Biochemistry and Molecular Biology

Research Output

Perturbation of Hsp90 interaction with nascent CFTR prevents its maturation and accelerates its degradation by the proteasome

Loo, M. A., Jensen, T. J., Cui, L., Hou, Y. X., Chang, X. B. & Riordan, J. R., Dec 1 1998, In : EMBO Journal. 17, 23, p. 6879-6887 9 p.

Research output: Contribution to journalArticle

287 Scopus citations

Peroxisome proliferator-activated receptor γ controls Muc1 transcription in trophoblasts

Shalom-Barak, T., Nicholas, J. M., Wang, Y., Zhang, X., Ong, E. S., Young, T. H., Gendler, S. J., Evans, R. M. & Barak, Y., Dec 2004, In : Molecular and cellular biology. 24, 24, p. 10661-10669 9 p.

Research output: Contribution to journalArticle

64 Scopus citations

Permeability of wild-type and mutant cystic fibrosis transmembrane conductance regulator chloride channels to polyatomic anions

Linsdell, P., Tabcharani, J. A., Rommens, J. M., Hou, Y. X., Chang, X. B., Tsui, L. C., Riordan, J. R. & Hanrahan, J. W., Oct 1997, In : Journal of General Physiology. 110, 4, p. 355-364 10 p.

Research output: Contribution to journalArticle

157 Scopus citations

Pediatric Eosinophilic Esophagitis Symptom Scores (PEESS v2.0) identify histologic and molecular correlates of the key clinical features of disease

Martin, L. J., Franciosi, J. P., Collins, M. H., Abonia, J. P., Lee, J. J., Hommel, K. A., Varni, J. W., Grotjan, J. T., Eby, M., He, H., Marsolo, K., Putnam, P. E., Garza, J. M., Kaul, A., Wen, T. & Rothenberg, M. E., Jun 1 2015, In : Journal of Allergy and Clinical Immunology. 135, 6, p. 1519-1528.e8

Research output: Contribution to journalArticle

56 Scopus citations

PDZ-RhoGEF Is a Signaling Effector for TROY-Induced Glioblastoma Cell Invasion and Survival

Ding, Z., Dhruv, H., Kwiatkowska-Piwowarczyk, A., Ruggieri, R., Kloss, J., Symons, M., Pirrotte, P., Eschbacher, J. M., Tran, N. L. & Loftus, J. C., Oct 2018, In : Neoplasia (United States). 20, 10, p. 1045-1058 14 p.

Research output: Contribution to journalArticle

2 Scopus citations

Patterns of MUC1 tissue expression defined by an Anti-MUC1 cytoplasmic tail monoclonal antibody in breast cancer

Croce, M. V., Isla-Larrain, M. T., Rua, C. E., Rabassa, M. E., Gendler, S. J. & Segal-Eiras, A., Jun 1 2003, In : Journal of Histochemistry and Cytochemistry. 51, 6, p. 781-788 8 p.

Research output: Contribution to journalArticle

Open Access
48 Scopus citations

Pattern of intra-family hetero-oligomerization involving the G-protein-coupled secretin receptor

Harikumar, K. G., Morfis, M. M., Sexton, P. M. & Miller, L. J., Nov 2008, In : Journal of Molecular Neuroscience. 36, 1-3, p. 279-285 7 p.

Research output: Contribution to journalArticle

42 Scopus citations

Pathology in practice

Gades, N. M. & Marier, R. J., Jun 15 2009, In : Journal of the American Veterinary Medical Association. 234, 12, p. 1535-1537 3 p.

Research output: Contribution to journalArticle

3 Scopus citations

Passively transferred anti-MUC1 antibodies cause neither autoimmune disorders nor immunity against transplanted tumors in MUC1 transgenic mice

Tempero, R. M., Rowse, G. J., Gendler, S. J. & Hollingsworth, M. A., Feb 4 1999, In : International Journal of Cancer. 80, 4, p. 595-599 5 p.

Research output: Contribution to journalArticle

19 Scopus citations

Partial structure, chromosome localization, and expression of the mouse Icln gene

Wickman, K., Seldin, M. F., James, M. R., Gendler, S. J. & Clapham, D. E., Mar 15 1997, In : Genomics. 40, 3, p. 402-408 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

Partial structure, chromosome localization, and expression of the mouse Girk4 gene

Wickman, K., Seldin, M. F., Gendler, S. J. & Clapham, D. E., Mar 15 1997, In : Genomics. 40, 3, p. 395-401 7 p.

Research output: Contribution to journalArticle

18 Scopus citations

Pancreatic ductal adenocarcinoma mice lacking mucin 1 have a profound defect in tumor growth and metastasis

Besmer, D. M., Curry, J. M., Roy, L. D., Tinder, T. L., Sahraei, M., Schettini, J., Hwang, S. I., Lee, Y. Y., Gendler, S. J. & Mukherjee, P., Jul 1 2011, In : Cancer research. 71, 13, p. 4432-4442 11 p.

Research output: Contribution to journalArticle

80 Scopus citations

Pancreatic cancer pain and its correlation with changes in tumor vasculature, macrophage infiltration, neuronal innervation, body weight and disease progression

Lindsay, T. H., Jonas, B. M., Sevcik, M. A., Kubota, K., Halvorson, K. G., Ghilardi, J. R., Kuskowski, M. A., Stelow, E. B., Mukherjee, P., Gendler, S. J., Wong, G. Y. & Mantyh, P. W., Dec 15 2005, In : Pain. 119, 1-3, p. 233-246 14 p.

Research output: Contribution to journalArticle

74 Scopus citations

Orientation-dependent backbone-only residue pair scoring functions for fixed backbone protein design

Bordner, A. J., Apr 16 2010, In : BMC bioinformatics. 11, 192.

Research output: Contribution to journalArticle

5 Scopus citations

Operator transformations between exactly solvable potentials and their Lie group generators

Bordner, A. J., Jun 7 1997, In : Journal of Physics A: Mathematical and General. 30, 11, p. 3927-3936 10 p.

Research output: Contribution to journalArticle

Occupancy of an adhesive glycoprotein receptor modulates expression of an antigenic site involved in cell adhesion

Frelinger, A. L., Lam, S. C. T., Plow, E. F., Smith, M. A., Loftus, J. C. & Ginsberg, M. H., Dec 1 1988, In : Journal of Biological Chemistry. 263, 25, p. 12397-12402 6 p.

Research output: Contribution to journalArticle

204 Scopus citations

Obese asthmatic patients have decreased surfactant protein A levels: Mechanisms and implications

Lugogo, N., Francisco, D., Addison, K. J., Manne, A., Pederson, W., Ingram, J. L., Green, C. L., Suratt, B. T., Lee, J. J., Sunday, M. E., Kraft, M. & Ledford, J. G., Mar 2018, In : Journal of Allergy and Clinical Immunology. 141, 3, p. 918-926.e3

Research output: Contribution to journalArticle

6 Scopus citations

Nucleotide-induced conformational changes in the human multidrug resistance protein MRP1 are related to the capacity of chemotherapeutic drugs to accumulate or not in resistant cells

Manciu, L., Chang, X. B., Riordan, J. R., Buyse, F. & Ruysschaert, J. M., Mar 23 2001, In : FEBS Letters. 493, 1, p. 31-35 5 p.

Research output: Contribution to journalArticle

19 Scopus citations

Nucleotide dissociation from NBD1 promotes solute transport by MRP1

Yang, R., McBride, A., Hou, Y. X., Goldberg, A. & Chang, X. B., Mar 1 2005, In : Biochimica et Biophysica Acta - Biomembranes. 1668, 2, p. 248-261 14 p.

Research output: Contribution to journalArticle

17 Scopus citations

Novel MUC1 splice variants contribute to mucin overexpression in CFTR-deficient mice

Hinojosa-Kurtzberg, A. M., Johansson, M. E. V., Madsen, C. S., Hansson, G. C. & Gendler, S. J., May 1 2003, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 284, 5 47-5, p. G853-G862

Research output: Contribution to journalArticle

23 Scopus citations

Novel model of TH2-polarized chronic ileitis: The SAMPl mouse

McNamee, E. N., Wermers, J. D., Masterson, J. C., Collins, C. B., Matthew, D. P., Lebsack, B. A., Fillon, S., Robinson, Z. D., Grenawalt, J., Lee, J. J., Jedlicka, P., Furuta, G. T. & Rivera-Nieves, J., 2010, In : Inflammatory bowel diseases. 16, 5, p. 743-752 10 p.

