Biochemistry and Molecular Biology

Research Output

Inhibition of focal adhesion kinase expression or activity disrupts epidermal growth factor-stimulated signaling promoting the migration of invasive human carcinoma cells

Hauck, C. R., Sieg, D. J., Hsia, D. A., Loftus, J. C., Gaarde, W. A., Monia, B. P. & Schlaepfer, D. D., Oct 1 2001, In : Cancer Research. 61, 19, p. 7079-7090 12 p.

Research output: Contribution to journalArticle

237 Scopus citations

Inhibition of phosphatidylinositol 3-kinase by PX-866 suppresses temozolomide-induced autophagy and promotes apoptosis in glioblastoma cells

Harder, B. G., Peng, S., Sereduk, C. P., Sodoma, A. M., Kitange, G. J., Loftus, J. C., Sarkaria, J. N. & Tran, N. L., Nov 14 2019, In : Molecular Medicine. 25, 1, 49.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Interleukin-5 expression in the lung epithelium of transgenic mice leads to pulmonary changes pathognomonic of asthma

Lee, J. J., McGarry, M. P., Farmer, S. C., Denzler, K. L., Larson, K. A., Carrigan, P. E., Brenneise, I. E., Horton, M. A., Haczku, A., Gelfand, E. W., Leikauf, G. D. & Lee, N. A., Jun 16 1997, In : Journal of Experimental Medicine. 185, 12, p. 2143-2156 14 p.

Research output: Contribution to journalArticle

442 Scopus citations

Interleukin 5 is protective during sepsis in an eosinophil-independent manner

Linch, S. N., Danielson, E. T., Kelly, A. M., Tamakawa, R. A., Lee, J. J. & Gold, J. A., Aug 1 2012, In : American Journal of Respiratory and Critical Care Medicine. 186, 3, p. 246-254 9 p.

Research output: Contribution to journalArticle

38 Scopus citations

Intermediate structural states involved in MRP1-mediated drug transport. Role of glutathione

Manciu, L., Chang, X-B. D., Buyse, F., Hou, Y. X., Gustot, A., Riordani, J. R. & Ruysschaert, J. M., Jan 31 2003, In : Journal of Biological Chemistry. 278, 5, p. 3347-3356 10 p.

Research output: Contribution to journalArticle

52 Scopus citations

Intestinal macrophage/epithelial cell-derived CCL11/eotaxin-1 mediates eosinophil recruitment and function in pediatric ulcerative colitis

Ahrens, R., Waddell, A., Seidu, L., Blanchard, C., Carey, R., Forbes, E., Lampinen, M., Wilson, T., Cohen, E., Stringer, K., Ballard, E., Munitz, A., Xu, H., Lee, N. A., Lee, J. J., Rothenberg, M. E., Denson, L. & Hogan, S. P., Nov 15 2008, In : Journal of Immunology. 181, 10, p. 7390-7399 10 p.

Research output: Contribution to journalArticle

103 Scopus citations

Intraocular use of rituximab

Kitzmann, A. S., Pulido, J. S., Mohney, B. G., Baratz, K., Grube, T., Marler, R. J., Donaldson, M. J., O'Neill, B. P., Johnston, P. B., Johnson, K. M., Dixon, L. E., Salomao, D. R. & Cameron, J. D., Dec 2007, In : Eye. 21, 12, p. 1524-1527 4 p.

Research output: Contribution to journalArticle

67 Scopus citations

Intratumoral delivery of CpG-conjugated anti-MUC1 antibody enhances NK cell anti-tumor activity

Schettini, J., Kidiyoor, A., Besmer, D. M., Tinder, T. L., Roy, L. D., Lustgarten, J., Gendler, S. J. & Mukherjee, P., Nov 2012, In : Cancer Immunology, Immunotherapy. 61, 11, p. 2055-2065 11 p.

