Research Output

2020

3D porous chitosan-chondroitin sulfate scaffolds promote epithelial to mesenchymal transition in prostate cancer cells

Xu, K., Wang, Z., Copland, J. A., Chakrabarti, R. & Florczyk, S. J., Sep 2020, In : Biomaterials. 254, 120126.

Research output: Contribution to journalArticle

Adipose-Derived Biogenic Nanoparticles for Suppression of Inflammation

Tian, M., Ticer, T., Wang, Q., Walker, S., Pham, A., Suh, A., Busatto, S., Davidovich, I., Al-Kharboosh, R., Lewis-Tuffin, L., Ji, B., Quinones-Hinojosa, A., Talmon, Y., Shapiro, S., Rückert, F. & Wolfram, J., Mar 1 2020, In : Small. 16, 10, 1904064.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Alzheimer's Risk Factors Age, APOE Genotype, and Sex Drive Distinct Molecular Pathways

Zhao, N., Ren, Y., Yamazaki, Y., Qiao, W., Li, F., Felton, L. M., Mahmoudiandehkordi, S., Kueider-Paisley, A., Sonoustoun, B., Arnold, M., Shue, F., Zheng, J., Attrebi, O. N., Martens, Y. A., Li, Z., Bastea, L., Meneses, A. D., Chen, K., Thompson, J. W., St John-Williams, L. & 12 others, Tachibana, M., Aikawa, T., Oue, H., Job, L., Yamazaki, A., Liu, C. C., Storz, P., Asmann, Y. W., Ertekin-Taner, N., Kanekiyo, T., Kaddurah-Daouk, R. & Bu, G., 2020, (Accepted/In press) In : Neuron.

Research output: Contribution to journalArticle

Application of a risk-management framework for integration of stromal tumor-infiltrating lymphocytes in clinical trials

International Immuno-Oncology Biomarker Working Group, Dec 1 2020, In : npj Breast Cancer. 6, 1, 15.

Research output: Contribution to journalReview article

Open Access
2 Scopus citations

Automated sample preparation for nucleosome positioning analysis using droplet microfluidics

Xu, Y., Lee, J. H., Zhao, Y., Li, Z., Ordog, T. & Bailey, R. C., 2020, 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017. Chemical and Biological Microsystems Society, p. 213-214 2 p. (21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Carryover effects of aromatase inhibitors in prevention

Chumsri, S. & Thompson, E. A., Jan 11 2020, In : The Lancet. 395, 10218, p. 91-92 2 p.

Research output: Contribution to journalComment/debate

Open Access

Chromosome 3q26 Gain Is an Early Event Driving Coordinated Overexpression of the PRKCI, SOX2, and ECT2 Oncogenes in Lung Squamous Cell Carcinoma

Liu, Y., Yin, N., Wang, X., Khoor, A., Sambandam, V., Ghosh, A. B., Fields, Z. A., Murray, N. R., Justilien, V. & Fields, A. P., Jan 21 2020, In : Cell reports. 30, 3, p. 771-782.e6

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Complete remission with immunotherapy: Case report of a patient with metastatic bladder cancer to the humerus

Abdelhakam, D., Young, P. R., Jain, M. K., Nassar, A., Copland, J. A. & Tan, W., May 2020, In : Urology Case Reports. 30, 101130.

Research output: Contribution to journalArticle

Open Access

Controlled drug release from polyelectrolyte-drug conjugate nanoparticles

Catarata, R., Azim, N., Bhattacharya, S. & Zhai, L., Apr 14 2020, In : Journal of Materials Chemistry B. 8, 14, p. 2887-2894 8 p.

Research output: Contribution to journalArticle

Cytotoxic T cell depletion with increasing epithelial abnormality in women with benign breast disease

Adhikary, S., Hoskin, T. L., Stallings-Mann, M. L., Arshad, M., Frost, M. H., Winham, S. J., Peña, A., Lee, D. J., Murphy, L. M., Rakoff, M., Denison, L. A., Knutson, K. L., Radisky, D. C., Visscher, D. W. & Degnim, A. C., Feb 1 2020, In : Breast Cancer Research and Treatment. 180, 1, p. 55-61 7 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Defining the human kidney N-glycome in normal and cancer tissues using MALDI imaging mass spectrometry