Research output: Contribution to journalArticle

26 Scopus citations

Novel approach to inhibit asthma-mediated lung inflammation using Anti-CD147 intervention

Gwinn, W. M., Damsker, J. M., Falahati, R., Okwumabua, I., Kelly-Welch, A., Keegan, A. D., Vanpouille, C., Lee, J. J., Dent, L. A., Leitenberg, D., Bukrinsky, M. I. & Constant, S. L., Oct 1 2006, In : Journal of Immunology. 177, 7, p. 4870-4879 10 p.

Research output: Contribution to journalArticle

Open Access
98 Scopus citations

Normalized serum eosinophil peroxidase levels are inversely correlated with esophageal eosinophilia in eosinophilic esophagitis

Wright, B. L., Ochkur, S. I., Olson, N. S., Shim, K. P., Jacobsen, E. A., Rank, M. A., Dellon, E. S. & Lee, J. J., Feb 1 2018, In : Diseases of the Esophagus. 31, 2, p. 1-9 9 p., dox139.

Research output: Contribution to journalReview article

9 Scopus citations

New insights into integrin-ligand interaction

Loftus, J. C. & Liddington, R. C., Dec 1 1997, In : Journal of Clinical Investigation. 100, 11 SUPPL., p. S77-S81

Research output: Contribution to journalReview article

30 Scopus citations

New insights into integrin-ligand interaction

Loftus, J. C. & Liddington, R. C., May 15 1997, In : Journal of Clinical Investigation. 99, 10, p. 2302-2306 5 p.

Research output: Contribution to journalReview article

Open Access
103 Scopus citations

Nasal and pharyngeal eosinophil peroxidase levels in adults with poorly controlled asthma correlate with sputum eosinophilia

Rank, M. A., Ochkur, S. I., Lewis, J. C., Teaford, H. G., Wesselius, L. J., Helmers, R. A., Lee, N. A., Nair, P. & Lee, J. J., 2015, (Accepted/In press) In : Allergy: European Journal of Allergy and Clinical Immunology.

Research output: Contribution to journalArticle

22 Scopus citations

Myeloid-derived suppressor cells adhere to physiologic STAT3-vs STAT5-dependent hematopoietic programming, establishing diverse tumor-mediated mechanisms of immunologic escape

Cohen, P. A., Ko, J. S., Storkus, W. J., Spencer, C. D., Bradley, J. M., Gorman, J. E., McCurry, D. B., Zorro-Manrique, S., Dominguez, A. L., Pathangey, L. B., Rayman, P. A., Rini, B. I., Gendler, S. J. & Finke, J. H., Aug 1 2012, In : Immunological Investigations. 41, 6-7, p. 680-710 31 p.

Research output: Contribution to journalArticle

30 Scopus citations

Mutations of the Walker B motif in the first nucleotide binding domain of multidrug resistance protein MRP1 prevent conformational maturation

Cui, L., Hou, Y. X., Riordan, J. R. & Chang, X. B., Aug 1 2001, In : Archives of Biochemistry and Biophysics. 392, 1, p. 153-161 9 p.

Research output: Contribution to journalArticle

24 Scopus citations

Mutation of the aromatic amino acid interacting with adenine moiety of ATP to a polar residue alters the properties of multidrug resistance protein 1

Zhao, Q. & Chang, X. B., Nov 19 2004, In : Journal of Biological Chemistry. 279, 47, p. 48505-48512 8 p.

Research output: Contribution to journalArticle

23 Scopus citations
139 Scopus citations

Muscle development and lineage-specific expression of CiMDF, the MyoD-family gene of Ciona intestinalis

Meedel, T. H., Lee, J. J. & Whittaker, J. R., Jan 15 2002, In : Developmental Biology. 241, 2, p. 238-246 9 p.

Research output: Contribution to journalArticle

21 Scopus citations

Murine lung eosinophil activation and chemokine production in allergic airway inflammation

Rose, C. E., Lannigan, J. A., Kim, P., Lee, J. J., Fu, S. M. & Sung, S. S. J., 2010, In : Cellular and Molecular Immunology. 7, 5, p. 361-374 14 p.

Research output: Contribution to journalArticle

41 Scopus citations

MultiRTA: A simple yet reliable method for predicting peptide binding affinities for multiple class II MHC allotypes

Bordner, A. J. & Mittelmann, H. D., Sep 24 2010, In : BMC bioinformatics. 11, 482.

Research output: Contribution to journalArticle

31 Scopus citations

Multiple flavonoid-binding sites within multidrug resistance protein MRP1

Trompier, D., Baubichon-Cortay, H., Chang, X. B., Maitrejean, M., Barron, D., Riordan, J. R. & Di Pietro, A., Oct 1 2003, In : Cellular and Molecular Life Sciences. 60, 10, p. 2164-2177 14 p.

Research output: Contribution to journalArticle

63 Scopus citations

Multi-parametric MRI and texture analysis to visualize spatial histologic heterogeneity and tumor extent in glioblastoma

Hu, L. S., Ning, S., Eschbacher, J. M., Gaw, N., Dueck, A. C., Smith, K. A., Nakaji, P., Plasencia, J., Ranjbar, S., Price, S. J., Tran, N., Loftus, J., Jenkins, R., O'Neill, B. P., Elmquist, W., Baxter, L. C., Gao, F., Frakes, D., Karis, J. P., Zwart, C. & 5 others, Swanson, K. R., Sarkaria, J., Wu, T., Mitchell, J. R. & Li, J., Nov 1 2015, In : PloS one. 10, 11, e0141506.

Research output: Contribution to journalArticle

56 Scopus citations

Multi-ion pore behaviour in the CFTR chloride channel

Tabcharani, J. A., Rommens, J. M., Hou, Y. X., Chang, X. B., Tsui, L. C., Riordan, J. R. & Hanrahan, J. W., Jan 1 1993, In : Nature. 366, 6450, p. 79-82 4 p.

Research output: Contribution to journalArticle

197 Scopus citations

Multidrug resistance protein MRP1 reconstituted into lipid vesicles: Secondary structure and nucleotide-induced tertiary structure changes

Manciu, L., Chang, X. B., Riordan, J. R. & Ruysschaert, J. M., Oct 24 2000, In : Biochemistry. 39, 42, p. 13026-13033 8 p.

Research output: Contribution to journalArticle

26 Scopus citations

Multidrug resistance protein 1 is not associated to detergent-resistant membranes

Cerf, E., Gasper, R., Rychnovsky, S., Chang, X. B., Buyse, F. & Ruysschaert, J. M., Apr 20 2007, In : Biochemical and Biophysical Research Communications. 355, 4, p. 1025-1030 6 p.

Research output: Contribution to journalArticle

10 Scopus citations

Mucin antigens: Molecular structure and potential use in immunotherapy

Taylor-Papadimitriou, J., Lalani, E. N., Burchell, J. & Gendler, S. J., Jan 1 1990, In : Journal of Nuclear Medicine and Allied Sciences. 34, 3 SUPPL., p. 144-150 7 p.

Research output: Contribution to journalArticle

3 Scopus citations

Mucin 1-specific immunotherapy in a mouse model of spontaneous breast cancer

Mukherjee, P., Madsen, C. S., Ginardi, A. R., Tinder, T. L., Jacobs, F., Parker, J., Agrawal, B., Longenecker, B. M. & Gendler, S. J., Jan 1 2003, In : Journal of Immunotherapy. 26, 1, p. 47-62 16 p.

Research output: Contribution to journalArticle

74 Scopus citations

MUC4 mucin expression in human pancreatic tumours is affected by organ environment: The possible role of TGFβ2

Choudhury, A., Moniaux, N., Ulrich, A. B., Schmied, B. M., Standop, J., Pour, P. M., Gendler, S. J., Hollingsworth, M. A., Aubert, J. P. & Batra, S. K., Feb 9 2004, In : British journal of cancer. 90, 3, p. 657-664 8 p.

