Biochemistry and Molecular Biology

Research Output

2000

A novel CFTR disease-associated mutation causes addition of an extra N-linked oligosaccharide

Hämmerle, M. M., Aleksandrov, A. A., Chang, X. B. & Riordan, J. R., Jan 1 2000, In : Glycoconjugate Journal. 17, 11, p. 807-813 7 p.

Research output: Contribution to journalArticle

9 Scopus citations

CD23 exhibits negative regulatory effects on allergic sensitization and airway hyperresponsiveness

Haczku, A., Takeda, K., Hamelmann, E., Loader, J., Joetham, A., Redai, I., Irvin, C. G., Lee, J. J., Kikutani, H., Conrad, D. & Gelfand, E. W., 2000, In : American journal of respiratory and critical care medicine. 161, 3 I, p. 952-960 9 p.

Research output: Contribution to journalArticle

65 Scopus citations

Differential recognition of snake venom proteins expressing specific Arg-Gly-Asp (RGD) sequence motifs by wild-type and variant integrin αIIbβ3: Further evidence for distinct sites of RGD ligand recognition exhibiting negative allostery

Rahman, S., Flynn, G., Aitken, A., Patel, Y., Hussain, F., Lu, X., Loftus, J. C., French, D., Wijelath, E., Strand, K. & Savidge, G. F., Dec 1 2000, In : Biochemical Journal. 345, 3, p. 701-709 9 p.

Research output: Contribution to journalArticle

16 Scopus citations

Effect of alcohols on G-protein coupling of serotonin(1A) receptors from bovine hippocampus

Harikumar, K. G. & Chattopadhyay, A., Aug 1 2000, In : Brain Research Bulletin. 52, 6, p. 597-601 5 p.

Research output: Contribution to journalArticle

17 Scopus citations

Eosinophil major basic protein-1 does not contribute to allergen-induced airway pathologies in mouse models of asthma

Denzler, K. L., Farmer, S. C., Crosby, J. R., Borchers, M., Cieslewicz, G., Larson, K. A., Cormier-Regard, S., Lee, N. A. & Lee, J. J., Nov 15 2000, In : Journal of Immunology. 165, 10, p. 5509-5517 9 p.

Research output: Contribution to journalArticle

Open Access
102 Scopus citations

Eosinophils are cellular targets of the novel uteroplacental heparin-binding cytokine decidual/trophoblast prolactin-related protein

Wang, D., Ishimura, R., Walia, D. S., Muller, H., Dai, G., Hunt, J. S., Lee, N. A., Lee, J. J. & Soares, M. J., Jan 1 2000, In : Journal of Endocrinology. 167, 1, p. 15-28 14 p.

Research output: Contribution to journalArticle

Open Access
25 Scopus citations

Identification of a new murine eosinophil major basic protein (mMBP) gene: Cloning and characterization of mMBP-2

Macias, M. P., Welch, K. C., Denzler, K. L., Larson, K. A., Lee, N. A. & Lee, J. J., Jan 1 2000, In : Journal of Leukocyte Biology. 67, 4, p. 567-576 10 p.

Research output: Contribution to journalArticle

24 Scopus citations

Immobilization of silver ions onto paramagnetic particles for binding and release of a biotin-labeled oligonucleotide

Ramírez-Vick, J. E., García, A. A. & Lee, J., Feb 16 2000, In : Reactive and Functional Polymers. 43, 1, p. 53-62 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

Induction of antitumor immunity by vaccination of dendritic cells transfected with MUC1 RNA

Koido, S., Kashiwaba, M., Chen, D., Gendler, S., Kufe, D. & Gong, J., Nov 15 2000, In : Journal of Immunology. 165, 10, p. 5713-5719 7 p.

Research output: Contribution to journalArticle

Open Access
141 Scopus citations

Inhibition of epidermal growth factor receptor tyrosine kinase fails to suppress adenoma formation in Apc(Min) mice but induces duodenal injury

Ritland, S. R., Gendler, S. J., Burgart, L. J., Fry, D. W., Nelson, J. M., Bridges, A. J., Andress, L. & Karnes, J., Sep 1 2000, In : Cancer research. 60, 17, p. 4678-4681 4 p.

Research output: Contribution to journalArticle

16 Scopus citations

Ligand binding to integrins

Plow, E. F., Haas, T. A., Zhang, L., Loftus, J. & Smith, J. W., Jul 21 2000, In : Journal of Biological Chemistry. 275, 29, p. 21785-21788 4 p.

