Research Output 2003 2019

2019

3D porous chitosan-alginate scaffold stiffness promotes differential responses in prostate cancer cell lines

Xu, K., Ganapathy, K., Andl, T., Wang, Z., Copland, J. A. III., Chakrabarti, R. & Florczyk, S. J., Oct 1 2019, In : Biomaterials. 217, 119311.

Research output: Contribution to journalArticle

Alginate
Chitosan
Scaffolds
Prostatic Neoplasms
Cells

Aberrant lipid metabolism as a therapeutic target in liver cancer

Pope, E. D., Kimbrough, E. O., Vemireddy, L. P., Surapaneni, P. K., Copland, J. A. III. & Mody, K., Jun 3 2019, In : Expert opinion on therapeutic targets. 23, 6, p. 473-483 11 p.

Research output: Contribution to journalArticle

Liver Neoplasms
Lipid Metabolism
Liver
Hepatocellular Carcinoma
Fatty Acids

AFM study: Cell cycle and probe geometry influences nanomechanical characterization of Panc1 cells

Kulkarni, T., Tam, A., Mukhopadhyay, D. & Bhattacharya, S., May 1 2019, In : Biochimica et Biophysica Acta - General Subjects. 1863, 5, p. 802-812 11 p.

Research output: Contribution to journalArticle

Cell Cycle
Microscopes
Cells
Geometry
Cell Cycle Resting Phase

A phase 1 and randomized, placebo-controlled phase 2 trial of bevacizumab plus dasatinib in patients with recurrent glioblastoma: Alliance/North Central Cancer Treatment Group N0872

Galanis, E., Anderson, S. K., Twohy, E. L., Carrero, X. W., Dixon, J. G., Tran, D. D., Jeyapalan, S. A., Anderson, D. M., Kaufmann, T. J., Feathers, R. W., Giannini, C., Buckner, J. C., Anastasiadis, P. Z. & Schiff, D., Jan 1 2019, In : Cancer.

Research output: Contribution to journalArticle

Glioblastoma
Placebos
Neoplasms
Therapeutics
National Cancer Institute (U.S.)
4 Citations (Scopus)

Comprehensive genetic characterization of human thyroid cancer cell lines: A validated panel for preclinical studies

Landa, I., Pozdeyev, N., Korch, C., Marlow, L. A., Smallridge, R. C., Copland, J. A. III., Henderson, Y. C., Lai, S. Y., Clayman, G. L., Onoda, N., Tan, A. C., Garcia-Rendueles, M. E. R., Knauf, J. A., Haugen, B. R., Fagin, J. A. & Schweppe, R. E., Jan 1 2019, In : Clinical Cancer Research. 25, 10, p. 3141-3151 11 p.

Research output: Contribution to journalArticle

Medical Genetics
Thyroid Neoplasms
Cell Line
Neoplasms
Mutation

Directed evolution of the metalloproteinase inhibitor TIMP-1 reveals that its N- and C-terminal domains cooperate in matrix metalloproteinase recognition

Raeeszadeh-Sarmazdeh, M., Greene, K. A., Sankaran, B., Downey, G. P., Radisky, D. C. & Radisky, E. S., Jan 1 2019, In : Journal of Biological Chemistry. 294, 24, p. 9476-9488 13 p.

Research output: Contribution to journalArticle

Tissue Inhibitor of Metalloproteinase-1
Tissue Inhibitor of Metalloproteinases
Metalloproteases
Matrix Metalloproteinases
Matrix Metalloproteinase 3
1 Citation (Scopus)

Disulfide engineering of human Kunitz-type serine protease inhibitors enhances proteolytic stability and target affinity toward mesotrypsin

Cohen, I., Coban, M., Shahar, A., Sankaran, B., Hockla, A., Lacham, S., Caulfield, T., Radisky, E. S. & Papo, N., Jan 1 2019, In : Journal of Biological Chemistry. 294, 13, p. 5105-5120 16 p.

