Biochemistry and Molecular Biology

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2011

CCR3 blockade attenuates eosinophilic ileitis and associated remodeling

Masterson, J. C., McNamee, E. N., Jedlicka, P., Fillon, S., Ruybal, J., Hosford, L., Rivera-Nieves, J., Lee, J. J. & Furuta, G. T., Nov 1 2011, In : American Journal of Pathology. 179, 5, p. 2302-2314 13 p.

Research output: Contribution to journalArticle

27 Scopus citations

Cereblon expression is required for the antimyeloma activity of lenalidomide and pomalidomide

Zhu, Y. X., Braggio, E., Shi, C. X., Bruins, L. A., Schmidt, J. E., Van Wier, S., Chang, X. B., Bjorklund, C. C., Fonseca, R., Bergsagel, P. L., Orlowski, R. Z. & Stewart, A. K., Nov 3 2011, In : Blood. 118, 18, p. 4771-4779 9 p.

Research output: Contribution to journalArticle

375 Scopus citations

Core-glycosylated mucin-like repeats from MUC1 are an apical targeting signal

Kinlough, C. L., Poland, P. A., Gendler, S. J., Mattila, P. E., Mo, D., Weisz, O. A. & Hughey, R. P., Nov 11 2011, In : Journal of Biological Chemistry. 286, 45, p. 39072-39081 10 p.

Research output: Contribution to journalArticle

22 Scopus citations

Efficient molecular mechanics simulations of the folding, orientation, and assembly of peptides in lipid bilayers using an implicit atomic solvation model

Bordner, A. J., Zorman, B. & Abagyan, R., Oct 1 2011, In : Journal of Computer-Aided Molecular Design. 25, 10, p. 895-911 17 p.

Research output: Contribution to journalArticle

3 Scopus citations

Eosinophils are necessary for pulmonary arterial remodeling in a mouse model of eosinophilic inflammation-induced pulmonary hypertension

Weng, M., Baron, D. M., Bloch, K. D., Luster, A. D., Lee, J. J. & Medoff, B. D., Dec 2011, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 301, 6, p. L927-L936

Research output: Contribution to journalArticle

21 Scopus citations

Eosinophils are required for the maintenance of plasma cells in the bone marrow

Chu, V. T., Fröhlich, A., Steinhauser, G., Scheel, T., Roch, T., Fillatreau, S., Lee, J. J., Löhning, M. & Berek, C., Feb 1 2011, In : Nature immunology. 12, 2, p. 151-159 9 p.

Research output: Contribution to journalArticle

307 Scopus citations

Eosinophils increase neuron branching in human and murine skin and in vitro

Foster, E. L., Simpson, E. L., Fredrikson, L. J., Lee, J. J., Lee, N. A., Fryer, A. D. & Jacoby, D. B., 2011, In : PloS one. 6, 7, e22029.

Research output: Contribution to journalArticle

48 Scopus citations

Eosinophils regulate dendritic cells and Th2 pulmonary immune responses following allergen provocation

Jacobsen, E. A., Zellner, K. R., Colbert, D., Lee, N. A. & Lee, J. J., Dec 1 2011, In : Journal of Immunology. 187, 11, p. 6059-6068 10 p.

Research output: Contribution to journalArticle

77 Scopus citations

Fluorescence polarization screening for allosteric small molecule ligands of the cholecystokinin receptor

Harikumar, K. G., Cawston, E. E. & Miller, L. J., Aug 1 2011, In : Assay and Drug Development Technologies. 9, 4, p. 394-402 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

Glutamine residues in Q-loops of multidrug resistance protein MRP1 contribute to ATP binding via interaction with metal cofactor

Yang, R., Hou, Y. X., Campbell, C. A., Palaniyandi, K., Zhao, Q., Bordner, A. J. & Chang, X. B., Jul 1 2011, In : Biochimica et Biophysica Acta - Biomembranes. 1808, 7, p. 1790-1796 7 p.

Research output: Contribution to journalArticle

4 Scopus citations

Immunodetection of occult eosinophils in lung tissue biopsies may help predict survival in acute lung injury

Willetts, L., Parker, K., Wesselius, L. J., Protheroe, C. A., Jaben, E., Graziano, P., Moqbel, R., Leslie, K. O., Lee, N. A. & Lee, J. J., Aug 26 2011, In : Respiratory Research. 12, 116.

Research output: Contribution to journalArticle

19 Scopus citations

Importance and regulation of the colonic mucus barrier in a mouse model of colitis

Petersson, J., Schreiber, O., Hansson, G. C., Gendler, S. J., Velcich, A., Lundberg, J. O., Roos, S., Holm, L. & Phillipson, M., Feb 2011, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 300, 2, p. G327-G333

Research output: Contribution to journalArticle

181 Scopus citations

Importance of each residue within secretin for receptor binding and biological activity

Dong, M., Le, A., Te, J. A., Pinon, D. I., Bordner, A. J. & Miller, L. J., Apr 12 2011, In : Biochemistry. 50, 14, p. 2983-2993 11 p.

Research output: Contribution to journalArticle

20 Scopus citations
6 Scopus citations

Lactam constraints provide insights into the receptor-bound conformation of secretin and stabilize a receptor antagonist

Dong, M., Te, J. A., Xu, X., Wang, J., Pinon, D. I., Storjohann, L., Bordner, A. J. & Miller, L. J., Sep 27 2011, In : Biochemistry. 50, 38, p. 8181-8192 12 p.

Research output: Contribution to journalArticle

15 Scopus citations

Local proliferation and mobilization of CCR3+ CD34+ eosinophil-lineage-committed cells in the lung

Rådinger, M., Bossios, A., Sjöstrand, M., Lu, Y., Malmhäll, C., Dahlborn, A. K., Lee, J. J. & Lötvall, J., Jan 1 2011, In : Immunology. 132, 1, p. 144-154 11 p.

Research output: Contribution to journalArticle

24 Scopus citations

Major basic protein from eosinophils and myeloperoxidase from neutrophils are required for protective immunity to Strongyloides stercoralis in mice

O'Connell, A. E., Hess, J. A., Santiago, G. A., Nolan, T. J., Lok, J. B., Lee, J. J. & Abraham, D., Jul 1 2011, In : Infection and Immunity. 79, 7, p. 2770-2778 9 p.

Research output: Contribution to journalArticle

62 Scopus citations

MUC1 enhances invasiveness of pancreatic cancer cells by inducing epithelial to mesenchymal transition

Roy, L. D., Sahraei, M., Subramani, D. B., Besmer, D., Nath, S., Tinder, T. L., Bajaj, E., Shanmugam, K., Lee, Y. Y., Hwang, S. I. L., Gendler, S. J. & Mukherjee, P., Mar 24 2011, In : Oncogene. 30, 12, p. 1449-1459 11 p.

Research output: Contribution to journalArticle

158 Scopus citations

Pancreatic ductal adenocarcinoma mice lacking mucin 1 have a profound defect in tumor growth and metastasis

Besmer, D. M., Curry, J. M., Roy, L. D., Tinder, T. L., Sahraei, M., Schettini, J., Hwang, S. I., Lee, Y. Y., Gendler, S. J. & Mukherjee, P., Jul 1 2011, In : Cancer research. 71, 13, p. 4432-4442 11 p.

Research output: Contribution to journalArticle

80 Scopus citations

Recombinant plant-expressed tumour-associated MUC1 peptide is immunogenic and capable of breaking tolerance in MUC1.Tg mice

Pinkhasov, J., Alvarez, M. L., Rigano, M. M., Piensook, K., Larios, D., Pabst, M., Grass, J., Mukherjee, P., Gendler, S. J., Walmsley, A. M. & Mason, H. S., Dec 1 2011, In : Plant Biotechnology Journal. 9, 9, p. 991-1001 11 p.

