
Mutation
6 Citations (Scopus)

Valve hemodynamic deterioration and cardiovascular outcomes in TAVR: A report from the STS/ACC TVT Registry

Vemulapalli, S., Holmes, D., Dai, D., Matsouaka, R., Mack, M. J., Grover, F. L., Makkar, R. R., Thourani, V. H. & Douglas, P. S., Jan 1 2018, In : American Heart Journal. 195, p. 1-13 13 p.

Research output: Contribution to journalArticle

Registries
Hemodynamics
Aortic Valve
Incidence
Transcatheter Aortic Valve Replacement
22 Citations (Scopus)

Variability in Ejection Fraction Measured By Echocardiography, Gated Single-Photon Emission Computed Tomography, and Cardiac Magnetic Resonance in Patients With Coronary Artery Disease and Left Ventricular Dysfunction

Pellikka, P., She, L., Holly, T. A., Lin, G. D., Varadarajan, P., Pai, R. G., Bonow, R. O., Pohost, G. M., Panza, J. A., Berman, D. S., Prior, D. L., Asch, F. M., Borges-Neto, S., Grayburn, P., Al-Khalidi, H. R., Miszalski-Jamka, K., Desvigne-Nickens, P., Lee, K. L., Velazquez, E. J. & Oh, J. K., Aug 3 2018, In : JAMA network open. 1, 4, p. e181456

Research output: Contribution to journalArticle

Open Access
Left Ventricular Dysfunction
Single-Photon Emission-Computed Tomography
Stroke Volume
Echocardiography
Coronary Artery Disease
8 Citations (Scopus)

Variation in post-TAVR antiplatelet therapy utilization and associated outcomes: Insights from the STS/ACC TVT Registry

Sherwood, M. W., Vemulapalli, S., Harrison, J. K., Dai, D., Vora, A. N., Mack, M. J., Holmes, D., Rumsfeld, J. S., Cohen, D. J., Thourani, V. H., Kirtane, A. & Peterson, E. D., Oct 1 2018, In : American Heart Journal. 204, p. 9-16 8 p.

Research output: Contribution to journalArticle

Registries
Therapeutics
Stroke
Myocardial Infarction
Hemorrhage

Vasopressor magnitude predicts poor outcome in adults with congenital heart disease after cardiac surgery

Poterucha, J. T., Vallabhajosyula, S., Egbe, A., Krien, J. S., Aganga, D. O., Holst, K., Golden, A. W., Dearani, J. A. & Crow, S. S., Jan 1 2018, (Accepted/In press) In : Congenital Heart Disease.

Research output: Contribution to journalArticle

Thoracic Surgery
Heart Diseases
Morbidity
Hospital Mortality
Artificial Respiration
1 Citation (Scopus)

Venous congestion and pulmonary vascular function in Fontan circulation: Implications for prognosis and treatment

Egbe, A., Reddy, Y. N. V., Khan, A. R., Al-Otaibi, M., Akintoye, E., Obokata, M. & Borlaug, B. A., Jan 1 2018, (Accepted/In press) In : International Journal of Cardiology.

Research output: Contribution to journalArticle

Flavin-Adenine Dinucleotide
Hyperemia
Central Venous Pressure
Blood Vessels
Vascular Resistance
2 Citations (Scopus)

Venous Thromboembolism (VTE) Incidence and VTE-Associated Survival among Olmsted County Residents of Local Nursing Homes

Petterson, T. M., Smith, C. Y., Emerson, J. A., Bailey, K. R., Ashrani, A. A., Heit, J. A. & Leibson, C. L., Jul 1 2018, In : Thrombosis and Haemostasis. 118, 7, p. 1316-1328 13 p.

Research output: Contribution to journalArticle

Venous Thromboembolism
Nursing Homes
Survival
Incidence
Internship and Residency
6 Citations (Scopus)

Ventilatory constraints influence physiological dead space in heart failure

Smith, J. R. & Olson, T. P., Jan 1 2018, (Accepted/In press) In : Experimental Physiology.

