Biochemistry and Molecular Biology

Research Output

2002

A tale of two controversies. Defining both the role of peroxidases in nitrotyrosine formation in vivo using eosinophil peroxidase and myeloperoxidase-deficient mice, and the nature of peroxidase-generated reactive nitrogen species

Brennan, M. L., Wu, W., Fu, X., Shen, Z., Song, W., Frost, H., Vadseth, C., Narine, L., Lenkiewicz, E., Borchers, M. T., Lusis, A. J., Lee, J. J., Lee, N. A., Abu-Soud, H. M., Ischiropoulos, H. & Hazen, S. L., May 17 2002, In : Journal of Biological Chemistry. 277, 20, p. 17415-17427 13 p.

Research output: Contribution to journalArticle

430 Scopus citations

ATP binding to the first nucleotide-binding domain of multidrug resistance protein MRP1 increases binding and hydrolysis of ATP and trapping of ADP at the second domain

Hou, Y. X., Cui, L., Riordan, J. R. & Chang, X. B., Feb 15 2002, In : Journal of Biological Chemistry. 277, 7, p. 5110-5119 10 p.

Research output: Contribution to journalArticle

52 Scopus citations

Cardiac myocyte-specific excision of the β1 integrin gene results in myocardial fibrosis and cardiac failure

Shai, S. Y., Harpf, A. E., Babbitt, C. J., Jordan, M. C., Fishbein, M. C., Chen, J., Omura, M., Leil, T. A., Becker, K. D., Jiang, M., Smith, D. J., Cherry, S. R., Loftus, J. C. & Ross, R. S., Mar 8 2002, In : Circulation research. 90, 4, p. 458-464 7 p.

Research output: Contribution to journalArticle

217 Scopus citations

CD4+ T cell-dependent airway mucus production occurs in response to IL-5 expression in lung

Paul Justice, J., Crosby, J., Borchers, M. T., Tomkinson, A., Lee, J. J. & Lee, N. A., Jun 29 2002, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 282, 5 26-5, p. L1066-L1074

Research output: Contribution to journalArticle

40 Scopus citations

CFTR is a monomer: Biochemical and functional evidence

Chen, J. H., Chang, X. B., Aleksandrov, A. A. & Riordan, J. R., Jul 1 2002, In : Journal of Membrane Biology. 188, 1, p. 55-71 17 p.

Research output: Contribution to journalArticle

33 Scopus citations

Dendritic cell-tumor cell fusion and staphylococcal enterotoxin B treatment in a pancreatic tumor model

McConnell, E. J., Pathangey, L. B., Madsen, C. S., Gendler, S. J. & Mukherjee, P., Jan 1 2002, In : Journal of Surgical Research. 107, 2, p. 196-202 7 p.

Research output: Contribution to journalArticle

17 Scopus citations

Early phase bronchoconstriction in the mouse requires allergen-specific IgG

Crosby, J. R., Cieslewicz, G., Borchers, M., Hines, E., Carrigan, P., Lee, J. J. & Lee, N. A., Apr 15 2002, In : Journal of Immunology. 168, 8, p. 4050-4054 5 p.

Research output: Contribution to journalArticle

Open Access
26 Scopus citations

Ectopic expression of IL-5 identifies an additional CD4+ T cell mechanism of airway eosinophil recruitment

Crosby, J. R., Shen, H. H., Borchers, M. T., Justice, J. P., Ansay, T., Lee, J. J. & Lee, N. A., Jun 29 2002, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 282, 1 26-1, p. L99-L108

Research output: Contribution to journalArticle

16 Scopus citations

Environment and mobility of a series of fluorescent reporters at the amino terminus of structurally related peptide agonists and antagonists bound to the cholecystokinin receptor

Harikumar, K. G., Pinon, D. I., Wessels, W. S., Prendergast, F. G. & Miller, L. J., May 24 2002, In : Journal of Biological Chemistry. 277, 21, p. 18552-18560 9 p.