Drake, R. R., McDowell, C., West, C., David, F., Powers, T. W., Nowling, T., Bruner, E., Mehta, A. S., Angel, P. M., Marlow, L. A., Tun, H. W. & Copland, J. A., Apr 1 2020, In : Journal of Mass Spectrometry. 55, 4, e4490.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Durable Complete Response With Immune Checkpoint Inhibitor in Breast Cancer With High Tumor Mutational Burden and APOBEC Signature

Chumsri, S., Sokol, E. S., Soyano-Muller, A. E., Parrondo, R. D., Reynolds, G. A., Nassar, A. & Thompson, E. A., May 1 2020, In : Journal of the National Comprehensive Cancer Network : JNCCN. 18, 5, p. 517-521 5 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Early detection and imaging strategies to reveal and target developing pancreatic cancer

Crawford, H. H., Wallace, M. B. & Storz, P., Feb 1 2020, In : Expert review of anticancer therapy. 20, 2, p. 81-83 3 p.

Research output: Contribution to journalEditorial

Open Access

Elevated methylation levels, reduced expression levels, and frequent contractions in a clinical cohort of C9orf72 expansion carriers

Jackson, J. L., Finch, N. C. A., Baker, M. C., Kachergus, J. M., Dejesus-Hernandez, M., Pereira, K., Christopher, E., Prudencio, M., Heckman, M. G., Thompson, E. A., Dickson, D. W., Shah, J., Oskarsson, B., Petrucelli, L., Rademakers, R. & Van Blitterswijk, M., Jan 30 2020, In : Molecular neurodegeneration. 15, 1, 7.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

FAM111A protects replication forks from protein obstacles via its trypsin-like domain

Kojima, Y., Machida, Y., Palani, S., Caulfield, T. R., Radisky, E. S., Kaufmann, S. H. & Machida, Y. J., Dec 1 2020, In : Nature communications. 11, 1, 1318.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Folate receptor alpha expression associates with improved disease-free survival in triple negative breast cancer patients

Norton, N., Youssef, B., Hillman, D. W., Nassar, A., Geiger, X. J., Necela, B. M., Liu, H., Ruddy, K. J., Polley, M. Y. C., Ingle, J. N., Couch, F. J., Perez, E. A., Liu, M. C., Carter, J. M., Leon-Ferre, R. A., Boughey, J. C., Somers, E. B., Kalari, K. R., Visscher, D. W., Goetz, M. P. & 1 others, Knutson, K. L., Dec 1 2020, In : npj Breast Cancer. 6, 1, 4.

Research output: Contribution to journalArticle

Open Access

Impact of Depression and Anxiety on Opioid Use in Hospitalized Hematopoietic Cell Transplantation Recipients

Iqbal, M., Spaulding, A., Niazi, S., Wood, C., Ahmed, S., Jani, P., Kharfan-Dabaja, M. A., Ayala, E., Manochakian, R., Ames, S., Paulus, A., Ailawadhi, S., Roy, V., Chanan-Khan, A. & Sher, T., 2020, (Accepted/In press) In : Psychosomatics.

Research output: Contribution to journalArticle

Integration of Comprehensive Genomic Analysis and Functional Screening of Affected Molecular Pathways to Inform Cancer Therapy

Vasmatzis, G., Liu, M. C., Reganti, S., Feathers, R. W., Smadbeck, J., Johnson, S. H., Schaefer Klein, J. L., Harris, F. R., Yang, L., Kosari, F., Murphy, S. J., Borad, M. J., Thompson, E. A., Cheville, J. C. & Anastasiadis, P. Z., Feb 2020, In : Mayo Clinic proceedings. 95, 2, p. 306-318 13 p.

Research output: Contribution to journalArticle

Open Access

Mirolysin structures open a window on gum disease

Radisky, E. S., Jan 1 2020, In : IUCrJ. 7, p. 3-4 2 p.

Research output: Contribution to journalComment/debate

Open Access

Molecular inhibitor of QSOX1 suppresses tumor growth in vivo

Fifield, A. L., Hanavan, P. D., Faigel, D. O., Sergienko, E., Bobkov, A., Meurice, N., Petit, J. L., Polito, A., Caulfield, T. R., Castle, E. P., Copland, J. A., Mukhopadhyay, D., Pal, K., Dutta, S. K., Luo, H., Ho, T. H. & Lake, D. F., 2020, In : Molecular cancer therapeutics. 19, 1, p. 112-122 11 p.

Research output: Contribution to journalArticle

1 Scopus citations
1 Scopus citations

Pitfalls in assessing stromal tumor infiltrating lymphocytes (sTILs) in breast cancer

the International Immuno-Oncology Biomarker Working Group, Dec 1 2020, In : npj Breast Cancer. 6, 1, 17.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Predictive Biomarkers for Adjuvant Capecitabine Benefit in Early-Stage Triple-Negative Breast Cancer in the FinXX Clinical Trial

Asleh, K., Brauer, H. A., Sullivan, A., Lauttia, S., Lindman, H., Nielsen, T. O., Joensuu, H., Thompson, E. A. & Chumsri, S., Jun 1 2020, In : Clinical Cancer Research. 26, 11, p. 2603-2614 12 p.

Research output: Contribution to journalArticle

Protein kinase Cι promotes UBF1-ECT2 binding on ribosomal DNA to drive rRNA synthesis and transformed growth of non-small-cell lung cancer cells

Justilien, V., Lewis, K. C., Meneses, K. M., Jamieson, L., Murray, N. R. & Fields, A. P., Jun 12 2020, In : The Journal of biological chemistry. 295, 24, p. 8214-8226 13 p.

Research output: Contribution to journalArticle

Quantitative mapping of binding specificity landscapes for homologous targets by using a high-throughput method

Aharon, L., Aharoni, S. L., Radisky, E. S. & Papo, N., May 2020, In : Biochemical Journal. 477, 9, p. 1701-1719 19 p.

Research output: Contribution to journalArticle

Open Access

Rapid Generation of Sustainable HER2-specific T-cell Immunity in Patients with HER2 Breast Cancer using a Degenerate HLA Class II Epitope Vaccine

Knutson, K. L., Block, M. S., Norton, N., Erskine, C. L., Hobday, T. J., Dietz, A. B., Padley, D., Gustafson, M. P., Puglisi-Knutson, D., Mangskau, T. K., Chumsri, S., Dueck, A. C., Karyampudi, L., Wilson, G. & Degnim, A. C., Mar 1 2020, In : Clinical Cancer Research. 26, 5, p. 1045-1053 9 p.

Research output: Contribution to journalArticle

Retinoid X receptor alpha is a spatiotemporally predominant therapeutic target for anthracycline-induced cardiotoxicity

Ma, X., Zhu, P., Ding, Y., Zhang, H., Qiu, Q., Dvornikov, A. V., Wang, Z., Kim, M., Wang, Y., Lowerison, M., Yu, Y., Norton, N., Herrmann, J., Ekker, S. C., Hsiai, T. K., Lin, X. & Xu, X., Jan 29 2020, In : Science Advances. 6, 5, eaay2939.

Research output: Contribution to journalArticle

Open Access

Targeting CD38 is lethal to Breg-like chronic lymphocytic leukemia cells and Tregs, but restores CD81 T-cell responses

Manna, A., Kellett, T., Aulakh, S., Lewis-Tuffin, L. J., Dutta, N., Knutson, K., Chini, E., Pinilla-Ibarz, J., Lamanna, N., Manochakian, R., Malavasi, F., Sher, T., Chanan-Khan, A. A., Ailawadhi, S. & Paulus, A., May 26 2020, In : Blood Advances. 4, 10, p. 2143-2157 15 p.

Research output: Contribution to journalArticle

Open Access

The GEF-H1/PKD3 signaling pathway promotes the maintenance of triple-negative breast cancer stem cells

Lieb, W. S., Lungu, C., Tamas, R., Berreth, H., Rathert, P., Storz, P., Olayioye, M. A. & Hausser, A., Jun 15 2020, In : International Journal of Cancer. 146, 12, p. 3423-3434 12 p.