Research output: Contribution to journalArticle

Heart Failure
Ventilation
Exercise
Tidal Volume
Inspiratory Capacity
4 Citations (Scopus)

Voice Signal Characteristics Are Independently Associated With Coronary Artery Disease

Maor, E., Sara, J. D., Orbelo, D. M., Lerman, L. O., Levanon, Y. & Lerman, A., Jan 1 2018, (Accepted/In press) In : Mayo Clinic Proceedings.

Research output: Contribution to journalArticle

Coronary Artery Disease
Angiography
Cardiovascular Diseases
Logistic Models
Reading
5 Citations (Scopus)

Wearable cardioverter defibrillators for patients with long QT syndrome

Owen, H. J., Bos, J. M. & Ackerman, M. J., Jan 1 2018, (Accepted/In press) In : International Journal of Cardiology.

Research output: Contribution to journalArticle

Long QT Syndrome
Defibrillators
Implantable Defibrillators
Romano-Ward Syndrome
Channelopathies
22 Citations (Scopus)

What to do when you question cardiac troponin values

Mair, J., Lindahl, B., Müller, C., Giannitsis, E., Huber, K., Möckel, M., Plebani, M., Thygesen, K. & Jaffe, A. S., Sep 1 2018, In : European heart journal. Acute cardiovascular care. 7, 6, p. 577-586 10 p.

Research output: Contribution to journalArticle

Troponin
Myocardial Infarction
Troponin T
Troponin I
Myocardial Ischemia
1 Citation (Scopus)
Point-of-Care Systems
Cross-Over Studies
United States National Aeronautics and Space Administration
Workload
Physical Examination
1 Citation (Scopus)
Open Access
Advisory Committees
Echocardiography
Open Access
Advisory Committees
Echocardiography
18 Citations (Scopus)

2019 HRS expert consensus statement on evaluation, risk stratification, and management of arrhythmogenic cardiomyopathy

Towbin, J. A., McKenna, W. J., Abrams, D. J., Ackerman, M. J., Calkins, H., Darrieux, F. C. C., Daubert, J. P., de Chillou, C., DePasquale, E. C., Desai, M. Y., Estes, N. A. M., Hua, W., Indik, J. H., Ingles, J., James, C. A., John, R. M., Judge, D. P., Keegan, R., Krahn, A. D., Link, M. S. & 10 others, Marcus, F. I., McLeod, C. J., Mestroni, L., Priori, S. G., Saffitz, J. E., Sanatani, S., Shimizu, W., van Tintelen, J. P., Wilde, A. A. M. & Zareba, W., Nov 2019, In : Heart rhythm. 16, 11, p. e301-e372

Research output: Contribution to journalArticle

Open Access
Risk Management
Cardiomyopathies
Arrhythmogenic Right Ventricular Dysplasia
Cardiac Arrhythmias
Heart Valve Diseases
8 Citations (Scopus)

2019 HRS expert consensus statement on evaluation, risk stratification, and management of arrhythmogenic cardiomyopathy: Executive summary

Towbin, J. A., McKenna, W. J., Abrams, D. J., Ackerman, M. J., Calkins, H., Darrieux, F. C. C., Daubert, J. P., de Chillou, C., DePasquale, E. C., Desai, M. Y., Estes, N. A. M., Hua, W., Indik, J. H., Ingles, J., James, C. A., John, R. M., Judge, D. P., Keegan, R., Krahn, A. D., Link, M. S. & 10 others, Marcus, F. I., McLeod, C. J., Mestroni, L., Priori, S. G., Saffitz, J. E., Sanatani, S., Shimizu, W., van Tintelen, J. P., Wilde, A. A. M. & Zareba, W., Nov 2019, In : Heart rhythm. 16, 11, p. e373-e407

Research output: Contribution to journalArticle

Open Access
Risk Management
Cardiomyopathies
Arrhythmogenic Right Ventricular Dysplasia
Cardiac Arrhythmias
Heart Valve Diseases
10 Citations (Scopus)

Ablation of adipocyte creatine transport impairs thermogenesis and causes diet-induced obesity

Kazak, L., Rahbani, J. F., Samborska, B., Lu, G. Z., Jedrychowski, M. P., Lajoie, M., Zhang, S., Ramsay, L. A., Dou, F. Y., Tenen, D., Chouchani, E. T., Dzeja, P., Watson, I. R., Tsai, L., Rosen, E. D. & Spiegelman, B. M., Mar 1 2019, In : Nature Metabolism. 1, 3, p. 360-370 11 p.

Research output: Contribution to journalArticle

Open Access
Creatine
Thermogenesis
Adipocytes
Obesity
Diet

Abnormal Pulmonary Arterial Elastance Is Associated With Reduced Exercise Capacity in Tetralogy of Fallot

Egbe, A., Anavekar, N. S. & Connolly, H. M., Jun 18 2019, In : Journal of the American Heart Association. 8, 12, p. e011731

Research output: Contribution to journalArticle

Open Access
Tetralogy of Fallot
Pulmonary Artery
Exercise
Lung
Blood Vessels

A comparison of finger and forehead pulse oximeters in heart failure patients during maximal exercise

Kelly, K. L., Carlson, A. R., Allison, T. G. & Johnson, B. D., Jan 1 2019, (Accepted/In press) In : Heart and Lung.

Research output: Contribution to journalArticle

Forehead
Fingers
Pulse
Heart Failure
Exercise

Active clearance of chest tubes is associated with reduced postoperative complications and costs after cardiac surgery: A propensity matched analysis

Baribeau, Y., Westbrook, B., Baribeau, Y., Maltais, S., Boyle, E. M. & Perrault, L. P., Nov 8 2019, In : Journal of Cardiothoracic Surgery. 14, 1, 192.

Research output: Contribution to journalArticle

Open Access
Chest Tubes
Thoracic Surgery
Costs and Cost Analysis
Pleural Effusion
Atrial Fibrillation

Active compression garment prevents tilt-induced orthostatic tachycardia in humans

Kelly, K. L., Johnson, C. P., Dunne, L. E., Holschuh, B., Joyner, M. J. & Johnson, B. D., Apr 1 2019, In : Physiological reports. 7, 7, e14050.

Research output: Contribution to journalArticle

Open Access
Clothing
Tachycardia
Arterial Pressure
Heart Rate
Orthostatic Intolerance
17 Citations (Scopus)

Acute Noncardiac Organ Failure in Acute Myocardial Infarction With Cardiogenic Shock

Vallabhajosyula, S., Dunlay, S. M., Prasad, A., Kashani, K., Sakhuja, A., Gersh, B. J., Jaffe, A. S., Holmes, D. & Barsness, G. W., Apr 16 2019, In : Journal of the American College of Cardiology. 73, 14, p. 1781-1791 11 p.

Research output: Contribution to journalArticle

Cardiogenic Shock
Hospital Mortality
Myocardial Infarction
Odds Ratio
Confidence Intervals

Acute renal failure due to bilateral renal vein thromboses: A rare complication of heparin-induced thrombocytopenia

Klompas, A., Albright, R., Maltais, S. & Demirci, O., Apr 1 2019, In : Annals of cardiac anaesthesia. 22, 2, p. 204-206 3 p.

Research output: Contribution to journalArticle

Open Access
Renal Veins
Acute Kidney Injury
Thrombocytopenia
Heparin
Thrombosis
3 Citations (Scopus)

Acute respiratory failure and mechanical ventilation in cardiogenic shock complicating acute myocardial infarction in the USA, 2000–2014

Vallabhajosyula, S., Kashani, K., Dunlay, S. M., Vallabhajosyula, S., Vallabhajosyula, S., Sundaragiri, P. R., Gersh, B. J., Jaffe, A. S. & Barsness, G. W., Dec 1 2019, In : Annals of Intensive Care. 9, 1, 96.

