Biochemistry and Molecular Biology

Research Output

Article

G-protein-dependent cell surface dynamics of the human serotonin 1A receptor tagged to yellow fluorescent protein

Pucadyil, T. J., Kalipatnapu, S., Harikumar, K. G., Rangaraj, N., Karnik, S. S. & Chattopadhyay, A., Dec 21 2004, In : Biochemistry. 43, 50, p. 15852-15862 11 p.

Research output: Contribution to journalArticle

58 Scopus citations

Gq signaling is required for allergen-induced pulmonary eosinophilia

Borchers, M. T., Justice, P. J., Ansay, T., Mancino, V., McGarry, M. P., Crosby, J., Simon, M. I., Lee, N. A. & Lee, J. J., Apr 1 2002, In : Journal of Immunology. 168, 7, p. 3543-3549 7 p.

Research output: Contribution to journalArticle

Open Access
17 Scopus citations

i2-mediated signaling events in the endothelium are involved in controlling leukocyte extravasation

Pero, R. S., Borchers, M. T., Spicher, K., Ochkur, S. I., Sikora, L., Rao, S. P., Abdala-Valencia, H., O'Neill, K. R., Shen, H., McGarry, M. P., Lee, N. A., Cook-Mills, J. M., Sriramarao, P., Simon, M. I., Birnbaumer, L. & Lee, J. J., Mar 13 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 11, p. 4371-4376 6 p.

Research output: Contribution to journalArticle

47 Scopus citations

Heterodimerization of Type A and B Cholecystokinin Receptors Enhance Signaling and Promote Cell Growth

Cheng, Z. J., Harikumar, K. G., Holicky, E. L. & Miller, L. J., Dec 26 2003, In : Journal of Biological Chemistry. 278, 52, p. 52972-52979 8 p.

Research output: Contribution to journalArticle

57 Scopus citations

Heterologous expression systems for study of cystic fibrosis transmembrane conductance regulator

Chang, X. B., Kartner, N., Seibert, F. S., Aleksandrov, A. A., Kloser, A. W., Kiser, G. L. & Riordan, J. R., Jan 1 1998, In : Methods in Enzymology. 292, p. 616-629 14 p.

Research output: Contribution to journalArticle

14 Scopus citations

Histological studies of gene-ablated mice support important functional roles for natural killer cells in the uterus during pregnancy

Croy, B. A., Ashkar, A. A., Foster, R. A., DiSanto, J. P., Magram, J., Carson, D., Gendler, S. J., Grusby, M. J., Wagner, N., Muller, W. & Guimond, M. J., Nov 15 1997, In : Journal of Reproductive Immunology. 35, 2, p. 111-133 23 p.

Research output: Contribution to journalArticle

63 Scopus citations

Homologous recombination into the eosinophil peroxidase locus generates a strain of mice expressing Cre recombinase exclusively in eosinophils

Doyle, A. D., Jacobsen, E. A., Ochkur, S. I., Willetts, L., Shim, K., Neely, J., Kloeber, J., LeSuer, W. E., Pero, R. S., Lacy, P., Moqbel, R., Lee, N. A. & Lee, J. J., Jul 1 2013, In : Journal of Leukocyte Biology. 94, 1, p. 17-24 8 p.

Research output: Contribution to journalArticle

47 Scopus citations

Human and mouse eosinophils have antiviral activity against parainfluenza virus

Drake, M. G., Bivins-Smith, E. R., Proskocil, B. J., Nie, Z., Scott, G. D., Lee, J. J., Lee, N. A., Fryer, A. D. & Jacoby, D. B., Sep 1 2016, In : American Journal of Respiratory Cell and Molecular Biology. 55, 3, p. 387-394 8 p.

Research output: Contribution to journalArticle

27 Scopus citations
13 Scopus citations
8 Scopus citations

Hβ58, and insertional mutation affecting early postimplantation development of the mouse embryo

Radice, G., Lee, J. J. & Costantini, F., Apr 4 1991, In : Development. 111, 3, p. 801-811 11 p.

