Biochemistry and Molecular Biology

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2014

Targeting aPKC disables oncogenic signaling by both the EGFR and the proinflammatory cytokine TNFα in glioblastoma

Kusne, Y., Carrera-Silva, E. A., Perry, A. S., Rushing, E. J., Mandell, E. K., Dietrich, J. D., Errasti, A. E., Gibbs, D., Berens, M. E., Loftus, J. C., Hulme, C., Yang, W., Lu, Z., Aldape, K., Sanai, N., Rothlin, C. V. & Ghosh, S., Aug 12 2014, In : Science Signaling. 7, 338, ra75.

Research output: Contribution to journalArticle

32 Scopus citations

T-helper 2 cytokines, transforming growth factor β1, and eosinophil products induce fibrogenesis and alter muscle motility in patients with eosinophilic esophagitis

Rieder, F., Nonevski, I., Ma, J., Ouyang, Z., West, G., Protheroe, C., Depetris, G., Schirbel, A., Lapinski, J., Goldblum, J., Bonfield, T., Lopez, R., Harnett, K., Lee, J., Hirano, I., Falk, G., Biancani, P. & Fiocchi, C., May 2014, In : Gastroenterology. 146, 5, p. 1266-1277.e9

Research output: Contribution to journalArticle

67 Scopus citations

Transmembrane peptides as unique tools to demonstrate the in vivo action of a cross-class GPCR heterocomplex

Lee, L. T. O., Ng, S. Y. L., Chu, J. Y. S., Sekar, R., Harikumar, K. G., Miller, L. J. & Chow, B. K. C., Jun 2014, In : FASEB Journal. 28, 6, p. 2632-2644 13 p.

Research output: Contribution to journalArticle

30 Scopus citations
2013

Adenomatous polyps are drivenbymicrobe-instigated focal inflammation and are controlled by IL-10-producing T cells

Dennis, K. L., Wang, Y., Blatner, N. R., Wang, S., Saadalla, A., Trudeau, E., Roers, A., Weaver, C. T., Lee, J. J., Gilbert, J. A., Chang, E. B. & Khazaie, K., Oct 1 2013, In : Cancer research. 73, 19, p. 5905-5913 9 p.

Research output: Contribution to journalArticle

159 Scopus citations

An essential role for Rab27a GTPase in eosinophil exocytosis

Kim, J. D., Willetts, L., Ochkur, S., Srivastava, N., Hamburg, R., Shayeganpour, A., Seabra, M. C., Lee, J. J., Moqbel, R. & Lacy, P., Dec 1 2013, In : Journal of Leukocyte Biology. 94, 6, p. 1265-1274 10 p.

Research output: Contribution to journalArticle

14 Scopus citations

Comparison of three staining methods to identify eosinophils in formalin-fixed canine skin

Gomes, P., Torres, S. M. F., Plager, D. A., Jessen, C. R. & Lee, J. J., Jun 1 2013, In : Veterinary Dermatology. 24, 3, p. 323-e72

Research output: Contribution to journalArticle

14 Scopus citations

Cys-leukotrienes promote fibrosis in a mouse model of eosinophil-mediated respiratory inflammation

Ochkur, S. I., Protheroe, C. A., Li, W., Colbert, D. C., Zellner, K. R., Shen, H. H., Luster, A. D., Irvin, C. G., Lee, J. J. & Lee, N. A., Dec 1 2013, In : American journal of respiratory cell and molecular biology. 49, 6, p. 1074-1084 11 p.

Research output: Contribution to journalArticle

17 Scopus citations

Downregulation of hematopoietic MUC1 during Experimental colitis increases tumor-promoting myeloid-derived suppressor cells

Poh, T. W., Madsen, C. S., Gorman, J. E., Marler, R. J., Leighton, J. A., Cohen, P. A. & Gendler, S. J., Sep 15 2013, In : Clinical Cancer Research. 19, 18, p. 5039-5052 14 p.

Research output: Contribution to journalArticle

9 Scopus citations

Effect of proton pump inhibitor on esophageal eosinophilia

Schroeder, S., Capocelli, K. E., Masterson, J. C., Harris, R., Protheroe, C., Lee, J. J. & Furuta, G. T., Feb 2013, In : Journal of pediatric gastroenterology and nutrition. 56, 2, p. 166-172 7 p.

Research output: Contribution to journalArticle

53 Scopus citations

Eosinophil peroxidase in sputum represents a unique biomarker of airway eosinophilia

Nair, P., Ochkur, S. I., Protheroe, C., Radford, K., Efthimiadis, A., Lee, N. A. & Lee, J. J., Sep 1 2013, In : Allergy: European Journal of Allergy and Clinical Immunology. 68, 9, p. 1177-1184 8 p.