Research output: Contribution to journalArticle

33 Scopus citations

The identification of eosinophilic gastroenteritis in prednisone-dependent eosinophilic bronchitis and asthma

Nair, P., Ochkur, S. I., Protheroe, C., Simms, E., Lee, N. A. & Lee, J. J., Mar 1 2011, In : Allergy, Asthma and Clinical Immunology. 7, 1, 4.

Research output: Contribution to journalArticle

8 Scopus citations

The Pyk2 FERM regulates Pyk2 complex formation and phosphorylation

Riggs, D., Yang, Z., Kloss, J. & Loftus, J. C., Jan 1 2011, In : Cellular Signalling. 23, 1, p. 288-296 9 p.

Research output: Contribution to journalArticle

17 Scopus citations
2010

Airway eosinophilia in remission and progression of asthma: Accumulation with a fast decline of FEV1

Broekema, M., Volbeda, F., Timens, W., Dijkstra, A., Lee, N. A., Lee, J. J., Lodewijk, M. E., Postma, D. S., Hylkema, M. N. & Ten Hacken, N. H. T., Sep 1 2010, In : Respiratory Medicine. 104, 9, p. 1254-1262 9 p.

Research output: Contribution to journalArticle

46 Scopus citations

Altered eosinophil profile in mice with ST6Gal-1 deficiency: An additional role for ST6Gal-1 generated by the P1 promoter in regulating allergic inflammation

Nasirikenari, M., Chandrasekaran, E. V., Matta, K. L., Segal, B. H., Bogner, P. N., Lugade, A. A., Thanavala, Y., Lee, J. J. & Lau, J. T. Y., Mar 1 2010, In : Journal of Leukocyte Biology. 87, 3, p. 457-466 10 p.

Research output: Contribution to journalArticle

25 Scopus citations

Analysis of a cholera toxin B subunit (CTB) and human mucin 1 (MUC1) conjugate protein in a MUC1-tolerant mouse model

Pinkhasov, J., Alvarez, M. L., Pathangey, L. B., Tinder, T. L., Mason, H. S., Walmsley, A. M., Gendler, S. J. & Mukherjee, P., Dec 1 2010, In : Cancer Immunology, Immunotherapy. 59, 12, p. 1801-1811 11 p.

Research output: Contribution to journalArticle

12 Scopus citations

Dimeric arrangement of the parathyroid hormone receptor and a structural mechanism for ligand-induced dissociation

Pioszak, A. A., Harikumar, K. G., Parker, N. R., Miller, L. J. & Xu, H. E., Apr 16 2010, In : Journal of Biological Chemistry. 285, 16, p. 12435-12444 10 p.

Research output: Contribution to journalArticle

49 Scopus citations

Elucidation of the active conformation of the amino terminus of receptor-bound secretin using intramolecular disulfide bond constraints

Dong, M., Pinon, D. I., Bordner, A. J. & Miller, L. J., Oct 1 2010, In : Bioorganic and Medicinal Chemistry Letters. 20, 20, p. 6040-6044 5 p.

Research output: Contribution to journalArticle

5 Scopus citations

Importance of lipid-exposed residues in transmembrane segment four for family B calcitonin receptor homo-dimerization

Harikumar, K. G., Ball, A. M., Sexton, P. M. & Miller, L. J., Sep 1 2010, In : Regulatory Peptides. 164, 2-3, p. 113-119 7 p.

Research output: Contribution to journalArticle

22 Scopus citations

Longevity and age-related pathology of mice deficient in pregnancy-associated plasma protein-a

Conover, C. A., Bale, L. K., Mader, J. R., Mason, M. A., Keenan, K. P. & Marler, R. J., Jun 2010, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 65 A, 6, p. 590-599 10 p.

Research output: Contribution to journalArticle

58 Scopus citations

Modulation of cell surface expression of nonactivated cholecystokinin receptors using bivalent ligand-induced internalization

Harikumar, K. G., Akgün, E., Portoghese, P. S. & Miller, L. J., Apr 8 2010, In : Journal of Medicinal Chemistry. 53, 7, p. 2836-2842 7 p.

Research output: Contribution to journalArticle

14 Scopus citations

MultiRTA: A simple yet reliable method for predicting peptide binding affinities for multiple class II MHC allotypes

Bordner, A. J. & Mittelmann, H. D., Sep 24 2010, In : BMC bioinformatics. 11, 482.

Research output: Contribution to journalArticle

31 Scopus citations

Murine lung eosinophil activation and chemokine production in allergic airway inflammation

Rose, C. E., Lannigan, J. A., Kim, P., Lee, J. J., Fu, S. M. & Sung, S. S. J., Dec 1 2010, In : Cellular and Molecular Immunology. 7, 5, p. 361-374 14 p.

Research output: Contribution to journalArticle

40 Scopus citations

Novel model of TH2-polarized chronic ileitis: The SAMPl mouse

McNamee, E. N., Wermers, J. D., Masterson, J. C., Collins, C. B., Matthew, D. P., Lebsack, B. A., Fillon, S., Robinson, Z. D., Grenawalt, J., Lee, J. J., Jedlicka, P., Furuta, G. T. & Rivera-Nieves, J., Apr 16 2010, In : Inflammatory bowel diseases. 16, 5, p. 743-752 10 p.

Research output: Contribution to journalArticle

26 Scopus citations

Orientation-dependent backbone-only residue pair scoring functions for fixed backbone protein design

Bordner, A. J., Apr 16 2010, In : BMC bioinformatics. 11, 192.

Research output: Contribution to journalArticle

5 Scopus citations

Prediction of the binding affinities of peptides to class II MHC using a regularized thermodynamic model

Bordner, A. J. & Mittelmann, H. D., Jan 20 2010, In : BMC bioinformatics. 11, 41.

Research output: Contribution to journalArticle

23 Scopus citations

Refinement of the pharmacophore of an agonist ligand of the secretin receptor using conformationally constrained cyclic hexapeptides

Dong, M., Narang, P., Pinon, D. I., Bordner, A. J. & Miller, L. J., Jun 1 2010, In : Peptides. 31, 6, p. 1094-1098 5 p.

Research output: Contribution to journalArticle

3 Scopus citations

Structural conservation in band 4.1, ezrin, radixin, moesin (FERM) domains as a guide to identify inhibitors of the proline-rich tyrosine kinase 2

Meurice, N., Wang, L., Lipinski, C. A., Yang, Z., Hulme, C. & Loftus, J. C., Mar 1 2010, In : Journal of Medicinal Chemistry. 53, 2, p. 669-677 9 p.

Research output: Contribution to journalArticle

10 Scopus citations

Towards universal structure-based prediction of class II MHC epitopes for diverse allotypes

Bordner, A. J., 2010, In : PloS one. 5, 12, e14383.

Research output: Contribution to journalArticle

17 Scopus citations

TROY (TNFRSF19) is overexpressed in advanced glial tumors and promotes glioblastoma cell invasion via Pyk2-Rac1 signaling

Paulino, V. M., Yang, Z., Kloss, J., Ennis, M. J., Armstrong, B. A., Loftus, J. C. & Tran, N. L., Nov 2010, In : Molecular Cancer Research. 8, 11, p. 1558-1567 10 p.

Research output: Contribution to journalArticle

45 Scopus citations
2009

A Novel Histologic Scoring System to Evaluate Mucosal Biopsies From Patients With Eosinophilic Esophagitis

Protheroe, C., Woodruff, S. A., de Petris, G., Mukkada, V., Ochkur, S. I., Janarthanan, S., Lewis, J. C., Pasha, S., Lunsford, T., Harris, L., Sharma, V. K., McGarry, M. P., Lee, N. A., Furuta, G. T. & Lee, J. J., Jul 2009, In : Clinical Gastroenterology and Hepatology. 7, 7, p. 749-755.e11

Research output: Contribution to journalArticle

138 Scopus citations
2 Scopus citations

Differential effects of Pyk2 and FAK on the hypertrophic response of cardiac myocytes

Menashi, E. B. & Loftus, J. C., Aug 1 2009, In : Cell and Tissue Research. 337, 2, p. 243-255 13 p.

Research output: Contribution to journalArticle

7 Scopus citations

Effects of putative catalytic base mutation E211Q on ABCG2-mediated methotrexate transport

Hou, Y. X., Li, C. Z., Palaniyandi, K., Magtibay, P. M., Homolya, L., Sarkadi, B. & Chang, X. B., Oct 14 2009, In : Biochemistry. 48, 38, p. 9122-9131 10 p.

Research output: Contribution to journalArticle

8 Scopus citations

Eosinophil deficiency compromises parasite survival in chronic nematode infection

Fabre, V., Beiting, D. P., Bliss, S. K., Gebreselassie, N. G., Gagliardo, L. F., Lee, N. A., Lee, J. J. & Appleton, J. A., Feb 1 2009, In : Journal of Immunology. 182, 3, p. 1577-1583 7 p.

Research output: Contribution to journalArticle

Open Access
107 Scopus citations

Eosinophils oxidize damage-associated molecular pattern molecules derived from stressed cells

Lotfi, R., Herzog, G. I., DeMarco, R. A., Beer-Stolz, D., Lee, J. J., Rubartelli, A., Schrezenmeier, H. & Lotze, M. T., Oct 15 2009, In : Journal of Immunology. 183, 8, p. 5023-5031 9 p.

Research output: Contribution to journalArticle

67 Scopus citations

Eosinophils utilize multiple chemokine receptors for chemotaxis to the parasitic nematode strongyloides stercoralis

Stein, L. H., Redding, K. M., Lee, J. J., Nolan, T. J., Schad, G. A., Lok, J. B. & Abraham, D., Oct 1 2009, In : Journal of Innate Immunity. 1, 6, p. 618-630 13 p.

Research output: Contribution to journalArticle

24 Scopus citations

Expression of human MUC1 during early pregnancy in the human MUC1 transgenic mouse model

Dharmaraj, N., Gendler, S. J. & Carson, D. D., Dec 1 2009, In : Biology of Reproduction. 81, 6, p. 1182-1188 7 p.

Research output: Contribution to journalArticle

19 Scopus citations

Functional importance of a structurally distinct homodimeric complex of the family B G protein-coupled secretin receptor

Gao, F., Harikumar, K. G., Dong, M., Lam, P. C. H., Sexton, P. M., Christopoulos, A., Bordner, A., Abagyan, R. & Miller, L. J., Aug 1 2009, In : Molecular pharmacology. 76, 2, p. 264-274 11 p.

Research output: Contribution to journalArticle

43 Scopus citations

Induced association of μ opioid (MOP) and type 2 cholecystokinin (CCK 2) receptors by novel bivalent ligands

Zheng, Y., Akgiin, E., Harikumar, K. G., Hopson, J., Powers, M. D., Lunzer, M. M., Miller, L. J. & Portoghese, P. S., Jan 22 2009, In : Journal of Medicinal Chemistry. 52, 2, p. 247-258 12 p.

Research output: Contribution to journalArticle

46 Scopus citations

Intravitreal alemtuzumab penetrates full-thickness retina in rabbit eyes

Ekdawi, N. S., Pulido, J. S., Itty, S., Marler, R. J., Herman, D. C., Hardwig, P., Mohney, B. G., Valyi-Nagy, T. & Shukla, D., Nov 1 2009, In : Retina. 29, 10, p. 1532-1534 3 p.

Research output: Contribution to journalArticle

3 Scopus citations