Research output: Contribution to journalArticle

49 Scopus citations

Identification and characterization of a novel, evolutionarily conserved gene disrupted by the murine Hβ58 embryonic lethal transgene insertion

Lee, J. J., Radice, G., Perkins, C. P. & Costantini, F., Jan 1 1992, In : Development. 115, 1, p. 277-288 12 p.

Research output: Contribution to journalArticle

76 Scopus citations

Identification and characterization of high molecular-mass mucin-like glycoproteins in the plasma membrane of airway epithelial cells

Paul, E., Lee, D. I., Hyun, S. W., Gendler, S. & Kim, K. C., Jan 1 1998, In : American journal of respiratory cell and molecular biology. 19, 4, p. 681-690 10 p.

Research output: Contribution to journalArticle

16 Scopus citations

Identification of a new murine eosinophil major basic protein (mMBP) gene: Cloning and characterization of mMBP-2

Macias, M. P., Welch, K. C., Denzler, K. L., Larson, K. A., Lee, N. A. & Lee, J. J., Jan 1 2000, In : Journal of Leukocyte Biology. 67, 4, p. 567-576 10 p.

Research output: Contribution to journalArticle

24 Scopus citations

Identification of aurintricarboxylic acid as a selective inhibitor of the TWEAK-Fn14 signaling pathway in glioblastoma cells

Roos, A., Dhruv, H. D., Mathews, I. T., Inge, L. J., Tuncali, S., Hartman, L. K., Chow, D., Millard, N., Yin, H. H., Kloss, J., Loftus, J. C., Winkles, J. A., Berens, M. E. & Tran, N. L., 2017, In : Oncotarget. 8, 7, p. 12234-12246 13 p.

Research output: Contribution to journalArticle

11 Scopus citations

Identification of cereblon-binding proteins and relationship with response and survival after IMiDs in multiple myeloma

Zhu, Y. X., Braggio, E., Shi, C. X., Kortuem, K. M., Bruins, L. A., Schmidt, J. E., Chang, X. B., Langlais, P., Luo, M., Jedlowski, P., LaPlant, B., Laumann, K., Fonseca, R., Bergsagel, P. L., Mikhael, J., Lacy, M., Champion, M. D. & Stewart, A. K., Jul 24 2014, In : Blood. 124, 4, p. 536-545 10 p.

Research output: Contribution to journalArticle

101 Scopus citations

Identification of kinetin riboside as a repressor of CCND1 and CCND2 with preclinical antimyeloma activity

Tiedemann, R. E., Mao, X., Shi, C. X., Yuan, X. Z., Palmer, S. E., Sebag, M., Marler, R., Chesi, M., Fonseca, R., Bergsagel, P. L., Schimmer, A. D. & Stewart, A. K., May 1 2008, In : Journal of Clinical Investigation. 118, 5, p. 1750-1764 15 p.

Research output: Contribution to journalArticle

47 Scopus citations

IL-33 drives eosinophil infiltration and pathogenic type 2 helper T-cell immune responses leading to chronic experimental ileitis

De Salvo, C., Wang, X. M., Pastorelli, L., Mattioli, B., Omenetti, S., Buela, K. A., Chowdhry, S., Garg, R. R., Goodman, W. A., Rodriguez-Palacios, A., Smith, D. E., Abbott, D. W., Cominelli, F., Bamias, G., Xin, W., Lee, J. J., Vecchi, M. & Pizarro, T. T., Apr 1 2016, In : American Journal of Pathology. 186, 4, p. 885-898 14 p.

Research output: Contribution to journalArticle

30 Scopus citations

Immobilization of silver ions onto paramagnetic particles for binding and release of a biotin-labeled oligonucleotide

Ramírez-Vick, J. E., García, A. A. & Lee, J., Feb 16 2000, In : Reactive and Functional Polymers. 43, 1, p. 53-62 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

Immune and anticancer responses elicited by fully synthetic aberrantly glycosylated MUC1 tripartite vaccines modified by a TLR2 or TLR9 agonist

Abdel-Aal, A. B. M., Lakshminarayanan, V., Thompson, P., Supekar, N., Bradley, J. M., Wolfert, M. A., Cohen, P. A., Gendler, S. J. & Boons, G. J., Jul 7 2014, In : ChemBioChem. 15, 10, p. 1508-1513 6 p.

