Biochemistry and Molecular Biology

Research Output

2011

The Pyk2 FERM regulates Pyk2 complex formation and phosphorylation

Riggs, D., Yang, Z., Kloss, J. & Loftus, J. C., Jan 2011, In : Cellular Signalling. 23, 1, p. 288-296 9 p.

Research output: Contribution to journalArticle

17 Scopus citations

Update on clinical and immunological features of eosinophilic gastrointestinal diseases

Masterson, J. C., Furuta, G. T. & Lee, J. J., Oct 2011, In : Current Opinion in Gastroenterology. 27, 6, p. 515-522 8 p.

Research output: Contribution to journalReview article

29 Scopus citations

What is the functional role of the thalidomide binding protein cereblon?

Chang, X. B. & Keith Stewart, A., Dec 1 2011, In : International Journal of Biochemistry and Molecular Biology. 2, 3, p. 287-294 8 p.

Research output: Contribution to journalReview article

45 Scopus citations
2010

Airway eosinophilia in remission and progression of asthma: Accumulation with a fast decline of FEV1

Broekema, M., Volbeda, F., Timens, W., Dijkstra, A., Lee, N. A., Lee, J. J., Lodewijk, M. E., Postma, D. S., Hylkema, M. N. & Ten Hacken, N. H. T., Sep 1 2010, In : Respiratory Medicine. 104, 9, p. 1254-1262 9 p.

Research output: Contribution to journalArticle

47 Scopus citations

Altered eosinophil profile in mice with ST6Gal-1 deficiency: An additional role for ST6Gal-1 generated by the P1 promoter in regulating allergic inflammation

Nasirikenari, M., Chandrasekaran, E. V., Matta, K. L., Segal, B. H., Bogner, P. N., Lugade, A. A., Thanavala, Y., Lee, J. J. & Lau, J. T. Y., Mar 2010, In : Journal of Leukocyte Biology. 87, 3, p. 457-466 10 p.

Research output: Contribution to journalArticle

25 Scopus citations

Analysis of a cholera toxin B subunit (CTB) and human mucin 1 (MUC1) conjugate protein in a MUC1-tolerant mouse model

Pinkhasov, J., Alvarez, M. L., Pathangey, L. B., Tinder, T. L., Mason, H. S., Walmsley, A. M., Gendler, S. J. & Mukherjee, P., Dec 2010, In : Cancer Immunology, Immunotherapy. 59, 12, p. 1801-1811 11 p.

Research output: Contribution to journalArticle

12 Scopus citations

Dimeric arrangement of the parathyroid hormone receptor and a structural mechanism for ligand-induced dissociation

Pioszak, A. A., Harikumar, K. G., Parker, N. R., Miller, L. J. & Xu, H. E., Apr 16 2010, In : Journal of Biological Chemistry. 285, 16, p. 12435-12444 10 p.

Research output: Contribution to journalArticle

49 Scopus citations

Elucidation of the active conformation of the amino terminus of receptor-bound secretin using intramolecular disulfide bond constraints

Dong, M., Pinon, D. I., Bordner, A. J. & Miller, L. J., Oct 2010, In : Bioorganic and Medicinal Chemistry Letters. 20, 20, p. 6040-6044 5 p.

Research output: Contribution to journalArticle

5 Scopus citations

Eosinophils in health and disease: The LIAR hypothesis

Lee, J. J., Jacobsen, E. A., McGarry, M. P., Schleimer, R. P. & Lee, N. A., Apr 2010, In : Clinical and Experimental Allergy. 40, 4, p. 563-575 13 p.

Research output: Contribution to journalComment/debate

166 Scopus citations

Importance of lipid-exposed residues in transmembrane segment four for family B calcitonin receptor homo-dimerization

Harikumar, K. G., Ball, A. M., Sexton, P. M. & Miller, L. J., Sep 2010, In : Regulatory Peptides. 164, 2-3, p. 113-119 7 p.

Research output: Contribution to journalArticle

22 Scopus citations

Longevity and age-related pathology of mice deficient in pregnancy-associated plasma protein-a

Conover, C. A., Bale, L. K., Mader, J. R., Mason, M. A., Keenan, K. P. & Marler, R. J., Jun 2010, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 65 A, 6, p. 590-599 10 p.

Research output: Contribution to journalArticle

60 Scopus citations

Modulation of cell surface expression of nonactivated cholecystokinin receptors using bivalent ligand-induced internalization

Harikumar, K. G., Akgün, E., Portoghese, P. S. & Miller, L. J., Apr 8 2010, In : Journal of Medicinal Chemistry. 53, 7, p. 2836-2842 7 p.