Research output: Contribution to journalArticle

Open Access
Open Access
2 Scopus citations

Timeliness of initial therapy in multiple myeloma: Trends and factors affecting patient care

Kumar, V., Alhaj-Moustafa, M., Bojanini, L., Sher, T., Roy, V., Manochakian, R., Vishnu, P., Bodepudi, S., Shareef, Z., Ahmed, S., Jani, P., Paulus, A., Grover, A., Alegria, V. R., Ailawadhi, M., Chanan-Khan, A. & Ailawadhi, S., Apr 1 2020, In : Journal of oncology practice. 16, 4, p. E341-E349

Research output: Contribution to journalArticle

Transgenic expression of human PRSS2 exacerbates pancreatitis in mice

Wan, J., Haddock, A., Edenfield, B., Ji, B. & Bi, Y., Jan 1 2020, (Accepted/In press) In : Gut.

Research output: Contribution to journalLetter

Transgenic Expression of PRSS1R122H Sensitizes Mice to Pancreatitis

Huang, H., Swidnicka-Siergiejko, A. K., Daniluk, J., Gaiser, S., Yao, Y., Peng, L., Zhang, Y., Liu, Y., Dong, M., Zhan, X., Wang, H., Bi, Y., Li, Z., Ji, B. & Logsdon, C. D., Mar 2020, In : Gastroenterology. 158, 4, p. 1072-1082.e7

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Trypsin activity governs increased susceptibility to pancreatitis in mice expressing human PRSS1R122H

Gui, F., Zhang, Y., Wan, J., Zhan, X., Yao, Y., Li, Y., Haddock, A. N., Shi, J., Guo, J., Chen, J., Zhu, X., Edenfield, B. H., Zhuang, L., Hu, C., Wang, Y., Mukhopadhyay, D., Radisky, E. S., Zhang, L., Lugea, A., Pandol, S. J. & 2 others, Bi, Y. & Ji, B., Jan 2 2020, In : Journal of Clinical Investigation. 130, 1, p. 189-202 14 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
2019

3D porous chitosan-alginate scaffold stiffness promotes differential responses in prostate cancer cell lines

Xu, K., Ganapathy, K., Andl, T., Wang, Z., Copland, J. A. III., Chakrabarti, R. & Florczyk, S. J., Oct 1 2019, In : Biomaterials. 217, 119311.

Research output: Contribution to journalArticle

12 Scopus citations

Aberrant lipid metabolism as a therapeutic target in liver cancer

Pope, E. D., Kimbrough, E. O., Vemireddy, L. P., Surapaneni, P. K., Copland, J. A. III. & Mody, K., Jun 3 2019, In : Expert opinion on therapeutic targets. 23, 6, p. 473-483 11 p.

Research output: Contribution to journalArticle

5 Scopus citations

AFM study: Cell cycle and probe geometry influences nanomechanical characterization of Panc1 cells

Kulkarni, T., Tam, A., Mukhopadhyay, D. & Bhattacharya, S., May 1 2019, In : Biochimica et Biophysica Acta - General Subjects. 1863, 5, p. 802-812 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

A phase 1 and randomized, placebo-controlled phase 2 trial of bevacizumab plus dasatinib in patients with recurrent glioblastoma: Alliance/North Central Cancer Treatment Group N0872

Galanis, E., Anderson, S. K., Twohy, E. L., Carrero, X. W., Dixon, J. G., Tran, D. D., Jeyapalan, S. A., Anderson, D. M., Kaufmann, T. J., Feathers, R. W., Giannini, C., Buckner, J. C., Anastasiadis, P. Z. & Schiff, D., Nov 1 2019, In : Cancer. 125, 21, p. 3790-3800 11 p.

Research output: Contribution to journalArticle

6 Scopus citations

Bioinformatics and DNA-extraction strategies to reliably detect genetic variants from FFPE breast tissue samples

Bhagwate, A. V., Liu, Y., Winham, S. J., McDonough, S. J., Stallings-Mann, M. L., Heinzen, E. P., Davila, J. I., Vierkant, R. A., Hoskin, T. L., Frost, M., Carter, J., Radisky, D. C., Cunningham, J. M., Degnim, A. C. & Wang, C., Sep 2 2019, In : BMC genomics. 20, 1, 689.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Comprehensive genetic characterization of human thyroid cancer cell lines: A validated panel for preclinical studies

Landa, I., Pozdeyev, N., Korch, C., Marlow, L. A., Smallridge, R. C., Copland, J. A., Henderson, Y. C., Lai, S. Y., Clayman, G. L., Onoda, N., Tan, A. C., Garcia-Rendueles, M. E. R., Knauf, J. A., Haugen, B. R., Fagin, J. A. & Schweppe, R. E., 2019, In : Clinical Cancer Research. 25, 10, p. 3141-3151 11 p.