Research output: Contribution to journalArticle

39 Scopus citations

Immune recognition of tumor-associated mucin MUC1 is achieved by a fully synthetic aberrantly glycosylated MUC1 tripartite vaccine

Lakshminarayanan, V., Thompson, P., Wolfert, M. A., Buskas, T., Bradley, J. M., Pathangey, L. B., Madsen, C. S., Cohen, P. A., Gendler, S. J. & Boons, G. J., Jan 3 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 1, p. 261-266 6 p.

Research output: Contribution to journalArticle

200 Scopus citations

Immunochemical and amino-terminal sequence comparison of two cytoadhesins indicates they contain similar or identical β subunits and distinct α subunits

Ginsberg, M. H., Loftus, J., Ryckwaert, J. J., Pierschbacher, M., Pytela, R., Ruoslahti, E. & Plow, E. F., Sep 15 1987, In : Journal of Biological Chemistry. 262, 12, p. 5437-5440 4 p.

Research output: Contribution to journalArticle

56 Scopus citations

Immunodetection of occult eosinophils in lung tissue biopsies may help predict survival in acute lung injury

Willetts, L., Parker, K., Wesselius, L. J., Protheroe, C. A., Jaben, E., Graziano, P., Moqbel, R., Leslie, K. O., Lee, N. A. & Lee, J. J., Aug 26 2011, In : Respiratory Research. 12, 116.

Research output: Contribution to journalArticle

19 Scopus citations

Immunoglobulin E and Eosinophil-Dependent Protective Immunity to Larval Onchocerca volvulus in Mice Immunized with Irradiated Larvae

Abraham, D., Leon, O., Schnyder-Candrian, S., Wang, C. C., Galioto, A. M., Kerepesi, L. A., Lee, J. J. & Lustigman, S., Feb 2004, In : Infection and Immunity. 72, 2, p. 810-817 8 p.

Research output: Contribution to journalArticle

58 Scopus citations

Immunological analysis of mucin molecules expressed by normal and malignant mammary epithelial cells

Griffiths, A. B., Burchell, J., Gendler, S., Lewis, A., Blight, K., Tilly, R. & Taylor‐Papadimitriou, J., Sep 15 1987, In : International Journal of Cancer. 40, 3, p. 319-327 9 p.

Research output: Contribution to journalArticle

43 Scopus citations

Immunologic relationship between platelet membrane glycoprotein GPIIb/IIIa and cell surface molecules expressed by a variety of cells

Plow, E. F., Loftus, J. C., Levin, E. G., Fair, D. S., Dixon, D., Forsyth, J. & Ginsberg, M. H., Dec 19 1986, In : Proceedings of the National Academy of Sciences of the United States of America. 83, 16, p. 6002-6006 5 p.

Research output: Contribution to journalArticle

76 Scopus citations

Immunopathogenesis of Experimental Ulcerative Colitis is Mediated by Eosinophil Peroxidase

Forbes, E., Murase, T., Yang, M., Matthaei, K. I., Lee, J. J., Lee, N. A., Foster, P. S. & Hogan, S. P., May 1 2004, In : Journal of Immunology. 172, 9, p. 5664-5675 12 p.

Research output: Contribution to journalArticle

Open Access
126 Scopus citations

Immunotherapy of spontaneous mammary carcinoma with fusions of dendritic cells and mucin 1-positive carcinoma cells

Chen, D., Xia, J., Tanaka, Y., Chen, H., Koido, S., Wernet, O., Mukherjee, P., Gendler, S. J., Kufe, D. & Gong, J., Jun 1 2003, In : Immunology. 109, 2, p. 300-307 8 p.

Research output: Contribution to journalArticle

62 Scopus citations
7 Scopus citations

Importance and regulation of the colonic mucus barrier in a mouse model of colitis

Petersson, J., Schreiber, O., Hansson, G. C., Gendler, S. J., Velcich, A., Lundberg, J. O., Roos, S., Holm, L. & Phillipson, M., Feb 2011, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 300, 2, p. G327-G333

Research output: Contribution to journalArticle

181 Scopus citations

Importance of each residue within secretin for receptor binding and biological activity

Dong, M., Le, A., Te, J. A., Pinon, D. I., Bordner, A. J. & Miller, L. J., Apr 12 2011, In : Biochemistry. 50, 14, p. 2983-2993 11 p.

Research output: Contribution to journalArticle

20 Scopus citations

Importance of lipid-exposed residues in transmembrane segment four for family B calcitonin receptor homo-dimerization

Harikumar, K. G., Ball, A. M., Sexton, P. M. & Miller, L. J., Sep 1 2010, In : Regulatory Peptides. 164, 2-3, p. 113-119 7 p.

Research output: Contribution to journalArticle

22 Scopus citations

Inactivation of the transcription factor GLI1 accelerates pancreatic cancer progression

Mills, L. D., Zhang, L., Marler, R., Svingen, P., Fernandez-Barrena, M. G., Dave, M., Bamlet, W., McWilliams, R. R., Petersen, G. M., Faubion, W. & Fernandez-Zapico, M. E., Jun 6 2014, In : Journal of Biological Chemistry. 289, 23, p. 16516-16525 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

Incidence of a split α2-glycoprotein band in the electrophoretic pattern for serum of adenocarcinoma patients

Dermer, G. B., Silverman, L. M., Gendler, S. J. & Tokes, Z. A., Jan 1 1980, In : Clinical chemistry. 26, 3, p. 392-395 4 p.

Research output: Contribution to journalArticle

2 Scopus citations

Increased fibroblast growth factor-inducible 14 expression levels promote glioma cell invasion via Rac1 and nuclear factor-κB and correlate with poor patient outcome

Tran, N. L., McDonough, W. S., Savitch, B. A., Fortin, S. P., Winkles, J. A., Symons, M., Nakada, M., Cunliffe, H. E., Hostetter, G., Hoelzinger, D. B., Rennert, J. L., Michaelson, J. S., Burkly, L. C., Lipinski, C. A., Loftus, J. C., Mariani, L. & Berens, M. E., Oct 1 2006, In : Cancer research. 66, 19, p. 9535-9542 8 p.

Research output: Contribution to journalArticle

138 Scopus citations

Increased GATA-3 and T-bet expression in eosinophilic esophagitis versus gastroesophageal reflux disease

Wright, B. L., Nguyen, N., Shim, K. P., Masterson, J. C., Jacobsen, E. A., Ochkur, S. I., Lee, J. J. & Furuta, G. T., May 2018, In : Journal of Allergy and Clinical Immunology. 141, 5, p. 1919-1921.e5

Research output: Contribution to journalArticle

2 Scopus citations

Increased levels of mucins in the cystic fibrosis mouse small intestine, and modulator effects of the Muc1 mucin expression

Malmberg, E. K., Noaksson, K. A., Phillipson, M., Johansson, M. E. V., Hinojosa-Kurtzberg, M., Holm, L., Gendler, S. J. & Hansson, G. C., Jul 14 2006, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 291, 2, p. G203-G210

Research output: Contribution to journalArticle

41 Scopus citations

Induced association of μ opioid (MOP) and type 2 cholecystokinin (CCK 2) receptors by novel bivalent ligands

Zheng, Y., Akgiin, E., Harikumar, K. G., Hopson, J., Powers, M. D., Lunzer, M. M., Miller, L. J. & Portoghese, P. S., Jan 22 2009, In : Journal of Medicinal Chemistry. 52, 2, p. 247-258 12 p.

Research output: Contribution to journalArticle

46 Scopus citations

Induction of airway allergic inflammation by hypothiocyanite via epithelial cells

Suzuki, S., Ogawa, M., Ohta, S., Nunomura, S., Nanri, Y., Shiraishi, H., Mitamura, Y., Yoshihara, T., Lee, J. J. & Izuhara, K., Dec 30 2016, In : Journal of Biological Chemistry. 291, 53, p. 27219-27227 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

Induction of antitumor immunity by vaccination of dendritic cells transfected with MUC1 RNA

Koido, S., Kashiwaba, M., Chen, D., Gendler, S., Kufe, D. & Gong, J., Nov 15 2000, In : Journal of Immunology. 165, 10, p. 5713-5719 7 p.

Research output: Contribution to journalArticle

Open Access
141 Scopus citations
6 Scopus citations

Influence of organ site and tumor cell type on MUC1-specific tumor immunity

Morikane, K., Tempero, R. M., Sivinski, C. L., Kitajima, S., Gendler, S. J. & Hollingsworth, M. A., Jan 1 2001, In : International Immunology. 13, 2, p. 233-240 8 p.

Research output: Contribution to journalArticle

Open Access
16 Scopus citations

Inhibiting focal adhesion kinase (FAK) blocks IL-4 induced VCAM-1 expression and eosinophil recruitment in vitro and in vivo

Aulakh, G. K., Petri, B., Wojcik, K. M., Colarusso, P., Lee, J. J. & Patel, K. D., Jan 1 2018, (Accepted/In press) In : Journal of Leukocyte Biology.

Research output: Contribution to journalArticle

2 Scopus citations

Inhibition of adaptive immunity by IL9 can be disrupted to achieve rapid t-cell sensitization and rejection of progressive tumor challenges

Hoelzinger, D. B., Dominguez, A. L., Cohen, P. A. & Gendler, S. J., Dec 1 2014, In : Cancer research. 74, 23, p. 6845-6855 11 p.

Research output: Contribution to journalArticle

26 Scopus citations

Inhibition of epidermal growth factor receptor tyrosine kinase fails to suppress adenoma formation in Apc(Min) mice but induces duodenal injury

Ritland, S. R., Gendler, S. J., Burgart, L. J., Fry, D. W., Nelson, J. M., Bridges, A. J., Andress, L. & Karnes, J., Sep 1 2000, In : Cancer research. 60, 17, p. 4678-4681 4 p.

Research output: Contribution to journalArticle

16 Scopus citations

Inhibition of focal adhesion kinase expression or activity disrupts epidermal growth factor-stimulated signaling promoting the migration of invasive human carcinoma cells

Hauck, C. R., Sieg, D. J., Hsia, D. A., Loftus, J. C., Gaarde, W. A., Monia, B. P. & Schlaepfer, D. D., Oct 1 2001, In : Cancer research. 61, 19, p. 7079-7090 12 p.

Research output: Contribution to journalArticle

238 Scopus citations

Inhibition of phosphatidylinositol 3-kinase by PX-866 suppresses temozolomide-induced autophagy and promotes apoptosis in glioblastoma cells

Harder, B. G., Peng, S., Sereduk, C. P., Sodoma, A. M., Kitange, G. J., Loftus, J. C., Sarkaria, J. N. & Tran, N. L., Nov 14 2019, In : Molecular Medicine. 25, 1, 49.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Insertional Mutations in Transgenic Mice

Costantini, F., Radice, G., Lee, J. J., Perry, W. & Son, H. J., Jan 1 1989, In : Progress in Nucleic Acid Research and Molecular Biology. 36, C, p. 159-169 11 p.

Research output: Contribution to journalArticle

37 Scopus citations

Integrin cytoplasmic domains mediate inside-out signal transduction

O'Toole, T. E., Katagiri, Y., Faull, R. J., Peter, K., Tamura, R., Quaranta, V., Loftus, J. C., Shattil, S. J. & Ginsberg, M. H., Mar 1994, In : Journal of Cell Biology. 124, 6, p. 1047-1059 13 p.

Research output: Contribution to journalArticle

Open Access
563 Scopus citations
5 Scopus citations