Research output: Contribution to journalArticle

44 Scopus citations

ErbB-β-catenin complexes are associated with human infiltrating ductal breast and murine mammary tumor virus (MMTV)-Wnt-1 and MMTV-c-Neu transgenic carcinomas

Schroeder, J. A., Adriance, M. C., McConnell, E. J., Thompson, M. C., Pockaj, B. & Gendler, S. J., Jun 21 2002, In : Journal of Biological Chemistry. 277, 25, p. 22692-22698 7 p.

Research output: Contribution to journalArticle

75 Scopus citations

Gq signaling is required for allergen-induced pulmonary eosinophilia

Borchers, M. T., Justice, P. J., Ansay, T., Mancino, V., McGarry, M. P., Crosby, J., Simon, M. I., Lee, N. A. & Lee, J. J., Apr 1 2002, In : Journal of Immunology. 168, 7, p. 3543-3549 7 p.

Research output: Contribution to journalArticle

Open Access
17 Scopus citations

Intestinal mucins from cystic fibrosis mice show increased fucosylation due to an induced Fucα1-2 glycosyltransferase

Thomsson, K. A., Hinojosa-Kurtzberg, M., Axelsson, K. A., Domino, S. E., Lowe, J. B., Gendler, S. J. & Hansson, G. C., Nov 1 2002, In : Biochemical Journal. 367, 3, p. 609-616 8 p.

Research output: Contribution to journalArticle

41 Scopus citations

In vitro assessment of chemokine receptor-ligand interactions mediating mouse eosinophil migration

Borchers, M. T., Ansay, T., DeSalle, R., Daugherty, B. L., Shen, H., Metzger, M., Lee, N. A. & Lee, J. J., Jun 1 2002, In : Journal of Leukocyte Biology. 71, 6, p. 1033-1041 9 p.

Research output: Contribution to journalArticle

73 Scopus citations

In vitro selection of fibronectin gain-of-function mutations

Tani, P. H., Loftus, J. C. & Bowditch, R. D., Jul 1 2002, In : Biochemical Journal. 365, 1, p. 287-294 8 p.

Research output: Contribution to journalArticle

6 Scopus citations

Many αIIbβ3 autoepitopes in chronic immune thrombocytopenic purpura are localized to αIIb between amino acids L1 and Q459

Mcmillan, R., Wang, L., Lopez-Dee, J., Jiu, S. & Loftus, J. C., Sep 25 2002, In : British journal of haematology. 118, 4, p. 1132-1136 5 p.

Research output: Contribution to journalArticle

12 Scopus citations

MUC1 epithelial mucin (CD227) is expressed by activated dendritic cells

Wykes, M., MacDonald, K. P. A., Tran, M., Quin, R. J., Xing, P. X., Gendler, S. J., Hart, D. N. J. & McGuckin, M. A., Oct 1 2002, In : Journal of Leukocyte Biology. 72, 4, p. 692-701 10 p.

Research output: Contribution to journalArticle

64 Scopus citations

Muscle development and lineage-specific expression of CiMDF, the MyoD-family gene of Ciona intestinalis

Meedel, T. H., Lee, J. J. & Whittaker, J. R., Jan 15 2002, In : Developmental Biology. 241, 2, p. 238-246 9 p.

Research output: Contribution to journalArticle

21 Scopus citations

Pulmonary pathologies in pallid mice result from nonhematopoietic defects

McGarry, M. P., Borchers, M., Novak, E. K., Lee, N. A., Ohtake, P. J., Lee, J. J. & Swank, R. T., Jan 1 2002, In : Experimental and Molecular Pathology. 72, 3, p. 213-220 8 p.

Research output: Contribution to journalArticle

8 Scopus citations

Ragweed-induced expression of GATA-3, IL-4, and IL-5 by eosinophils in the lungs of allergic C57BL/6J mice

Paul Justice, J., Borchers, M. T., Lee, J. J., Rowan, W. H., Shibata, Y. & Van Scott, M. R., Jun 29 2002, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 282, 2 26-2, p. L302-L309

Research output: Contribution to journalArticle

35 Scopus citations

Solubilization of high affinity G-protein-coupled serotonin1A receptors from bovine hippocampus using pre-micellar CHAPS at low concentration

Chattopadhyay, A., Harikumar, K. G. & Kalipatnapu, S., Jul 1 2002, In : Molecular Membrane Biology. 19, 3, p. 211-220 10 p.