Research output: Contribution to journalArticle

14 Scopus citations

Directed evolution of the metalloproteinase inhibitor TIMP-1 reveals that its N- and C-terminal domains cooperate in matrix metalloproteinase recognition

Raeeszadeh-Sarmazdeh, M., Greene, K. A., Sankaran, B., Downey, G. P., Radisky, D. C. & Radisky, E. S., Jun 14 2019, In : Journal of Biological Chemistry. 294, 24, p. 9476-9488 13 p.

Research output: Contribution to journalArticle

Disulfide engineering of human Kunitz-type serine protease inhibitors enhances proteolytic stability and target affinity toward mesotrypsin

Cohen, I., Coban, M., Shahar, A., Sankaran, B., Hockla, A., Lacham, S., Caulfield, T. R., Radisky, E. S. & Papo, N., Mar 29 2019, In : Journal of Biological Chemistry. 294, 13, p. 5105-5120 16 p.

Research output: Contribution to journalArticle

6 Scopus citations

DNA-SWCNT biosensors allow real-time monitoring of therapeutic responses in pancreatic ductal adenocarcinoma

Bhattacharya, S., Gong, X., Wang, E., Dutta, S. K., Caplette, J. R., Son, M., Nguyen, F. T., Strano, M. S. & Mukhopadhyay, D., Sep 1 2019, In : Cancer research. 79, 17, p. 4515-4523 9 p.

Research output: Contribution to journalArticle

1 Scopus citations

Effects of age and immune landscape on outcome in HER2-positive breast cancer in the NCCTG N9831 (Alliance) and NSABP B-31 (NRG) trials

Chumsri, S., Serie, D. J., Li, Z., Pogue-Geile, K. L., Soyano-Muller, A. E., Mashadi-Hossein, A., Warren, S., Lou, Y., Colon-Otero, G., Knutson, K. L., Perez, E. A., Moreno-Aspitia, A. & Thompson, E. A., Jan 1 2019, In : Clinical Cancer Research. 25, 14, p. 4422-4430 9 p.

Research output: Contribution to journalArticle

1 Scopus citations

Elevated intracellular trypsin exacerbates acute pancreatitis and chronic pancreatitis in mice

Zhan, X., Wan, J., Zhang, G., Song, L., Gui, F., Zhang, Y., Li, Y., Guo, J., Dawra, R. K., Saluja, A. K., Haddock, A. N., Zhang, L., Bi, Y. & Ji, B., Jun 2019, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 316, 6, p. G816-G825

Research output: Contribution to journalArticle

5 Scopus citations

Erratum: Chemically-Modified Peptides Targeting the PDZ Domain of GIPC as a Therapeutic Approach for Cancer (ACS Chemical Biology (2012) 7:4 (770-779) DOI: 10.1021/cb200536r)

Patra, C. R., Rupasinghe, C. N., Dutta, S. K., Bhattacharya, S., Wang, E., Spaller, M. R. & Mukhopadhyay, D., Oct 18 2019, In : ACS Chemical Biology. 14, 10, 1 p.

Research output: Contribution to journalComment/debate

Erratum: The Immune Landscape of Cancer (Immunity (2018) 48(4) (812–830.e14), (S1074761318301213), (10.1016/j.immuni.2018.03.023))

The Cancer Genome Atlas Research Network, Aug 20 2019, In : Immunity. 51, 2, p. 411-412 2 p.

Research output: Contribution to journalComment/debate

Open Access
6 Scopus citations
Open Access

Hyaline fibrous involution of breast lobules: a histologic finding associated with germline BRCA mutation

Lee, H. E., Arshad, M., Brahmbhatt, R. D., Hoskin, T. L., Winham, S. J., Frost, M. H., Radisky, D. C., Denison, L. A., Degnim, A. C. & Visscher, D. W., Sep 1 2019, In : Modern Pathology. 32, 9, p. 1263-1270 8 p.

Research output: Contribution to journalArticle

1 Scopus citations