Biochemistry and Molecular Biology

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2020

A feasibility study fornoninvasive measurement of shear wave speed in live zebrafish

Zhang, X., Zhang, A. X., Zhou, B. & Xu, X., Sep 2020, In : Ultrasonics. 107, 106170.

Research output: Contribution to journalArticle

Aging-associated sinus arrest and sick sinus syndrome in adult zebrafish

Yan, J., Li, H., Bu, H., Jiao, K., Zhang, A. X., Le, T., Cao, H., Li, Y., Ding, Y. & Xu, X., May 2020, In : PloS one. 15, 5, e0232457.

Research output: Contribution to journalArticle

Open Access

Analysis of the polycystin complex (PCC) in human urinary exosome–like vesicles (ELVs)

Lea, W. A., McGreal, K., Sharma, M., Parnell, S. C., Zelenchuk, L., Charlesworth, M. C., Madden, B. J., Johnson, K. L., McCormick, D. J., Hogan, M. C. & Ward, C. J., Dec 1 2020, In : Scientific reports. 10, 1, 1500.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

A novel transplantable model of lung cancer-associated tissue loss and disrupted muscle regeneration

Arneson-Wissink, P. C., Ducharme, A. M. & Doles, J. D., Mar 9 2020, In : Skeletal Muscle. 10, 1, 6.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Antitumor activity of Z-endoxifen in aromatase inhibitor-sensitive and aromatase inhibitor-resistant estrogen receptor-positive breast cancer

Jayaraman, S., Hou, X., Kuffel, M. J., Suman, V. J., Hoskin, T. L., Reinicke, K. E., Monroe, D. G., Kalari, K. R., Tang, X., Zeldenrust, M. A., Cheng, J., Bruinsma, E. S., Buhrow, S. A., McGovern, R. M., Safgren, S. L., Walden, C. A., Carter, J. M., Reid, J. M., Ingle, J. N., Ames, M. M. & 2 others, Hawse, J. R. & Goetz, M. P., May 19 2020, In : Breast Cancer Research. 22, 1, 51.

Research output: Contribution to journalArticle

Open Access

Changes in PGC‐1α/SIRT1 Signaling Impact on Mitochondrial Homeostasis in Amyloid-Beta Peptide Toxicity Model

Panes, J. D., Godoy, P. A., Silva-Grecchi, T., Celis, M. T., Ramirez-Molina, O., Gavilan, J., Muñoz-Montecino, C., Castro, P. A., Moraga-Cid, G., Yévenes, G. E., Guzmán, L., Salisbury, J. L., Trushina, E. & Fuentealba, J., May 21 2020, In : Frontiers in Pharmacology. 11, 709.

Research output: Contribution to journalArticle

Open Access

Distinct Influence of Omega-3 Fatty Acids on the Plasma Metabolome of Healthy Older Adults

Xyda, S. E., Vuckovic, I., Petterson, X. M., Dasari, S., Lalia, A. Z., Parvizi, M., Macura, S. I. & Lanza, I. R., Apr 17 2020, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 75, 5, p. 875-884 10 p.

Research output: Contribution to journalArticle

2 Scopus citations

Evidence for the Misfolding of the A1 Domain within Multimeric von Willebrand Factor in Type 2 von Willebrand Disease

Tischer, A., Brehm, M. A., Machha, V. R., Moon-Tasson, L., Benson, L. M., Nelton, K. J., Leger, R. R., Obser, T., Martinez-Vargas, M., Whitten, S. T., Chen, D., Pruthi, R. K., Bergen, H. R., Cruz, M. A., Schneppenheim, R. & Auton, M., Jan 17 2020, In : Journal of Molecular Biology. 432, 2, p. 305-323 19 p.

Research output: Contribution to journalArticle

Fructose-1,6-bisphosphatase loss modulates STAT3-dependent expression of PD-L1 and cancer immunity

Wang, B., Zhou, Y., Zhang, J., Jin, X., Wu, H. & Huang, H., Jan 1 2020, In : Theranostics. 10, 3, p. 1033-1045 13 p.

Research output: Contribution to journalArticle

Open Access

Functional Analysis of Hydrolethalus Syndrome Protein HYLS1 in Ciliogenesis and Spermatogenesis in Drosophila

Hou, Y., Wu, Z., Zhang, Y., Chen, H., Hu, J., Guo, Y., Peng, Y. & Wei, Q., May 21 2020, In : Frontiers in Cell and Developmental Biology. 8, 301.

