Biomedical Statistics and Informatics

2023

Activation of homology-directed DNA repair plays key role in CRISPR-mediated genome correction

Mondal, G., VanLith, C. J., Nicolas, C. T., Thompson, W. S., Cao, W. S., Hillin, L., Haugo, B. J., O’Brien, D. R., Kocher, J. P., Kaiser, R. A. & Lillegard, J. B., Apr 2023, In: Gene Therapy. 30, 3-4, p. 386-397 12 p.

Research output: Contribution to journal › Article › peer-review

2022

B cell receptor signaling drives APOBEC3 expression via direct enhancer regulation in chronic lymphocytic leukemia B cells

Wang, Z., Yan, H., Boysen, J. C., Secreto, C. R., Tschumper, R. C., Ali, D., Guo, Q., Zhong, J., Zhou, J., Gan, H., Yu, C., Jelinek, D. F., Slager, S. L., Parikh, S. A., Braggio, E. & Kay, N. E., Jul 2022, In: Blood cancer journal. 12, 7, 99.

Research output: Contribution to journal › Article › peer-review

Open Access

CRISPR/Cas9-mediated excision of ALS/FTD-causing hexanucleotide repeat expansion in C9ORF72 rescues major disease mechanisms in vivo and in vitro

Meijboom, K. E., Abdallah, A., Fordham, N. P., Nagase, H., Rodriguez, T., Kraus, C., Gendron, T. F., Krishnan, G., Esanov, R., Andrade, N. S., Rybin, M. J., Ramic, M., Stephens, Z. D., Edraki, A., Blackwood, M. T., Kahriman, A., Henninger, N., Kocher, J. P. A., Benatar, M., Brodsky, M. H., & 6 othersPetrucelli, L., Gao, F. B., Sontheimer, E. J., Brown, R. H., Zeier, Z. & Mueller, C., Dec 2022, In: Nature communications. 13, 1, 6286.

Research output: Contribution to journal › Article › peer-review

Open Access

In vivo lentiviral vector gene therapy to cure hereditary tyrosinemia type 1 and prevent development of precancerous and cancerous lesions

Nicolas, C. T., VanLith, C. J., Hickey, R. D., Du, Z., Hillin, L. G., Guthman, R. M., Cao, W. J., Haugo, B., Lillegard, A., Roy, D., Bhagwate, A., O’Brien, D., Kocher, J. P., Kaiser, R. A., Russell, S. J. & Lillegard, J. B., Dec 2022, In: Nature communications. 13, 1, 5012.

Research output: Contribution to journal › Article › peer-review

Open Access

Quality Performance of a Transfer Center Reduces Interhospital Transfer and Direct Admission-Related ED Evaluations

Pagali, S., Kocher, J. P., Coons, T., King, K., Hansel, S., Van Brunt, N., Smith, C., Williams, A. & Newman, J., Jan 1 2022, In: American Journal of Medical Quality. 37, 1, p. 14-21 8 p.

Research output: Contribution to journal › Article › peer-review

RBBP4-p300 axis modulates expression of genes essential for cell survival and is a potential target for therapy in glioblastoma

Mladek, A. C., Yan, H., Tian, S., Decker, P. A., Burgenske, D. M., Bakken, K., Hu, Z., He, L., Connors, M. A., Carlson, B. L., Wilson, J., Bommi-Reddy, A., Conery, A., Eckel-Passow, J. E., Sarkaria, J. N. & Kitange, G. J., Aug 1 2022, In: Neuro-oncology. 24, 8, p. 1261-1272 12 p.

Research output: Contribution to journal › Article › peer-review

Telogator: A method for reporting chromosome-specific telomere lengths from long reads

Stephens, Z., Ferrer, A., Boardman, L., Iyer, R. K. & Kocher, J. P. A., Apr 1 2022, In: Bioinformatics. 38, 7, p. 1788-1793 6 p.

Research output: Contribution to journal › Article › peer-review

2021

CpGtools: a python package for DNA methylation analysis

Wei, T., Nie, J., Larson, N. B., Ye, Z., Eckel-Passow, J. E., Robertson, K. D., Kocher, J. P. A. & Wang, L., Jun 1 2021, In: Bioinformatics. 37, 11, p. 1598-1599 2 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Determining mutational burden and signature using RNA-seq from tumor-only samples

Jessen, E., Liu, Y., Davila, J., Kocher, J. P. & Wang, C., Dec 2021, In: BMC medical genomics. 14, 1, 65.