Research output: Contribution to journalArticle

19 Scopus citations

Intravitreal alemtuzumab penetrates full-thickness retina in rabbit eyes

Ekdawi, N. S., Pulido, J. S., Itty, S., Marler, R. J., Herman, D. C., Hardwig, P., Mohney, B. G., Valyi-Nagy, T. & Shukla, D., Nov 2009, In : Retina. 29, 10, p. 1532-1534 3 p.

Research output: Contribution to journalArticle

2 Scopus citations

Intrinsic AHR in IL-5 transgenic mice is dependent on C4+ cells and CD49d-mediated signaling

Borchers, M. T., Crosby, J., Justice, P., Farmer, S., Hines, E., Lee, J. J. & Lee, N. A., 2001, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 281, 3 25-3

Research output: Contribution to journalArticle

17 Scopus citations

In vitro assessment of chemokine receptor-ligand interactions mediating mouse eosinophil migration

Borchers, M. T., Ansay, T., DeSalle, R., Daugherty, B. L., Shen, H., Metzger, M., Lee, N. A. & Lee, J. J., Jun 1 2002, In : Journal of Leukocyte Biology. 71, 6, p. 1033-1041 9 p.

Research output: Contribution to journalArticle

72 Scopus citations

In vitro kinetic analysis of cellular anti-MUC1 immune responses in MUC1 transgenic mice

VanLith, M. L., Tempero, R. M., Gendler, S. J. & Hollingsworth, M. A., Mar 20 1998, In : FASEB Journal. 12, 5

Research output: Contribution to journalArticle

In vivo radioiodide imaging and treatment of breast cancer xenografts after MUC1-driven expression of the sodium iodide symporter

Dwyer, R. M., Bergert, E. R., O'Connor, M. K., Gendler, S. J. & Morris, J. C., Feb 15 2005, In : Clinical Cancer Research. 11, 4, p. 1483-1489 7 p.

Research output: Contribution to journalArticle

74 Scopus citations

Lack of eosinophil peroxidase or major basic protein impairs defense against murine filarial infection

Specht, S., Saeftel, M., Arndt, M., Endl, E., Dubben, B., Lee, N. A., Lee, J. J. & Hoerauf, A., Sep 2006, In : Infection and Immunity. 74, 9, p. 5236-5243 8 p.

Research output: Contribution to journalArticle

61 Scopus citations

Lack of muc1-regulated β-catenin stability results in aberrant expansion of cd11b +gr1 + Myeloid-derived suppressor cells from the bone marrow

Poh, T. W., Bradley, J. M., Mukherjee, P. & Gendler, S. J., Apr 15 2009, In : Cancer Research. 69, 8, p. 3554-3562 9 p.

Research output: Contribution to journalArticle

25 Scopus citations
20 Scopus citations

Lactam constraints provide insights into the receptor-bound conformation of secretin and stabilize a receptor antagonist

Dong, M., Te, J. A., Xu, X., Wang, J., Pinon, D. I., Storjohann, L., Bordner, A. J. & Miller, L. J., Sep 27 2011, In : Biochemistry. 50, 38, p. 8181-8192 12 p.

Research output: Contribution to journalArticle

13 Scopus citations

Letter for Joyce

Gendler, S. J., Nov 2001, In : Glycoconjugate Journal. 18, 11-12, p. 839-840 2 p.

Research output: Contribution to journalArticle

Ligand binding and activation of the secretin receptor, a prototypic family B G protein-coupled receptor

Miller, L. J., Dong, M. & Harikumar, K. G., May 2012, In : British Journal of Pharmacology. 166, 1, p. 18-26 9 p.

Research output: Contribution to journalArticle

11 Scopus citations

Ligand binding to integrins

Plow, E. F., Haas, T. A., Zhang, L., Loftus, J. C. & Smith, J. W., Jul 21 2000, In : Journal of Biological Chemistry. 275, 29, p. 21785-21788 4 p.

Research output: Contribution to journalArticle

994 Scopus citations
2 Scopus citations

Linear synthesis and immunological properties of a fully synthetic vaccine candidate containing a sialylated MUC1 glycopeptide

Thompson, P., Lakshminarayanan, V., Supekar, N. T., Bradley, J. M., Cohen, P. A., Wolfert, M. A., Gendler, S. J. & Boons, G. J., May 28 2015, In : Chemical Communications. 51, 50, p. 10214-10217 4 p.

Research output: Contribution to journalArticle

24 Scopus citations

Local hypersensitivity reaction in transgenic mice with squamous epithelial IL-5 overexpression provides a novel model of eosinophilic oesophagitis

Masterson, J. C., McNamee, E. N., Hosford, L., Capocelli, K. E., Ruybal, J., Fillon, S. A., Doyle, A. D., Eltzschig, H. K., Rustgi, A. K., Protheroe, C. A., Lee, N. A., Lee, J. J. & Furuta, G. T., Jan 2014, In : Gut. 63, 1, p. 43-53 11 p.

Research output: Contribution to journalArticle

24 Scopus citations

Local proliferation and mobilization of CCR3+ CD34+ eosinophil-lineage-committed cells in the lung

Rådinger, M., Bossios, A., Sjöstrand, M., Lu, Y., Malmhäll, C., Dahlborn, A. K., Lee, J. J. & Lötvall, J., Jan 2011, In : Immunology. 132, 1, p. 144-154 11 p.

Research output: Contribution to journalArticle

21 Scopus citations

Longevity and age-related pathology of mice deficient in pregnancy-associated plasma protein-a

Conover, C. A., Bale, L. K., Mader, J. R., Mason, M. A., Keenan, K. P. & Marler, R. J., Jun 2010, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 65 A, 6, p. 590-599 10 p.

Research output: Contribution to journalArticle

56 Scopus citations

Loss of heterozygosity analysis in primary mammary tumors and lung metastases of MMTV-MTAg and MMTV-neu transgenic mice

Ritland, S. R., Rowse, G. J., Chang, Y. & Gendler, S. J., Aug 15 1997, In : Cancer Research. 57, 16, p. 3520-3525 6 p.

Research output: Contribution to journalArticle

40 Scopus citations

Loss of the transcription factor GLI1 identifies a signaling network in the tumor microenvironment mediating KRAS oncogene-induced transformation

Mills, L. D., Zhang, Y., Marler, R. J., Herreros-Villanueva, M., Zhang, L., Almada, L. L., Couch, F. J., Wetmore, C., Di Magliano, M. P. & Fernandez-Zapico, M. E., Apr 26 2013, In : Journal of Biological Chemistry. 288, 17, p. 11786-11794 9 p.

Research output: Contribution to journalArticle

67 Scopus citations

Low-Dose Gamma Irradiation of Decellularized Heart Valves Results in Tissue Injury In Vitro and In Vivo

Helder, M. R. K., Hennessy, R. S., Spoon, D. B., Tefft, B. J., Witt, T. A., Marler, R. J., Pislaru, S. V., Simari, R. D., Stulak, J. M. & Lerman, A., 2015, (Accepted/In press) In : Annals of Thoracic Surgery.

Research output: Contribution to journalArticle

9 Scopus citations

Lung pathologies in a chronic inflammation mouse model are independent of eosinophil degranulation

Jacobsen, E., Ochkur, S. I., Doyle, A. D., LeSuer, W. E., Li, W., Protheroe, C. A., Colbert, D., Zellner, K. R., Shen, H. H., Irvin, C. G., Lee, J. J. & Lee, N. A., May 15 2017, In : American Journal of Respiratory and Critical Care Medicine. 195, 10, p. 1321-1332 12 p.