Research output: Contribution to journalArticle

Open Access

IgM AL amyloidosis: delineating disease biology and outcomes with clinical, genomic and bone marrow morphological features

Sidana, S., Larson, D. P., Greipp, P. T., He, R., McPhail, E. D., Dispenzieri, A., Murray, D. L., Dasari, S., Ansell, S. M., Muchtar, E., Gonsalves, W. I., Kourelis, T. V., Ramirez-Alvarado, M., Kapoor, P., Rajkumar, S. V., Lacy, M. Q., Buadi, F. K., Leung, N., Kyle, R. A., Kumar, S. K. & 2 others, King, R. L. & Gertz, M. A., May 1 2020, In : Leukemia. 34, 5, p. 1373-1382 10 p.

Research output: Contribution to journalArticle

2 Scopus citations

Influence of water based embedding media composition on the relaxation properties of fixed tissue

Vučković, I., Nayfeh, T., Mishra, P. K., Periyanan, S., Sussman, C. R., Kline, T. L. & Macura, S., Apr 2020, In : Magnetic Resonance Imaging. 67, p. 7-17 11 p.

Research output: Contribution to journalArticle

Light chain amyloidosis induced inflammatory changes in cardiomyocytes and adipose-derived mesenchymal stromal cells

Jordan, T. L., Maar, K., Redhage, K. R., Misra, P., Blancas-Mejia, L. M., Dick, C. J., Wall, J. S., Williams, A., Dietz, A. B., van Wijnen, A. J., Lin, Y. & Ramirez-Alvarado, M., May 1 2020, In : Leukemia. 34, 5, p. 1383-1393 11 p.

Research output: Contribution to journalArticle

Male breast cancer in the United States: Treatment patterns and prognostic factors in the 21st century

Yadav, S., Karam, D., Bin Riaz, I., Xie, H., Durani, U., Duma, N., Giridhar, K. V., Hieken, T. J., Boughey, J. C., Mutter, R. W., Hawse, J. R., Jimenez, R. E., Couch, F. J., Leon-Ferre, R. A. & Ruddy, K. J., Jan 1 2020, In : Cancer. 126, 1, p. 26-36 11 p.

Research output: Contribution to journalArticle

6 Scopus citations

Novel role of Tieg1 in muscle metabolism and mitochondrial oxidative capacities

Kammoun, M., Piquereau, J., Nadal-Desbarats, L., Même, S., Beuvin, M., Bonne, G., Veksler, V., Le Fur, Y., Pouletaut, P., Même, W., Szeremeta, F., Constans, J. M., Bruinsma, E. S., Nelson Holte, M. H., Najafova, Z., Johnsen, S. A., Subramaniam, M., Hawse, J. R. & Bensamoun, S. F., Mar 1 2020, In : Acta Physiologica. 228, 3, e13394.

Research output: Contribution to journalArticle

Optimized immunohistochemical detection of estrogen receptor beta using two validated monoclonal antibodies confirms its expression in normal and malignant breast tissues

Hawse, J. R., Carter, J. M., Aspros, K. G. M., Bruinsma, E. S., Koepplin, J. W., Negron, V., Subramaniam, M., Ingle, J. N., Rech, K. L. & Goetz, M. P., Jan 1 2020, In : Breast Cancer Research and Treatment. 179, 1, p. 241-249 9 p.

Research output: Contribution to journalArticle

Radiation Induced Metabolic Alterations Associate With Tumor Aggressiveness and Poor Outcome in Glioblastoma

Gupta, K., Vuckovic, I., Zhang, S., Xiong, Y., Carlson, B. L., Jacobs, J., Olson, I., Petterson, X. M., Macura, S. I., Sarkaria, J. & Burns, T. C., May 5 2020, In : Frontiers in Oncology. 10, 535.

Research output: Contribution to journalArticle

Open Access

Regulation of polycystin expression, maturation and trafficking

Hu, J. & Harris, P. C., Aug 2020, In : Cellular Signalling. 72, 109630.

Research output: Contribution to journalArticle

Retinoid X receptor alpha is a spatiotemporally predominant therapeutic target for anthracycline-induced cardiotoxicity

Ma, X., Zhu, P., Ding, Y., Zhang, H., Qiu, Q., Dvornikov, A. V., Wang, Z., Kim, M., Wang, Y., Lowerison, M., Yu, Y., Norton, N., Herrmann, J., Ekker, S. C., Hsiai, T. K., Lin, X. & Xu, X., Jan 29 2020, In : Science Advances. 6, 5, eaay2939.