Research output: Contribution to journalArticle

23 Scopus citations

MUC1 vaccines, comprised of glycosylated or non-glycosylated peptides or tumor-derived MUC1, can circumvent immunoediting to control tumor growth in MUC1 transgenic mice

Lakshminarayanan, V., Supekar, N. T., Wei, J., McCurry, D. B., Dueck, A. C., Kosiorek, H. E., Trivedi, P. P., Bradley, J. M., Madsen, C. S., Pathangey, L. B., Hoelzinger, D. B., Wolfert, M. A., Boons, G. J., Cohen, P. A. & Gendler, S. J., Jan 1 2016, In : PloS one. 11, 1, e0145920.

Research output: Contribution to journalArticle

21 Scopus citations

MUC1-specific immune therapy generates a strong anti-tumor response in a MUC1-tolerant colon cancer model

Mukherjee, P., Pathangey, L. B., Bradley, J. B., Tinder, T. L., Basu, G. D., Akporiaye, E. T. & Gendler, S. J., Feb 19 2007, In : Vaccine. 25, 9, p. 1607-1618 12 p.

Research output: Contribution to journalArticle

52 Scopus citations

MUC1-specific cytotoxic T lymphocytes eradicate tumors when adoptively transferred in vivo

Mukherjee, P., Ginardi, A. R., Tinder, T. L., Sterner, C. J. & Gendler, S. J., Mar 1 2001, In : Clinical Cancer Research. 7, 11 SUPPL., p. 848s-855s

Research output: Contribution to journalArticle

45 Scopus citations

MUC1-specific CTLs are non-functional within a pancreatic tumor microenvironment

Mukherjee, P., Ginardi, A. R., Madsen, C. S., Tinder, T. L., Jacobs, F., Parker, J., Agrawal, B., Longenecker, B. M. & Gendler, S. J., Nov 1 2001, In : Glycoconjugate Journal. 18, 11-12, p. 931-942 12 p.

Research output: Contribution to journalArticle

49 Scopus citations

MUC1 regulates PDGFA expression during pancreatic cancer progression

Sahraei, M., Roy, L. D., Curry, J. M., Teresa, T. L., Nath, S., Besmer, D., Kidiyoor, A., Dalia, R., Gendler, S. J. & Mukherjee, P., Nov 22 2012, In : Oncogene. 31, 47, p. 4935-4945 11 p.

Research output: Contribution to journalArticle

37 Scopus citations

MUC1 overexpression results in mammary gland tumorigenesis and prolonged alveolar differentiation

Schroeder, J. A., Al Masri, A., Adriance, M. C., Tessier, J. C., Kotlarczyk, K. L., Thompson, M. C. & Gendler, S. J., Jul 29 2004, In : Oncogene. 23, 34, p. 5739-5747 9 p.

Research output: Contribution to journalArticle

110 Scopus citations

MUC1 mucin is a negative regulator of toll-like receptor signaling

Ueno, K., Koga, T., Kato, K., Golenbock, D. T., Gendler, S. J., Kai, H. & Kim, K. C., Mar 1 2008, In : American journal of respiratory cell and molecular biology. 38, 3, p. 263-268 6 p.

Research output: Contribution to journalArticle

112 Scopus citations

Muc1 is protective during kidney ischemia - Reperfusion injury

Pastor-Soler, N. M., Sutton, T. A., Mang, H. E., Kinlough, C. L., Gendler, S. J., Madsen, C. S., Bastacky, S. I., Ho, J., Al-Bataineh, M. M., Hallows, K. R., Singh, S., Monga, S. P., Kobayashi, H., Haase, V. H. & Hughey, R. P., Jun 15 2015, In : American Journal of Physiology - Renal Physiology. 308, 12, p. F1452-F1462

Research output: Contribution to journalArticle

22 Scopus citations

MUC1 epithelial mucin (CD227) is expressed by activated dendritic cells

Wykes, M., MacDonald, K. P. A., Tran, M., Quin, R. J., Xing, P. X., Gendler, S. J., Hart, D. N. J. & McGuckin, M. A., Oct 1 2002, In : Journal of Leukocyte Biology. 72, 4, p. 692-701 10 p.

Research output: Contribution to journalArticle

66 Scopus citations