Research output: Contribution to journal › Article › peer-review

Open Access

Elevated expression of plasminogen activator inhibitor (PAI-1/SERPINE1) is independent from rs1799889 genotypes in arthrofibrosis

Bayram, B., Owen, A. R., Dudakovic, A., Bettencourt, J. W., Limberg, A. K., Morrey, M. E., Sanchez-Sotelo, J., Berry, D. J., Kocher, J. P. A., van Wijnen, A. J. & Abdel, M. P., Jun 2021, In: Meta Gene. 28, 100877.

Research output: Contribution to journal › Article › peer-review

Open Access

Epigenetic alteration contributes to the transcriptional reprogramming in T-cell prolymphocytic leukemia

Tian, S., Zhang, H., Zhang, P., Kalmbach, M., Lee, J. H., Ordog, T., Hampel, P. J., Call, T. G., Witzig, T. E., Kay, N. E., Klee, E. W., Slager, S. L., Yan, H. & Ding, W., Dec 2021, In: Scientific reports. 11, 1, 8318.

Research output: Contribution to journal › Article › peer-review

Open Access

Exogene: A performant workflow for detecting viral integrations from paired-end next-generation sequencing data

Stephens, Z., O'Brien, D., Dehankar, M., Roberts, L. R., Iyer, R. K. & Kocher, J. P., Sep 2021, In: PloS one. 16, 9 September, e0250915.

Research output: Contribution to journal › Article › peer-review

Open Access

P²T²: Protein Panoramic annoTation Tool for the interpretation of protein coding genetic variants

Devoe, E., Oliver, G. R., Zenka, R., Blackburn, P. R., Cousin, M. A., Boczek, N. J., Kocher, J. P. A., Urrutia, R., Klee, E. W. & Zimmermann, M. T., Jul 1 2021, In: JAMIA Open. 4, 3, ooab065.

Research output: Contribution to journal › Article › peer-review

Open Access

Pancreatic cancer intrinsic PI3Kα activity accelerates metastasis and rewires macrophage component

Thibault, B., Ramos-Delgado, F., Pons-Tostivint, E., Therville, N., Cintas, C., Arcucci, S., Cassant-Sourdy, S., Reyes-Castellanos, G., Tosolini, M., Villard, A. V., Cayron, C., Baer, R., Bertrand-Michel, J., Pagan, D., Ferreira Da Mota, D., Yan, H., Falcomatà, C., Muscari, F., Bournet, B., Delord, J. P., & 6 othersAksoy, E., Carrier, A., Cordelier, P., Saur, D., Basset, C. & Guillermet-Guibert, J., Jul 7 2021, In: EMBO Molecular Medicine. 13, 7, e13502.

Research output: Contribution to journal › Article › peer-review

Open Access

PB-Motif—A Method for Identifying Gene/Pseudogene Rearrangements With Long Reads: An Application to CYP21A2 Genotyping

Stephens, Z., Milosevic, D., Kipp, B., Grebe, S., Iyer, R. K. & Kocher, J. P. A., Jul 28 2021, In: Frontiers in Genetics. 12, 716586.

Research output: Contribution to journal › Article › peer-review

Open Access

phase1RMD: An R package for repeated measures dose-finding designs with novel toxicity and efficacy endpoints

Yin, J., Du, Y., Qin, R., Shen, S. & Mandrekar, S., Sep 2021, In: PloS one. 16, 9 September, e0256391.

Research output: Contribution to journal › Article › peer-review

Open Access

Re-Evaluate Fusion Genes in Prostate Cancer

Wei, T., Lu, J., Ma, T., Huang, H., Kocher, J. P. & Wang, L., 2021, In: Cancer Informatics. 20

Research output: Contribution to journal › Article › peer-review

Open Access

Super enhancer regulation of cytokine-induced chemokine production in alcoholic hepatitis

Liu, M., Cao, S., He, L., Gao, J., Arab, J. P., Cui, H., Xuan, W., Gao, Y., Sehrawat, T. S., Hamdan, F. H., Ventura-Cots, M., Argemi, J., Pomerantz, W. C. K., Johnsen, S. A., Lee, J. H., Gao, F., Ordog, T., Mathurin, P., Revzin, A., Bataller, R., & 2 othersYan, H. & Shah, V. H., Dec 1 2021, In: Nature communications. 12, 1, 4560.

Research output: Contribution to journal › Article › peer-review

Open Access

Surface Roughness of Titanium Orthopedic Implants Alters the Biological Phenotype of Human Mesenchymal Stromal Cells

Lewallen, E. A., Trousdale, W. H., Thaler, R., Yao, J. J., Xu, W., Denbeigh, J. M., Nair, A., Kocher, J. P., Dudakovic, A., Berry, D. J., Cohen, R. C., Abdel, M. P., Lewallen, D. G. & Van Wijnen, A. J., Dec 2021, In: Tissue Engineering - Part A. 27, 23-24, p. 1503-1516 14 p.

Research output: Contribution to journal › Article › peer-review

Wnt-induced, TRP53-mediated Cell Cycle Arrest of Precursors Underlies Interstitial Cell of Cajal Depletion During Aging

Hayashi, Y., Asuzu, D. T., Bardsley, M. R., Gajdos, G. B., Kvasha, S. M., Linden, D. R., Nagy, R. A., Saravanaperumal, S. A., Syed, S. A., Toyomasu, Y., Yan, H., Chini, E. N., Gibbons, S. J., Kellogg, T. A., Khazaie, K., Kuro-o, M., Machado Espindola Netto, J., Singh, M. P., Tidball, J. G., Wehling-Henricks, M., & 2 othersFarrugia, G. & Ordog, T., Jan 2021, In: CMGH. 11, 1, p. 117-145 29 p.

Research output: Contribution to journal › Article › peer-review

Open Access

ZNF416 is a pivotal transcriptional regulator of fibroblast mechanoactivation

Jones, D. L., Meridew, J. A., Link, P. A., Ducharme, M. T., Lydon, K. L., Choi, K. M., Caporarello, N., Tan, Q., Espinosa, A. M. D., Xiong, Y., Lee, J. H., Ye, Z., Yan, H., Ordog, T., Ligresti, G., Varelas, X. & Tschumperlin, D. J., Feb 2021, In: Journal of Cell Biology. 220, 5, e202007152.

Research output: Contribution to journal › Article › peer-review

Open Access

2020

8q24 clear cell renal cell carcinoma germline variant is associated with VHL mutation status and clinical aggressiveness

Eckel-Passow, J. E., Yan, H., Kosel, M. L., Serie, D., Decker, P. A., Jenkins, R. B., Costello, B., Leibovich, B., Ho, T. H. & Parker, A., Dec 1 2020, In: BMC Urology. 20, 1, 173.

Research output: Contribution to journal › Article › peer-review

Open Access

A potential theragnostic regulatory axis for arthrofibrosis involving adiponectin (Adipoq) receptor 1 and 2 (adipor1 and adipor2), tgfβ1, and smooth muscle α-actin (acta2)

Bayram, B., Owen, A. R., Dudakovic, A., Dagneaux, L., Turner, T. W., Bettencourt, J. W., Limberg, A. K., Tibbo, M. E., Morrey, M. E., Sanchez-Sotelo, J., Berry, D. J., Kocher, J. P. A., van Wijnen, A. J. & Abdel, M. P., Nov 2020, In: Journal of Clinical Medicine. 9, 11, p. 1-15 15 p., 3690.

Research output: Contribution to journal › Article › peer-review

Open Access

A randomized phase II trial evaluating two non-pharmacologic interventions in cancer survivors for the treatment of sleep-wake disturbances: NCCTG N07C4 (Alliance)

Barton, D. L., Atherton, P. J., Satele, D. V., Qin, R., Dakhil, S., Pipe, T., Hobday, T., Fee-Schroeder, K. & Loprinzi, C. L., Dec 2020, In: Supportive Care in Cancer. 28, 12, p. 6085-6094 10 p.

Research output: Contribution to journal › Article › peer-review

Chronic lymphocytic leukemia (CLL) risk is mediated by multiple enhancer variants within CLL risk loci

Yan, H., Tian, S., Kleinstern, G., Wang, Z., Lee, J. H., Boddicker, N. J., Cerhan, J. R., Kay, N. E., Braggio, E. & Slager, S. L., Aug 15 2020, In: Human molecular genetics. 29, 16, p. 2761-2774 14 p.

Research output: Contribution to journal › Article › peer-review

Combining copy number, methylation markers, and mutations as a panel for endometrial cancer detection via intravaginal tampon collection

Sangtani, A., Wang, C., Weaver, A., Hoppman, N. L., Kerr, S. E., Abyzov, A., Shridhar, V., Staub, J., Kocher, J. P. A., Voss, J. S., Podratz, K. C., Wentzensen, N., Kisiel, J. B., Sherman, M. E. & Bakkum-Gamez, J. N., Feb 2020, In: Gynecologic oncology. 156, 2, p. 387-392 6 p.

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Epigenetic Alterations Are Associated With Gastric Emptying Disturbances in Diabetes Mellitus

Puthanmadhom Narayanan, S., Lee, J. H., Bhagwate, A., Kuwelker, S., Yan, H., Ordog, T. & Bharucha, A. E., Mar 1 2020, In: Clinical and translational gastroenterology. 11, 3, p. e00136

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Ex Vivo Cell Therapy by Ectopic Hepatocyte Transplantation Treats the Porcine Tyrosinemia Model of Acute Liver Failure

Nicolas, C. T., Kaiser, R. A., Hickey, R. D., Allen, K. L., Du, Z., VanLith, C. J., Guthman, R. M., Amiot, B., Suksanpaisan, L., Han, B., Francipane, M. G., Cheikhi, A., Jiang, H., Bansal, A., Pandey, M. K., Garg, I., Lowe, V., Bhagwate, A., O'Brien, D., Kocher, J. P. A., & 4 othersDeGrado, T. R., Nyberg, S. L., Lagasse, E. & Lillegard, J. B., Sep 11 2020, In: Molecular Therapy - Methods and Clinical Development. 18, p. 738-750 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Genomic and epigenomic landscaping defines new therapeutic targets for adenosquamous carcinoma of the pancreas

Lenkiewicz, E., Malasi, S., Hogenson, T. L., Flores, L. F., Barham, W., Phillips, W. J., Roesler, A. S., Chambers, K. R., Rajbhandari, N., Hayashi, A., Antal, C. E., Downes, M., Grandgenett, P. M., Hollingsworth, M. A., Cridebring, D., Xiong, Y., Lee, J. H., Ye, Z., Yan, H., Hernandez, M. C., & 9 othersLeiting, J. L., Evans, R. M., Ordog, T., Truty, M. J., Borad, M. J., Reya, T., von Hoff, D. D., Fernandez-Zapico, M. E. & Barrett, M. T., Oct 15 2020, In: Cancer research. 80, 20, p. 4324-4334 11 p.

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Genomic and phenotypic characterization of a broad panel of patient-derived xenografts reflects the diversity of glioblastoma

Vaubel, R. A., Tian, S., Remonde, D., Schroeder, M. A., Mladek, A. C., Kitange, G. J., Caron, A., Kollmeyer, T. M., Grove, R., Peng, S., Carlson, B. L., Ma, D. J., Sarkar, G., Evers, L., Decker, P. A., Yan, H., Dhruv, H. D., Berens, M. E., Wang, Q., Marin, B. M., & 14 othersKlee, E. W., Califano, A., LaChance, D. H., Eckel-Passow, J. E., Verhaak, R. G., Sulman, E. P., Burns, T. C., Meyer, F. B., O'Neill, B. P., Tran, N. L., Giannini, C., Jenkins, R. B., Parney, I. F. & Sarkaria, J. N., Mar 1 2020, In: Clinical Cancer Research. 26, 5, p. 1094-1104 11 p.

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Inherited variants at 3q13.33 and 3p24.1 are associated with risk of diffuse large B-cell lymphoma and implicate immune pathways

Kleinstern, G., Yan, H., Hildebrandt, M. A. T., Vijai, J., Berndt, S. I., Ghesquières, H., McKay, J., Wang, S. S., Nieters, A., Ye, Y., Monnereau, A., Brooks-Wilson, A. R., Lan, Q., Melbye, M., Jackson, R. D., Teras, L. R., Purdue, M. P., Vajdic, C. M., Vermeulen, R. C. H., Giles, G. G., & 18 othersCocco, P. L., Birmann, B. M., Kraft, P., Albanes, D., Zeleniuch-Jacquotte, A., Crouch, S., Zhang, Y., Sarangi, V., Asmann, Y., Offit, K., Salles, G., Wu, X., Smedby, K. E., Skibola, C. F., Slager, S. L., Rothman, N., Chanock, S. J. & Cerhan, J. R., Jan 1 2020, In: Human molecular genetics. 29, 1, p. 70-79 10 p.

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Time event ontology (TEO): To support semantic representation and reasoning of complex temporal relations of clinical events

Li, F., Du, J., He, Y., Song, H. Y., Madkour, M., Rao, G., Xiang, Y., Luo, Y., Chen, H. W., Liu, S., Wang, L., Liu, H., Xu, H. & Tao, C., Jul 1 2020, In: Journal of the American Medical Informatics Association. 27, 7, p. 1046-1056 11 p.

Research output: Contribution to journal › Article › peer-review

Tumor mutational load predicts time to first treatment in chronic lymphocytic leukemia (CLL) and monoclonal B-cell lymphocytosis beyond the CLL international prognostic index

Kleinstern, G., O'Brien, D. R., Li, X., Tian, S., Kabat, B. F., Rabe, K. G., Norman, A. D., Yan, H., Vachon, C. M., Boddicker, N. J., Call, T. G., Parikh, S. A., Bruins, L., Bonolo de Campos, C., Leis, J. F., Shanafelt, T. D., Ding, W., Cerhan, J. R., Kay, N. E., Slager, S. L., & 1 othersBraggio, E., Aug 1 2020, In: American journal of hematology. 95, 8, p. 906-917 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

2019

Ccne1 Overexpression Causes Chromosome Instability in Liver Cells and Liver Tumor Development in Mice

Aziz, K., Limzerwala, J. F., Sturmlechner, I., Hurley, E., Zhang, C., Jeganathan, K. B., Nelson, G., Bronk, S., Fierro Velasco, R. O., van Deursen, E. J., O'Brien, D. R., Kocher, J. P. A., Youssef, S. A., van Ree, J. H., de Bruin, A., van den Bos, H., Spierings, D. C. J., Foijer, F., van de Sluis, B., Roberts, L. R., & 3 othersGores, G. J., Li, H. & van Deursen, J. M., Jul 2019, In: Gastroenterology. 157, 1, p. 210-226.e12

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial

Sio, T. T., Le-Rademacher, J. G., Leenstra, J. L., Loprinzi, C. L., Rine, G., Curtis, A., Singh, A. K., Martenson, J. A., Novotny, P. J., Tan, A. D., Qin, R., Ko, S. J., Reiter, P. L. & Miller, R. C., Apr 16 2019, In: JAMA - Journal of the American Medical Association. 321, 15, p. 1481-1490 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

Enhanced and controlled chromatin extraction from FFPE tissues and the application to ChIP-seq

Zhong, J., Ye, Z., Clark, C. R., Lenz, S. W., Nguyen, J. H., Yan, H., Robertson, K. D., Farrugia, G., Zhang, Z., Ordog, T. & Lee, J. H., Mar 29 2019, In: BMC genomics. 20, 1, 249.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Identification of factors associated with duplicate rate in ChIP-seq data

Tian, S., Peng, S., Kalmbach, M., Gaonkar, K. S., Bhagwate, A., Ding, W., Eckel-Passow, J., Yan, H. & Slager, S. L., Apr 2019, In: PloS one. 14, 4, e0214723.

Research output: Contribution to journal › Article › peer-review

Open Access

Predict drug sensitivity of cancer cells with pathway activity inference

Wang, X., Sun, Z., Zimmermann, M. T., Bugrim, A. & Kocher, J. P., Jan 31 2019, In: BMC medical genomics. 12, 15.

Research output: Contribution to journal › Article › peer-review

Open Access

17 Scopus citations

Prognostic subclass of intrahepatic cholangiocarcinoma by integrative molecular–clinical analysis and potential targeted approach

Ahn, K. S., O’Brien, D., Kang, Y. N., Mounajjed, T., Kim, Y. H., Kim, T. S., Kocher, J. P. A., Allotey, L. K., Borad, M. J., Roberts, L. R. & Kang, K. J., Jul 1 2019, In: Hepatology International. 13, 4, p. 490-500 11 p.