Research output: Contribution to journalArticle

Open Access

Scientific societies fostering inclusive scientific environments through traveawards: Current practices and recommendations

Segarra, V. A., Vega, L. R., Primus, C., Etson, C., Guillory, A. N., Edwards, A., Flores, S. C., Fry, C., Ingram, S. L., Lawson, M., McGee, R., Paxson, S., Phelan, L., Suggs, K., Vuong, E., Hammonds-Odie, L., Leibowitz, M. J., Zavala, M., Lujan, J. L. & Ramirez-Alvarado, M., Jun 1 2020, In : CBE Life Sciences Education. 19, 2, es3.

Research output: Contribution to journalArticle

Open Access

Sclerostin antibody treatment rescues the osteopenic bone phenotype of TGFβ inducible early gene-1 knockout female mice

Gingery, A., Subramaniam, M., Pitel, K. S., Li, X., Ke, H. Z., Turner, R. T., Iwaniec, U. T. & Hawse, J. R., Jul 1 2020, In : Journal of Cellular Physiology. 235, 7-8, p. 5679-5688 10 p.

Research output: Contribution to journalArticle

TALPID3 and ANKRD26 selectively orchestrate FBF1 localization and cilia gating

Yan, H., Chen, C., Chen, H., Hong, H., Huang, Y., Ling, K., Hu, J. & Wei, Q., Dec 1 2020, In : Nature communications. 11, 1, 2196.

Research output: Contribution to journalArticle

Open Access

Transplant chimerism in porcine structural vascularized bone allotransplants

Houben, R. H., Aleff, R. A., Friedrich, P. F., Shin, A. Y., Wieben, E. D., van Wijnen, A. J. & Bishop, A. T., Jul 15 2020, In : Gene. 747, 144627.

Research output: Contribution to journalArticle

Ultrasound image processing to estimate the structural and functional properties of mouse skeletal muscle

Ternifi, R., Kammoun, M., Pouletaut, P., Subramaniam, M., Hawse, J. R. & Bensamoun, S. F., Feb 2020, In : Biomedical Signal Processing and Control. 56, 101735.

Research output: Contribution to journalArticle

Widening of the genetic and clinical spectrum of Lamb–Shaffer syndrome, a neurodevelopmental disorder due to SOX5 haploinsufficiency

Deciphering Developmental Disorder Study, Mar 1 2020, In : Genetics in Medicine. 22, 3, p. 524-537 14 p.

Research output: Contribution to journalArticle

1 Scopus citations
2019

A conditional mouse model of complex II deficiency manifesting as Leigh-like syndrome

Al Khazal, F., Holte, M. N., Bolon, B., White, T. A., LeBrasseur, N. & Maher, L. J., Dec 1 2019, In : FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33, 12, p. 13189-13201 13 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Acquisition, Processing and Analysis of Electrocardiogram in Awake Zebrafish

Le, T., Lenning, M., Clark, I., Bhimani, I., Fortunato, J., Marsh, P., Xu, X. & Cao, H., Jun 1 2019, In : IEEE Sensors Journal. 19, 11, p. 4283-4289 7 p., 8636511.

Research output: Contribution to journalArticle

1 Scopus citations

Amplification-free long-read sequencing of TCF4 expanded trinucleotide repeats in Fuchs Endothelial Corneal Dystrophy

Wieben, E. D., Aleff, R. A., Basu, S., Sarangi, V., Bowman, B., McLaughlin, I. J., Mills, J. R., Butz, M. L., Highsmith, E. W., Ida, C. M., Ekholm, J. M., Baratz, K. H. & Fautsch, M. P., 2019, In : PloS one. 14, 7, e0219446.

Research output: Contribution to journalArticle

Open Access

An in Vitro Selection Strategy Identifying Naked DNA That Localizes to Cell Nuclei

Smestad, J., Wilbanks, B. & Maher, L. J., Nov 20 2019, In : Journal of the American Chemical Society. 141, 46, p. 18375-18379 5 p.