Research output: Contribution to journalArticle

14 Scopus citations

Molecular mechanism of ATP-dependent solute transport by multidrug resistance-associated protein 1.

Chang, X. B., 2010, In : Methods in molecular biology (Clifton, N.J.). 596, p. 223-249 27 p.

Research output: Contribution to journalReview article

25 Scopus citations

MultiRTA: A simple yet reliable method for predicting peptide binding affinities for multiple class II MHC allotypes

Bordner, A. J. & Mittelmann, H. D., Sep 24 2010, In : BMC bioinformatics. 11, 482.

Research output: Contribution to journalArticle

31 Scopus citations

Murine lung eosinophil activation and chemokine production in allergic airway inflammation

Rose, C. E., Lannigan, J. A., Kim, P., Lee, J. J., Fu, S. M. & Sung, S. S. J., 2010, In : Cellular and Molecular Immunology. 7, 5, p. 361-374 14 p.

Research output: Contribution to journalArticle

42 Scopus citations

Novel model of TH2-polarized chronic ileitis: The SAMPl mouse

McNamee, E. N., Wermers, J. D., Masterson, J. C., Collins, C. B., Matthew, D. P., Lebsack, B. A., Fillon, S., Robinson, Z. D., Grenawalt, J., Lee, J. J., Jedlicka, P., Furuta, G. T. & Rivera-Nieves, J., 2010, In : Inflammatory bowel diseases. 16, 5, p. 743-752 10 p.

Research output: Contribution to journalArticle

26 Scopus citations

Orientation-dependent backbone-only residue pair scoring functions for fixed backbone protein design

Bordner, A. J., Apr 16 2010, In : BMC bioinformatics. 11, 192.

Research output: Contribution to journalArticle

5 Scopus citations

Prediction of the binding affinities of peptides to class II MHC using a regularized thermodynamic model

Bordner, A. J. & Mittelmann, H. D., Jan 20 2010, In : BMC bioinformatics. 11, 41.

Research output: Contribution to journalArticle

23 Scopus citations

Refinement of the pharmacophore of an agonist ligand of the secretin receptor using conformationally constrained cyclic hexapeptides

Dong, M., Narang, P., Pinon, D. I., Bordner, A. J. & Miller, L. J., Jun 2010, In : Peptides. 31, 6, p. 1094-1098 5 p.

Research output: Contribution to journalArticle

3 Scopus citations

Reprogrammed FoxP3+ T regulatory cells become IL-17+ antigen-specific autoimmune effectors in vitro and in vivo (The Journal of Immunology (2008) 181, (3137-3147))

Radhakrishnan, S., Cabrera, R., Schenk, E. L., Nava-Parada, P., Bell, M. P., Van Keulen, V. P., Marler, R. J., Felts, S. J. & Pease, L. R., Jun 1 2010, In : Journal of Immunology. 184, 11, p. 6556 1 p.

Research output: Contribution to journalComment/debate

5 Scopus citations

Secretin Receptor Dimerization: A Possible Functionally Important Paradigm for Family B G Protein-Coupled Receptors

Harikumar, K. G., Dong, M. & Miller, L. J., Jul 15 2010, GPCR Molecular Pharmacology and Drug Targeting: Shifting Paradigms and New Directions. John Wiley and Sons, p. 138-164 27 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Structural conservation in band 4.1, ezrin, radixin, moesin (FERM) domains as a guide to identify inhibitors of the proline-rich tyrosine kinase 2

Meurice, N., Wang, L., Lipinski, C. A., Yang, Z., Hulme, C. & Loftus, J. C., 2010, In : Journal of Medicinal Chemistry. 53, 2, p. 669-677 9 p.

Research output: Contribution to journalArticle

10 Scopus citations

Targeting Pyk2 for therapeutic intervention

Lipinski, C. A. & Loftus, J. C., Jan 2010, In : Expert opinion on therapeutic targets. 14, 1, p. 95-108 14 p.

Research output: Contribution to journalReview article

72 Scopus citations

Towards universal structure-based prediction of class II MHC epitopes for diverse allotypes

Bordner, A. J., 2010, In : PloS one. 5, 12, e14383.

Research output: Contribution to journalArticle

17 Scopus citations

TROY (TNFRSF19) is overexpressed in advanced glial tumors and promotes glioblastoma cell invasion via Pyk2-Rac1 signaling

Paulino, V. M., Yang, Z., Kloss, J., Ennis, M. J., Armstrong, B. A., Loftus, J. C. & Tran, N. L., Nov 2010, In : Molecular Cancer Research. 8, 11, p. 1558-1567 10 p.

Research output: Contribution to journalArticle

45 Scopus citations
2009

A Novel Histologic Scoring System to Evaluate Mucosal Biopsies From Patients With Eosinophilic Esophagitis

Protheroe, C., Woodruff, S. A., de Petris, G., Mukkada, V., Ochkur, S. I., Janarthanan, S., Lewis, J. C., Pasha, S., Lunsford, T., Harris, L., Sharma, V. K., McGarry, M. P., Lee, N. A., Furuta, G. T. & Lee, J. J., Jul 2009, In : Clinical Gastroenterology and Hepatology. 7, 7, p. 749-755.e11

Research output: Contribution to journalArticle

139 Scopus citations
2 Scopus citations

Differential effects of Pyk2 and FAK on the hypertrophic response of cardiac myocytes

Menashi, E. B. & Loftus, J. C., Aug 2009, In : Cell and Tissue Research. 337, 2, p. 243-255 13 p.

Research output: Contribution to journalArticle

7 Scopus citations

Effects of putative catalytic base mutation E211Q on ABCG2-mediated methotrexate transport

Hou, Y. X., Li, C. Z., Palaniyandi, K., Magtibay, P. M., Homolya, L., Sarkadi, B. & Chang, X. B., 2009, In : Biochemistry. 48, 38, p. 9122-9131 10 p.

Research output: Contribution to journalArticle

8 Scopus citations

Eosinophil deficiency compromises parasite survival in chronic nematode infection

Fabre, V., Beiting, D. P., Bliss, S. K., Gebreselassie, N. G., Gagliardo, L. F., Lee, N. A., Lee, J. J. & Appleton, J. A., Feb 1 2009, In : Journal of Immunology. 182, 3, p. 1577-1583 7 p.

Research output: Contribution to journalArticle

Open Access
109 Scopus citations

Eosinophils oxidize damage-associated molecular pattern molecules derived from stressed cells

Lotfi, R., Herzog, G. I., DeMarco, R. A., Beer-Stolz, D., Lee, J. J., Rubartelli, A., Schrezenmeier, H. & Lotze, M. T., Oct 15 2009, In : Journal of Immunology. 183, 8, p. 5023-5031 9 p.

Research output: Contribution to journalArticle

70 Scopus citations

Eosinophils utilize multiple chemokine receptors for chemotaxis to the parasitic nematode strongyloides stercoralis

Stein, L. H., Redding, K. M., Lee, J. J., Nolan, T. J., Schad, G. A., Lok, J. B. & Abraham, D., Oct 2009, In : Journal of Innate Immunity. 1, 6, p. 618-630 13 p.

Research output: Contribution to journalArticle

24 Scopus citations

Expression of human MUC1 during early pregnancy in the human MUC1 transgenic mouse model

Dharmaraj, N., Gendler, S. J. & Carson, D. D., 2009, In : Biology of Reproduction. 81, 6, p. 1182-1188 7 p.

Research output: Contribution to journalArticle

20 Scopus citations

Functional importance of a structurally distinct homodimeric complex of the family B G protein-coupled secretin receptor

Gao, F., Harikumar, K. G., Dong, M., Lam, P. C. H., Sexton, P. M., Christopoulos, A., Bordner, A., Abagyan, R. & Miller, L. J., Aug 2009, In : Molecular pharmacology. 76, 2, p. 264-274 11 p.

Research output: Contribution to journalArticle

43 Scopus citations

Induced association of μ opioid (MOP) and type 2 cholecystokinin (CCK 2) receptors by novel bivalent ligands

Zheng, Y., Akgiin, E., Harikumar, K. G., Hopson, J., Powers, M. D., Lunzer, M. M., Miller, L. J. & Portoghese, P. S., Jan 22 2009, In : Journal of Medicinal Chemistry. 52, 2, p. 247-258 12 p.

Research output: Contribution to journalArticle

47 Scopus citations

Intravitreal alemtuzumab penetrates full-thickness retina in rabbit eyes

Ekdawi, N. S., Pulido, J. S., Itty, S., Marler, R. J., Herman, D. C., Hardwig, P., Mohney, B. G., Valyi-Nagy, T. & Shukla, D., Nov 1 2009, In : Retina. 29, 10, p. 1532-1534 3 p.

Research output: Contribution to journalArticle

3 Scopus citations

Lack of muc1-regulated β-catenin stability results in aberrant expansion of cd11b +gr1 + Myeloid-derived suppressor cells from the bone marrow

Poh, T. W., Bradley, J. M., Mukherjee, P. & Gendler, S. J., Apr 15 2009, In : Cancer research. 69, 8, p. 3554-3562 9 p.