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Recurrent MSC^E116K mutations in ALK-negative anaplastic large cell lymphoma

Luchtel, R. A., Zimmermann, M. T., Hu, G., Dasari, S., Jiang, M., Oishi, N., Jacobs, H. K., Zeng, Y., Hundal, T., Rech, K. L., Ketterling, R. P., Lee, J. H., Eckloff, B. W., Yan, H., Gaonkar, K. S., Tian, S., Ye, Z., Kadin, M. E., Sidhu, J., Jiang, L., & 11 othersVoss, J., Link, B. K., Syrbu, S. I., Facchetti, F., Bennani, N. N., Slager, S. L., Ordog, T., Kocher, J. P., Cerhan, J. R., Ansell, S. M. & Feldman, A. L., Jun 27 2019, In: Blood. 133, 26, p. 2776-2789 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

Serum Proteomics on the Basis of Discovery of Predictive Biomarkers of Response to Androgen Deprivation Therapy in Advanced Prostate Cancer

Kohli, M., Oberg, A. L., Mahoney, D. W., Riska, S. M., Sherwood, R., Zhang, Y., Zenka, R. M., Sahasrabudhe, D., Qin, R. & Zhang, S., Aug 2019, In: Clinical Genitourinary Cancer. 17, 4, p. 248-253.e7

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

TGFβ-induced fibroblast activation requires persistent and targeted HDAC-mediated gene repression

Jones, D. L., Haak, A. J., Caporarello, N., Choi, K. M., Ye, Z., Yan, H., Varelas, X., Ordog, T., Ligresti, G. & Tschumperlin, D. J., 2019, In: Journal of cell science. 132, 20, jcs233486.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

2018

A Comprehensive Pan-Cancer Molecular Study of Gynecologic and Breast Cancers

The Cancer Genome Atlas Research Network, Apr 9 2018, In: Cancer cell. 33, 4, p. 690-705.e9

Research output: Contribution to journal › Article › peer-review

Open Access

168 Scopus citations

A data science approach for the classification of low-grade and high-grade ovarian serous carcinomas

Lin, S., Wang, C., Zarei, S., Bell, D. A., Kerr, S. E., Runger, G. C. & Kocher, J. P. A., Nov 27 2018, In: BMC genomics. 19, 1, 841.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

A hierarchical Bayesian design for randomized Phase II clinical trials with multiple groups

Yin, J., Qin, R., Sargent, D. J., Erlichman, C. & Shi, Q., May 4 2018, In: Journal of Biopharmaceutical Statistics. 28, 3, p. 451-462 12 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics

The Cancer Genome Atlas Research Network, Apr 5 2018, In: Cell. 173, 2, p. 400-416.e11

Research output: Contribution to journal › Article › peer-review

Open Access

600 Scopus citations

A Pan-Cancer Analysis of Enhancer Expression in Nearly 9000 Patient Samples

The Cancer Genome Atlas Research Network, Apr 5 2018, In: Cell. 173, 2, p. 386-399.e12

Research output: Contribution to journal › Article › peer-review

Open Access

87 Scopus citations

A Pan-Cancer Analysis Reveals High-Frequency Genetic Alterations in Mediators of Signaling by the TGF-β Superfamily

The Cancer Genome Atlas Research Network, Oct 24 2018, In: Cell Systems. 7, 4, p. 422-437.e7

Research output: Contribution to journal › Article › peer-review

Open Access

44 Scopus citations

CARM1-expressing ovarian cancer depends on the histone methyltransferase EZH2 activity

Karakashev, S., Zhu, H., Wu, S., Yokoyama, Y., Bitler, B. G., Park, P. H., Lee, J. H., Kossenkov, A. V., Gaonkar, K. S., Yan, H., Drapkin, R., Conejo-Garcia, J. R., Speicher, D. W., Ordog, T. & Zhang, R., Dec 1 2018, In: Nature communications. 9, 1, 631.

Research output: Contribution to journal › Article › peer-review

Open Access

33 Scopus citations

Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer

The Cancer Genome Atlas Network, Apr 5 2018, In: Cell. 173, 2, p. 291-304.e6

Research output: Contribution to journal › Article › peer-review

Open Access

538 Scopus citations

Biomedical Statistics and Informatics

Research output

Search results