Research output: Contribution to journalArticle

Association of rs613872 and Trinucleotide Repeat Expansion in the TCF4 Gene of German Patients With Fuchs Endothelial Corneal Dystrophy

Okumura, N., Hayashi, R., Nakano, M., Tashiro, K., Yoshii, K., Aleff, R., Butz, M., Highsmith, W. E. J., Wieben, E. D., Fautsch, M. P., Baratz, K., Komori, Y., Ueda, E., Nakahara, M., Weller, J., Tourtas, T., Schlötzer-Schrehardt, U., Kruse, F. & Koizumi, N., Jul 1 2019, In : Cornea. 38, 7, p. 799-805 7 p.

Research output: Contribution to journalArticle

1 Scopus citations

Case-Based Learning in Translational Biomedical Research Education: Providing Realistic and Adaptive Skills for Early-Career Scientists

Greenberg-Worisek, A. J., Campbell, K. A., Klee, E. W., Staff, N. P., Schimmenti, L. A., Weavers, K. M., Ekker, S. C. & Windebank, A. J., Feb 1 2019, In : Academic medicine : journal of the Association of American Medical Colleges. 94, 2, p. 213-216 4 p.

Research output: Contribution to journalArticle

Clinical features, laboratory characteristics and outcomes of patients with renal versus cardiac light chain amyloidosis

Sidana, S., Tandon, N., Gertz, M., Dispenzieri, A., Ramirez-Alvarado, M., Murray, D. L., Kourelis, T., Buadi, F. K., Kapoor, P., Gonsalves, W., Warsame, R., Lacy, M., Kyle, R. A., Rajkumar, S. V., Kumar, S. K. & Leung, N., Jan 1 2019, In : British journal of haematology.

Research output: Contribution to journalArticle

4 Scopus citations

Design, synthesis, and actions of an innovative bispecific designer peptide: NPA7

Meems, L. M. G., Andersen, I. A., Pan, S., Harty, G., Chen, Y., Zheng, Y., Harders, G. E., Ichiki, T., Heublein, D. M., Iyer, S. R., Sangaralingham, S. J., McCormick, D. J. & Burnett, J. C., Apr 1 2019, In : Hypertension. 73, 4, p. 900-909 10 p.

Research output: Contribution to journalArticle

4 Scopus citations

Development of a novel multiphysical approach for the characterization of mechanical properties of musculotendinous tissues

Kammoun, M., Ternifi, R., Dupres, V., Pouletaut, P., Même, S., Même, W., Szeremeta, F., Landoulsi, J., Constans, J. M., Lafont, F., Subramaniam, M., Hawse, J. R. & Bensamoun, S. F., Dec 1 2019, In : Scientific reports. 9, 1, 7733.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
Open Access
1 Scopus citations

Displacement analysis of myocardial mechanical deformation (DIAMOND) reveals segmental susceptibility to doxorubicin-induced injury and regeneration

Chen, J., Ding, Y., Chen, M., Gau, J., Jen, N., Nahal, C., Tu, S., Chen, C., Zhou, S., Chang, C. C., Lyu, J., Xu, X., Hsiai, T. K. & Packard, R. R. S., 2019, In : JCI Insight. 4, 8, e125362.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Distinct modes of mitochondrial metabolism uncouple T cell differentiation and function

Bailis, W., Shyer, J. A., Zhao, J., Canaveras, J. C. G., Al Khazal, F. J., Qu, R., Steach, H. R., Bielecki, P., Khan, O., Jackson, R., Kluger, Y., Maher, L. J., Rabinowitz, J., Craft, J. & Flavell, R. A., Jul 18 2019, In : Nature. 571, 7765, p. 403-407 5 p.

Research output: Contribution to journalArticle

13 Scopus citations

Drugging MYCN oncogenic signaling through the MYCN-PA2G4 binding interface

Koach, J., Holien, J. K., Massudi, H., Carter, D. R., Ciampa, O. C., Herath, M., Lim, T., Seneviratne, J. A., Milazzo, G., Murray, J. E., McCarroll, J. A., Liu, B., Mayoh, C., Keenan, B., Stevenson, B. W., Gorman, M. A., Bell, J. L., Doughty, L., Hüttelmaier, S., Oberthuer, A. & 13 others, Fischer, M., Gifford, A. J., Liu, T., Zhang, X., Zhu, S., Gustafson, W. C., Haber, M., Norris, M. D., Fletcher, J. I., Perini, G., Parker, M. W., Cheung, B. B. & Marshall, G. M., Nov 1 2019, In : Cancer research. 79, 21, p. 5652-5667 16 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Effect of trinucleotide repeat expansion on the expression of TCF4 mRNA in fuchs’ endothelial corneal dystrophy