Research output: Contribution to journalArticle

38 Scopus citations

TH2-mediated pulmonary inflammation leads to the differential expression of ribonuclease genes by alveolar macrophages

Cormier, S. A., Yuan, S., Crosby, J. R., Protheroe, C. A., Dimina, D. M., Hines, E. M., Lee, N. A. & Lee, J. J., Dec 1 2002, In : American journal of respiratory cell and molecular biology. 27, 6, p. 678-687 10 p.

Research output: Contribution to journalArticle

41 Scopus citations

The first nucleotide binding domain of cystic fibrosis transmembrane conductance regulator is a site of stable nucleotide interaction, whereas the second is a site of rapid turnover

Aleksandrov, L., Aleksandrov, A. A., Chang, X. B. & Riordan, J. R., May 3 2002, In : Journal of Biological Chemistry. 277, 18, p. 15419-15425 7 p.

Research output: Contribution to journalArticle

152 Scopus citations
2003

Ablation of eosinophils leads to a reduction of allergen-induced pulmonary pathology

Justice, J. P., Borchers, M. T., Crosby, J. R., Hines, E. M., Shen, H. H., Ochkur, S. I., McGarry, M. P., Lee, N. A. & Lee, J. J., Jan 1 2003, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 284, 1 28-1, p. L169-L178

Research output: Contribution to journalArticle

89 Scopus citations

A causative relationship exists between eosinophils and the development of allergic pulmonary pathologies in the mouse

Shen, H. H. H., Ochkur, S. I., McGarry, M. P., Crosby, J. R., Hines, E. M., Borchers, M. T., Wang, H., Biechelle, T. L., O'Neill, K. R., Ansay, T. L., Colbert, D. C., Cormier, S. A., Justice, J. P., Lee, N. A. & Lee, J. J., Mar 15 2003, In : Journal of Immunology. 170, 6, p. 3296-3305 10 p.

Research output: Contribution to journalArticle

Open Access
139 Scopus citations

A mutation in the integrin αIIb subunit that selectively inhibits αIIbβ3 receptor function

Perkins, K. B. & Loftus, J. C., Nov 2003, In : Thrombosis and Haemostasis. 90, 5, p. 853-862 10 p.

Research output: Contribution to journalArticle

2 Scopus citations

ATP binding, not hydrolysis, at the first nucleotide-binding domain of multidrug resistance-associated protein MRP1 enhances ADP·Vi trapping at the second domain

Hou, Y. X., Riordan, J. R. & Chang, X. B., Feb 7 2003, In : Journal of Biological Chemistry. 278, 6, p. 3599-3605 7 p.

Research output: Contribution to journalArticle

31 Scopus citations
42 Scopus citations
59 Scopus citations

Diesel exhaust particles exert acute effects on airway inflammation and function in murine allergen provocation models

Hao, M., Comier, S., Wang, M., Lee, J. J. & Nel, A., Nov 2003, In : Journal of Allergy and Clinical Immunology. 112, 5, p. 905-914 10 p.

Research output: Contribution to journalArticle

67 Scopus citations

Differential role of proline-rich tyrosine kinase 2 and focal adhesion kinase in determining glioblastoma migration and proliferation

Lipinski, C. A., Tran, N. L., Bay, C., Kloss, J., McDonough, W. S., Beaudry, C., Berens, M. E. & Loftus, J. C., Mar 1 2003, In : Molecular Cancer Research. 1, 5, p. 323-332 10 p.

Research output: Contribution to journalArticle

61 Scopus citations

Heterodimerization of Type A and B Cholecystokinin Receptors Enhance Signaling and Promote Cell Growth

Cheng, Z. J., Harikumar, K. G., Holicky, E. L. & Miller, L. J., Dec 26 2003, In : Journal of Biological Chemistry. 278, 52, p. 52972-52979 8 p.