Research output: Contribution to journalArticle

Proteolysis
Serine Proteinase Inhibitors
Human Engineering
Disulfides
Peptide Hydrolases

Effects of age and immune landscape on outcome in HER2-positive breast cancer in the NCCTG N9831 (Alliance) and NSABP B-31 (NRG) trials

Chumsri, S., Serie, D. J., Li, Z., Pogue-Geile, K. L., Soyano-Muller, A. E., Mashadi-Hossein, A., Warren, S., Lou, Y., Colon-Otero, G., Knutson, K. L., Perez, E. A., Moreno Aspitia, A. & Thompson, E. A., Jan 1 2019, In : Clinical Cancer Research. 25, 14, p. 4422-4430 9 p.

Research output: Contribution to journalArticle

Breast Neoplasms
adjuvant P40
B 31
Trastuzumab
2 Citations (Scopus)

Elevated intracellular trypsin exacerbates acute pancreatitis and chronic pancreatitis in mice

Zhan, X., Wan, J., Zhang, G., Song, L., Gui, F., Zhang, Y., Li, Y., Guo, J., Dawra, R. K., Saluja, A. K., Haddock, A. N., Zhang, L., Bi, Y. & Ji, B. D., Jun 1 2019, In : American journal of physiology. Gastrointestinal and liver physiology. 316, 6, p. G816-G825

Research output: Contribution to journalArticle

Chronic Pancreatitis
Pancreatitis
Trypsin
Trypsinogen
Transgenic Mice

Hyaline fibrous involution of breast lobules: a histologic finding associated with germline BRCA mutation

Lee, H. E., Arshad, M., Brahmbhatt, R. D., Hoskin, T. L., Winham, S. J., Frost, M. H., Radisky, D. C., Denison, L. A., Degnim, A. C. & Visscher, D. W., Jan 1 2019, In : Modern Pathology.

Research output: Contribution to journalArticle

Hyalin
Germ-Line Mutation
Breast
Breast Diseases
Basement Membrane

Induction of pancreatic inflammation accelerates pancreatic tumorigenesis in mice

Zhuang, L., Zhan, X., Bi, Y. & Ji, B. D., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 287-297 11 p. (Methods in Molecular Biology; vol. 1882).

Research output: Chapter in Book/Report/Conference proceedingChapter

Acinar Cells
Pancreatic Neoplasms
Pancreatitis
Carcinogenesis
Inflammation
1 Citation (Scopus)

Inhibition of miR-155 reduces impaired autophagy and improves prognosis in an experimental pancreatitis mouse model

Wan, J., Yang, X., Ren, Y., Li, X., Zhu, Y., Haddock, A. N., Ji, B. D., Xia, L. & Lu, N., Apr 1 2019, In : Cell Death and Disease. 10, 4, 303.

Research output: Contribution to journalArticle

Open Access
Autophagy
Pancreatitis
Inflammation
Pancreas
Ceruletide

Mimicking and Manipulating Pancreatic Acinar-to-Ductal Metaplasia in 3-dimensional Cell Culture

Fleming Martinez, A. K. & Storz, P., Feb 11 2019, In : Journal of visualized experiments : JoVE. 144

Research output: Contribution to journalArticle

Acinar Cells
Metaplasia
Cell culture
Cell Culture Techniques
Proteins

Mucin-1 is required for Coxsackie Virus B3-induced inflammation in pancreatitis

Liu, X., Clemens, D. L., Grunkemeyer, J. A., Price, J. D., O’Connell, K., Chapman, N. M., Storz, P., Wen, H., Cox, J. L., Reid, W. L., Hollingsworth, M. A. & Thayer, S., Dec 1 2019, In : Scientific reports. 9, 1, 10656.

Research output: Contribution to journalArticle

Open Access
Mucin-1
Enterovirus
Pancreatitis
Macrophages
Inflammation
1 Citation (Scopus)
Neuropilin-1
Endothelial cells
Angiotensin II
Endothelial Cells
Hypertension

Novel pathogenic PRSS1 variant p.Glu190Lys in a case of chronic pancreatitis

Jancsó, Z., Oracz, G., Kujko, A. A., Kolodziejczyk, E., Radisky, E. S., Rygiel, A. M. & Sahin-Tóth, M., Jan 1 2019, In : Frontiers in Genetics. 10, FEB, 46.