Research output: Contribution to journalArticle

10 Scopus citations

Major basic protein-1 promotes fibrosis of dystrophic muscle and attenuates the cellular immune response in muscular dystrophy

Wehling-henricks, M., Sokolow, S., Lee, J. J., Myung, K. H., Villalta, S. A. & Tidball, J. G., Aug 2008, In : Human Molecular Genetics. 17, 15, p. 2280-2292 13 p.

Research output: Contribution to journalArticle

50 Scopus citations

Major basic protein from eosinophils and myeloperoxidase from neutrophils are required for protective immunity to Strongyloides stercoralis in mice

O'Connell, A. E., Hess, J. A., Santiago, G. A., Nolan, T. J., Lok, J. B., Lee, J. J. & Abraham, D., Jul 2011, In : Infection and Immunity. 79, 7, p. 2770-2778 9 p.

Research output: Contribution to journalArticle

61 Scopus citations

Many αIIbβ3 autoepitopes in chronic immune thrombocytopenic purpura are localized to αIIb between amino acids L1 and Q459

Mcmillan, R., Wang, L., Lopez-Dee, J., Jiu, S. & Loftus, J. C., 2002, In : British Journal of Haematology. 118, 4, p. 1132-1136 5 p.

Research output: Contribution to journalArticle

12 Scopus citations

Mapping of cystic fibrosis transmembrane conductance regulator membrane topology by glycosylation site insertion

Chang, X-B. D., Hou, Y. X., Jensen, T. J. & Riordan, J. R., Jul 15 1994, In : Journal of Biological Chemistry. 269, 28, p. 18572-18575 4 p.

Research output: Contribution to journalArticle

113 Scopus citations
4 Scopus citations

Mast cells are required for full expression of allergen/SEB-Induced skin inflammation

Ando, T., Matsumoto, K., Namiranian, S., Yamashita, H., Glatthorn, H., Kimura, M., Dolan, B. R., Lee, J. J., Galli, S. J., Kawakami, Y., Jamora, C. & Kawakami, T., Dec 2013, In : Journal of Investigative Dermatology. 133, 12, p. 2695-2705 11 p.

Research output: Contribution to journalArticle

34 Scopus citations

Measurement of Intermolecular Distances for the Natural Agonist Peptide Docked at the Cholecystokinin Receptor Expressed in Situ Using Fluorescence Resonance Energy Transfer

Harikumar, K. G., Pinon, D. I., Wessels, W. S., Dawson, E. S., Lybrand, T. P., Prendergast, F. G. & Miller, L. J., Jan 2004, In : Molecular Pharmacology. 65, 1, p. 28-35 8 p.

Research output: Contribution to journalArticle

21 Scopus citations

Mechanism of immunomodulatory drugs' action in the treatment of multiple myeloma

Chang, X-B. D., Zhu, Y., Shi, C. & Stewart, A. K., Mar 2014, In : Acta Biochimica et Biophysica Sinica. 46, 3, p. 240-253 14 p.

Research output: Contribution to journalArticle

36 Scopus citations

Mechanisms underlying the growth inhibitory effects of the cyclo-oxygenase-2 inhibitor celecoxib in human breast cancer cells.

Basu, G. D., Pathangey, L. B., Tinder, T. L., Gendler, S. J. & Mukherjee, P., 2005, In : Breast cancer research : BCR. 7, 4

Research output: Contribution to journalArticle

114 Scopus citations

Membrane cholesterol affects stimulus-activity coupling in type 1, but not type 2, CCK receptors: Use of cell lines with elevated cholesterol

Harikumar, K. G., Potter, R. M., Patil, A., Echeveste, V. & Miller, L. J., Mar 2013, In : Lipids. 48, 3, p. 231-244 14 p.

Research output: Contribution to journalArticle

13 Scopus citations

Metabolic consequences of adenosine deaminase deficiency in mice are associated with defects in alveogenesis, pulmonary inflammation, and airway obstruction

Blackburn, M. R., Volmer, J. B., Thrasher, J. L., Zhong, H., Crosby, J. R., Lee, J. J. & Kellems, R. E., Jul 17 2000, In : Journal of Experimental Medicine. 192, 2, p. 159-170 12 p.

Research output: Contribution to journalArticle

183 Scopus citations

Methacholine-induced airway hyperresponsiveness is dependent on Gαq signaling

Borchers, M. T., Biechele, T., Justice, J. P., Ansay, T., Cormier, S., Mancino, V., Wilkie, T. M., Simon, M. I., Lee, N. A. & Lee, J. J., Jul 1 2003, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 285, 1 29-1

Research output: Contribution to journalArticle

18 Scopus citations

Methylprednisolone acetate induces, and ?7-dafachronic acid suppresses, Strongyloides stercoralis hyperinfection in NSG mice

Patton, J. B., Bonne-Année, S., Deckman, J., Hess, J. A., Torigian, A., Nolan, T. J., Wang, Z., Kliewer, S. A., Durham, A. C., Lee, J. J., Eberhard, M. L., Mangelsdorf, D. J., Lok, J. B. & Abraham, D., Jan 2 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 1, p. 204-209 6 p.

Research output: Contribution to journalArticle

16 Scopus citations

Mice deficient in PAPP-A show resistance to the development of diabetic nephropathy

Mader, J. R., Resch, Z. T., McLean, G. R., Mikkelsen, J. H., Oxvig, C., Marler, R. J. & Conover, C. A., 2013, In : Journal of Endocrinology. 219, 1, p. 51-58 8 p.

Research output: Contribution to journalArticle

16 Scopus citations

Mice with spontaneous pancreatic cancer naturally develop MUC-1-specific CTLs that eradicate tumors when adoptively transferred

Mukherjee, P., Ginardi, A. R., Madsen, C. S., Sterner, C. J., Adriance, M. C., Tevethia, M. J. & Gendler, S. J., Sep 15 2000, In : Journal of Immunology. 165, 6, p. 3451-3460 10 p.

Research output: Contribution to journalArticle

75 Scopus citations

Mimic 1 of MUC1

Finn, O. J. & Gendler, S. J., 1998, In : Nature Biotechnology. 16, 3, p. 236-237 2 p.

Research output: Contribution to journalArticle

5 Scopus citations

MiRNA expression profiling in migrating Glioblastoma cells: Regulation of cell migration and invasion by miR-23b via targeting of Pyk2

Loftus, J. C., Ross, J. T. D., Paquette, K. M., Paulino, V. M., Nasser, S., Yang, Z., Kloss, J., Kim, S., Berens, M. E. & Tran, N., Jun 22 2012, In : PLoS One. 7, 6, e39818.

Research output: Contribution to journalArticle

47 Scopus citations

Misassembled mutant ΔF508 CFTR in the distal secretory pathway alters cellular lipid trafficking

Gentzsch, M., Choudhury, A., Chang, X-B. D., Pagano, R. E. & Riordan, J. R., Feb 1 2007, In : Journal of Cell Science. 120, 3, p. 447-455 9 p.

Research output: Contribution to journalArticle

47 Scopus citations

Modification of the tumor microenvironment as a novel target of renal cell carcinoma therapeutics

Finke, J. H., Rayman, P. A., Ko, J. S., Bradley, J. M., Gendler, S. J. & Cohen, P. A., Jul 2013, In : Cancer Journal (United States). 19, 4, p. 353-364 12 p.

Research output: Contribution to journalArticle

31 Scopus citations

Modulation of cell surface expression of nonactivated cholecystokinin receptors using bivalent ligand-induced internalization

Harikumar, K. G., Akgün, E., Portoghese, P. S. & Miller, L. J., Apr 8 2010, In : Journal of Medicinal Chemistry. 53, 7, p. 2836-2842 7 p.

Research output: Contribution to journalArticle

14 Scopus citations