Biochemistry and Molecular Biology

Projects 1975 2021

A NEW CLASS OF EPSTEIN BARR VIRUS NUCLEAR ANTIGEN

Spelsberg, T. C.

National Institutes of Health

4/1/7912/31/85

Project: Research project

Epstein-Barr Virus Nuclear Antigens
Histones
Isoelectric Focusing
Acetylation
Chromatin

DNS SEQUENCES IN NUCLEAR BINDING OF PROGESTERONE

Spelsberg, T. C.

National Institutes of Health

7/1/8212/31/86

Project: Research project

progesterone
DNA
nucleotide sequences
proteins
nucleases
Antigens
Proteins
Systemic Lupus Erythematosus
Connective Tissue Diseases
Antibodies
Contractile Proteins
Cell Biology
Carrier Proteins
Calcium-Binding Proteins
Eukaryotic Cells
centrosomes
germ cells
spermatozoa
calcium-binding proteins
spermatocytes

BONE CELL PROTO-ONCOGENE PROMOTERS

Spelsberg, T. C.

National Institutes of Health

7/10/925/31/97

Project: Research project

Proto-Oncogenes
Bone and Bones
Transforming Growth Factor beta
Osteoclasts
Osteoblasts
RNA
Ligands
DNA
Bacteriophage T7
Nucleic Acids

NOVEL TGF-BETA INDUCIBLE GENE IN HUMAN OSTEOBLASTS

Spelsberg, T. C.

National Institutes of Health

7/5/966/30/99

Project: Research project

Osteoblasts
Transforming Growth Factor beta
Genes
Proteins
Bone and Bones
nucleic acid
RNA
DNA

MODE OF ACTION OF REPRODUCTIVE HORMONES

Wieben, E. D., David, C. S., Spelsberg, T. C., Tindall, D. J., Spelsberg, T. C., Pendergast, F., Tindall, D. J., Roche, P., Pendergast, F., Penniston, J., Ryan, R., Roche, P., Toft, D., Tindall, D. J., Tindall, D. J. & Mc Cormick, D. J.

National Institutes of Health

5/1/753/31/02

Project: Research project

Oviducts
Progesterone Receptors
Chromatin
LH Receptors
Monoclonal Antibodies

MOLECULAR ANGLE TRANSITIONS IN MUSCLE

Burghardt, T. P.

National Institutes of Health

1/1/906/30/03

Project: Research project

muscles
Muscle
probes
muscle fibers
electron paramagnetic resonance
Frizzled Receptors
Embryonic Development
Genes
Zebrafish
Xenopus

REGULATION OF THE PLASMA MEMBRANE CALCIUM ATPASE

Strehler, E. E.

National Institutes of Health

2/1/991/31/04

Project: Research project

Plasma Membrane Calcium-Transporting ATPases
Calcium-Transporting ATPases
Cell Membrane
Protein Isoforms
Proteins

MULTIDISCIPLINARY BASIC RESEARCH TRAINING IN CANCER

Smith, D. I., Salisbury, J. L., Getz, M. J., Scott, R. & Getz, M. J.

National Institutes of Health

6/1/833/31/04

Project: Research project

Research
Neoplasms
Molecular Biology
Medicine Chests
Animal Housing
Electrostatic force
DNA
Proteins
proteins
phosphates

Cell Surface Receptor Trafficking

Horazdovsky, B. F.

National Institutes of Health

7/1/036/30/07

Project: Research project

Cell Surface Receptors
Proteins
Endocytosis
Guanosine Triphosphate
Guanine Nucleotide Exchange Factors
Transforming Growth Factor beta
Steroids
Bone and Bones
Genes
Estrogen Receptor beta

PROPERTIES OF CALCIUM PUMPING ATPASE

Strehler, E. E. & Penniston, J.

National Institutes of Health

8/1/801/31/08

Project: Research project

Calcium-Transporting ATPases
Calcium
Ions
Protein Isoforms
Calmodulin

PROTEIN LOCALIZATION OF THE YEAST VACUOLE

Horazdovsky, B. F.

National Institutes of Health

6/1/974/30/08

Project: Research project

vacuoles
yeasts
protein transport
Protein Transport
Vacuoles
Centrosome
Breast Neoplasms
Hypertrophy
Centrioles
Microtubules
NF-kappa B
Genetic Selection
DNA-Binding Proteins
Yeasts
Nucleotide Aptamers

Differences in the Reaction Cycle among PMCA Isoforms

Strehler, E. E.

National Institutes of Health

4/1/053/31/10

Project: Research project

Protein Isoforms
Cell Membrane
Calcium
Cations
Ions
Phosphoproteins
Tandem Repeat Sequences
Phosphopeptides
Proteins
Histones

Membrane Targeting of Calcium-Pumping ATPase

Strehler, E. E.

National Institutes of Health

3/1/072/28/12

Project: Research project

Plasma Membrane Calcium-Transporting ATPases
Calcium-Transporting ATPases
Membranes
Neurons
Protein Isoforms
Zebrafish
Nicotine
Glucocorticoid Receptors
Homeostasis
Vertebrates
insertional mutagenesis
Zebrafish
Introns
Danio rerio
transposons
Myosins
Hypertrophy
Myosin Heavy Chains
Familial Hypertrophic Cardiomyopathy
Mutation
Nanoconjugates
gemcitabine
Gold
Nanoparticles
Pancreatic Neoplasms
Multivesicular Bodies
Endosomal Sorting Complexes Required for Transport
Membranes
Liddle Syndrome
Growth Factor Receptors

Visualizing Actomyosin Transients by Data Merging

Burghardt, T. P.

National Institutes of Health

12/1/026/30/15

Project: Research project

Actomyosin
Myosins
Merging
Adenosine Triphosphate
Conformations
Androgen Receptors
Prostatic Neoplasms
Androgens
Castration
Interleukin-6
Morphogenesis
Breast
Neoplasm Metastasis
Cell-Matrix Junctions
Cell Movement
Sarcomeres
Heart Diseases
Connectin
Cardiomyopathies
Zebrafish
Nucleosomes
Histones
DNA Replication
Acetylation
Genomic Instability
Pancreatic Neoplasms
Phosphotransferases
Lipids
Neoplasms
X Chromosome Inactivation
Origin Recognition Complex
Epigenomics
Maintenance
Untranslated RNA
Zebrafish Proteins
Zebrafish
Vertebrates
Genome
Proteome

ROLE OF A TGF-BETA REGULATED GENE IN HUMAN OSTEOBLASTS

Spelsberg, T. C., Hawse, J. R., Subramaniam, M. & Hawse, J. R.

National Institutes of Health

9/1/016/30/17

Project: Research project

Osteoblasts
Skeleton
Genes
Transforming Growth Factor beta
Wnt Signaling Pathway

Bmi-1, a potential therapeutic target in ovarian cancer

Bhattacharya, R. D.

National Institutes of Health

9/7/126/30/17

Project: Research project

Ovarian Neoplasms
Cisplatin
Apoptosis
Small Interfering RNA
Neoplasms
Fuchs' Endothelial Dystrophy
Trinucleotide Repeat Expansion
Transcription Factors
Corneal Endothelium
Disease Progression
temozolomide
Drug Resistance
Histones
Phosphorylation
Glioblastoma
Cilia
Dissection
Genes
Basal Bodies
Centrioles
Paraganglioma
Dioxygenases
Neoplasms
Neuroendocrine Cells
Caenorhabditis elegans

Cystathionine beta synthase (CBS) and angiogenesis

Mukherjee, P. H. & Bhattacharya, R. D.

National Institutes of Health

8/15/136/30/18

Project: Research project

Cystathionine beta-Synthase
Homocysteine
Homocystinuria
Cystathionine
Methionine
DNA Damage
Histones
Lysine
Methylation
Post Translational Protein Processing
Long Noncoding RNA
Erythrocytes
RNA
Biomedical Research
Anemia

CANCER CENTER SUPPORT GRANT (COMPREHENSIVE)

David, C. S., Jenkins, R. B., Cunningham, J. M., Wettstein, P. J., Buckner, J. C., Lingle, W. L., Kocher, J., Highsmith, W. E. J., Beebe, T. J., Vile, R. G., Okuno, S. H., Sarkaria, J. N., Alberts, S. R., Salisbury, J. L., Van Deursen, J., Diasio, R. B., Sargent, D. J., Thibodeau, S. N., Ingle, J. N., Reid, J. M., Colon-Otero, G., Galanis, E., Weinshilboum, R. M., Jenkins, R. B., Banks, P., Flotte, T., Kwon, E. D., Federspiel, M. J., Pitot, H. C., Dewald, G., Held, K., Liebson, P., Banks, P., Prendergast, F., Weiland, L., Wiebeu, E., Moertel, C., Clapham, D., Burnham, N., O'Connell, M., Spelsburg, T., Maihle, N., Katzmann, J., Wieand, H., Kovach, J., Wold, L., Grendahl, D., McCormick, D., Leibson, P., O'Fallon, J., Ames, M., Kline, B., Prendergast, F., Adjei, A., Chute, C., McKean, D., Highsmith, E., Raghavakaimal, S., Pitot, H., Greipp, P., Wieben, E., Roche, P., Leibson, P., Lawson, M., Grendahl, D., McCormick, D., Ames, M., Wieben, E. D., Flotte, T. J., Adjei, A. & Greipp, P. T.

National Institutes of Health

3/1/802/28/19

Project: Research project

Neoplasms
Research
Research Personnel
Cytogenetics
Biostatistics
Zebrafish
Cardiomyopathies
Sirolimus
Autophagy
Modifier Genes

Function of CAF-1 in Epigenetic Inheritance

Zhang, Z. H.

National Institutes of Health

9/20/058/31/19

Project: Research project

Epigenomics
Histone Chaperones
Nucleosomes
Chromatin
Histones
Chromosome Breakage
DNA Breaks
Ubiquitin
Histones
Homologous Recombination