Research output: Contribution to journalArticle

Open Access
Trypsinogen
Chronic Pancreatitis
trypsinogen activation peptide
Mutation
Enzyme Precursors
Open Access
Histone Code
Nucleosomes
Epigenomics
Biological Phenomena
Base Pairing

Pomalidomide alters pancreatic macrophage populations to generate an immune-responsive environment at precancerous and cancerous lesions

Bastea, L. I., Liou, G. Y., Pandey, V., Fleming, A. K., Von Roemeling, C. A., Doeppler, H., Li, Z., Qiu, Y., Edenfield, B., Copland, J. A. III., Tun, H. W. & Storz, P., Apr 1 2019, In : Cancer Research. 79, 7, p. 1535-1548 14 p.

Research output: Contribution to journalArticle

Open Access
Macrophages
Pancreatic Neoplasms
Population
Immunosuppressive Agents
Neoplasms

Porous chitosan-chondroitin sulfate scaffolds to mimic the prostate cancer microenvironment

Xu, K., Ganapathy, K., Wang, Z., Copland, J. A. III., Chakrabarti, R. & Florczyk, S. J., Jan 1 2019, Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials, 1 p. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; vol. 40).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Tumor Microenvironment
Chondroitin Sulfates
Chitosan
Scaffolds
Prostatic Neoplasms

PRSS3/Mesotrypsin and kallikrein-related peptidase 5 are associated with poor prognosis and contribute to tumor cell invasion and growth in lung adenocarcinoma

Ma, H., Hockla, A., Mehner, C., Coban, M., Papo, N., Radisky, D. C. & Radisky, E. S., Dec 1 2019, In : Scientific reports. 9, 1, 1844.

Research output: Contribution to journalArticle

Open Access
Kallikreins
Peptide Hydrolases
Growth
Neoplasms
Serine Proteases

Sexual dimorphism in the incidence of human cancers

Zheng, D., Trynda, J., Williams, C., Vold, J. A., Nguyen, J. H., Harnois, D., Bagaria, S. P., McLaughlin, S. A. & Li, Z., Jul 12 2019, In : BMC cancer. 19, 1, 684.

Research output: Contribution to journalArticle

Open Access
Sex Characteristics
Incidence
Neoplasms
Precision Medicine
Sweden

Survival trends in glioblastoma and association with treating facility volume

Aulakh, S., DeDeo, M. R., Free, J., Rosenfeld, S., Quinones-Hinojosa, A., Paulus, A., Manna, A., Manochakian, R., Chanan Khan, A. A. & Ailawadhi, S., Jan 1 2019, In : Journal of Clinical Neuroscience.

Research output: Contribution to journalArticle

Glioblastoma
temozolomide
Survival
Therapeutics
Neoplasms

Survival Trends in Young Patients With Multiple Myeloma: A Focus on Racial-Ethnic Minorities

Ailawadhi, S., Azzouqa, A. G., Hodge, D., Cochuyt, J., Jani, P., Ahmed, S., Sher, T., Roy, V., Ailawadhi, M., Alegria, V. R., Manochakian, R., Vishnu, P., Grover, A., Abdulazeez, M. F., Paulus, A. & Chanan Khan, A. A., Jan 1 2019, (Accepted/In press) In : Clinical Lymphoma, Myeloma and Leukemia.

Research output: Contribution to journalArticle

Multiple Myeloma
Survival
Survival Rate
Hispanic Americans
Epidemiology
1 Citation (Scopus)

Targeting CD38 enhances the antileukemic activity of ibrutinib in chronic lymphocytic leukemia

Manna, A., Aulakh, S., Jani, P., Ahmed, S., Akhtar, S., Coignet, M., Heckman, M., Meghji, Z., Bhatia, K., Sharma, A., Sher, T., Alegria, V., Malavasi, F., Chini, E. N., Chanan Khan, A. A., Ailawadhi, S. & Paulus, A., Jan 1 2019, In : Clinical Cancer Research. 25, 13, p. 3974-3985 12 p.

Research output: Contribution to journalArticle

B-Cell Chronic Lymphocytic Leukemia
Heterografts
B-Lymphocytes
Antibody-Dependent Cell Cytotoxicity
PCI 32765
1 Citation (Scopus)

Targeting the tumor microenvironment in pancreatic ductal adenocarcinoma

Pandey, V. & Storz, P., Jun 1 2019, In : Expert review of anticancer therapy. 19, 6, p. 473-482 10 p.

Research output: Contribution to journalArticle

Tumor Microenvironment
Pancreatic Neoplasms
Adenocarcinoma
Drug Therapy
Neoplasms

Transgenic expression of cyclooxygenase-2 in pancreatic acinar cells induces chronic pancreatitis

Huang, H., Chen, J., Peng, L., Yao, Y., Deng, D., Zhang, Y., Liu, Y., Wang, H., Li, Z., Bi, Y., Haddock, A. N., Zhan, X., Lu, W., Logsdon, C. D. & Ji, B. D., Jan 1 2019, In : American journal of physiology. Gastrointestinal and liver physiology. 316, 1, p. G179-G186

Research output: Contribution to journalArticle

Acinar Cells
Chronic Pancreatitis
Cyclooxygenase 2
Transgenic Mice
Pancreas
Open Access
Waldenstrom Macroglobulinemia
B-Cell Chronic Lymphocytic Leukemia
Therapeutic Human Experimentation
United States Food and Drug Administration
Therapeutics
2018
7 Citations (Scopus)

Accelerated bottom-up drug design platform enables the discovery of novel stearoyl-CoA desaturase 1 inhibitors for cancer therapy

von Roemeling, C. A., Caulfield, T., Marlow, L., Bok, I., Wen, J., Miller, J. L., Hughes, R., Hazlehurst, L., Pinkerton, A. B., Radisky, D. C., Tun, H. W., Kim, Y. S. B., Lane, A. L. & Copland, J. A. III., Jan 1 2018, In : Oncotarget. 9, 1, p. 3-20 18 p.

Research output: Contribution to journalArticle

Stearoyl-CoA Desaturase
Drug Design
Enzyme Inhibitors
Drug Discovery
Toxicology
33 Citations (Scopus)

A Comprehensive Pan-Cancer Molecular Study of Gynecologic and Breast Cancers

The Cancer Genome Atlas Research Network, Apr 9 2018, In : Cancer Cell. 33, 4, p. 690-705.e9

Research output: Contribution to journalArticle

Breast Neoplasms
Atlases
Long Noncoding RNA
Decision Trees
Genome
3 Citations (Scopus)

A droplet microfluidic platform for efficient enzymatic chromatin digestion enables robust determination of nucleosome positioning

Xu, Y., Lee, J. H., Li, Z., Wang, L., Ordog, T. & Bailey, R. C., Jan 1 2018, In : Lab on a Chip. 18, 17, p. 2583-2592 10 p.

Research output: Contribution to journalArticle

Microfluidics
Nucleosomes
Chromatin
Digestion
DNA
73 Citations (Scopus)

An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics

The Cancer Genome Atlas Research Network, Apr 5 2018, In : Cell. 173, 2, p. 400-416.e11

Research output: Contribution to journalArticle

Atlases
Genes
Genome
Survival
Neoplasms
24 Citations (Scopus)

A Pan-Cancer Analysis of Enhancer Expression in Nearly 9000 Patient Samples

The Cancer Genome Atlas Research Network, Apr 5 2018, In : Cell. 173, 2, p. 386-399.e12

Research output: Contribution to journalArticle

Genes
Tumors
Neoplasms
Computational methods
Chromatin
7 Citations (Scopus)

A Pan-Cancer Analysis Reveals High-Frequency Genetic Alterations in Mediators of Signaling by the TGF-β Superfamily

The Cancer Genome Atlas Research Network, Oct 24 2018, In : Cell Systems. 7, 4, p. 422-437.e7

Research output: Contribution to journalArticle

Transforming Growth Factors
Neoplasms
Sequence Deletion
Genes
Gastrointestinal Neoplasms
2 Citations (Scopus)

A potent, proteolysis-resistant inhibitor of kallikrein-related peptidase 6 (KLK6) for cancer therapy, developed by combinatorial engineering

Sananes, A., Cohen, I., Shahar, A., Hockla, A., De Vita, E., Miller, A. K., Radisky, E. S. & Papo, N., Jan 1 2018, In : Journal of Biological Chemistry. 293, 33, p. 12663-12680 18 p.