Research output: Contribution to journalShort survey

1010 Scopus citations

Mercury induces regional and cell-specific stress protein expression in rat kidney

Goering, P. L., Fisher, B. R., Noren, B. T., Papaconstantinou, A., Rojko, J. L. & Marler, R. J., Feb 28 2000, In : Toxicological Sciences. 53, 2, p. 447-457 11 p.

Research output: Contribution to journalArticle

71 Scopus citations

Mice with spontaneous pancreatic cancer naturally develop MUC-1-specific CTLs that eradicate tumors when adoptively transferred

Mukherjee, P., Ginardi, A. R., Madsen, C. S., Sterner, C. J., Adriance, M. C., Tevethia, M. J. & Gendler, S. J., Sep 15 2000, In : Journal of Immunology. 165, 6, p. 3451-3460 10 p.

Research output: Contribution to journalArticle

Open Access
75 Scopus citations

MUC1/episialin: A critical barrier in the female reproductive tract

Desouza, M. M., Surveyor, G. A., Price, R. E., Julian, J., Kardon, R., Zhou, X., Gendler, S., Hilkens, J. & Carson, D. D., Jan 1 2000, In : Journal of Reproductive Immunology. 45, 2, p. 127-158 32 p.

Research output: Contribution to journalArticle

127 Scopus citations

Multidrug resistance protein MRP1 reconstituted into lipid vesicles: Secondary structure and nucleotide-induced tertiary structure changes

Manciu, L., Chang, X. B., Riordan, J. R. & Ruysschaert, J. M., Oct 24 2000, In : Biochemistry. 39, 42, p. 13026-13033 8 p.

Research output: Contribution to journalArticle

26 Scopus citations

Role of disulfides and sulfhydryl groups in agonist and antagonist binding in serotonin(1A) receptors from bovine hippocampus

Harikumar, K. G., John, P. T. & Chattopadhyay, A., Jan 1 2000, In : Cellular and molecular neurobiology. 20, 6, p. 665-681 17 p.

Research output: Contribution to journalArticle

18 Scopus citations

Role of IL-5 in innate and adaptive immunity to larval Strongyloides stercoralis in mice

Herbert, D. R., Lee, J. J., Lee, N. A., Nolan, T. J., Schad, G. A. & Abraham, D., Oct 15 2000, In : Journal of Immunology. 165, 8, p. 4544-4551 8 p.

Research output: Contribution to journalArticle

Open Access
94 Scopus citations

Role of MUC1 in intestinal mucin accumulation in the CF mouse

Gendler, S. J., Hinojosa-Kurtzberg, M., Axelsson, K. A., Thomsson, K. A. & Hansson, G. C., Dec 1 2000, In : Pediatric pulmonology. 30, SUPPL. 20, 1 p.

Research output: Contribution to journalArticle

Selection and characterization of MUC1-specific CD8+ T cells from MUC1 transgenic mice immunized with dendritic-carcinoma fusion cells

Gong, J., Apostolopoulos, V., Chen, D., Chen, H., Koido, S., Gendler, S. J., Mckenzie, I. F. & Kufe, D., Dec 12 2000, In : Immunology. 101, 3, p. 316-324 9 p.

Research output: Contribution to journalArticle

49 Scopus citations

Striated muscle-specific β(1D)-integrin and FAK are involved in cardiac myocyte hypertrophic response pathway

Pham, C. G., Harpf, A. E., Keller, R. S., Vu, H. T., Shai, S. Y., Loftus, J. C. & Ross, R. S., Jan 1 2000, In : American Journal of Physiology - Heart and Circulatory Physiology. 279, 6 48-6, p. H2916-H2926

Research output: Contribution to journalArticle

104 Scopus citations

T cell suppression as a mechanism for tolerance to MUC1 antigen in MUC1 transgenic mice

Chen, D., Koido, S., Li, Y., Gendler, S. & Gong, J., May 31 2000, In : Breast Cancer Research and Treatment. 60, 2, p. 107-115 9 p.

Research output: Contribution to journalArticle

23 Scopus citations

The non-hydrolytic pathway of cystic fibrosis transmembrane conductance regulator ion channel gating

Aleksandrov, A. A., Chang, X. B., