Biochemistry and Molecular Biology

Research Output

Article

Eosinophils increase neuron branching in human and murine skin and in vitro

Foster, E. L., Simpson, E. L., Fredrikson, L. J., Lee, J. J., Lee, N. A., Fryer, A. D. & Jacoby, D. B., 2011, In : PloS one. 6, 7, e22029.

Research output: Contribution to journalArticle

48 Scopus citations

Eosinophils mediate protective immunity against secondary nematode infection

Huang, L., Gebreselassie, N. G., Gagliardo, L. F., Ruyechan, M. C., Luber, K. L., Lee, N. A., Lee, J. J. & Appleton, J. A., Jan 1 2015, In : Journal of Immunology. 194, 1, p. 283-290 8 p.

Research output: Contribution to journalArticle

32 Scopus citations

Eosinophils Mediate Tissue Injury in the Autoimmune Skin Disease Bullous Pemphigoid

Lin, L., Hwang, B. J., Culton, D. A., Li, N., Burette, S., Koller, B. H., Messingham, K. A., Fairley, J. A., Lee, J. J., Hall, R. P., An, L., Diaz, L. A. & Liu, Z., May 1 2018, In : Journal of Investigative Dermatology. 138, 5, p. 1032-1043 12 p.

Research output: Contribution to journalArticle

22 Scopus citations

Eosinophils oxidize damage-associated molecular pattern molecules derived from stressed cells

Lotfi, R., Herzog, G. I., DeMarco, R. A., Beer-Stolz, D., Lee, J. J., Rubartelli, A., Schrezenmeier, H. & Lotze, M. T., Oct 15 2009, In : Journal of Immunology. 183, 8, p. 5023-5031 9 p.

Research output: Contribution to journalArticle

67 Scopus citations

Eosinophils preserve parasitic nematode larvae by regulating local immunity

Gebreselassie, N. G., Moorhead, A. R., Fabre, V., Gagliardo, L. F., Lee, N. A., Lee, J. J. & Appleton, J. A., Jan 1 2012, In : Journal of Immunology. 188, 1, p. 417-425 9 p.

Research output: Contribution to journalArticle

60 Scopus citations

Eosinophils promote antiviral immunity in mice infected with influenza A virus

Samarasinghe, A. E., Melo, R. C. N., Duan, S., Le Messurier, K. S., Liedmann, S., Surman, S. L., Lee, J. J., Hurwitz, J. L., Thomas, P. G. & McCullers, J. A., Apr 15 2017, In : Journal of Immunology. 198, 8, p. 3214-3226 13 p.

Research output: Contribution to journalArticle

44 Scopus citations

Eosinophils regulate dendritic cells and Th2 pulmonary immune responses following allergen provocation

Jacobsen, E. A., Zellner, K. R., Colbert, D., Lee, N. A. & Lee, J. J., Dec 1 2011, In : Journal of Immunology. 187, 11, p. 6059-6068 10 p.

Research output: Contribution to journalArticle

77 Scopus citations

Eosinophils regulate peripheral B cell numbers in both mice and humans

Wong, T. W., Doyle, A. D., Lee, J. J. & Jelinek, D. F., Apr 15 2014, In : Journal of Immunology. 192, 8, p. 3548-3558 11 p.

Research output: Contribution to journalArticle

27 Scopus citations

Eosinophils utilize multiple chemokine receptors for chemotaxis to the parasitic nematode strongyloides stercoralis

Stein, L. H., Redding, K. M., Lee, J. J., Nolan, T. J., Schad, G. A., Lok, J. B. & Abraham, D., Oct 1 2009, In : Journal of Innate Immunity. 1, 6, p. 618-630 13 p.

Research output: Contribution to journalArticle

24 Scopus citations

ErbB-β-catenin complexes are associated with human infiltrating ductal breast and murine mammary tumor virus (MMTV)-Wnt-1 and MMTV-c-Neu transgenic carcinomas

Schroeder, J. A., Adriance, M. C., McConnell, E. J., Thompson, M. C., Pockaj, B. & Gendler, S. J., Jun 21 2002, In : Journal of Biological Chemistry. 277, 25, p. 22692-22698 7 p.

Research output: Contribution to journalArticle

75 Scopus citations

Estrogen receptor does not directly regulate the murine Muc-1 promoter

Zhou, X., DeSouza, M. M., Julian, J., Gendler, S. J. & Carson, D. D., Aug 25 1998, In : Molecular and Cellular Endocrinology. 143, 1-2, p. 65-78 14 p.

Research output: Contribution to journalArticle

21 Scopus citations

EUS-guided portal injection chemotherapy for treatment of hepatic metastases: Feasibility in the acute porcine model

Faigel, D. O., Lake, D. F., Landreth, T. L., Kelman, C. C. & Marler, R. J., Feb 1 2016, In : Gastrointestinal Endoscopy. 83, 2, p. 444-446 3 p.

Research output: Contribution to journalArticle

12 Scopus citations

Evaluation of 5-aminosalicylic acid (5-ASA) for cancer chemoprevention: Lack of efficacy against nascent adenomatous polyps in the Apc(Min) mouse

Ritland, S. R., Leighton, J. A., Hirsch, R. E., Morrow, J. D., Weaver, A. L. & Gendler, S. J., Apr 1 1999, In : Clinical Cancer Research. 5, 4, p. 855-863 9 p.

Research output: Contribution to journalArticle

39 Scopus citations

Evidence That Gallbladder Epithelial Mucin Enhances Cholesterol Cholelithogenesis in MUC1 Transgenic Mice

Wang, H. H., Afdhal, N. H., Gendler, S. J. & Wang, D. Q. H., Jul 2006, In : Gastroenterology. 131, 1, p. 210-222 13 p.

Research output: Contribution to journalArticle

24 Scopus citations

Exogenous interleukin-17a inhibits eosinophil differentiation and alleviates allergic airway inflammation

Tian, B. P., Hua, W., Xia, L. X., Jin, Y., Lan, F., Lee, J. J., Lee, N. A., Li, W., Ying, S. M., Chen, Z. H. & Shen, H. H., Apr 1 2015, In : American Journal of Respiratory Cell and Molecular Biology. 52, 4, p. 459-470 12 p.

Research output: Contribution to journalArticle

13 Scopus citations

Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells

Valadi, H., Ekström, K., Bossios, A., Sjöstrand, M., Lee, J. J. & Lötvall, J. O., Jun 1 2007, In : Nature Cell Biology. 9, 6, p. 654-659 6 p.

Research output: Contribution to journalArticle

6159 Scopus citations

Experimentally induced leptospirosis in coyotes (Canis latrans).

Marler, R. J., Cook, J. E. & Kerr, A. I., Aug 1 1979, In : American Journal of Veterinary Research. 40, 8, p. 1115-1119 5 p.

Research output: Contribution to journalArticle

2 Scopus citations

Expression and steroid hormonal control of muc-1 in the mouse uterus

Surveyor, G. A., Gendler, S. J., Pemberton, L., Das, S. K., Chakraborty, I., Julian, J., Pimental, R. A., Wegner, C. C., Dey, S. K. & Carson, D. D., Aug 1995, In : Endocrinology. 136, 8, p. 3639-3647 9 p.

Research output: Contribution to journalArticle

230 Scopus citations

Expression of an active proteinase inhibitor, α1-antichymotrypsin, by human breast epithelial cells

Gendler, S. J. & Tökés, Z. A., Jun 19 1986, In : BBA - General Subjects. 882, 2, p. 242-253 12 p.

Research output: Contribution to journalArticle

4 Scopus citations

Expression of human MUC1 during early pregnancy in the human MUC1 transgenic mouse model

Dharmaraj, N., Gendler, S. J. & Carson, D. D., Dec 1 2009, In : Biology of Reproduction. 81, 6, p. 1182-1188 7 p.

Research output: Contribution to journalArticle

19 Scopus citations

Expression of IL-5 alters bone metabolism and induces ossification of the spleen in transgenic mice

Macias, M. P., Fitzpatrick, L. A., Brenneise, I., McGarry, M. P., Lee, J. J. & Lee, N. A., Jan 1 2001, In : Journal of Clinical Investigation. 107, 8, p. 949-959 11 p.

Research output: Contribution to journalArticle

Open Access
47 Scopus citations

Expression of IL-5 in Thymocytes/T Cells Leads to the Development of a Massive Eosinophilia, Extramedullary Eosinophilopoiesis, and Unique Histopathologies

Lee, N. A., McGarry, M. P., Larson, K. A., Horton, M. A., Kristensen, A. B. & Lee, J. J., Feb 1 1997, In : Journal of Immunology. 158, 3, p. 1332-1344 13 p.

Research output: Contribution to journalArticle

181 Scopus citations

Expression of the cereblon binding protein argonaute 2 plays an important role for multiple myeloma cell growth and survival

Xu, Q., Hou, Y. X., Langlais, P. R., Erickson, P., Zhu, J., Shi, C. X., Luo, M., Zhu, Y., Xu, Y., Mandarino, L. J., Stewart, A. K. & Chang, X-B. D., May 3 2016, In : BMC Cancer. 16, 1, 297.

Research output: Contribution to journalArticle

20 Scopus citations

Expression of the gene coding for a human mucin in mouse mammary tumor cells can affect their tumorigenicity

Lalani, E. N., Berdichevsky, F., Boshell, M., Shearer, M., Wilson, D., Stauss, H., Gendler, S. J. & Taylor-Papadimitrious, J., Oct 2 1991, In : Journal of Biological Chemistry. 266, 23, p. 15420-15426 7 p.

Research output: Contribution to journalArticle

62 Scopus citations

Expression of the secondary granule proteins major basic protein 1 (MBP-1) and eosinophil peroxidase (EPX) is required for eosinophilopoiesis in mice

Doyle, A. D., Jacobsen, E. A., Ochkur, S. I., McGarry, M. P., Shim, K. G., Nguyen, D. T. C., Protheroe, C., Colbert, D., Kloeber, J., Neely, J., Shim, K. P., Dyer, K. D., Rosenberg, H. F., Lee, J. J. & Lee, N. A., Aug 1 2013, In : Blood. 122, 5, p. 781-790 10 p.

Research output: Contribution to journalArticle

47 Scopus citations

Expression of wild-type and mutant S20G hIAPP in physiologic knock-in mouse models fails to induce islet amyloid formation, but induces mild glucose intolerance

Hiddinga, H. J., Sakagashira, S., Ishigame, M., Madde, P., Sanke, T., Nanjo, K., Kudva, Y. C., Lee, J. J., van Deursen, J. & Eberhardt, N. L., Apr 1 2012, In : Journal of Diabetes Investigation. 3, 2, p. 138-147 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

Extended survival of Pyk2 or FAK deficient orthotopic glioma xenografts

Lipinski, C. A., Tran, N. L., Viso, C., Kloss, J., Yang, Z., Berens, M. E. & Loftus, J. C., Jul 24 2008, In : Journal of neuro-oncology. 90, 2, p. 181-189 9 p.

Research output: Contribution to journalArticle

18 Scopus citations

Extensive eosinophil degranulation and peroxidase-mediated oxidation of airway proteins do not occur in a mouse ovalbumin-challenge model of pulmonary inflammation

Denzler, K. L., Borchers, M. T., Crosby, J. R., Cieslewicz, G., Hines, E. M., Justice, J. P., Cormier, S. A., Lindenberger, K. A., Song, W., Wu, W., Hazen, S. L., Gleich, G. J., Lee, J. J. & Lee, N. A., Aug 1 2001, In : Journal of Immunology. 167, 3, p. 1672-1682 11 p.

Research output: Contribution to journalArticle

Open Access
101 Scopus citations

Extensive exploration of conformational space improves Rosetta results for short protein domains.