Research output: Contribution to journalArticle

57 Scopus citations

Immunotherapy of spontaneous mammary carcinoma with fusions of dendritic cells and mucin 1-positive carcinoma cells

Chen, D., Xia, J., Tanaka, Y., Chen, H., Koido, S., Wernet, O., Mukherjee, P., Gendler, S. J., Kufe, D. & Gong, J., Jun 1 2003, In : Immunology. 109, 2, p. 300-307 8 p.

Research output: Contribution to journalArticle

62 Scopus citations

Intermediate structural states involved in MRP1-mediated drug transport. Role of glutathione

Manciu, L., Chang, X. B., Buyse, F., Hou, Y. X., Gustot, A., Riordani, J. R. & Ruysschaert, J. M., Jan 31 2003, In : Journal of Biological Chemistry. 278, 5, p. 3347-3356 10 p.

Research output: Contribution to journalArticle

53 Scopus citations

Kinetics of cellular responses to intraperitoneal Brugia pahangi infections in normal and immunodeficient mice

Ramalingam, T., Rajan, B., Lee, J. & Rajan, T. V., Aug 1 2003, In : Infection and Immunity. 71, 8, p. 4361-4367 7 p.

Research output: Contribution to journalArticle

19 Scopus citations

Methacholine-induced airway hyperresponsiveness is dependent on Gαq signaling

Borchers, M. T., Biechele, T., Justice, J. P., Ansay, T., Cormier, S., Mancino, V., Wilkie, T. M., Simon, M. I., Lee, N. A. & Lee, J. J., Jul 1 2003, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 285, 1 29-1, p. L114-L120

Research output: Contribution to journalArticle

18 Scopus citations

Molecular analysis of human Siglec-8 orthologs relevant to mouse eosinophils: Identification of mouse orthologs of Siglec-5 (mSiglec-F) and Siglec-10 (mSiglec-G)

Aizawa, H., Zimmermann, N., Carrigan, P. E., Lee, J. J., Rothenberg, M. E. & Bochner, B. S., Nov 1 2003, In : Genomics. 82, 5, p. 521-530 10 p.

Research output: Contribution to journalArticle

38 Scopus citations

MUC1 alters β-catenin-dependent tumor formation and promotes cellular invasion

Schroeder, J. A., Adriance, M. C., Thompson, M. C., Camenisch, T. D. & Gendler, S. J., Mar 6 2003, In : Oncogene. 22, 9, p. 1324-1332 9 p.

Research output: Contribution to journalArticle

136 Scopus citations

Mucin 1-specific immunotherapy in a mouse model of spontaneous breast cancer

Mukherjee, P., Madsen, C. S., Ginardi, A. R., Tinder, T. L., Jacobs, F., Parker, J., Agrawal, B., Longenecker, B. M. & Gendler, S. J., Jan 1 2003, In : Journal of Immunotherapy. 26, 1, p. 47-62 16 p.

Research output: Contribution to journalArticle

74 Scopus citations

Multiple flavonoid-binding sites within multidrug resistance protein MRP1

Trompier, D., Baubichon-Cortay, H., Chang, X. B., Maitrejean, M., Barron, D., Riordan, J. R. & Di Pietro, A., Oct 1 2003, In : Cellular and Molecular Life Sciences. 60, 10, p. 2164-2177 14 p.

Research output: Contribution to journalArticle

63 Scopus citations

Novel MUC1 splice variants contribute to mucin overexpression in CFTR-deficient mice

Hinojosa-Kurtzberg, A. M., Johansson, M. E. V., Madsen, C. S., Hansson, G. C. & Gendler, S. J., May 1 2003, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 284, 5 47-5, p. G853-G862

Research output: Contribution to journalArticle

23 Scopus citations

Patterns of MUC1 tissue expression defined by an Anti-MUC1 cytoplasmic tail monoclonal antibody in breast cancer

Croce, M. V., Isla-Larrain, M. T., Rua, C. E., Rabassa, M. E., Gendler, S. J. & Segal-Eiras, A., Jun 1 2003, In : Journal of Histochemistry and Cytochemistry. 51, 6, p. 781-788 8 p.