Okumura, N., Hayashi, R., Nakano, M., Yoshii, K., Tashiro, K., Sato, T., Blake, D. J., Aleff, R., Butz, M., Highsmith, E. W., Wieben, E. D., Fautsch, M. P., Baratz, K. H., Komori, Y., Nakahara, M., Tourtas, T., Schlötzer-Schrehardt, U., Kruse, F. & Koizumi, N., Feb 2019, In : Investigative Ophthalmology and Visual Science. 60, 2, p. 779-786 8 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Establishment of TUSMi008-A, an induced pluripotent stem cell (iPSC) line from a 76-year old Alzheimer's disease (AD) patient with PAXIP1 gene mutation

Wang, Y., Zhang, J., Hu, J., Li, G., Lei, Y. & Zhao, J., Apr 2019, In : Stem Cell Research. 36, 101391.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Evidence for a bind-then-bend mechanism for architectural DNA binding protein yNhp6A

Sarangi, M. K., Zvoda, V., Holte, M. N., Becker, N. A., Peters, J. P., Maher III, L. J. & Ansari, A., Apr 8 2019, In : Nucleic acids research. 47, 6, p. 2871-2883 13 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

EZH2 cooperates with gain-of-function p53 mutants to promote cancer growth and metastasis

Zhao, Y., Ding, L., Wang, D., Ye, Z., He, Y., Ma, L., Zhu, R., Pan, Y., Wu, Q., Pang, K., Hou, X., Weroha, S. J., Han, C., Coleman, R., Coleman, I., Karnes, R. J., Zhang, J., Nelson, P. S., Wang, L. & Huang, H., Mar 1 2019, In : EMBO Journal. 38, 5, e99599.

Research output: Contribution to journalArticle

8 Scopus citations

Familial chronic megacolon presenting in childhood or adulthood: Seeking the presumed gene association

Camilleri, M., Wieben, E., Eckert, D., Carlson, P., Hurley O’Dwyer, R., Gibbons, D., Acosta, A. & Klee, E. W., Apr 2019, In : Neurogastroenterology and Motility. 31, 4, e13550.

Research output: Contribution to journalArticle

5 Scopus citations
Open Access

Haploinsufficiency of mechanistic target of rapamycin ameliorates bag3 cardiomyopathy in adult zebrafish

Ding, Y., Dvornikov, A. V., Ma, X., Zhang, H., Wang, Y., Lowerison, M., Packard, R. R., Wang, L., Chen, J., Zhang, Y., Hsiai, T., Lin, X. & Xu, X., Jan 1 2019, In : DMM Disease Models and Mechanisms. 12, 10, dmm040154.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

In vitro and in silico multidimensional modeling of oncolytic tumor virotherapy dynamics

Berg, D. R., Offord, C. P., Kemler, I., Ennis, M. K., Chang, L., Paulik, G., Bajzer, Z., Neuhauser, C. & Dingli, D., Mar 2019, In : PLoS computational biology. 15, 3, e1006773.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Master regulator analysis of paragangliomas carrying SDHx, VHL, or MAML3 genetic alterations

Smestad, J. A. & Maher, J. L., Jun 24 2019, In : BMC cancer. 19, 1, 619.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Mechanistic Insights into the Early Events in the Aggregation of Immunoglobulin Light Chains

Misra, P., Blancas-Mejia, L. M. & Ramirez-Alvarado, M., Jun 25 2019, In : Biochemistry. 58, 29, p. 3155-3168 14 p.

Research output: Contribution to journalArticle

1 Scopus citations

Mitsui-7, heat-treated, and nitrogen-doped multi-walled carbon nanotubes elicit genotoxicity in human lung epithelial cells

Siegrist, K. J., Reynolds, S. H., Porter, D. W., Mercer, R. R., Bauer, A. K., Lowry, D., Cena, L., Stueckle, T. A., Kashon, M. L., Wiley, J., Salisbury, J. L., Mastovich, J., Bunker, K., Sparrow, M., Lupoi, J. S., Stefaniak, A. B., Keane, M. J., Tsuruoka, S., Terrones, M., McCawley, M. & 1 others, Sargent, L. M., Oct 7 2019, In : Particle and Fibre Toxicology. 16, 1, 36.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations