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2020

Chromosome 3q26 Gain Is an Early Event Driving Coordinated Overexpression of the PRKCI, SOX2, and ECT2 Oncogenes in Lung Squamous Cell Carcinoma

Liu, Y., Yin, N., Wang, X., Khoor, A., Sambandam, V., Ghosh, A. B., Fields, Z. A., Murray, N. R., Justilien, V. & Fields, A. P., Jan 21 2020, In : Cell reports. 30, 3, p. 771-782.e6

Research output: Contribution to journalArticle

Open Access

Controlled drug release from polyelectrolyte-drug conjugate nanoparticles

Catarata, R., Azim, N., Bhattacharya, S. & Zhai, L., Apr 14 2020, In : Journal of Materials Chemistry B. 8, 14, p. 2887-2894 8 p.

Research output: Contribution to journalArticle

Defining the human kidney N-glycome in normal and cancer tissues using MALDI imaging mass spectrometry

Drake, R. R., McDowell, C., West, C., David, F., Powers, T. W., Nowling, T., Bruner, E., Mehta, A. S., Angel, P. M., Marlow, L. A., Tun, H. W. & Copland, J. A., Apr 1 2020, In : Journal of Mass Spectrometry. 55, 4, e4490.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Folate receptor alpha expression associates with improved disease-free survival in triple negative breast cancer patients

Norton, N., Youssef, B., Hillman, D. W., Nassar, A., Geiger, X. J., Necela, B. M., Liu, H., Ruddy, K. J., Polley, M. Y. C., Ingle, J. N., Couch, F. J., Perez, E. A., Liu, M. C., Carter, J. M., Leon-Ferre, R. A., Boughey, J. C., Somers, E. B., Kalari, K. R., Visscher, D. W., Goetz, M. P. & 1 others, Knutson, K. L., Dec 1 2020, In : npj Breast Cancer. 6, 1, 4.

Research output: Contribution to journalArticle

Open Access

Impact of Depression and Anxiety on Opioid Use in Hospitalized Hematopoietic Cell Transplantation Recipients

Iqbal, M., Spaulding, A., Niazi, S., Wood, C., Ahmed, S., Jani, P., Kharfan-Dabaja, M. A., Ayala, E., Manochakian, R., Ames, S., Paulus, A., Ailawadhi, S., Roy, V., Chanan-Khan, A. & Sher, T., Jan 1 2020, (Accepted/In press) In : Psychosomatics.

Research output: Contribution to journalArticle

Integration of Comprehensive Genomic Analysis and Functional Screening of Affected Molecular Pathways to Inform Cancer Therapy

Vasmatzis, G., Liu, M. C., Reganti, S., Feathers, R. W., Smadbeck, J., Johnson, S. H., Schaefer Klein, J. L., Harris, F. R., Yang, L., Kosari, F., Murphy, S. J., Borad, M. J., Thompson, E. A., Cheville, J. C. & Anastasiadis, P. Z., Feb 2020, In : Mayo Clinic proceedings. 95, 2, p. 306-318 13 p.

Research output: Contribution to journalArticle

Open Access

Molecular inhibitor of QSOX1 suppresses tumor growth in vivo

Fifield, A. L., Hanavan, P. D., Faigel, D. O., Sergienko, E., Bobkov, A., Meurice, N., Petit, J. L., Polito, A., Caulfield, T. R., Castle, E. P., Copland, J. A., Mukhopadhyay, D., Pal, K., Dutta, S. K., Luo, H., Ho, T. H. & Lake, D. F., Jan 1 2020, In : Molecular cancer therapeutics. 19, 1, p. 112-122 11 p.

Research output: Contribution to journalArticle

Rapid Generation of Sustainable HER2-specific T-cell Immunity in Patients with HER2 Breast Cancer using a Degenerate HLA Class II Epitope Vaccine

Knutson, K. L., Block, M. S., Norton, N., Erskine, C. L., Hobday, T. J., Dietz, A. B., Padley, D., Gustafson, M. P., Puglisi-Knutson, D., Mangskau, T. K., Chumsri, S., Dueck, A. C., Karyampudi, L., Wilson, G. & Degnim, A. C., Mar 1 2020, In : Clinical Cancer Research. 26, 5, p. 1045-1053 9 p.

Research output: Contribution to journalArticle

Retinoid X receptor alpha is a spatiotemporally predominant therapeutic target for anthracycline-induced cardiotoxicity

Ma, X., Zhu, P., Ding, Y., Zhang, H., Qiu, Q., Dvornikov, A. V., Wang, Z., Kim, M., Wang, Y., Lowerison, M., Yu, Y., Norton, N., Herrmann, J., Ekker, S. C., Hsiai, T. K., Lin, X. & Xu, X., Jan 29 2020, In : Science Advances. 6, 5, eaay2939.

Research output: Contribution to journalArticle

Open Access

Timeliness of initial therapy in multiple myeloma: Trends and factors affecting patient care

Kumar, V., Alhaj-Moustafa, M., Bojanini, L., Sher, T., Roy, V., Manochakian, R., Vishnu, P., Bodepudi, S., Shareef, Z., Ahmed, S., Jani, P., Paulus, A., Grover, A., Alegria, V. R., Ailawadhi, M., Chanan-Khan, A. & Ailawadhi, S., Apr 1 2020, In : Journal of oncology practice. 16, 4, p. E341-E349

Research output: Contribution to journalArticle

Transgenic Expression of PRSS1R122H Sensitizes Mice to Pancreatitis

Huang, H., Swidnicka-Siergiejko, A. K., Daniluk, J., Gaiser, S., Yao, Y., Peng, L., Zhang, Y., Liu, Y., Dong, M., Zhan, X., Wang, H., Bi, Y., Li, Z., Ji, B. & Logsdon, C. D., Mar 2020, In : Gastroenterology. 158, 4, p. 1072-1082.e7

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Trypsin activity governs increased susceptibility to pancreatitis in mice expressing human PRSS1R122H

Gui, F., Zhang, Y., Wan, J., Zhan, X., Yao, Y., Li, Y., Haddock, A. N., Shi, J., Guo, J., Chen, J., Zhu, X., Edenfield, B. H., Zhuang, L., Hu, C., Wang, Y., Mukhopadhyay, D., Radisky, E. S., Zhang, L., Lugea, A., Pandol, S. J. & 2 others, Bi, Y. & Ji, B., Jan 2 2020, In : Journal of Clinical Investigation. 130, 1, p. 189-202 14 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
2019

3D porous chitosan-alginate scaffold stiffness promotes differential responses in prostate cancer cell lines

Xu, K., Ganapathy, K., Andl, T., Wang, Z., Copland, J. A. III., Chakrabarti, R. & Florczyk, S. J., Oct 1 2019, In : Biomaterials. 217, 119311.

Research output: Contribution to journalArticle

10 Scopus citations

Aberrant lipid metabolism as a therapeutic target in liver cancer

Pope, E. D., Kimbrough, E. O., Vemireddy, L. P., Surapaneni, P. K., Copland, J. A. III. & Mody, K., Jun 3 2019, In : Expert opinion on therapeutic targets. 23, 6, p. 473-483 11 p.

Research output: Contribution to journalArticle

5 Scopus citations

AFM study: Cell cycle and probe geometry influences nanomechanical characterization of Panc1 cells

Kulkarni, T., Tam, A., Mukhopadhyay, D. & Bhattacharya, S., May 1 2019, In : Biochimica et Biophysica Acta - General Subjects. 1863, 5, p. 802-812 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

A phase 1 and randomized, placebo-controlled phase 2 trial of bevacizumab plus dasatinib in patients with recurrent glioblastoma: Alliance/North Central Cancer Treatment Group N0872

Galanis, E., Anderson, S. K., Twohy, E. L., Carrero, X. W., Dixon, J. G., Tran, D. D., Jeyapalan, S. A., Anderson, D. M., Kaufmann, T. J., Feathers, R. W., Giannini, C., Buckner, J. C., Anastasiadis, P. Z. & Schiff, D., Jan 1 2019, In : Cancer.

Research output: Contribution to journalArticle

2 Scopus citations

Bioinformatics and DNA-extraction strategies to reliably detect genetic variants from FFPE breast tissue samples

Bhagwate, A. V., Liu, Y., Winham, S. J., McDonough, S. J., Stallings-Mann, M. L., Heinzen, E. P., Davila, J. I., Vierkant, R. A., Hoskin, T. L., Frost, M., Carter, J., Radisky, D. C., Cunningham, J. M., Degnim, A. C. & Wang, C., Sep 2 2019, In : BMC genomics. 20, 1, 689.

Research output: Contribution to journalArticle

Open Access

Comprehensive genetic characterization of human thyroid cancer cell lines: A validated panel for preclinical studies

Landa, I., Pozdeyev, N., Korch, C., Marlow, L. A., Smallridge, R. C., Copland, J. A. III., Henderson, Y. C., Lai, S. Y., Clayman, G. L., Onoda, N., Tan, A. C., Garcia-Rendueles, M. E. R., Knauf, J. A., Haugen, B. R., Fagin, J. A. & Schweppe, R. E., Jan 1 2019, In : Clinical Cancer Research. 25, 10, p. 3141-3151 11 p.

Research output: Contribution to journalArticle

13 Scopus citations

Directed evolution of the metalloproteinase inhibitor TIMP-1 reveals that its N- and C-terminal domains cooperate in matrix metalloproteinase recognition

Raeeszadeh-Sarmazdeh, M., Greene, K. A., Sankaran, B., Downey, G. P., Radisky, D. C. & Radisky, E. S., Jan 1 2019, In : Journal of Biological Chemistry. 294, 24, p. 9476-9488 13 p.

Research output: Contribution to journalArticle

Disulfide engineering of human Kunitz-type serine protease inhibitors enhances proteolytic stability and target affinity toward mesotrypsin

Cohen, I., Coban, M., Shahar, A., Sankaran, B., Hockla, A., Lacham, S., Caulfield, T. R., Radisky, E. S. & Papo, N., Mar 29 2019, In : Journal of Biological Chemistry. 294, 13, p. 5105-5120 16 p.

Research output: Contribution to journalArticle

5 Scopus citations

DNA-SWCNT biosensors allow real-time monitoring of therapeutic responses in pancreatic ductal adenocarcinoma

Bhattacharya, S., Gong, X., Wang, E., Dutta, S. K., Caplette, J. R., Son, M., Nguyen, F. T., Strano, M. S. & Mukhopadhyay, D., Sep 1 2019, In : Cancer research. 79, 17, p. 4515-4523 9 p.

Research output: Contribution to journalArticle

Effects of age and immune landscape on outcome in HER2-positive breast cancer in the NCCTG N9831 (Alliance) and NSABP B-31 (NRG) trials

Chumsri, S., Serie, D. J., Li, Z., Pogue-Geile, K. L., Soyano-Muller, A. E., Mashadi-Hossein, A., Warren, S., Lou, Y., Colon-Otero, G., Knutson, K. L., Perez, E. A., Moreno Aspitia, A. & Thompson, E. A., Jan 1 2019, In : Clinical Cancer Research. 25, 14, p. 4422-4430 9 p.

Research output: Contribution to journalArticle

Elevated intracellular trypsin exacerbates acute pancreatitis and chronic pancreatitis in mice

Zhan, X., Wan, J., Zhang, G., Song, L., Gui, F., Zhang, Y., Li, Y., Guo, J., Dawra, R. K., Saluja, A. K., Haddock, A. N., Zhang, L., Bi, Y. & Ji, B. D., Jun 1 2019, In : American journal of physiology. Gastrointestinal and liver physiology. 316, 6, p. G816-G825

Research output: Contribution to journalArticle

4 Scopus citations

Hyaline fibrous involution of breast lobules: a histologic finding associated with germline BRCA mutation

Lee, H. E., Arshad, M., Brahmbhatt, R. D., Hoskin, T. L., Winham, S. J., Frost, M. H., Radisky, D. C., Denison, L. A., Degnim, A. C. & Visscher, D. W., Jan 1 2019, In : Modern Pathology.

Research output: Contribution to journalArticle

1 Scopus citations

Impact of Epithelial-Stromal Interactions on Peritumoral Fibroblasts in Ductal Carcinoma in Situ

Strell, C., Paulsson, J., Jin, S. B., Tobin, N. P., Mezheyeuski, A., Roswall, P., Mutgan, C., Mitsios, N., Johansson, H., Wickberg, S. M., Svedlund, J., Nilsson, M., Hall, P., Mulder, J., Radisky, D. C., Pietras, K., Bergh, J., Lendahl, U., Wärnberg, F. & Östman, A., Sep 1 2019, In : Journal of the National Cancer Institute. 111, 9, p. 983-995 13 p.

Research output: Contribution to journalArticle

8 Scopus citations

Incidence of late relapses in patients with HER2-positive breast cancer receiving adjuvant trastuzumab: Combined analysis of NCCTG N9831 (Alliance) and NRG oncology/NSABP B-31

Chumsri, S., Li, Z., Serie, D. J., Mashadi-Hossein, A., Colon-Otero, G., Song, N., Pogue-Geile, K. L., Gavin, P. G., Paik, S., Moreno-Aspitia, A., Perez, E. A. & Aubrey Thompson, E., Jan 1 2019, In : Journal of Clinical Oncology. 37, 35, p. 3425-3435 11 p.

Research output: Contribution to journalArticle

Inhibition of miR-155 reduces impaired autophagy and improves prognosis in an experimental pancreatitis mouse model

Wan, J., Yang, X., Ren, Y., Li, X., Zhu, Y., Haddock, A. N., Ji, B., Xia, L. & Lu, N., Apr 1 2019, In : Cell Death and Disease. 10, 4, 303.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Mimicking and Manipulating Pancreatic Acinar-to-Ductal Metaplasia in 3-dimensional Cell Culture

Fleming Martinez, A. K. & Storz, P., Feb 11 2019, In : Journal of visualized experiments : JoVE. 144

Research output: Contribution to journalArticle

1 Scopus citations

Monoclonal antibody utilization characteristics in patients with multiple myeloma

Ailawadhi, S., Sher, T., Azzouqa, A. G., Meghji, Z., Jain, T., Jani, P., Ahmed, S., Diehl, N., Roy, V., Shah, V., Hodge, D., Ailawadhi, M., Alegria, V. R., Paulus, A., Chanan Khan, A. A. & Fonseca, R., Sep 1 2019, In : Anti-cancer drugs. 30, 8, p. 859-865 7 p.

Research output: Contribution to journalArticle

Mucin-1 is required for Coxsackie Virus B3-induced inflammation in pancreatitis

Liu, X., Clemens, D. L., Grunkemeyer, J. A., Price, J. D., O’Connell, K., Chapman, N. M., Storz, P., Wen, H., Cox, J. L., Reid, W. L., Hollingsworth, M. A. & Thayer, S., Dec 1 2019, In : Scientific reports. 9, 1, 10656.

Research output: Contribution to journalArticle

Open Access

Nanomechanical insights: Amyloid beta oligomer-induced senescent brain endothelial cells

Kulkarni, T., Angom, R. S., Das, P., Bhattacharya, S. & Mukhopadhyay, D., Dec 1 2019, In : Biochimica et Biophysica Acta - Biomembranes. 1861, 12, 183061.

Research output: Contribution to journalArticle

1 Scopus citations
4 Scopus citations

Novel pathogenic PRSS1 variant p.Glu190Lys in a case of chronic pancreatitis

Jancsó, Z., Oracz, G., Kujko, A. A., Kolodziejczyk, E., Radisky, E. S., Rygiel, A. M. & Sahin-Tóth, M., Jan 1 2019, In : Frontiers in Genetics. 10, FEB, 46.

Research output: Contribution to journalArticle

Open Access
Open Access

Oncogenic Ect2 signaling regulates rRNA synthesis in NSCLC

Justilien, V., Lewis, K. C., Murray, N. R. & Fields, A. P., Sep 3 2019, In : Small GTPases. 10, 5, p. 388-394 7 p.

Research output: Contribution to journalArticle

3 Scopus citations

Oncogenic KRAS Reduces Expression of FGF21 in Acinar Cells to Promote Pancreatic Tumorigenesis in Mice on a High-Fat Diet

Luo, Y., Yang, Y., Liu, M., Wang, D., Wang, F., Bi, Y., Ji, J., Li, S., Liu, Y., Chen, R., Huang, H., Wang, X., Swidnicka-Siergiejko, A. K., Janowitz, T., Beyaz, S., Wang, G., Xu, S., Bialkowska, A. B., Luo, C. K., Pin, C. L. & 14 others, Liang, G., Lu, X., Wu, M., Shroyer, K. R., Wolff, R. A., Plunkett, W., Ji, B., Li, Z., Li, E., Li, X., Yang, V. W., Logsdon, C. D., Abbruzzese, J. L. & Lu, W., Nov 2019, In : Gastroenterology. 157, 5, p. 1413-1428.e11

Research output: Contribution to journalArticle

3 Scopus citations

Pomalidomide alters pancreatic macrophage populations to generate an immune-responsive environment at precancerous and cancerous lesions

Bastea, L. I., Liou, G. Y., Pandey, V., Fleming, A. K., Von Roemeling, C. A., Doeppler, H., Li, Z., Qiu, Y., Edenfield, B., Copland, J. A., Tun, H. W. & Storz, P., Apr 1 2019, In : Cancer research. 79, 7, p. 1535-1548 14 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Protein Kinase Cι and Wnt/β-Catenin Signaling: Alternative Pathways to Kras/Trp53-Driven Lung Adenocarcinoma

Yin, N., Liu, Y., Khoor, A., Wang, X., Thompson, E. A., Leitges, M., Justilien, V., Weems, C., Murray, N. R. & Fields, A. P., Aug 12 2019, In : Cancer cell. 36, 2, p. 156-167.e7

Research output: Contribution to journalArticle

3 Scopus citations

Protein kinase D up-regulates transcription of VEGF receptor-2 in endothelial cells by suppressing nuclear localization of the transcription factor AP2β

Wang, Y., Hoeppner, L. H., Angom, R. S., Wang, E., Dutta, S., Doeppler, H. R., Wang, F., Shen, T., Scarisbrick, I. A., Guha, S., Storz, P., Bhattacharya, R. & Mukhopadhyay, D., Oct 25 2019, In : Journal of Biological Chemistry. 294, 43, p. 15759-15767 9 p.

Research output: Contribution to journalArticle

PRSS3/Mesotrypsin and kallikrein-related peptidase 5 are associated with poor prognosis and contribute to tumor cell invasion and growth in lung adenocarcinoma

Ma, H., Hockla, A., Mehner, C., Coban, M., Papo, N., Radisky, D. C. & Radisky, E. S., Dec 1 2019, In : Scientific reports. 9, 1, 1844.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Sangivamycin and its derivatives inhibit Haspin-Histone H3-survivin signaling and induce pancreatic cancer cell death

Bastea, L. I., Hollant, L. M. A., Döppler, H. R., Reid, E. M. & Storz, P., Dec 1 2019, In : Scientific reports. 9, 1, 16588.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Sexual dimorphism in the incidence of human cancers

Zheng, D., Trynda, J., Williams, C., Vold, J. A., Nguyen, J. H., Harnois, D. M., Bagaria, S. P., McLaughlin, S. A. & Li, Z., Jul 12 2019, In : BMC cancer. 19, 1, 684.

Research output: Contribution to journalArticle

Open Access

Survival trends in glioblastoma and association with treating facility volume

Aulakh, S., DeDeo, M. R., Free, J., Rosenfeld, S., Quinones-Hinojosa, A., Paulus, A., Manna, A., Manochakian, R., Chanan Khan, A. A. & Ailawadhi, S., Jan 1 2019, In : Journal of Clinical Neuroscience.

Research output: Contribution to journalArticle

3 Scopus citations

Survival Trends in Young Patients With Multiple Myeloma: A Focus on Racial-Ethnic Minorities

Ailawadhi, S., Azzouqa, A. G., Hodge, D., Cochuyt, J., Jani, P., Ahmed, S., Sher, T., Roy, V., Ailawadhi, M., Alegria, V. R., Manochakian, R., Vishnu, P., Grover, A., Abdulazeez, M. F., Paulus, A. & Chanan Khan, A. A., Jan 1 2019, (Accepted/In press) In : Clinical Lymphoma, Myeloma and Leukemia.

Research output: Contribution to journalArticle

Targeting CD38 enhances the antileukemic activity of ibrutinib in chronic lymphocytic leukemia

Manna, A., Aulakh, S., Jani, P., Ahmed, S., Akhtar, S., Coignet, M., Heckman, M., Meghji, Z., Bhatia, K., Sharma, A., Sher, T., Alegria, V., Malavasi, F., Chini, E. N., Chanan-Khan, A., Ailawadhi, S. & Paulus, A., Jan 1 2019, In : Clinical Cancer Research. 25, 13, p. 3974-3985 12 p.

Research output: Contribution to journalArticle

2 Scopus citations

Targeting the tumor microenvironment in pancreatic ductal adenocarcinoma

Pandey, V. & Storz, P., Jun 1 2019, In : Expert review of anticancer therapy. 19, 6, p. 473-482 10 p.

Research output: Contribution to journalArticle

2 Scopus citations

Transgenic expression of cyclooxygenase-2 in pancreatic acinar cells induces chronic pancreatitis

Huang, H., Chen, J., Peng, L., Yao, Y., Deng, D., Zhang, Y., Liu, Y., Wang, H., Li, Z., Bi, Y., Haddock, A. N., Zhan, X., Lu, W., Logsdon, C. D. & Ji, B. D., Jan 1 2019, In : American journal of physiology. Gastrointestinal and liver physiology. 316, 1, p. G179-G186

Research output: Contribution to journalArticle

Trends in the risk of second primary malignancies among survivors of chronic lymphocytic leukemia

Kumar, V., Ailawadhi, S., Bojanini, L., Mehta, A., Biswas, S., Sher, T., Roy, V., Vishnu, P., Marin-Acevedo, J., Alegria, V. R., Paulus, A., Aulakh, S., Iqbal, M., Manochakian, R., Tan, W., Chanan-Khan, A. & Ailawadhi, M., Oct 1 2019, In : Blood cancer journal. 9, 10, 75.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

VEGF receptor-1 modulates amyloid β 1–42 oligomer-induced senescence in brain endothelial cells

Angom, R. S., Wang, Y., Wang, E., Pal, K., Bhattacharya, S., Watzlawik, J. O., Rosenberry, T. L., Das, P. & Mukhopadhyay, D., Mar 1 2019, In : FASEB Journal. 33, 3, p. 4626-4637 12 p.

Research output: Contribution to journalArticle

3 Scopus citations