Research output: Contribution to journalArticle

46 Scopus citations

Expression of the secondary granule proteins major basic protein 1 (MBP-1) and eosinophil peroxidase (EPX) is required for eosinophilopoiesis in mice

Doyle, A. D., Jacobsen, E. A., Ochkur, S. I., McGarry, M. P., Shim, K. G., Nguyen, D. T. C., Protheroe, C., Colbert, D., Kloeber, J., Neely, J., Shim, K. P., Dyer, K. D., Rosenberg, H. F., Lee, J. J. & Lee, N. A., Aug 1 2013, In : Blood. 122, 5, p. 781-790 10 p.

Research output: Contribution to journalArticle

47 Scopus citations

Homologous recombination into the eosinophil peroxidase locus generates a strain of mice expressing Cre recombinase exclusively in eosinophils

Doyle, A. D., Jacobsen, E. A., Ochkur, S. I., Willetts, L., Shim, K., Neely, J., Kloeber, J., LeSuer, W. E., Pero, R. S., Lacy, P., Moqbel, R., Lee, N. A. & Lee, J. J., Jul 1 2013, In : Journal of Leukocyte Biology. 94, 1, p. 17-24 8 p.

Research output: Contribution to journalArticle

47 Scopus citations

Loss of the transcription factor GLI1 identifies a signaling network in the tumor microenvironment mediating KRAS oncogene-induced transformation

Mills, L. D., Zhang, Y., Marler, R. J., Herreros-Villanueva, M., Zhang, L., Almada, L. L., Couch, F., Wetmore, C., Di Magliano, M. P. & Fernandez-Zapico, M. E., Apr 26 2013, In : Journal of Biological Chemistry. 288, 17, p. 11786-11794 9 p.

Research output: Contribution to journalArticle

67 Scopus citations

Mast cells are required for full expression of allergen/SEB-Induced skin inflammation

Ando, T., Matsumoto, K., Namiranian, S., Yamashita, H., Glatthorn, H., Kimura, M., Dolan, B. R., Lee, J. J., Galli, S. J., Kawakami, Y., Jamora, C. & Kawakami, T., Dec 2013, In : Journal of Investigative Dermatology. 133, 12, p. 2695-2705 11 p.

Research output: Contribution to journalArticle

35 Scopus citations

Membrane cholesterol affects stimulus-activity coupling in type 1, but not type 2, CCK receptors: Use of cell lines with elevated cholesterol

Harikumar, K. G., Potter, R. M., Patil, A., Echeveste, V. & Miller, L. J., Mar 1 2013, In : Lipids. 48, 3, p. 231-244 14 p.

Research output: Contribution to journalArticle

13 Scopus citations

Mice deficient in PAPP-A show resistance to the development of diabetic nephropathy

Mader, J. R., Resch, Z. T., McLean, G. R., Mikkelsen, J. H., Oxvig, C., Marler, R. J. & Conover, C. A., 2013, In : Journal of Endocrinology. 219, 1, p. 51-58 8 p.

Research output: Contribution to journalArticle

17 Scopus citations

Molecular basis for benzodiazepine agonist action at the type 1 cholecystokinin receptor

Harikumar, K. G., Cawston, E. E., Lam, P. C. H., Patil, A., Orry, A., Henke, B. R., Abagyan, R., Christopoulos, A., Sexton, P. M. & Miller, L. J., Jul 19 2013, In : Journal of Biological Chemistry. 288, 29, p. 21082-21095 14 p.

Research output: Contribution to journalArticle

11 Scopus citations

Reciprocal Activation of Transcription Factors Underlies the Dichotomy between Proliferation and Invasion of Glioma Cells

Dhruv, H. D., McDonough Winslow, W. S., Armstrong, B., Tuncali, S., Eschbacher, J., Kislin, K., Loftus, J. C., Tran, N. L. & Berens, M. E., Aug 15 2013, In : PloS one. 8, 8, e72134.

Research output: Contribution to journalArticle

31 Scopus citations

Structural basis and targeting of the interaction between fibroblast growth factor-inducible 14 and tumor necrosis factor-like weak inducer of apoptosis

Dhruv, H., Loftus, J. C., Narang, P., Petit, J. L., Fameree, M., Burton, J., Tchegho, G., Chow, D., Yin, H., Al-Abed, Y., Berens, M. E., Tran, N. L. & Meurice, N., Nov 8 2013, In : Journal of Biological Chemistry. 288, 45, p. 32261-32276 16 p.