Li, Y., Bordner, A. J., Tian, Y., Tao, X. & Gorin, A. A., 2008, In : Computational systems bioinformatics / Life Sciences Society. Computational Systems Bioinformatics Conference. 7, p. 203-209 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

Extensive pulmonary arterial thrombosis without subsequent infarction.

Marler, R. J., Kennedy, G. A., Cook, J. E. & Willard, M., Feb 1 1978, In : Veterinary medicine, small animal clinician : VM, SAC. 73, 2, p. 145-147 3 p.

Research output: Contribution to journalArticle

F508del CFTR with two altered RXR motifs escapes from ER quality control but its channel activity is thermally sensitive

Hegedus, T., Aleksandrov, A., Cui, L., Gentzsch, M., Chang, X. B. & Riordan, J. R., May 1 2006, In : Biochimica et Biophysica Acta - Biomembranes. 1758, 5, p. 565-572 8 p.

Research output: Contribution to journalArticle

47 Scopus citations

Fluorescence characteristics of hydrophobic partial agonist probes of the cholecystokinin receptor

Harikumar, K. G., Pinon, D. I. & Miller, L. J., Apr 1 2006, In : Bioscience reports. 26, 2, p. 89-100 12 p.

Research output: Contribution to journalArticle

3 Scopus citations

Fluorescence polarization screening for allosteric small molecule ligands of the cholecystokinin receptor

Harikumar, K. G., Cawston, E. E. & Miller, L. J., Aug 1 2011, In : Assay and Drug Development Technologies. 9, 4, p. 394-402 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

Fluorescence resonance energy transfer analysis of secretin docking to its receptor: Mapping distances between residues distributed throughout the ligand pharmacophore and distinct receptor residues

Harikumar, K. G., Lam, P. C. H., Dong, M., Sexton, P. M., Abagyan, R. & Miller, L. J., Nov 9 2007, In : Journal of Biological Chemistry. 282, 45, p. 32834-32843 10 p.

Research output: Contribution to journalArticle

25 Scopus citations

Fluorescence resonance energy transfer analysis of the antagonist- and partial agonist-occupied states of the cholecystokinin receptor

Harikumar, K. G. & Miller, L. J., May 13 2005, In : Journal of Biological Chemistry. 280, 19, p. 18631-18635 5 p.

Research output: Contribution to journalArticle

13 Scopus citations
19 Scopus citations

Fluorescent modified phosphatidylcholine floppase activity of reconstituted multidrug resistance-associated protein MRP1

Huang, Z., Chang, X., Riordan, J. R. & Huang, Y., Jan 28 2004, In : Biochimica et Biophysica Acta - Biomembranes. 1660, 1-2, p. 155-163 9 p.

Research output: Contribution to journalArticle

18 Scopus citations

Formation of deletions after initiation of simian virus 40 replication: Influence of packaging limit of the capsid

Chang, X. B. & Wilson, J. H., 1986, In : Journal of virology. 58, 2, p. 393-401 9 p.

Research output: Contribution to journalArticle

Open Access
20 Scopus citations

Frontline science: Eosinophil-deficient MBP-1 and EPX double-knockout mice link pulmonary remodeling and airway dysfunction with type 2 inflammation

Ochkur, S. I., Doyle, A. D., Jacobsen, E., LeSuer, W. E., Li, W., Protheroe, C. A., Zellner, K. R., Colbert, D., Shen, H. H. H., Irvin, C. G., Lee, J. J. & Lee, N. A., Sep 1 2017, In : Journal of Leukocyte Biology. 102, 3, p. 589-599 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

Fumarylacetoacetate hydrolase deficient pigs are a novel large animal model of metabolic liver disease

Hickey, R. D., Mao, S. A., Glorioso, J., Lillegard, J. B., Fisher, J. E., Amiot, B., Rinaldo, P., Harding, C. O., Marler, R., Finegold, M. J., Grompe, M. & Nyberg, S. L., Jul 2014, In : Stem Cell Research. 13, 1, p. 144-153 10 p.

