Biochemistry and Molecular Biology

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2020

Fructose-1,6-bisphosphatase loss modulates STAT3-dependent expression of PD-L1 and cancer immunity

Wang, B., Zhou, Y., Zhang, J., Jin, X., Wu, H. & Huang, H., Jan 1 2020, In : Theranostics. 10, 3, p. 1033-1045 13 p.

Research output: Contribution to journalArticle

Open Access

Influence of water based embedding media composition on the relaxation properties of fixed tissue

Vučković, I., Nayfeh, T., Mishra, P. K., Periyanan, S., Sussman, C. R., Kline, T. L. & Macura, S., Apr 2020, In : Magnetic Resonance Imaging. 67, p. 7-17 11 p.

Research output: Contribution to journalArticle

Retinoid X receptor alpha is a spatiotemporally predominant therapeutic target for anthracycline-induced cardiotoxicity

Ma, X., Zhu, P., Ding, Y., Zhang, H., Qiu, Q., Dvornikov, A. V., Wang, Z., Kim, M., Wang, Y., Lowerison, M., Yu, Y., Norton, N., Herrmann, J., Ekker, S. C., Hsiai, T. K., Lin, X. & Xu, X., Jan 29 2020, In : Science Advances. 6, 5, eaay2939.

Research output: Contribution to journalArticle

Open Access

Ultrasound image processing to estimate the structural and functional properties of mouse skeletal muscle

Ternifi, R., Kammoun, M., Pouletaut, P., Subramaniam, M., Hawse, J. R. & Bensamoun, S. F., Feb 2020, In : Biomedical Signal Processing and Control. 56, 101735.

Research output: Contribution to journalArticle

2019

A conditional mouse model of complex II deficiency manifesting as Leigh-like syndrome

Al Khazal, F., Holte, M. N., Bolon, B., White, T. A., LeBrasseur, N. & Maher, L. J., Dec 1 2019, In : FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33, 12, p. 13189-13201 13 p.

Research output: Contribution to journalArticle

Acquisition, Processing and Analysis of Electrocardiogram in Awake Zebrafish

Le, T., Lenning, M., Clark, I., Bhimani, I., Fortunato, J., Marsh, P., Xu, X. H. & Cao, H., Jun 1 2019, In : IEEE Sensors Journal. 19, 11, p. 4283-4289 7 p., 8636511.

Research output: Contribution to journalArticle

1 Scopus citations

Amplification-free long-read sequencing of TCF4 expanded trinucleotide repeats in Fuchs Endothelial Corneal Dystrophy

Wieben, E. D., Aleff, R. A., Basu, S., Sarangi, V., Bowman, B., McLaughlin, I. J., Mills, J. R., Butz, M. L., Highsmith, W. E. J., Ida, C. M., Ekholm, J. M., Baratz, K. & Fautsch, M. P., Jan 1 2019, In : PloS one. 14, 7, e0219446.

Research output: Contribution to journalArticle

Open Access

An in Vitro Selection Strategy Identifying Naked DNA That Localizes to Cell Nuclei

Smestad, J., Wilbanks, B. & Maher, L. J., Nov 20 2019, In : Journal of the American Chemical Society. 141, 46, p. 18375-18379 5 p.

Research output: Contribution to journalArticle

Association of rs613872 and Trinucleotide Repeat Expansion in the TCF4 Gene of German Patients With Fuchs Endothelial Corneal Dystrophy

Okumura, N., Hayashi, R., Nakano, M., Tashiro, K., Yoshii, K., Aleff, R., Butz, M., Highsmith, W. E. J., Wieben, E. D., Fautsch, M. P., Baratz, K., Komori, Y., Ueda, E., Nakahara, M., Weller, J., Tourtas, T., Schlötzer-Schrehardt, U., Kruse, F. & Koizumi, N., Jul 1 2019, In : Cornea. 38, 7, p. 799-805 7 p.

Research output: Contribution to journalArticle

Case-Based Learning in Translational Biomedical Research Education: Providing Realistic and Adaptive Skills for Early-Career Scientists

Greenberg-Worisek, A. J., Campbell, K. A., Klee, E. W., Staff, N. P., Schimmenti, L. A., Weavers, K. M., Ekker, S. C. & Windebank, A. J., Feb 1 2019, In : Academic medicine : journal of the Association of American Medical Colleges. 94, 2, p. 213-216 4 p.

Research output: Contribution to journalArticle

Clinical features, laboratory characteristics and outcomes of patients with renal versus cardiac light chain amyloidosis

Sidana, S., Tandon, N., Gertz, M., Dispenzieri, A., Ramirez-Alvarado, M., Murray, D. L., Kourelis, T., Buadi, F. K., Kapoor, P., Gonsalves, W., Warsame, R., Lacy, M., Kyle, R. A., Rajkumar, S. V., Kumar, S. K. & Leung, N., Jan 1 2019, In : British journal of haematology.

Research output: Contribution to journalArticle

3 Scopus citations

Design, Synthesis, and Actions of an Innovative Bispecific Designer Peptide

Meems, L. M. G., Andersen, I. A., Pan, S., Harty, G., Chen, Y., Zheng, Y., Harders, G. E., Ichiki, T., Heublein, D. M., Iyer, S. R., Sangaralingham, S. J., Mc Cormick, D. J. & Burnett, J. C. J., Apr 1 2019, In : Hypertension (Dallas, Tex. : 1979). 73, 4, p. 900-909 10 p.

Research output: Contribution to journalArticle

3 Scopus citations

Development of a novel multiphysical approach for the characterization of mechanical properties of musculotendinous tissues

Kammoun, M., Ternifi, R., Dupres, V., Pouletaut, P., Même, S., Même, W., Szeremeta, F., Landoulsi, J., Constans, J. M., Lafont, F., Subramaniam, M., Hawse, J. R. & Bensamoun, S. F., Dec 1 2019, In : Scientific reports. 9, 1, 7733.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Displacement analysis of myocardial mechanical deformation (DIAMOND) reveals segmental susceptibility to doxorubicin-induced injury and regeneration

Chen, J., Ding, Y., Chen, M., Gau, J., Jen, N., Nahal, C., Tu, S., Chen, C., Zhou, S., Chang, C. C., Lyu, J., Xu, X. H., Hsiai, T. K. & Packard, R. R. S., Jan 1 2019, In : JCI Insight. 4, 8, e125362.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Effect of Trinucleotide Repeat Expansion on the Expression of TCF4 mRNA in Fuchs' Endothelial Corneal Dystrophy

Okumura, N., Hayashi, R., Nakano, M., Yoshii, K., Tashiro, K., Sato, T., Blake, D. J., Aleff, R., Butz, M., Highsmith, W. E. J., Wieben, E. D., Fautsch, M. P., Baratz, K., Komori, Y., Nakahara, M., Tourtas, T., Schlötzer-Schrehardt, U., Kruse, F. & Koizumi, N., Feb 1 2019, In : Investigative ophthalmology & visual science. 60, 2, p. 779-786 8 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Establishment of TUSMi008-A, an induced pluripotent stem cell (iPSC) line from a 76-year old Alzheimer's disease (AD) patient with PAXIP1 gene mutation

Wang, Y., Zhang, J., Hu, J., Li, G., Lei, Y. & Zhao, J., Apr 1 2019, In : Stem Cell Research. 36, 101391.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Evidence for a bind-then-bend mechanism for architectural DNA binding protein yNhp6A

Sarangi, M. K., Zvoda, V., Holte, M. N., Becker, N. A., Peters, J. P., Maher III, L. J. & Ansari, A., Apr 8 2019, In : Nucleic acids research. 47, 6, p. 2871-2883 13 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

EZH2 cooperates with gain-of-function p53 mutants to promote cancer growth and metastasis

Zhao, Y., Ding, L., Wang, D., Ye, Z., He, Y., Ma, L., Zhu, R., Pan, Y., Wu, Q., Pang, K., Hou, X., Weroha, S. J., Han, C., Coleman, R., Coleman, I., Karnes, R. J., Zhang, J., Nelson, P. S., Wang, L. & Huang, H., Jan 1 2019, In : EMBO Journal. e99599.

Research output: Contribution to journalArticle

7 Scopus citations

Familial chronic megacolon presenting in childhood or adulthood: Seeking the presumed gene association

Camilleri, M., Wieben, E. D., Eckert, D., Carlson, P., Hurley O’Dwyer, R., Gibbons, D., Acosta, A. & Klee, E. W., Jan 1 2019, (Accepted/In press) In : Neurogastroenterology and Motility. e13550.

Research output: Contribution to journalArticle

3 Scopus citations
Open Access

Glial cells as therapeutic targets in progressive multiple sclerosis

Wilbanks, B., Maher III, L. J. & Rodriguez, M., Jun 1 2019, In : Expert review of neurotherapeutics. 19, 6, p. 481-494 14 p.

Research output: Contribution to journalArticle

2 Scopus citations

Haploinsufficiency of mechanistic target of rapamycin ameliorates bag3 cardiomyopathy in adult zebrafish

Ding, Y., Dvornikov, A. V., Ma, X., Zhang, H., Wang, Y., Lowerison, M., Packard, R. R., Wang, L., Chen, J., Zhang, Y., Hsiai, T., Lin, X. & Xu, X., Oct 1 2019, In : Disease models & mechanisms. 12, 10

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Male breast cancer in the United States: Treatment patterns and prognostic factors in the 21st century

Yadav, S., Karam, D., Bin Riaz, I., Xie, H., Durani, U., Duma, N., Giridhar, K. V., Hieken, T. J., Boughey, J. C., Mutter, R. W., Hawse, J. R., Jimenez, R. E., Couch, F. J., Leon-Ferre, R. A. & Ruddy, K. J., Jan 1 2019, (Accepted/In press) In : Cancer.

Research output: Contribution to journalArticle

4 Scopus citations

Master regulator analysis of paragangliomas carrying SDHx, VHL, or MAML3 genetic alterations

Smestad, J. A. & Maher, J. L., Jun 24 2019, In : BMC cancer. 19, 1, 619.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Measurement of murine kidney functional biomarkers using DCE-MRI: A multi-slice TRICKS technique and semi-automated image processing algorithm

Jiang, K., Tang, H., Mishra, P. K., Macura, S. I. & Lerman, L. O., Nov 1 2019, In : Magnetic Resonance Imaging. 63, p. 226-234 9 p.

Research output: Contribution to journalArticle

Mechanistic Insights into the Early Events in the Aggregation of Immunoglobulin Light Chains

Misra, P., Blancas-Mejia, L. M. & Ramirez-Alvarado, M., Jun 25 2019, In : Biochemistry. 58, 29, p. 3155-3168 14 p.

Research output: Contribution to journalArticle

Mitsui-7, heat-treated, and nitrogen-doped multi-walled carbon nanotubes elicit genotoxicity in human lung epithelial cells

Siegrist, K. J., Reynolds, S. H., Porter, D. W., Mercer, R. R., Bauer, A. K., Lowry, D., Cena, L., Stueckle, T. A., Kashon, M. L., Wiley, J., Salisbury, J. L., Mastovich, J., Bunker, K., Sparrow, M., Lupoi, J. S., Stefaniak, A. B., Keane, M. J., Tsuruoka, S., Terrones, M., McCawley, M. & 1 others, Sargent, L. M., Oct 7 2019, In : Particle and Fibre Toxicology. 16, 1, 36.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Modeling succinate dehydrogenase loss disorders in C. elegans through effects on hypoxia-inducible factor

Braun, M. M., Damjanac, T., Zhang, Y., Chen, C., Hu, J. & Maher, L. J., Jan 1 2019, In : PloS one. 14, 12, e0227033.

Research output: Contribution to journalArticle

Open Access

Molecular characterization of known and novel ACVR1 variants in phenotypes of aberrant ossification

Gupta, A., Zimmermann, M. T., Wang, H., Broski, S. M., Sigafoos, A. N., Macklin, S. K., Urrutia, R. A., Clark, K. J., Atwal, P. S., Pignolo, R. J. & Klee, E. W., Jan 1 2019, In : American Journal of Medical Genetics, Part A.

Research output: Contribution to journalArticle

Novel role of Tieg1 in muscle metabolism and mitochondrial oxidative capacities

Kammoun, M., Piquereau, J., Nadal-Desbarats, L., Même, S., Beuvin, M., Bonne, G., Veksler, V., Le Fur, Y., Pouletaut, P., Même, W., Szeremeta, F., Constans, J. M., Bruinsma, E. S., Nelson Holte, M. H., Najafova, Z., Johnsen, S. A., Subramaniam, M., Hawse, J. R. & Bensamoun, S. F., Jan 1 2019, (Accepted/In press) In : Acta Physiologica. e13394.

Research output: Contribution to journalArticle

Novel zebrafish behavioral assay to identify modifiers of the rapid, nongenomic stress response

Lee, H. B., Schwab, T. L., Sigafoos, A. N., Gauerke, J. L., Krug, R. G., Serres, M. K. R., Jacobs, D. C., Cotter, R. P., Das, B., Petersen, M. O., Daby, C. L., Urban, R. M., Berry, B. C. & Clark, K. J., Jan 1 2019, (Accepted/In press) In : Genes, Brain and Behavior. e12549.

Research output: Contribution to journalArticle

3 Scopus citations

Optimization of a 40-mer Antimyelin DNA Aptamer Identifies a 20-mer with Enhanced Properties for Potential Multiple Sclerosis Therapy

Wilbanks, B., Smestad, J., Heider, R. M., Warrington, A. E., Rodriguez, M. & Maher III, L. J., Jun 1 2019, In : Nucleic Acid Therapeutics. 29, 3, p. 126-135 10 p.

Research output: Contribution to journalArticle

3 Scopus citations

Optimized immunohistochemical detection of estrogen receptor beta using two validated monoclonal antibodies confirms its expression in normal and malignant breast tissues

Hawse, J. R., Carter, J. M., Aspros, K. G. M., Bruinsma, E. S., Koepplin, J. W., Negron, V., Subramaniam, M., Ingle, J. N., Rech, K. L. & Goetz, M. P., Jan 1 2019, (Accepted/In press) In : Breast Cancer Research and Treatment.

Research output: Contribution to journalArticle

Overcoming EZH2 inhibitor resistance by taxane in PTEN-mutated cancer

Ma, L., Yan, Y., Bai, Y., Yang, Y., Pan, Y., Gang, X., Karnes, R. J., Zhang, J., Lv, Q., Wu, Q. & Huang, H., Jan 1 2019, In : Theranostics. 9, 17, p. 5020-5034 15 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Phenotyping an adult zebrafish lamp2 cardiomyopathy model identifies mTOR inhibition as a candidate therapy

Dvornikov, A. V., Wang, M., Yang, J., Zhu, P., Le, T., Lin, X., Cao, H. & Xu, X. H., Aug 1 2019, In : Journal of Molecular and Cellular Cardiology. 133, p. 199-208 10 p.

Research output: Contribution to journalArticle

2 Scopus citations

Phosphorylated RB Promotes Cancer Immunity by Inhibiting NF-κB Activation and PD-L1 Expression

Jin, X., Ding, D., Yan, Y., Li, H., Wang, B., Ma, L., Ye, Z., Ma, T., Wu, Q., Rodrigues, D. N., Kohli, M., Jimenez, R. E., Wang, L., Goodrich, D. W., de Bono, J., Dong, H. M., Wu, H., Zhu, R. & Huang, H., Jan 3 2019, In : Molecular Cell. 73, 1, p. 22-35.e6

Research output: Contribution to journalArticle

15 Scopus citations

Recommendations for performance optimizations when using GATK3.8 and GATK4

Heldenbrand, J. R., Baheti, S., Bockol, M. A., Drucker, T. M., Hart, S. N., Hudson, M. E., Iyer, R. K., Kalmbach, M. T., Kendig, K. I., Klee, E. W., Mattson, N. R., Wieben, E. D., Wiepert, M., Wildman, D. E. & Mainzer, L. S., Nov 8 2019, In : BMC bioinformatics. 20, 1, 557.

Research output: Contribution to journalArticle

Open Access

RINT1 Bi-allelic Variations Cause Infantile-Onset Recurrent Acute Liver Failure and Skeletal Abnormalities

Cousin, M. A., Conboy, E., Wang, J. S., Lenz, D., Schwab, T. L., Williams, M., Abraham, R. S., Barnett, S., El-Youssef, M., Graham, R. P., Gutierrez Sanchez, L. H., Hasadsri, L., Hoffmann, G. F., Hull, N. C., Kopajtich, R., Kovacs-Nagy, R., Li, J. Q., Marx-Berger, D., McLin, V., McNiven, M. A. & 9 others, Mounajjed, T., Prokisch, H., Rymen, D., Schulze, R. J., Staufner, C., Yang, Y., Clark, K. J., Lanpher, B. C. & Klee, E. W., Jul 3 2019, In : American journal of human genetics. 105, 1, p. 108-121 14 p.