Research output: Contribution to journalArticle

Proteolysis
Kallikreins
Peptide Hydrolases
Neoplasms
Protease Inhibitors
6 Citations (Scopus)

A soft microenvironment protects from failure of Midbody abscission and multinucleation downstream of the EMT-promoting transcription factor snail

Simi, A. K., Anlaş, A. A., Stallings-Mann, M., Zhang, S., Hsia, T., Cichon, M., Radisky, D. C. & Nelson, C. M., May 1 2018, In : Cancer Research. 78, 9, p. 2277-2289 13 p.

Research output: Contribution to journalArticle

Septins
Carcinogenesis
Neoplasms
Tumor Microenvironment
Cell Cycle
110 Citations (Scopus)

Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer

The Cancer Genome Atlas Network, Apr 5 2018, In : Cell. 173, 2, p. 291-304.e6

Research output: Contribution to journalArticle

Tumors
Tissue
Histology
Methylation
Oncology
4 Citations (Scopus)

Chloroquine and nanoparticle drug delivery: A promising combination

Pelt, J., Busatto, S., Ferrari, M., Thompson, E. A., Mody, K. & Wolfram, J., Jan 1 2018, (Accepted/In press) In : Pharmacology and Therapeutics.

Research output: Contribution to journalArticle

Chloroquine
Nanoparticles
Pharmaceutical Preparations
Neoplasms
Cellular Microenvironment

Chromoanasynthesis is a common mechanism that leads to ERBB2 amplifications in a cohort of early stage HER2+ breast cancer samples

Vasmatzis, G., Wang, X., Smadbeck, J. B., Murphy, S. J., Geiersbach, K. B., Johnson, S. H., Gaitatzes, A. G., Asmann, Y., Kosari, F., Borad, M. J., Serie, D. J., McLaughlin, S. A., Kachergus, J. M., Necela, B. M. & Thompson, E. A., Jul 13 2018, In : BMC Cancer. 18, 1, 738.

Research output: Contribution to journalArticle

Chromosomes, Human, Pair 8
Breast Neoplasms
Chromosomes, Human, Pair 17
Transcriptome
Genome

Close encounters of the RNAi kind: the silencing life of the adherens junctions

Kourtidis, A. & Anastasiadis, P. Z., Oct 1 2018, In : Current Opinion in Cell Biology. 54, p. 30-36 7 p.

Research output: Contribution to journalReview article

Adherens Junctions
RNA Interference
Disease Progression
Epithelium
2 Citations (Scopus)

Combinatorial engineering of N-TIMP2 variants that selectively inhibit MMP9 and MMP14 function in the cell

Arkadash, V., Radisky, E. S. & Papo, N., Aug 10 2018, In : Oncotarget. 9, 62, p. 32036-32053 18 p.

Research output: Contribution to journalArticle

Tissue Inhibitor of Metalloproteinase-2
Peptide Hydrolases
Matrix Metalloproteinase Inhibitors
MCF-7 Cells
Sequence Homology
1 Citation (Scopus)

Combined alkylation and histone deacetylase inhibition with EDO-S101 has significant therapeutic activity against brain tumors in preclinical models

Qiu, Y., Li, Z., Copland, J. A. III., Mehrling, T. & Tun, H. W., Jun 15 2018, In : Oncotarget. 9, 46, p. 28155-28164 10 p.

Research output: Contribution to journalArticle

Histone Deacetylases
Alkylation
Brain Neoplasms
Central Nervous System
Triple Negative Breast Neoplasms
32 Citations (Scopus)

Comparative Molecular Analysis of Gastrointestinal Adenocarcinomas

The Cancer Genome Atlas Research Network, Apr 9 2018, In : Cancer Cell. 33, 4, p. 721-735.e8

Research output: Contribution to journalArticle

Adenocarcinoma
Neoplasms
Genome
Chromosomal Instability
Rectum
30 Citations (Scopus)

Comprehensive Analysis of Alternative Splicing Across Tumors from 8,705 Patients

The Cancer Genome Atlas Research Network, Aug 13 2018, In : Cancer Cell. 34, 2, p. 211-224.e6

Research output: Contribution to journalArticle

Alternative Splicing
Neoplasms
Exons
Exome
Peptides
129 Citations (Scopus)

Comprehensive Characterization of Cancer Driver Genes and Mutations

The MC3 Working Group & The Cancer Genome Atlas Research Network, Apr 5 2018, In : Cell. 173, 2, p. 371-385.e18

Research output: Contribution to journalArticle

Neoplasm Genes
Tumors
Genes
Mutation
Neoplasms
7 Citations (Scopus)

Comprehensive Molecular Characterization of the Hippo Signaling Pathway in Cancer

The Cancer Genome Atlas Research Network, Oct 30 2018, In : Cell Reports. 25, 5, p. 1304-1317.e5

Research output: Contribution to journalArticle

Genes
Neoplasms
Squamous Cell Neoplasms
Tumors
Atlases
9 Citations (Scopus)

Constitutive Interferon Pathway Activation in Tumors as an Efficacy Determinant Following Oncolytic Virotherapy

Kurokawa, C., Iankov, I. D., Anderson, S. K., Aderca, I., Leontovich, A. A., Maurer, M. J., Oberg, A. L., Schroeder, M. A., Giannini, C., Greiner, S. M., Becker, M. A., Thompson, E. A., Haluska, P., Jentoft, M. E., Parney, I. F., Weroha, S. J., Jen, J., Sarkaria, J. N. & Galanis, E., Oct 1 2018, In : Journal of the National Cancer Institute. 110, 10, p. 1123-1132 10 p.

Research output: Contribution to journalArticle

Oncolytic Virotherapy
Measles virus
Interferons
Glioblastoma
Heterografts
4 Citations (Scopus)

Converting a broad matrix metalloproteinase family inhibitor into a specific inhibitor of MMP-9 and MMP-14

Shirian, J., Arkadash, V., Cohen, I., Sapir, T., Radisky, E. S., Papo, N. & Shifman, J. M., Jan 1 2018, (Accepted/In press) In : FEBS Letters.

Research output: Contribution to journalArticle

Matrix Metalloproteinase Inhibitors
Matrix Metalloproteinases
Yeast
Yeasts
Technology
2 Citations (Scopus)

Cytokeratin-8 in anaplastic thyroid carcinoma: More than a simple structural cytoskeletal protein

Guo, D., Xu, Q., Pabla, S., Koomen, J., Biddinger, P., Sharma, A., Pabla, S., Pacholczyk, R., Chang, C. C., Friedrich, K., Mohammed, K., Smallridge, R. C., Copland, J. A. III., She, J. X. & Weinberger, P. M., Feb 14 2018, In : International Journal of Molecular Sciences. 19, 2, 577.

Research output: Contribution to journalArticle

Keratin-8
keratins
Keratin
Cytoskeletal Proteins
cancer
8 Citations (Scopus)

Determining the genetic basis of anthracycline-cardiotoxicity by molecular response QTL mapping in induced cardiomyocytes

Knowles, D. A., Burrows, C. K., Blischak, J. D., Patterson, K. M., Serie, D. J., Norton, N., Ober, C., Pritchard, J. K. & Gilad, Y., May 8 2018, In : eLife. 7, e33480.

Research output: Contribution to journalArticle

Quantitative Trait Loci
Anthracyclines
Cardiac Myocytes
Doxorubicin
Genes
2 Citations (Scopus)

Diagnostic and prognostic biomarker potential of kallikrein family genes in different cancer types

Tailor, P. D., Kodeboyina, S. K., Bai, S., Patel, N., Sharma, S., Ratnani, A., Copland, J. A. III., She, J. X. & Sharma, A., Apr 1 2018, In : Oncotarget. 9, 25, p. 17876-17888 13 p.

Research output: Contribution to journalArticle

Kallikreins
Renal Cell Carcinoma
Biomarkers
Genes
Neoplasms