Research output: Contribution to journalArticle

31 Scopus citations

Functional importance of a structurally distinct homodimeric complex of the family B G protein-coupled secretin receptor

Gao, F., Harikumar, K. G., Dong, M., Lam, P. C. H., Sexton, P. M., Christopoulos, A., Bordner, A., Abagyan, R. & Miller, L. J., Aug 1 2009, In : Molecular pharmacology. 76, 2, p. 264-274 11 p.

Research output: Contribution to journalArticle

43 Scopus citations

Function and dysfunction of the CFTR chloride channel

Hanrahan, J. W., Tabcharani, J. A., Becq, F., Mathews, C. J., Augustinas, O., Jensen, T. J., Chang, X. B. & Riordan, J. R., Jul 26 1995, In : Journal of General Physiology. 48 TH ANN. SYMP., p. 125-137 13 p.

Research output: Contribution to journalArticle

34 Scopus citations

Fundamental signals that regulate eosinophil homing to the gastrointestinal tract

Mishra, A., Hogan, S. P., Lee, J. J., Foster, P. S. & Rothenberg, M. E., Jun 1999, In : Journal of Clinical Investigation. 103, 12, p. 1719-1727 9 p.

Research output: Contribution to journalArticle

Open Access
287 Scopus citations

G2A signaling dampens colitic inflammation via production of IFN-γ

Frasch, S. C., McNamee, E. N., Kominsky, D., Jedlicka, P., Jakubzick, C., Berry, K. Z., Mack, M., Furuta, G. T., Lee, J. J., Henson, P. M., Colgan, S. P. & Bratton, D. L., Aug 15 2016, In : Journal of Immunology. 197, 4, p. 1425-1434 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

Generalised Calogero-Moser models and universal Lax pair operators

Bordner, A. J., Corrigan, E. & Sasaki, R., Sep 1999, In : Progress of Theoretical Physics. 102, 3, p. 499-529 31 p.

Research output: Contribution to journalArticle

Open Access
56 Scopus citations

Genetic mapping of the tumor-associated mucin 1 gene on mouse Chromosome 3

Kingsmore, S. F., Spicer, A. P., Gendler, S. J. & Seldin, M. F., May 1 1995, In : Mammalian Genome. 6, 5, p. 378-379 2 p.

Research output: Contribution to journalArticle

3 Scopus citations

Genetic modulation of neu proto-oncogene-induced mammary tumorigenesis

Rowse, G. J., Ritland, S. R. & Gendler, S. J., Jun 15 1998, In : Cancer research. 58, 12, p. 2675-2679 5 p.

Research output: Contribution to journalArticle

46 Scopus citations

Glucagon-like peptide-1 receptor dimerization differentially regulates agonist signaling but does not affect small molecule allostery

Harikumar, K. G., Wootten, D., Pinon, D. I., Koole, C., Ball, A. M., Furness, S. G. B., Graham, B., Dong, M., Christopoulos, A., Miller, L. J. & Sexton, P. M., Nov 6 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 45, p. 18607-18612 6 p.

Research output: Contribution to journalArticle

42 Scopus citations

Glutamine residues in Q-loops of multidrug resistance protein MRP1 contribute to ATP binding via interaction with metal cofactor

Yang, R., Hou, Y. X., Campbell, C. A., Palaniyandi, K., Zhao, Q., Bordner, A. J. & Chang, X. B., Jul 1 2011, In : Biochimica et Biophysica Acta - Biomembranes. 1808, 7, p. 1790-1796 7 p.

Research output: Contribution to journalArticle

4 Scopus citations

Glycocalyx restricts adenoviral vector access to apical receptors expressed on respiratory epithelium in vitro and in vivo: Role for tethered mucins as barriers to lumenal infection

Stonebraker, J. R., Wagner, D., Lefensty, R. W., Burns, K., Gendler, S. J., Bergelson, J. M., Boucher, R. C., O'Neal, W. K. & Pickles, R. J., Dec 2004, In : Journal of virology. 78, 24, p. 13755-13768 14 p.

Research output: Contribution to journalArticle

59 Scopus citations