Research output: Contribution to journalArticle

15 Scopus citations

Structure and function of Norrin in assembly and activation of a Frizzled 4-Lrp5/6 complex

Ke, J., Harikumar, K. G., Erice, C., Chen, C., Gu, X., Wang, L., Parker, N., Cheng, Z., Xu, W., Williams, B. O., Melcher, K., Miller, L. J. & Eric Xu, H., Nov 1 2013, In : Genes and Development. 27, 21, p. 2305-2319 15 p.

Research output: Contribution to journalArticle

47 Scopus citations

Targeted imaging of breast tumor progression and therapeutic response in a human uMUC-1 expressing transgenic mouse model

Ghosh, S. K., Uchida, M., Yoo, B., Ross, A. W., Gendler, S. J., Gong, J., Moore, A. & Medarova, Z., Apr 15 2013, In : International Journal of Cancer. 132, 8, p. 1860-1867 8 p.

Research output: Contribution to journalArticle

13 Scopus citations

The oesophageal string test: A novel, minimally invasive method measures mucosal inflammation in eosinophilic oesophagitis

Furuta, G. T., Kagalwalla, A. F., Lee, J. J., Alumkal, P., Maybruck, B. T., Fillon, S., Masterson, J. C., Ochkur, S., Protheroe, C., Moore, W., Pan, Z., Amsden, K., Robinson, Z., Capocelli, K., Mukkada, V., Atkins, D., Fleischer, D., Hosford, L., Kwatia, M. A., Schroeder, S. & 4 others, Kelly, C., Lovell, M., Melin-Aldana, H. & Ackerman, S. J., Oct 2013, In : Gut. 62, 10, p. 1395-1405 11 p.

Research output: Contribution to journalArticle

138 Scopus citations
21 Scopus citations

TROY (TNFRSF19) promotes glioblastoma survival signaling and therapeutic resistance

Loftus, J. C., Dhruv, H., Tuncali, S., Kloss, J., Yang, Z., Schumacher, C. A., Cao, B., Williams, B. O., Eschbacher, J. M., Ross, J. T. D. & Tran, N. L., Aug 1 2013, In : Molecular Cancer Research. 11, 8, p. 865-874 10 p.

Research output: Contribution to journalArticle

28 Scopus citations
2012

A sensitive high throughput ELISA for human eosinophil peroxidase: A specific assay to quantify eosinophil degranulation from patient-derived sources

Ochkur, S. I., Kim, J. D., Protheroe, C. A., Colbert, D., Condjella, R. M., Bersoux, S., Helmers, R. A., Moqbel, R., Lacy, P., Kelly, E. A., Jarjour, N. N., Kern, R., Peters, A., Schleimer, R. P., Furuta, G. T., Nair, P., Lee, J. J. & Lee, N. A., Oct 31 2012, In : Journal of Immunological Methods. 384, 1-2, p. 10-20 11 p.

Research output: Contribution to journalArticle

18 Scopus citations
14 Scopus citations

Cdc42 and the guanine nucleotide exchange factors Ect2 and trio mediate Fn14-induced migration and invasion of glioblastoma cells

Fortin, S. P., Ennis, M. J., Schumacher, C. A., Zylstra-Diegel, C. R., Williams, B. O., Ross, J. T. D., Winkles, J. A., Loftus, J. C., Symons, M. H. & Tran, N. L., Jul 1 2012, In : Molecular Cancer Research. 10, 7, p. 958-968 11 p.

Research output: Contribution to journalArticle

59 Scopus citations

Detection of Progressive Myocardial Tissue Injury by Ultrasonic Integrated Backscatter Immediately After Coronary Reperfusion

Katayama, M., Jiamsripong, P., McMahon, E. M., Lombari, T. R., Bukatina, A. E., Wu, Q., Marler, R. J. & Belohlavek, M., Sep 2012, In : Ultrasound in Medicine and Biology. 38, 9, p. 1662-1669 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Differential sensitivity of types 1 and 2 cholecystokinin receptors to membrane cholesterol

Potter, R. M., Harikumar, K. G., Wu, S. V. & Miller, L. J., Jan 1 2012, In : Journal of Lipid Research. 53, 1, p. 137-148 12 p.

Research output: Contribution to journalArticle

29 Scopus citations

Elevated expression of Fn14 in non-small cell lung cancer correlates with activated EGFR and promotes tumor cell migration and invasion

Whitsett, T. G., Cheng, E., Inge, L., Asrani, K., Jameson, N. M., Hostetter, G., Weiss, G. J., Kingsley, C. B., Loftus, J. C., Bremner, R., Tran, N. L. & Winkles, J. A., Jul 1 2012, In : American Journal of Pathology. 181, 1, p. 111-120 10 p.

Research output: Contribution to journalArticle

36 Scopus citations

Eosinophilic esophagitis: Epithelial mesenchymal transition contributes to esophageal remodeling and reverses with treatment

Kagalwalla, A. F., Akhtar, N., Woodruff, S. A., Rea, B. A., Masterson, J. C., Mukkada, V., Parashette, K. R., Du, J., Fillon, S., Protheroe, C. A., Lee, J. J., Amsden, K., Melin-Aldana, H., Capocelli, K. E., Furuta, G. T. & Ackerman, S. J., May 2012, In : Journal of Allergy and Clinical Immunology. 129, 5, p. 1387-1396.e6

Research output: Contribution to journalArticle

123 Scopus citations

Eosinophils preserve parasitic nematode larvae by regulating local immunity

Gebreselassie, N. G., Moorhead, A. R., Fabre, V., Gagliardo, L. F., Lee, N. A., Lee, J. J. & Appleton, J. A., Jan 1 2012, In : Journal of Immunology. 188, 1, p. 417-425 9 p.

Research output: Contribution to journalArticle

60 Scopus citations

Expression of wild-type and mutant S20G hIAPP in physiologic knock-in mouse models fails to induce islet amyloid formation, but induces mild glucose intolerance

Hiddinga, H. J., Sakagashira, S., Ishigame, M., Madde, P., Sanke, T., Nanjo, K., Kudva, Y. C., Lee, J. J., van Deursen, J. & Eberhardt, N. L., Apr 1 2012, In : Journal of Diabetes Investigation. 3, 2, p. 138-147 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

Glucagon-like peptide-1 receptor dimerization differentially regulates agonist signaling but does not affect small molecule allostery

Harikumar, K. G., Wootten, D., Pinon, D. I., Koole, C., Ball, A. M., Furness, S. G. B., Graham, B., Dong, M., Christopoulos, A., Miller, L. J. & Sexton, P. M., Nov 6 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 45, p. 18607-18612 6 p.

Research output: Contribution to journalArticle

43 Scopus citations
13 Scopus citations

Immune recognition of tumor-associated mucin MUC1 is achieved by a fully synthetic aberrantly glycosylated MUC1 tripartite vaccine

Lakshminarayanan, V., Thompson, P., Wolfert, M. A., Buskas, T., Bradley, J. M., Pathangey, L. B., Madsen, C. S., Cohen, P. A., Gendler, S. J. & Boons, G. J., Jan 3 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 1, p. 261-266 6 p.

Research output: Contribution to journalArticle

201 Scopus citations

Interleukin 5 is protective during sepsis in an eosinophil-independent manner

Linch, S. N., Danielson, E. T., Kelly, A. M., Tamakawa, R. A., Lee, J. J. & Gold, J. A., Aug 1 2012, In : American journal of respiratory and critical care medicine. 186, 3, p. 246-254 9 p.

Research output: Contribution to journalArticle

38 Scopus citations

Intratumoral delivery of CpG-conjugated anti-MUC1 antibody enhances NK cell anti-tumor activity

Schettini, J., Kidiyoor, A., Besmer, D. M., Tinder, T. L., Roy, L. D., Lustgarten, J., Gendler, S. J. & Mukherjee, P., Nov 1 2012, In : Cancer Immunology, Immunotherapy. 61, 11, p. 2055-2065 11 p.

Research output: Contribution to journalArticle

19 Scopus citations

Ligand-induced internalization of the type 1 cholecystokinin receptor independent of recognized signaling activity

Cawston, E. E., Harikumar, K. G. & Miller, L. J., Feb 2012, In : American Journal of Physiology - Cell Physiology. 302, 3, p. C615-C627

Research output: Contribution to journalArticle

2 Scopus citations

MiRNA expression profiling in migrating Glioblastoma cells: Regulation of cell migration and invasion by miR-23b via targeting of Pyk2

Loftus, J. C., Ross, J. T. D., Paquette, K. M., Paulino, V. M., Nasser, S., Yang, Z., Kloss, J., Kim, S., Berens, M. E. & Tran, N. L., Jun 22 2012, In : PloS one. 7, 6, e39818.

Research output: Contribution to journalArticle

50 Scopus citations

Modulation of β-catenin signaling by glucagon receptor activation

Ke, J., Zhang, C., Harikumar, K. G., Zylstra-Diegel, C. R., Wang, L., Mowry, L. E., Miller, L. J., Williams, B. O. & Xu, H. E., Mar 16 2012, In : PloS one. 7, 3, e33676.

Research output: Contribution to journalArticle

13 Scopus citations

Molecular basis for binding and subtype selectivity of 1,4-benzodiazepine antagonist ligands of the cholecystokinin receptor

Cawston, E. E., Lam, P. C. H., Harikumar, K. G., Dong, M., Ball, A. M., Augustine, M. L., Akgün, E., Portoghese, P. S., Orry, A., Abagyan, R., Sexton, P. M. & Miller, L. J., May 25 2012, In : Journal of Biological Chemistry. 287, 22, p. 18618-18635 18 p.

Research output: Contribution to journalArticle

15 Scopus citations

MUC1 regulates PDGFA expression during pancreatic cancer progression

Sahraei, M., Roy, L. D., Curry, J. M., Teresa, T. L., Nath, S., Besmer, D., Kidiyoor, A., Dalia, R., Gendler, S. J. & Mukherjee, P., Nov 22 2012, In : Oncogene. 31, 47, p. 4935-4945 11 p.

Research output: Contribution to journalArticle

36 Scopus citations

Myeloid-derived suppressor cells adhere to physiologic STAT3-vs STAT5-dependent hematopoietic programming, establishing diverse tumor-mediated mechanisms of immunologic escape

Cohen, P. A., Ko, J. S., Storkus, W. J., Spencer, C. D., Bradley, J. M., Gorman, J. E., McCurry, D. B., Zorro-Manrique, S., Dominguez, A. L., Pathangey, L. B., Rayman, P. A., Rini, B. I., Gendler, S. J. & Finke, J. H., Aug 1 2012, In : Immunological Investigations. 41, 6-7, p. 680-710 31 p.

Research output: Contribution to journalArticle

30 Scopus citations

PHF20 is an effector protein of p53 double lysine methylation that stabilizes and activates p53

Cui, G., Park, S., Badeaux, A. I., Kim, D., Lee, J., Thompson, J. R., Yan, F., Kaneko, S., Yuan, Z., Botuyan, M. V., Bedford, M. T., Cheng, J. Q. & Mer, G., Sep 1 2012, In : Nature Structural and Molecular Biology. 19, 9, p. 916-924 9 p.

Research output: Contribution to journalArticle

51 Scopus citations

Placental protein 13 and decidual zones of necrosis: An immunologic diversion that may be linked to preeclampsia

Kliman, H. J., Sammar, M., Grimpel, Y. I., Lynch, S. K., Milano, K. M., Pick, E., Bejar, J., Arad, A., Lee, J. J., Meiri, H. & Gonen, R., Jan 1 2012, In : Reproductive Sciences. 19, 1, p. 16-30 15 p.

Research output: Contribution to journalArticle

47 Scopus citations
3 Scopus citations

Protein tyrosine phosphatase SHP2 regulates TGF-β1 production in airway epithelia and asthmatic airway remodeling in mice

Qin, X. J., Zhang, G. S., Zhang, X., Qiu, Z. W., Wang, P. L., Li, Y. W., Li, W., Xie, Q. M., Ke, Y. H., Lee, J. J. & Shen, H. H., Dec 1 2012, In : Allergy: European Journal of Allergy and Clinical Immunology. 67, 12, p. 1547-1556 10 p.

Research output: Contribution to journalArticle

25 Scopus citations

The development of a sensitive and specific ELISA for mouse eosinophil peroxidase: Assessment of eosinophil degranulation ex vivo and in models of human disease

Ochkur, S. I., Kim, J. D., Protheroe, C. A., Colbert, D., Moqbel, R., Lacy, P., Lee, J. J. & Lee, N. A., Jan 31 2012, In : Journal of Immunological Methods. 375, 1-2, p. 138-147 10 p.

Research output: Contribution to journalArticle

28 Scopus citations

Workshop report from the national institutes of health taskforce on the research needs of eosinophil-associated diseases (TREAD)

Bochner, B. S., Book, W., Busse, W. W., Butterfield, J., Furuta, G. T., Gleich, G. J., Klion, A. D., Lee, J. J., Leiferman, K. M., Minnicozzi, M., Moqbel, R., Rothenberg, M. E., Schwartz, L. B., Simon, H. U., Wechsler, M. E. & Weller, P. F., Sep 1 2012, In : Journal of Allergy and Clinical Immunology. 130, 3, p. 587-596 10 p.

Research output: Contribution to journalArticle

36 Scopus citations