Research output: Contribution to journalArticle

3 Scopus citations

RUNX2 overexpression and PTEN haploinsufficiency cooperate to promote CXCR7 expression and cellular trafficking, AKT hyperactivation and prostate tumorigenesis

Bai, Y., Yang, Y., Yan, Y., Zhong, J., Blee, A. M., Pan, Y., Ma, T., Karnes, R. J., Jimenez, R. E., Xu, W. & Huang, H., Jan 1 2019, In : Theranostics. 9, 12, p. 3459-3475 17 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

SentIeon DNaSeq variant calling workflow demonstrates strong computational performance and accuracy

Kendig, K. I., Baheti, S., Bockol, M. A., Drucker, T. M., Hart, S., Heldenbrand, J. R., Hernaez, M., Hudson, M. E., Kalmbach, M. T., Klee, E. W., Mattson, N. R., Ross, C. A., Taschuk, M., Wieben, E. D., Wiepert, M., Wildman, D. E. & Mainzer, L. S., Jan 1 2019, In : Frontiers in Genetics. 10, JUL, 736.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Serial Block Face SEM Service

Salisbury, J. L., Sanders, M., Charlesworth, J., Christensen, T. & Jaspersen, A., Dec 1 2019, In : Journal of biomolecular techniques : JBT. 30, p. S60

Research output: Contribution to journalArticle

Single and double box HMGB proteins differentially destabilize nucleosomes

McCauley, M. J., Huo, R., Becker, N., Holte, M. N., Muthurajan, U. M., Rouzina, I., Luger, K., Maher III, L. J., Israeloff, N. E. & Williams, M. C., Jan 25 2019, In : Nucleic Acids Research. 47, 2, p. 666-678 13 p.

Research output: Contribution to journalArticle

Skeletal Muscle Progenitor Cell Heterogeneity

Cho, D. S. & Doles, J., Jan 1 2019, In : Advances in experimental medicine and biology. 1169, p. 179-193 15 p.

Research output: Contribution to journalArticle

1 Scopus citations

Taking a closer look at whole organisms

Ichino, N. & Ekker, S. C., Jun 14 2019, In : eLife. 8

Research output: Contribution to journalArticle

Open Access

The Gene Sculpt Suite: a set of tools for genome editing

Mann, C. M., Martínez-Gálvez, G., Welker, J. M., Wierson, W. A., Ata, H., Almeida, M. P., Clark, K. J., Essner, J. J., McGrail, M., Ekker, S. C. & Dobbs, D., Jul 2 2019, In : Nucleic acids research. 47, W1, p. W175-W182

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

The LipoGlo reporter system for sensitive and specific monitoring of atherogenic lipoproteins

Thierer, J. H., Ekker, S. C. & Farber, S. A., Jul 31 2019, In : Nature communications. 10, 1, 1 p.

Research output: Contribution to journalArticle

Open Access

The novel BET-CBP/p300 dual inhibitor NEO2734 is active in SPOP mutant and wild-type prostate cancer

Yan, Y., Ma, J., Wang, D., Lin, D., Pang, X., Wang, S., Zhao, Y., Shi, L., Xue, H., Pan, Y., Zhang, J., Wahlestedt, C., Giles, F. J., Chen, Y., Gleave, M. E., Collins, C. C., Ye, D., Wang, Y. & Huang, H., Jan 1 2019, (Accepted/In press) In : EMBO Molecular Medicine. e10659.

Research output: Contribution to journalArticle

Open Access

Widening of the genetic and clinical spectrum of Lamb–Shaffer syndrome, a neurodevelopmental disorder due to SOX5 haploinsufficiency

Deciphering Developmental Disorder Study, Jan 1 2019, (Accepted/In press) In : Genetics in Medicine.

Research output: Contribution to journalArticle

2018

1α,25-dihydroxyvitamin D3 mitigates cancer cell mediated mitochondrial dysfunction in human skeletal muscle cells

Ryan, Z. C., Craig, T. A., Wang, X., Delmotte, P., Salisbury, J. L., Lanza, I. R., Sieck, G. C. & Kumar, R., Feb 5 2018, In : Biochemical and Biophysical Research Communications. 496, 2, p. 746-752 7 p.

Research output: Contribution to journalArticle

4 Scopus citations
8 Scopus citations