Biochemistry and Molecular Biology

Research Output

Eosinophil-mediated signalling attenuates inflammatory responses in experimental colitis

Masterson, J. C., McNamee, E. N., Fillon, S. A., Hosford, L., Harris, R., Fernando, S. D., Jedlicka, P., Iwamoto, R., Jacobsen, E., Protheroe, C., Eltzschig, H. K., Colgan, S. P., Arita, M., Lee, J. J. & Furuta, G. T., Aug 1 2015, In : Gut. 64, 8, p. 1236-1247 12 p.

Research output: Contribution to journalArticle

53 Scopus citations

Eosinophilopoiesis

Maltby, S., McNagny, K. M., Ackerman, S. J., Du, J., Mori, Y., Iwasaki, H., Akashi, K., Takatsu, K., Rådinger, M., Bossios, A., Lötvall, J. & Lee, N. A., Aug 29 2013, Eosinophils in Health and Disease. Elsevier Inc., p. 73-119 47 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Eosinophil peroxidase, GATA3, and T-bet as tissue biomarkers in chronic rhinosinusitis

Lal, D., Wright, B. L., Shim, K. P., Zarka, M. A., Lee, J. J., Chang, Y. H., Ochkur, S. I., Divekar, R., Doyle, A. D., Jacobsen, E. A., Kita, H. & Rank, M. A., Jun 2019, In : Journal of Allergy and Clinical Immunology. 143, 6, p. 2284-2287.e6

Research output: Contribution to journalArticle

1 Scopus citations

Eosinophil peroxidase catalyzed protein carbamylation participates in asthma

Wang, Z., DiDonato, J. A., Buffa, J., Comhair, S. A., Aronica, M. A., Dweik, R. A., Lee, N. A., Lee, J. J., Thomassen, M. J., Kavuru, M., Erzurum, S. C. & Hazen, S. L., Oct 14 2016, In : Journal of Biological Chemistry. 291, 42, p. 22118-22135 18 p.

Research output: Contribution to journalArticle

13 Scopus citations

Eosinophil peroxidase in sputum represents a unique biomarker of airway eosinophilia

Nair, P., Ochkur, S. I., Protheroe, C., Radford, K., Efthimiadis, A., Lee, N. A. & Lee, J. J., Sep 1 2013, In : Allergy: European Journal of Allergy and Clinical Immunology. 68, 9, p. 1177-1184 8 p.

Research output: Contribution to journalArticle

46 Scopus citations

Eosinophils: Singularly destructive effector cells or purveyors of immunoregulation?

Jacobsen, E. A., Taranova, A. G., Lee, N. A. & Lee, J. J., Jun 1 2007, In : Journal of Allergy and Clinical Immunology. 119, 6, p. 1313-1320 8 p.

Research output: Contribution to journalArticle

153 Scopus citations

Eosinophils

Lee, N. A., Dahl, M. V., Jacobsen, E. A. & Ochkur, S. I., Jul 27 2011, Inflammation and Allergy Drug Design. Wiley-Blackwell, p. 107-121 15 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Eosinophils act as antigen-presenting cells to induce immunity to Strongyloides stercoralis in mice

Padigel, U. M., Hess, J. A., Lee, J. J., Lok, J. B., Nolan, T. J., Schad, G. A. & Abraham, D., Dec 15 2007, In : Journal of Infectious Diseases. 196, 12, p. 1844-1851 8 p.

Research output: Contribution to journalArticle

67 Scopus citations

Eosinophils alter colonic epithelial barrier function: Role for major basic protein

Furuta, G. T., Nieuwenhuis, E. E. S., Karhausen, J., Gleich, G., Blumberg, R. S., Lee, J. J. & Ackerman, S. J., Nov 1 2005, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 289, 5 52-5, p. G890-G897

Research output: Contribution to journalArticle

98 Scopus citations

Eosinophils and asthma

Jacobsen, E. A., Ochkur, S. I., Lee, N. A. & Lee, J. J., Apr 1 2007, In : Current Allergy and Asthma Reports. 7, 1, p. 18-26 9 p.

Research output: Contribution to journalReview article

55 Scopus citations

Eosinophils and IL-33 Perpetuate Chronic Inflammation and Fibrosis in a Pediatric Population with Stricturing Crohn's Ileitis

Masterson, J. C., Capocelli, K. E., Hosford, L., Biette, K., McNamee, E. N., De Zoeten, E. F., Harris, R., Fernando, S. D., Jedlicka, P., Protheroe, C., Lee, J. J. & Furuta, G. T., Jul 20 2015, In : Inflammatory bowel diseases. 21, 10, p. 2429-2440 12 p.

Research output: Contribution to journalArticle

30 Scopus citations

Eosinophils and IL-4 Support Nematode Growth Coincident with an Innate Response to Tissue Injury

Huang, L., Beiting, D. P., Gebreselassie, N. G., Gagliardo, L. F., Ruyechan, M. C., Lee, N. A., Lee, J. J. & Appleton, J. A., 2015, In : PLoS pathogens. 11, 12, e1005347.

Research output: Contribution to journalArticle

24 Scopus citations

Eosinophils are cellular targets of the novel uteroplacental heparin-binding cytokine decidual/trophoblast prolactin-related protein

Wang, D., Ishimura, R., Walia, D. S., Muller, H., Dai, G., Hunt, J. S., Lee, N. A., Lee, J. J. & Soares, M. J., Jan 1 2000, In : Journal of Endocrinology. 167, 1, p. 15-28 14 p.

Research output: Contribution to journalArticle

Open Access
25 Scopus citations

Eosinophils Are Important for Protection, Immunoregulation and Pathology during Infection with Nematode Microfilariae

Cadman, E. T., Thysse, K. A., Bearder, S., Cheung, A. Y. N., Johnston, A. C., Lee, J. J. & Lawrence, R. A., Mar 2014, In : PLoS pathogens. 10, 3, e1003988.

Research output: Contribution to journalArticle

35 Scopus citations

Eosinophils are necessary for pulmonary arterial remodeling in a mouse model of eosinophilic inflammation-induced pulmonary hypertension

Weng, M., Baron, D. M., Bloch, K. D., Luster, A. D., Lee, J. J. & Medoff, B. D., Dec 2011, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 301, 6, p. L927-L936

Research output: Contribution to journalArticle

21 Scopus citations

Eosinophils are required for the maintenance of plasma cells in the bone marrow

Chu, V. T., Fröhlich, A., Steinhauser, G., Scheel, T., Roch, T., Fillatreau, S., Lee, J. J., Löhning, M. & Berek, C., Feb 1 2011, In : Nature immunology. 12, 2, p. 151-159 9 p.

Research output: Contribution to journalArticle

307 Scopus citations

Eosinophils contribute to the resolution of lung-allergic responses following repeated allergen challenge

Takeda, K., Shiraishi, Y., Ashino, S., Han, J., Jia, Y., Wang, M., Lee, N. A., Lee, J. J. & Gelfand, E. W., Feb 1 2015, In : Journal of Allergy and Clinical Immunology. 135, 2, p. 451-460.e5

Research output: Contribution to journalArticle

18 Scopus citations

Eosinophil shape change and secretion

Willetts, L., Ochkur, S. I., Jacobsen, E. A., Lee, J. J. & Lacy, P., 2014, Eosinophils: Methods and Protocols. Humana Press Inc., p. 111-128 18 p. (Methods in Molecular Biology; vol. 1178).

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Scopus citations

Eosinophils increase neuron branching in human and murine skin and in vitro

Foster, E. L., Simpson, E. L., Fredrikson, L. J., Lee, J. J., Lee, N. A., Fryer, A. D. & Jacoby, D. B., 2011, In : PloS one. 6, 7, e22029.

Research output: Contribution to journalArticle

48 Scopus citations

Eosinophils in health and disease: The LIAR hypothesis

Lee, J. J., Jacobsen, E. A., McGarry, M. P., Schleimer, R. P. & Lee, N. A., Apr 1 2010, In : Clinical and Experimental Allergy. 40, 4, p. 563-575 13 p.

Research output: Contribution to journalComment/debate

162 Scopus citations

Eosinophils in Health and Disease

Lee, J. & Rosenberg, H., 2013, Elsevier Inc.

Research output: Book/ReportBook

20 Scopus citations

Eosinophils mediate protective immunity against secondary nematode infection

Huang, L., Gebreselassie, N. G., Gagliardo, L. F., Ruyechan, M. C., Luber, K. L., Lee, N. A., Lee, J. J. & Appleton, J. A., Jan 1 2015, In : Journal of Immunology. 194, 1, p. 283-290 8 p.

Research output: Contribution to journalArticle

32 Scopus citations

Eosinophils Mediate Tissue Injury in the Autoimmune Skin Disease Bullous Pemphigoid

Lin, L., Hwang, B. J., Culton, D. A., Li, N., Burette, S., Koller, B. H., Messingham, K. A., Fairley, J. A., Lee, J. J., Hall, R. P., An, L., Diaz, L. A. & Liu, Z., May 1 2018, In : Journal of Investigative Dermatology. 138, 5, p. 1032-1043 12 p.

Research output: Contribution to journalArticle

22 Scopus citations

Eosinophils oxidize damage-associated molecular pattern molecules derived from stressed cells

Lotfi, R., Herzog, G. I., DeMarco, R. A., Beer-Stolz, D., Lee, J. J., Rubartelli, A., Schrezenmeier, H. & Lotze, M. T., Oct 15 2009, In : Journal of Immunology. 183, 8, p. 5023-5031 9 p.

Research output: Contribution to journalArticle

67 Scopus citations

Eosinophils preserve parasitic nematode larvae by regulating local immunity

Gebreselassie, N. G., Moorhead, A. R., Fabre, V., Gagliardo, L. F., Lee, N. A., Lee, J. J. & Appleton, J. A., Jan 1 2012, In : Journal of Immunology. 188, 1, p. 417-425 9 p.

Research output: Contribution to journalArticle

60 Scopus citations

Eosinophils promote antiviral immunity in mice infected with influenza A virus

Samarasinghe, A. E., Melo, R. C. N., Duan, S., Le Messurier, K. S., Liedmann, S., Surman, S. L., Lee, J. J., Hurwitz, J. L., Thomas, P. G. & McCullers, J. A., Apr 15 2017, In : Journal of Immunology. 198, 8, p. 3214-3226 13 p.

Research output: Contribution to journalArticle

44 Scopus citations

Eosinophils regulate dendritic cells and Th2 pulmonary immune responses following allergen provocation

Jacobsen, E. A., Zellner, K. R., Colbert, D., Lee, N. A. & Lee, J. J., Dec 1 2011, In : Journal of Immunology. 187, 11, p. 6059-6068 10 p.

Research output: Contribution to journalArticle

77 Scopus citations

Eosinophils regulate peripheral B cell numbers in both mice and humans

Wong, T. W., Doyle, A. D., Lee, J. J. & Jelinek, D. F., Apr 15 2014, In : Journal of Immunology. 192, 8, p. 3548-3558 11 p.

Research output: Contribution to journalArticle

27 Scopus citations

Eosinophils utilize multiple chemokine receptors for chemotaxis to the parasitic nematode strongyloides stercoralis

Stein, L. H., Redding, K. M., Lee, J. J., Nolan, T. J., Schad, G. A., Lok, J. B. & Abraham, D., Oct 1 2009, In : Journal of Innate Immunity. 1, 6, p. 618-630 13 p.

Research output: Contribution to journalArticle

24 Scopus citations

Epithelial mucin genes

Gendler, S. J. & Spicer, A. P., Jan 1 1995, In : Annual Review of Physiology. 57, p. 607-634 28 p.

Research output: Contribution to journalReview article

813 Scopus citations

ErbB-β-catenin complexes are associated with human infiltrating ductal breast and murine mammary tumor virus (MMTV)-Wnt-1 and MMTV-c-Neu transgenic carcinomas

Schroeder, J. A., Adriance, M. C., McConnell, E. J., Thompson, M. C., Pockaj, B. & Gendler, S. J., Jun 21 2002, In : Journal of Biological Chemistry. 277, 25, p. 22692-22698 7 p.

Research output: Contribution to journalArticle

75 Scopus citations

Erratum: Mast cells are required for full expression of allergen/SEB-induced skin inflammation (Journal of Investigative Dermatology (2013) 133 (2695-2705) DOI: 10.1038/jid.2013.250)

Ando, T., Matsumoto, K., Namiranian, S., Yamashita, H., Glatthorn, H., Kimura, M., Dolan, B. R., Lee, J. J., Galli, S. J., Kawakami, Y., Jamora, C. & Kawakami, T., Mar 12 2015, In : Journal of Investigative Dermatology. 135, 3, 1 p.

Research output: Contribution to journalComment/debate

Erratum: Integrin-ligand binding properties govern cell migration speed through cell-substratum adhesiveness (Nature (1997) 385 (537-540))

Palecek, S. P., Loftus, J. C., Ginsberg, M. H., Lauffenburger, D. A. & Horwitz, A. F., 1997, In : Nature. 388, 6638, 1 p.

Research output: Contribution to journalComment/debate

Open Access
7 Scopus citations

Erratum: Chromosome 1 Charcot-Marie-Tooth disease (CMT1B) locus in the Fcγ receptor gene region (Human Genetics (1991) 88 (1-12))

Lebo, R. V., Chance, P. F., Dyck, P. J., Redila-Flores Ma., T., Lynch, E. D., Golbus, M. S., Bird, T. D., King, M. C., Anderson, L. A., Hall, J., Wiegant, J., Jiang, Z., Dazin, P. F., Punnett, H. H., Schonberg, S. A., Moore, K., Shull, M. M., Gendler, S. & Hurko, O., Jan 1 1993, In : Human genetics. 91, 3, 1 p.

Research output: Contribution to journalComment/debate

Erratum: ATPase activity of purified multidrug resistance-associated protein (Journal of Biological Chemistry (1997) 272 (30962-30968))

Chang, X. B., Hou, Y. X. & Riordan, J. R., Mar 27 1998, In : Journal of Biological Chemistry. 273, 13, 1 p.

Research output: Contribution to journalComment/debate

1 Scopus citations

Estrogen receptor does not directly regulate the murine Muc-1 promoter

Zhou, X., DeSouza, M. M., Julian, J., Gendler, S. J. & Carson, D. D., Aug 25 1998, In : Molecular and Cellular Endocrinology. 143, 1-2, p. 65-78 14 p.

Research output: Contribution to journalArticle

21 Scopus citations

EUS-guided portal injection chemotherapy for treatment of hepatic metastases: Feasibility in the acute porcine model

Faigel, D. O., Lake, D. F., Landreth, T. L., Kelman, C. C. & Marler, R. J., Feb 1 2016, In : Gastrointestinal Endoscopy. 83, 2, p. 444-446 3 p.

Research output: Contribution to journalArticle

12 Scopus citations

Evaluation of 5-aminosalicylic acid (5-ASA) for cancer chemoprevention: Lack of efficacy against nascent adenomatous polyps in the Apc(Min) mouse

Ritland, S. R., Leighton, J. A., Hirsch, R. E., Morrow, J. D., Weaver, A. L. & Gendler, S. J., Apr 1 1999, In : Clinical Cancer Research. 5, 4, p. 855-863 9 p.

Research output: Contribution to journalArticle

39 Scopus citations

Evidence That Gallbladder Epithelial Mucin Enhances Cholesterol Cholelithogenesis in MUC1 Transgenic Mice

Wang, H. H., Afdhal, N. H., Gendler, S. J. & Wang, D. Q. H., Jul 2006, In : Gastroenterology. 131, 1, p. 210-222 13 p.

Research output: Contribution to journalArticle

24 Scopus citations

Exogenous interleukin-17a inhibits eosinophil differentiation and alleviates allergic airway inflammation

Tian, B. P., Hua, W., Xia, L. X., Jin, Y., Lan, F., Lee, J. J., Lee, N. A., Li, W., Ying, S. M., Chen, Z. H. & Shen, H. H., Apr 1 2015, In : American Journal of Respiratory Cell and Molecular Biology. 52, 4, p. 459-470 12 p.

Research output: Contribution to journalArticle

13 Scopus citations

Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells

Valadi, H., Ekström, K., Bossios, A., Sjöstrand, M., Lee, J. J. & Lötvall, J. O., Jun 1 2007, In : Nature Cell Biology. 9, 6, p. 654-659 6 p.

Research output: Contribution to journalArticle

6167 Scopus citations

Experimentally induced leptospirosis in coyotes (Canis latrans).

Marler, R. J., Cook, J. E. & Kerr, A. I., Aug 1 1979, In : American Journal of Veterinary Research. 40, 8, p. 1115-1119 5 p.

Research output: Contribution to journalArticle

2 Scopus citations

Expression and steroid hormonal control of muc-1 in the mouse uterus

Surveyor, G. A., Gendler, S. J., Pemberton, L., Das, S. K., Chakraborty, I., Julian, J., Pimental, R. A., Wegner, C. C., Dey, S. K. & Carson, D. D., Aug 1995, In : Endocrinology. 136, 8, p. 3639-3647 9 p.

Research output: Contribution to journalArticle

230 Scopus citations

Expression of an active proteinase inhibitor, α1-antichymotrypsin, by human breast epithelial cells

Gendler, S. J. & Tökés, Z. A., Jun 19 1986, In : BBA - General Subjects. 882, 2, p. 242-253 12 p.

Research output: Contribution to journalArticle

4 Scopus citations

Expression of human MUC1 during early pregnancy in the human MUC1 transgenic mouse model

Dharmaraj, N., Gendler, S. J. & Carson, D. D., Dec 1 2009, In : Biology of Reproduction. 81, 6, p. 1182-1188 7 p.

Research output: Contribution to journalArticle

19 Scopus citations

Expression of IL-5 alters bone metabolism and induces ossification of the spleen in transgenic mice

Macias, M. P., Fitzpatrick, L. A., Brenneise, I., McGarry, M. P., Lee, J. J. & Lee, N. A., Jan 1 2001, In : Journal of Clinical Investigation. 107, 8, p. 949-959 11 p.

Research output: Contribution to journalArticle

Open Access
47 Scopus citations

Expression of IL-5 in Thymocytes/T Cells Leads to the Development of a Massive Eosinophilia, Extramedullary Eosinophilopoiesis, and Unique Histopathologies

Lee, N. A., McGarry, M. P., Larson, K. A., Horton, M. A., Kristensen, A. B. & Lee, J. J., Feb 1 1997, In : Journal of Immunology. 158, 3, p. 1332-1344 13 p.

Research output: Contribution to journalArticle

181 Scopus citations

Expression of the cereblon binding protein argonaute 2 plays an important role for multiple myeloma cell growth and survival

Xu, Q., Hou, Y. X., Langlais, P. R., Erickson, P., Zhu, J., Shi, C. X., Luo, M., Zhu, Y., Xu, Y., Mandarino, L. J., Stewart, A. K. & Chang, X-B. D., May 3 2016, In : BMC Cancer. 16, 1, 297.

Research output: Contribution to journalArticle

20 Scopus citations

Expression of the gene coding for a human mucin in mouse mammary tumor cells can affect their tumorigenicity

Lalani, E. N., Berdichevsky, F., Boshell, M., Shearer, M., Wilson, D., Stauss, H., Gendler, S. J. & Taylor-Papadimitrious, J., Oct 2 1991, In : Journal of Biological Chemistry. 266, 23, p. 15420-15426 7 p.

Research output: Contribution to journalArticle

62 Scopus citations

Expression of the secondary granule proteins major basic protein 1 (MBP-1) and eosinophil peroxidase (EPX) is required for eosinophilopoiesis in mice

Doyle, A. D., Jacobsen, E. A., Ochkur, S. I., McGarry, M. P., Shim, K. G., Nguyen, D. T. C., Protheroe, C., Colbert, D., Kloeber, J., Neely, J., Shim, K. P., Dyer, K. D., Rosenberg, H. F., Lee, J. J. & Lee, N. A., Aug 1 2013, In : Blood. 122, 5, p. 781-790 10 p.

Research output: Contribution to journalArticle

47 Scopus citations