Research output: Contribution to journalArticle

Open Access
Cardiogenic Shock
Artificial Respiration
Respiratory Insufficiency
Myocardial Infarction
Hospital Mortality

Added value of exercise test findings beyond traditional risk factors for cardiovascular risk stratification

Bonikowske, A. R., Lopez-Jimenez, F., Barillas-Lara, M. I., Barout, A., Fortin-Gamero, S., Sydo, N. & Allison, T. G., Jan 1 2019, In : International Journal of Cardiology.

Research output: Contribution to journalArticle

Exercise Test
Exercise
Mortality
Cardiovascular Abnormalities
Cardiovascular Diseases
1 Citation (Scopus)

Addressing cardiovascular health disparities in minnesota: Establishment of a community steering committee by FAITH! (fostering african-american improvement in total health)

Manjunath, C., Ifelayo, O., Jones, C., Washington, M., Shanedling, S., Williams, J., Patten, C. A., Cooper, L. A. & Brewer, L. C., Nov 2019, In : International journal of environmental research and public health. 16, 21, 4144.

Research output: Contribution to journalArticle

Open Access
Foster Home Care
African Americans
Community-Based Participatory Research
Health
Constitution and Bylaws
1 Citation (Scopus)

Admission Braden Skin Score Independently Predicts Mortality in Cardiac Intensive Care Patients

Jentzer, J. C., Anavekar, N. S., Brenes-Salazar, J. A., Wiley, B., Murphree, D. H., Bennett, C., Murphy, J. G., Keegan, M. T. & Barsness, G. W., Oct 1 2019, In : Mayo Clinic proceedings. 94, 10, p. 1994-2003 10 p.

Research output: Contribution to journalArticle

Open Access
Critical Care
Hospital Mortality
Skin
Mortality
Intensive Care Units
1 Citation (Scopus)

Adverse Renal Response to Decongestion in the Obese Phenotype of Heart Failure With Preserved Ejection Fraction

Reddy, Y. N. V., Obokata, M., Testani, J. M., Felker, G. M., Tang, W. H. W., Abou-Ezzeddine, O. F., Sun, J. L., Chakrabothy, H., McNulty, S., Shah, S. J., Lewis, G. D., Stevenson, L. W., Redfield, M. M. & Borlaug, B. A., Jan 1 2019, (Accepted/In press) In : Journal of Cardiac Failure.

Research output: Contribution to journalArticle

Heart Failure
Phenotype
Kidney
Ventricular Remodeling
Plasma Volume
3 Citations (Scopus)

Age and Sex Estimation Using Artificial Intelligence From Standard 12-Lead ECGs

Attia, Z. I., Friedman, P. A., Noseworthy, P., Lopez-Jimenez, F., Ladewig, D. J., Satam, G., Pellikka, P., Munger, T. M., Asirvatham, S. J., Scott, C. G., Carter, R. E. & Kapa, S., Sep 1 2019, In : Circulation. Arrhythmia and electrophysiology. 12, 9, p. e007284

Research output: Contribution to journalArticle

Open Access
Artificial Intelligence
Electrocardiography
Aptitude
Health
Lead

Age-Related Differences in the Noninvasive Evaluation for Possible Coronary Artery Disease: Insights from the Prospective Multicenter Imaging Study for Evaluation of Chest Pain (PROMISE) Trial

Lowenstern, A., Alexander, K. P., Hill, C. L., Alhanti, B., Pellikka, P. A., Nanna, M. G., Mehta, R. H., Cooper, L. S., Bullock-Palmer, R. P., Hoffmann, U. & Douglas, P. S., Jan 1 2019, (Accepted/In press) In : JAMA cardiology.

Research output: Contribution to journalArticle

Chest Pain
Multicenter Studies
Coronary Artery Disease
Myocardial Infarction
Coronary Vessels
1 Citation (Scopus)

A hybrid technique for treatment of commissural primary mitral regurgitation

Raphael, C. E., Malouf, J. F., Maor, E., Panaich, S. S., Pollak, P. M., Reeder, G. S., Rihal, C. & Eleid, M., Mar 1 2019, In : Catheterization and Cardiovascular Interventions. 93, 4, p. 692-698 7 p.

Research output: Contribution to journalArticle

Mitral Valve Insufficiency
Therapeutics
Blood Vessels
Hemolysis
Surgical Instruments

Alcohol septal ablation in patients with concomitant hypertrophic cardiomyopathy and aortic valvular stenosis

El-Sabawi, B., Nishimura, R. A., Guerrero, M., Rihal, C. & Eleid, M., Jan 1 2019, (Accepted/In press) In : Catheterization and Cardiovascular Interventions.

Research output: Contribution to journalArticle

Hypertrophic Cardiomyopathy
Aortic Valve Stenosis
Alcohols
Ventricular Outflow Obstruction
Hemodynamics
5 Citations (Scopus)

Alcohol Septal Ablation to Prevent Left Ventricular Outflow Tract Obstruction During Transcatheter Mitral Valve Replacement: First-in-Man Study

Wang, D. D., Guerrero, M., Eng, M. H., Eleid, M., Meduri, C. U., Rajagopal, V., Yadav, P. K., Fifer, M. A., Palacios, I. F., Rihal, C., Feldman, T. E. & O'Neill, W. W., Jul 8 2019, In : JACC: Cardiovascular Interventions. 12, 13, p. 1268-1279 12 p.

Research output: Contribution to journalArticle

Ventricular Outflow Obstruction
Mitral Valve
Alcohols
Mortality
Lacerations

Alterations in genetic and protein content of swine adipose tissue-derived mesenchymal stem cells in the metabolic syndrome

Pawar, A. S., Eirin, A., Krier, J. D., Woollard, J. R., Zhu, X. Y., Lerman, A., van Wijnen, A. J. & Lerman, L. O., May 1 2019, In : Stem Cell Research. 37, 101423.

Research output: Contribution to journalArticle

Open Access
Mesenchymal Stromal Cells
Adipose Tissue
Swine
MicroRNAs
Messenger RNA

Amyloidosis in surgically resected atrial appendages: a study of 345 consecutive cases with clinical implications

Fayyaz, A. U., Bois, M. C., Dasari, S., Padmanabhan, D., Vrana, J. A., Stulak, J. M., Edwards, W. D., Kurtin, P. J., Asirvatham, S. J., Grogan, M. & Maleszewski, J. J., Jan 1 2019, (Accepted/In press) In : Modern Pathology.

Research output: Contribution to journalArticle

Atrial Appendage
Amyloidosis
Amyloid
Cardiac Arrhythmias
Laser Capture Microdissection

Analysis of Temporal Trends and Variation in the Use of Defibrillation Testing in Contemporary Practice

Borne, R. T., Randolph, T., Wang, Y., Curtis, J. P., Peterson, P. N., Masoudi, F. A., Sandhu, A., Zipse, M. M., Thomas, K., Kutyifa, V., Desai, N. R., Cha, Y. M., Hsu, J. C. & Russo, A. M., Oct 2 2019, In : JAMA Network Open. 2, 10, p. e1913553

Research output: Contribution to journalArticle

Open Access
Implantable Defibrillators
Registries
Odds Ratio
Institutional Practice
Ventricular Tachycardia
12 Citations (Scopus)
Artificial Intelligence
Atrial Fibrillation
Electrocardiography
Area Under Curve
Point-of-Care Systems
52 Citations (Scopus)

Angiotensin–neprilysin inhibition in heart failure with preserved ejection fraction

Solomon, S. D., McMurray, J. J. V., Anand, I. S., Ge, J., Lam, C. S. P., Maggioni, A. P., Martinez, F., Packer, M., Pfeffer, M. A., Pieske, B., Redfield, M. M., Rouleau, J. L., Van Veldhuisen, D. J., Zannad, F., Zile, M. R., Desai, A. S., Claggett, B., Jhund, P. S., Boytsov, S. A., Comin-Colet, J. & 14 others, Cleland, J., Düngen, H. D., Goncalvesova, E., Katova, T., Kerr Saraiva, J. F., Lelonek, M., Merkely, B., Senni, M., Shah, S. J., Zhou, J., Rizkala, A. R., Gong, J., Shi, V. C. & Lefkowitz, M. P., Oct 24 2019, In : New England Journal of Medicine. 381, 17, p. 1609-1620 12 p.

Research output: Contribution to journalArticle

Valsartan
Heart Failure
Confidence Intervals
Cause of Death
Hospitalization

A novel, highly discriminatory risk model predicting acute severe right ventricular failure in patients undergoing continuous-flow left ventricular assist device implant

Tchantchaleishvili, V., Maltais, S., Sharma, S., Haglund, N. A., Davis, M. E., Cowger, J., Shah, P., Desai, S. S., Aaronson, K. D., Pagani, F. D., Dunlay, S. M. & Stulak, J. M., Jan 1 2019, (Accepted/In press) In : Artificial Organs.

Research output: Contribution to journalArticle

Left ventricular assist devices
Heart-Assist Devices
Area Under Curve
Blood Urea Nitrogen
Registries

A novel percutaneous stabilizing sheath for minimal invasive epicardial echocardiography and ablation

Sugrue, A., Vaidya, V. R., Padmanabhan, D., Yasin, O., Abudan, A., Isath, A., Killu, A. M., Naksuk, N., Bolon, B., Friedman, P. A. & Asirvatham, S. J., Jan 1 2019, In : Journal of Interventional Cardiac Electrophysiology.

Research output: Contribution to journalArticle

Echocardiography
Coronary Vessels
Cardiac Catheters
Canidae
Epicardial Mapping
1 Citation (Scopus)
Filamins
Mitral Valve Prolapse
Mothers
Exome
Ambulatory Monitoring
Atrial Appendage
Mitral Valve
Atrial Fibrillation
Equipment and Supplies
Population

Aortopathy and regurgitation in bicuspid valve patients increase the risk of aortopathy in relatives

Bicuspid Aortic Valve Consortium – BAVCON, Jul 1 2019, In : International Journal of Cardiology. 286, p. 117-120 4 p.

Research output: Contribution to journalArticle

Mitral Valve
Tricuspid Valve
Aortic Valve
Aortic Valve Insufficiency
Bicuspid Aortic Valve
1 Citation (Scopus)

A phenome-wide association study to discover pleiotropic effects of PCSK9, APOB, and LDLR

Safarova, M. S., Satterfield, B. A., Fan, X., Austin, E. E., Ye, Z., Bastarache, L., Zheng, N., Ritchie, M. D., Borthwick, K. M., Williams, M. S., Larson, E. B., Scrol, A., Jarvik, G. P., Crosslin, D. R., Leppig, K., Rasmussen-Torvik, L. J., Pendergrass, S. A., Sturm, A. C., Namjou, B., Shah, A. S. & 12 others, Carroll, R. J., Chung, W. K., Wei, W. Q., Feng, Q. P., Stein, C. M., Roden, D. M., Manolio, T. A., Schaid, D. J., Denny, J. C., Hebbring, S. J., De Andrade, M. & Kullo, I. J., Dec 1 2019, In : npj Genomic Medicine. 4, 1, 3.

Research output: Contribution to journalArticle

Open Access
Electronic Health Records
Precision Medicine
Genetic Models
Myopia
Linkage Disequilibrium