Biomedical Statistics and Informatics

Research Output 2007 2019

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2011
10 Citations (Scopus)

Statistical considerations for the next generation of clinical trials

Wu, W., Shi, Q. D. & Sargent, D. J., Aug 2011, In : Seminars in Oncology. 38, 4, p. 598-604 7 p.

Research output: Contribution to journalArticle

Clinical Trials
Biomarkers
Phase III Clinical Trials
Phase II Clinical Trials
Clinical Trials, Phase I
70 Citations (Scopus)

Validation of EORTC prognostic factors for adults with low-grade glioma: A report using intergroup 86-72-51

Daniels, T. B., Brown, P. D., Felten, S. J., Wu, W., Buckner, J. C., Arusell, R. M., Curran, W. J., Abrams, R. A., Schiff, D. & Shaw, E. G., Sep 1 2011, In : International Journal of Radiation Oncology Biology Physics. 81, 1, p. 218-224 7 p.

Research output: Contribution to journalArticle

Glioma
grade
cancer
Survival
Research
2010
6 Citations (Scopus)

Classification of medication status change in clinical narratives

Sohn, S., Murphy, S. P., Masanz, J. J., Kocher, J-P. & Savova, G. K., 2010, In : AMIA ... Annual Symposium proceedings / AMIA Symposium. AMIA Symposium. 2010, p. 762-766 5 p.

Research output: Contribution to journalArticle

Machine Learning
Therapeutics
53 Citations (Scopus)
temozolomide
Glioblastoma
Radiation
Antibiotic Prophylaxis
Chemoradiotherapy
18 Citations (Scopus)

Comparing neuropsychological tasks to optimize brief cognitive batteries for brain tumor clinical trials

Lageman, S. K., Cerhan, J. H., Locke, D. E., Anderson, S. K., Wu, W. & Brown, P. D., Jan 2010, In : Journal of Neuro-Oncology. 96, 2, p. 271-276 6 p.

Research output: Contribution to journalArticle

Brain Neoplasms
Clinical Trials
Neuropsychological Tests
Glioma
Retrospective Studies
18 Citations (Scopus)

Copy number variation and cytidine analogue cytotoxicity: A genome-wide association approach

Kalari, K. R., Hebbring, S. J., Chai, H. S., Li, L., Kocher, J-P., Wang, L. M. & Weinshilboum, R. M., Jun 4 2010, In : BMC Genomics. 11, 1, 357.

Research output: Contribution to journalArticle

Cytidine
gemcitabine
Genome
Cytarabine
Phenotype
28 Citations (Scopus)

Expression of CD74 in high grade gliomas: A potential role in temozolomide resistance

Kitange, G. J., Carlson, B. L., Schroeder, M. A., Decker, P. A., Morlan, B. W., Wu, W., Ballman, K. V., Giannini, C. & Sarkaria, J. N., Nov 2010, In : Journal of Neuro-Oncology. 100, 2, p. 177-186 10 p.

Research output: Contribution to journalArticle

temozolomide
Glioblastoma
Glioma
Small Interfering RNA
Methyltransferases
49 Citations (Scopus)

Joint NCCTG and NABTC prognostic factors analysis for high-grade recurrent glioma

Wu, W., Lamborn, K. R., Buckner, J. C., Novotny, P. J., Chang, S. M., O'Fallon, J. R., Jaeckle, K. A. & Prados, M. D., Feb 2010, In : Neuro-Oncology. 12, 2, p. 164-172 9 p.

Research output: Contribution to journalArticle

Brain Neoplasms
Glioma
Statistical Factor Analysis
Joints
Disease-Free Survival
29 Citations (Scopus)

Model-based phase I designs incorporating toxicity and efficacy for single and dual agent drug combinations: Methods and challenges

Mandrekar, S. J., Qin, R. & Sargent, D. J., May 10 2010, In : Statistics in Medicine. 29, 10, p. 1077-1083 7 p.

Research output: Contribution to journalArticle

Drug Combinations
Toxicity
Efficacy
Dose
Drugs
31 Citations (Scopus)

Pentostatin and rituximab therapy for previously untreated patients with B-cell chronic lymphocytic leukemia

Kay, N. E., Wu, W., Kabat, B., LaPlant, B., Lin, T. S., Byrd, J. C., Jelinek, D. F., Grever, M. R., Zent, C. S., Call, T. G. & Shanafelt, T. D., May 1 2010, In : Cancer. 116, 9, p. 2180-2187 8 p.

Research output: Contribution to journalArticle

Pentostatin
B-Cell Chronic Lymphocytic Leukemia
Therapeutics
Polymerase Chain Reaction
Cyclophosphamide
10 Citations (Scopus)

Peutz-Jeghers syndrome: A study of long-term surgical morbidity and causes of mortality

You, Y. N., Wolff, B. G., Boardman, L. A., Riegert-Johnson, D. L. & Qin, R., Dec 2010, In : Familial Cancer. 9, 4, p. 609-616 8 p.

Research output: Contribution to journalArticle

Peutz-Jeghers Syndrome
Morbidity
Mortality
Neoplasms
Short Bowel Syndrome
72 Citations (Scopus)

Phase III, randomized, double-blind, placebo-controlled evaluation of pregabalin for alleviating hot flashes, N07C1

Loprinzi, C. L., Qin, R., Baclueva, E. P., Flynn, K. A., Rowland, K. M., Graham, D. L., Erwin, N. K., Dakhil, S. R., Jurgens, D. J. & Burger, K. N., Feb 1 2010, In : Journal of Clinical Oncology. 28, 4, p. 641-647 7 p.

Research output: Contribution to journalArticle

Hot Flashes
Placebos
Nonparametric Statistics
Therapeutics
Pregabalin
25 Citations (Scopus)

Phase II trials of single-agent anti-VEGF therapy for patients with chronic lymphocytic leukemia

Shanafelt, T., Zent, C., Byrd, J., Erlichman, C., Laplant, B., Ghosh, A., Call, T., Villalona-Calero, M., Jelinek, D. F., Bowen, D., Laumann, K., Wu, W., Hanson, C. & Kay, N. E., Dec 2010, In : Leukemia and Lymphoma. 51, 12, p. 2222-2229 8 p.

Research output: Contribution to journalArticle

B-Cell Chronic Lymphocytic Leukemia
Vascular Endothelial Growth Factor A
Therapeutics
Receptor Protein-Tyrosine Kinases
Anti-Idiotypic Antibodies
79 Citations (Scopus)

Platelet-derived growth factor (PDGF)-PDGF receptor interaction activates bone marrow-derived mesenchymal stromal cells derived from chronic lymphocytic leukemia: Implications for an angiogenic switch

Ding, W. D., Knox, T. R., Tschumper, R. C., Wu, W., Schwager, S. M., Boysen, J. C., Jelinek, D. F. & Kay, N. E., Oct 21 2010, In : Blood. 116, 16, p. 2984-2993 10 p.

Research output: Contribution to journalArticle

Platelet-Derived Growth Factor Receptors
Platelet-Derived Growth Factor
B-Cell Chronic Lymphocytic Leukemia
Conditioned Culture Medium
Mesenchymal Stromal Cells
6 Citations (Scopus)
Genotype
Normalization
Single Nucleotide Polymorphism
Microarrays
Chip
41 Citations (Scopus)
Propensity Score
Asthma
Railroads
Censuses
Incidence
2 Citations (Scopus)

The unique contribution of the nursing intervention pain management on length of stay in older patients undergoing hip procedures

Kerr, P., Shever, L., Titler, M. G., Qin, R., Kim, T. & Picone, D. M., Feb 2010, In : Applied Nursing Research. 23, 1, p. 36-44 9 p.

Research output: Contribution to journalArticle

Pain Management
Hip
Length of Stay
Nursing
Hospitalization
2009
118 Citations (Scopus)
Gene Expression Profiling
Genome
RNA
Gene Expression
Brain
45 Citations (Scopus)

5-Azacitidine has limited therapeutic activity in myelofibrosis

Mesa, R. A., Verstovsek, S., Rivera, C. E., Pardanani, A. D., Hussein, K., Lasho, T., Wu, W. & Tefferi, A., 2009, In : Leukemia. 23, 1, p. 180-182 3 p.

Research output: Contribution to journalArticle

Azacitidine
Primary Myelofibrosis
Treatment Failure
Therapeutics
82 Citations (Scopus)

A phase 2 study of vorinostat in acute myeloid leukemia

Schaefer, E. W., Loaiza-Bonilla, A., Juckett, M., DiPersio, J. F., Roy, V., Slack, J. L., Wu, W., Laumann, K., Espinoza-Delgado, I. & Gore, S. D., Oct 2009, In : Haematologica. 94, 10, p. 1375-1382 8 p.

Research output: Contribution to journalArticle

Acute Myeloid Leukemia
Treatment Failure
Therapeutics
Histone Deacetylase Inhibitors
vorinostat
51 Citations (Scopus)

Evaluation of MGMT promoter methylation status and correlation with temozolomide response in orthotopic glioblastoma xenograft model

Kitange, G. J., Carlson, B. L., Mladek, A. C., Decker, P. A., Schroeder, M. A., Wu, W., Grogan, P. T., Giannini, C., Ballman, K. V., Buckner, J. C., David James, C. & Sarkaria, J. N., 2009, In : Journal of Neuro-Oncology. 92, 1, p. 23-31 9 p.

Research output: Contribution to journalArticle

temozolomide
Methyltransferases
Glioblastoma
Heterografts
Methylation
18 Citations (Scopus)

Factors influencing lymph node recovery from the operative specimen after gastrectomy for gastric adenocarcinoma

Schoenleber, S. J., Schnelldorfer, T., Wood, C. M., Qin, R., Sarr, M. G. & Donohue, J. H., Jul 2009, In : Journal of Gastrointestinal Surgery. 13, 7, p. 1233-1237 5 p.

Research output: Contribution to journalArticle

Gastrectomy
Stomach
Adenocarcinoma
Lymph Nodes
Pathology
28 Citations (Scopus)

GLOSSI: A method to assess the association of genetic loci-sets with complex diseases

Chai, H. S., Sicotte, H., Bailey, K. R., Turner, S. T., Asmann, Y. & Kocher, J-P., Apr 3 2009, In : BMC Bioinformatics. 10, 102.

Research output: Contribution to journalArticle

Genetic Loci
Single Nucleotide Polymorphism
Locus
Genes
Gene
116 Citations (Scopus)

Induction of MGMT expression is associated with temozolomide resistance in glioblastoma xenografts

Kitange, G. J., Carlson, B. L., Schroeder, M. A., Grogan, P. T., Lamont, J. D., Decker, P. A., Wu, W., James, C. D. & Sarkaria, J. N., Jun 2009, In : Neuro-Oncology. 11, 3, p. 281-291 11 p.

Research output: Contribution to journalArticle

temozolomide
Methyltransferases
Glioblastoma
Heterografts
DNA
47 Citations (Scopus)

Mcl-1 expression predicts progression-free survival in chronic lymphocytic leukemia patients treated with pentostatin, cyclophosphamide, and rituximab

Awan, F. T., Kay, N. E., Davis, M. E., Wu, W., Geyer, S. M., Leung, N., Jelinek, D. F., Tschumper, R. C., Secreto, C. R., Lin, T. S., Grever, M. R., Shanafelt, T. D., Zent, C. S., Call, T. G., Heerema, N. A., Lozanski, G., Byrd, J. C. & Lucas, D. M., Jan 15 2009, In : Blood. 113, 3, p. 535-537 3 p.

Research output: Contribution to journalArticle

Pentostatin
Myeloid Leukemia
Myeloid Cells
B-Cell Chronic Lymphocytic Leukemia
Cyclophosphamide
14 Citations (Scopus)

N9986: A phase II trial of thalidomide in patients with relapsed chronic lymphocytic leukemia

Kay, N. E., Shanafelt, T. D., Call, T. G., Wu, W. & Laplant, B. R., 2009, In : Leukemia and Lymphoma. 50, 4, p. 588-592 5 p.

Research output: Contribution to journalArticle

Thalidomide
B-Cell Chronic Lymphocytic Leukemia
Lymphocyte Count
Neoplasms
Therapeutics
24 Citations (Scopus)

Phase II trial of two different irinotecan schedules with pharmacokinetic analysis in patients with recurrent glioma: North Central Cancer Treatment Group results

Santisteban, M., Buckner, J. C., Reid, J. M., Wu, W., Scheithauer, B. W., Ames, M. M., Felten, S. J., Nikcevich, D. A., Wiesenfeld, M., Jaeckle, K. A. & Galanis, E., 2009, In : Journal of Neuro-Oncology. 92, 2, p. 165-175 11 p.

Research output: Contribution to journalArticle

irinotecan
Glioma
Appointments and Schedules
Pharmacokinetics
Neoplasms
56 Citations (Scopus)

Predictive and prognostic value of CA 19-9 in resected pancreatic adenocarcinoma

Barton, J. G., Bois, J. P., Sarr, M. G., Wood, C. M., Qin, R., Thomsen, K. M., Kendrick, M. L. & Farnell, M. B., 2009, In : Journal of Gastrointestinal Surgery. 13, 11, p. 2050-2058 9 p.

Research output: Contribution to journalArticle

Adenocarcinoma
Survival
Pancreaticoduodenectomy
Lymph Nodes
Portal Vein
49 Citations (Scopus)

Radiosensitizing Effects of Temozolomide Observed in vivo only in a Subset of O6-Methylguanine-DNA Methyltransferase Methylated Glioblastoma Multiforme Xenografts

Carlson, B. L., Grogan, P. T., Mladek, A. C., Schroeder, M. A., Kitange, G. J., Decker, P. A., Giannini, C., Wu, W., Ballman, K. A., James, C. D. & Sarkaria, J. N., Sep 1 2009, In : International Journal of Radiation Oncology Biology Physics. 75, 1, p. 212-219 8 p.

Research output: Contribution to journalArticle

temozolomide
Radiation-Sensitizing Agents
Methyltransferases
Glioblastoma
Heterografts
2008
16 Citations (Scopus)

Bortezomib therapy in myelofibrosis: A phase II clinical trial

Mesa, R. A., Verstovsek, S., Rivera, C. E., Pardanani, A. D., Hussein, K., Lasho, T., Wu, W. & Tefferi, A., 2008, In : Leukemia. 22, 8, p. 1636-1638 3 p.

Research output: Contribution to journalArticle

Boronic Acids
Pyrazines
Phase II Clinical Trials
Primary Myelofibrosis
Antineoplastic Agents
71 Citations (Scopus)

Cognitive rehabilitation and problem-solving to improve quality of life of patients with primary brain tumors: A pilot study

Locke, D. E., Cerhan, J. H., Wu, W., Malec, J. F., Clark, M. M., Rummans, T. A. & Brown, P. D., 2008, In : Journal of Supportive Oncology. 6, 8, p. 383-391 9 p.

Research output: Contribution to journalArticle

Brain Neoplasms
Rehabilitation
Quality of Life
Caregivers
Research
18 Citations (Scopus)

Estimating effects of nursing intervention via propensity score analysis

Qin, R., Titler, M. G., Shever, L. L. & Kim, T., Nov 2008, In : Nursing Research. 57, 6, p. 444-452 9 p.

Research output: Contribution to journalArticle

Propensity Score
Nursing
Pain Management
Length of Stay
Nursing Models
170 Citations (Scopus)

Experience with 208 resections for intraductal papillary mucinous neoplasm of the pancreas

Schnelldorfer, T., Sarr, M. G., Nagorney, D. M., Zhang, L., Smyrk, T. C., Qin, R., Chari, S. T. & Farnell, M. B., Jul 2008, In : Archives of Surgery. 143, 7, p. 639-646 8 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Pancreatectomy
Neoplasms
Recurrence
Survival
83 Citations (Scopus)

Genomic association analysis suggests chromosome 12 locus influencing antihypertensive response to thiazide diuretic

Turner, S. T., Bailey, K. R., Fridley, B. L., Chapman, A. B., Schwartz, G. L., Chai, H. S., Sicotte, H., Kocher, J-P., Rodin, A. S. & Boerwinkle, E., Aug 2008, In : Hypertension. 52, 2, p. 359-365 7 p.

Research output: Contribution to journalArticle

Sodium Chloride Symporter Inhibitors
Chromosomes, Human, Pair 12
Antihypertensive Agents
Blood Pressure
Single Nucleotide Polymorphism
173 Citations (Scopus)

Low JAK2V617F allele burden in primary myelofibrosis, compared to either a higher allele burden or unmutated status, is associated with inferior overall and leukemia-free survival

Tefferi, A., Lasho, T. L., Huang, J., Finke, C., Mesa, R. A., Li, C. Y., Wu, W., Hanson, C. A. & Pardanani, A. D., Apr 2008, In : Leukemia. 22, 4, p. 756-761 6 p.

Research output: Contribution to journalArticle

Primary Myelofibrosis
Leukemia
Alleles
Survival
Platelet Count
68 Citations (Scopus)

Neither serum ferritin nor the number of red blood cell transfusions affect overall survival in refractory anemia with ringed sideroblasts

Chee, C. E., Steensma, D. P., Wu, W., Hanson, C. A. & Tefferi, A., Aug 2008, In : American Journal of Hematology. 83, 8, p. 611-613 3 p.

Research output: Contribution to journalArticle

Hemosiderosis
Refractory Anemia
Erythrocyte Transfusion
Myelodysplastic Syndromes
Ferritins
184 Citations (Scopus)

Phase I/II trial of erlotinib and temozolomide with radiation therapy in the treatment of newly diagnosed glioblastoma multiforme: North central cancer treatment group study N0177

Brown, P. D., Krishnan, S., Sarkaria, J. N., Wu, W., Jaeckle, K. A., Uhm, J. H., Geoffroy, F. J., Arusell, R., Kitange, G., Jenkins, R. B., Kugler, J. W., Morton, R. F., Rowland, K. M., Mischel, P., Yong, W. H., Scheithauer, B. W., Schiff, D., Giannini, C. & Buckner, J. C., Dec 1 2008, In : Journal of Clinical Oncology. 26, 34, p. 5603-5609 7 p.

Research output: Contribution to journalArticle

temozolomide
Glioblastoma
Radiotherapy
Epidermal Growth Factor Receptor
Neoplasms
45 Citations (Scopus)

Predictors of medication errors among elderly hospitalized patients

Picone, D. M., Titler, M. G., Dochterman, J., Shever, L., Kim, T., Abramowitz, P., Kanak, M. & Qin, R., Mar 2008, In : American Journal of Medical Quality. 23, 2, p. 115-127 13 p.

Research output: Contribution to journalArticle

Medication Errors
Nursing
Polypharmacy
Risk Management
Teaching Hospitals
61 Citations (Scopus)
Lymphoma
Adrenal Cortex Hormones
Central Nervous System
Biopsy
Brain
Antineoplastic Protocols
Libido
Testosterone
Randomized Controlled Trials
Neoplasms
83 Citations (Scopus)

Risk factors for leukemic transformation in patients with primary myelofibrosis

Huang, J., Li, C. Y., Mesa, R. A., Wu, W., Hanson, C. A., Pardanani, A. D. & Tefferi, A., Jun 15 2008, In : Cancer. 112, 12, p. 2726-2732 7 p.

Research output: Contribution to journalArticle

Primary Myelofibrosis
Hematinics
Danazol
Leukemia
Survival
24 Citations (Scopus)

Robust and efficient identification of biomarkers by classifying features on graphs

Hwang, T., Sicotte, H., Tian, Z., Wu, B., Kocher, J-P., Wigle, D. A., Kumar, V. & Kuang, R., Sep 2008, In : Bioinformatics. 24, 18, p. 2023-2029 7 p.

Research output: Contribution to journalArticle

Biomarkers
Graph in graph theory
Single nucleotide Polymorphism
Bipartite Graph
Nucleotides
11 Citations (Scopus)

The effect of high nursing surveillance on hospital cost

Shever, L. L., Titler, M. G., Kerr, P., Qin, R., Kim, T. & Picone, D. M., Jun 2008, In : Journal of Nursing Scholarship. 40, 2, p. 161-169 9 p.

Research output: Contribution to journalArticle

Hospital Costs
Nursing
Costs and Cost Analysis
Propensity Score
Observational Studies
2007
64 Citations (Scopus)

A unified approach for assessing agreement for continuous and categorical data

Lin, L., Hedayat, A. S. & Wu, W., Jul 2007, In : Journal of Biopharmaceutical Statistics. 17, 4, p. 629-652 24 p.

Research output: Contribution to journalArticle

Nominal or categorical data
Reading
Concordance
Correlation coefficient
Estimate
128 Citations (Scopus)

Clinical correlates of JAK2V617F allele burden in essential thrombocythemia

Kittur, J., Knudson, R. A., Lasho, T. L., Finke, C. M., Gangat, N., Wolanskyj, A. P., Li, C. Y., Wu, W., Ketterling, R. P., Pardanani, A. D. & Tefferi, A., Jun 1 2007, In : Cancer. 109, 11, p. 2279-2284 6 p.

Research output: Contribution to journalArticle

Essential Thrombocythemia
Alleles
Platelet Count
Leukocyte Count
Venous Thrombosis
60 Citations (Scopus)

Combination of measles virus virotherapy and radiation therapy has synergistic activity in the treatment of glioblastoma multiforme

Liu, C., Sarkaria, J. N., Petell, C. A., Paraskevakou, G., Zollman, P. J., Schroeder, M., Carlson, B., Decker, P. A., Wu, W., James, C. D., Russell, S. J. & Galanis, E., Dec 1 2007, In : Clinical Cancer Research. 13, 23, p. 7155-7165 11 p.

Research output: Contribution to journalArticle

Measles virus
Glioblastoma
Radiotherapy
Glioma
Caspase Inhibitors
29 Citations (Scopus)

Effects of technological interventions on the safety of a medication-use system

Skibinski, K. A., White, B. A., Lin, L. I. K., Dong, Y. & Wu, W., Jan 1 2007, In : American Journal of Health-System Pharmacy. 64, 1, p. 90-96 7 p.

Research output: Contribution to journalArticle

Medication Systems
Technology
Safety
Pharmacists
Practical Nursing
30 Citations (Scopus)

Histopathologic grading of adult medulloblastomas

Rodriguez, F. J., Eberhart, C., O'Neill, B. P., Slezak, J., Burger, P. C., Goldthwaite, P., Wu, W. & Giannini, C., Jun 15 2007, In : Cancer. 109, 12, p. 2557-2565 9 p.

Research output: Contribution to journalArticle

Anaplasia
Medulloblastoma
Survival
Recurrence
Pediatrics
139 Citations (Scopus)

Identification of molecular characteristics correlated with glioblastoma sensitivity to EGFR kinase inhibition through use of an intracranial xenograft test panel

Sarkaria, J. N., Yang, L., Grogan, P. T., Kitange, G. J., Carlson, B. L., Schroeder, M. A., Galanis, E., Giannini, C., Wu, W., Dinca, E. B. & James, C. D., Mar 2007, In : Molecular Cancer Therapeutics. 6, 3, p. 1167-1174 8 p.

Research output: Contribution to journalArticle

Glioblastoma
Epidermal Growth Factor Receptor
Heterografts
Neoplasms
Complementary DNA
96 Citations (Scopus)

Leucocytosis in polycythaemia vera predicts both inferior survival and leukaemic transformation

Gangat, N., Strand, J., Li, C. Y., Wu, W., Pardanani, A. D. & Tefferi, A., Aug 2007, In : British Journal of Haematology. 138, 3, p. 354-358 5 p.

Research output: Contribution to journalArticle

Polycythemia Vera
Leukocytosis
Survival
Leukocyte Count
Venous Thrombosis