Research output: Contribution to journalArticle

Open Access
48 Scopus citations

Phosphorylation of protein kinase C sites in NBD1 and the R domain control CFTR channel activation by PKA

Chappe, V., Hinkson, D. A., Zhu, T., Chang, X. B., Riordan, J. R. & Hanrahan, J. W., Apr 1 2003, In : Journal of Physiology. 548, 1, p. 39-52 14 p.

Research output: Contribution to journalReview article

62 Scopus citations

Prevention of spontaneous breast carcinoma by prophylactic vaccination with dendritic/tumor fusion cells

Xia, J., Tanaka, Y., Koido, S., Liu, C., Mukherjee, P., Gendler, S. J. & Gong, J., Feb 15 2003, In : Journal of Immunology. 170, 4, p. 1980-1986 7 p.

Research output: Contribution to journalArticle

Open Access
74 Scopus citations

The PDZ-binding chloride channel ClC-3B localizes to the Golgi and associates with cystic fibrosis transmembrane conductance regulator-interacting PDZ proteins

Gentzsch, M., Cui, L., Mengos, A., Chang, X. B., Chen, J. H. & Riordan, J. R., Feb 21 2003, In : Journal of Biological Chemistry. 278, 8, p. 6440-6449 10 p.

Research output: Contribution to journalArticle

108 Scopus citations
2004

A3 adenosine receptor signaling contributes to airway inflammation and mucus production in adenosine deaminase-deficient mice

Young, H. W. J., Molina, J. G., Dimina, D., Zhong, H., Jacobson, M., Chan, L. N. L., Chan, T. S., Lee, J. J. & Blackburn, M. R., Jul 15 2004, In : Journal of Immunology. 173, 2, p. 1380-1389 10 p.

Research output: Contribution to journalArticle

Open Access
111 Scopus citations

Allergen-induced traffic of bone marrow eosinophils, neutrophils and lymphocytes to airways

Johansson, A. K., Sergejeva, S., Sjöstrand, M., Lee, J. J. & Lötvall, J., Nov 1 2004, In : European Journal of Immunology. 34, 11, p. 3135-3145 11 p.

Research output: Contribution to journalArticle

21 Scopus citations

Cyclooxygenase-2 inhibitor induces apoptosis in breast cancer cells in an in vivo model of spontaneous metastatic breast cancer

Basu, G. D., Pathangey, L. B., Tinder, T. L., LaGioia, M., Gendler, S. J. & Mukherjee, P., Nov 1 2004, In : Molecular Cancer Research. 2, 11, p. 632-642 11 p.

Research output: Contribution to journalArticle

130 Scopus citations

Defining a link with asthma in mice congenitally deficient in eosinophils

Lee, J. J., Dimina, D., Macias, M. M. P., Ochkur, S. I., McGarry, M. P., O'Neill, K. R., Protheroe, C., Pero, R., Nguyen, T., Cormier, S. A., Lenkiewicz, E., Colbert, D., Rinaldi, L., Ackerman, S. J., Irvin, C. G. & Lee, N. A., Sep 17 2004, In : Science. 305, 5691, p. 1773-1776 4 p.

Research output: Contribution to journalArticle

555 Scopus citations

Designer Glycopeptides for Cytotoxic T Cell-based Elimination of Carcinomas

Xu, Y., Gendler, S. J. & Franco, A., Mar 1 2004, In : Journal of Experimental Medicine. 199, 5, p. 707-716 10 p.

Research output: Contribution to journalArticle

64 Scopus citations

Downregulation of Muc1 in MMTV-c-Neu tumors

Adriance, M. C. & Gendler, S. J., Jan 22 2004, In : Oncogene. 23, 3, p. 697-705 9 p.

Research output: Contribution to journalArticle

9 Scopus citations