Research output: Contribution to journalArticle

25 Scopus citations

Molecular basis of association of receptor activity-modifying protein 3 with the family B G protein-coupled secretin receptor

Harikumar, K. G., Simms, J., Christopoulos, G., Sexton, P. M. & Miller, L. J., Dec 15 2009, In : Biochemistry. 48, 49, p. 11773-11785 13 p.

Research output: Contribution to journalArticle

39 Scopus citations

Molecular basis of metastasis [8]

Lee, J. J. & Lotze, M. T., Apr 16 2009, In : New England Journal of Medicine. 360, 16, 1 p.

Research output: Contribution to journalLetter

9 Scopus citations

Mouse eosinophils possess potent antibacterial properties in vivo

Linch, S. N., Kelly, A. M., Danielson, E. T., Pero, R., Lee, J. J. & Gold, J. A., Nov 2009, In : Infection and Immunity. 77, 11, p. 4976-4982 7 p.

Research output: Contribution to journalArticle

55 Scopus citations

Pathology in practice

Gades, N. M. & Marier, R. J., Jun 15 2009, In : Journal of the American Veterinary Medical Association. 234, 12, p. 1535-1537 3 p.

Research output: Contribution to journalArticle

3 Scopus citations

Predicting protein-protein binding sites in membrane proteins

Bordner, A. J., Sep 24 2009, In : BMC bioinformatics. 10, p. 312 1 p., 312.

Research output: Contribution to journalArticle

22 Scopus citations

Synthesis and in vitro characterization of radioiodinatable benzodiazepines selective for type 1 and Type 2 cholecystokinin receptors

Akgün, E., Körner, M., Gao, F., Harikumar, K. G., Waser, B., Reubi, J. C., Portoghese, P. S. & Miller, L. J., Apr 9 2009, In : Journal of Medicinal Chemistry. 52, 7, p. 2138-2147 10 p.

Research output: Contribution to journalArticle

22 Scopus citations

Telomerase deficiency and telomere dysfunction inhibit mammary tumors induced by polyomavirus middle T oncogene

Jaskelioff, M., Song, W., Xia, J., Liu, C., Kramer, J., Koido, S., Gendler, S. J., Calderwood, S. K. & Gong, J., Dec 1 2009, In : Oncogene. 28, 48, p. 4225-4236 12 p.

Research output: Contribution to journalArticle

16 Scopus citations

The Pyk2 FERM domain as a target to inhibit glioma migration

Loftus, J. C., Yang, Z., Tran, N. L., Kloss, J., Viso, C., Berens, M. E. & Lipinski, C. A., Jun 2009, In : Molecular cancer therapeutics. 8, 6, p. 1505-1514 10 p.

Research output: Contribution to journalArticle

25 Scopus citations

Tumor necrosis factor-like weak inducer of apoptosis stimulation of glioma cell survival is dependent on Akt2 function

Fortin, S. P., Ennis, M. J., Savitch, B. A., Carpentieri, D., McDonough, W. S., Winkles, J. A., Loftus, J. C., Kingsley, C., Hostetter, G. & Tran, N. L., Nov 2009, In : Molecular Cancer Research. 7, 11, p. 1871-1881 11 p.

Research output: Contribution to journalArticle

43 Scopus citations

Use of fluorescence indicators in receptor ligands.

Harikumar, K. G. & Miller, L. J., 2009, In : Methods in molecular biology (Clifton, N.J.). 552, p. 279-291 13 p.

Research output: Contribution to journalArticle

2 Scopus citations
2008

A3 adenosine receptor signaling influences pulmonary inflammation and fibrosis

Morschl, E., Molina, J. G., Volmer, J. B., Mohsenin, A., Pero, R. S., Hong, J. S., Kheradmand, F., Lee, J. J. & Blackburn, M. R., Dec 1 2008, In : American journal of respiratory cell and molecular biology. 39, 6, p. 697-705 9 p.

Research output: Contribution to journalArticle

39 Scopus citations

Absence of histologic retinal toxicity of intravitreal nanogold in a rabbit model

Bakri, S. J., Pulido, J. S., Mukherjee, P., Marler, R. J. & Mukhopadhyay, D., Jan 1 2008, In : Retina. 28, 1, p. 147-149 3 p.

Research output: Contribution to journalArticle

44 Scopus citations

Allergic pulmonary inflammation in mice is dependent on eosinophil-induced recruitment of effector T cells

Jacobsen, E. A., Ochkur, S. I., Pero, R. S., Taranova, A. G., Protheroe, C. A., Colbert, D. C., Lee, N. A. & Lee, J. J., Mar 17 2008, In : Journal of Experimental Medicine. 205, 3, p. 699-710 12 p.

Research output: Contribution to journalArticle

180 Scopus citations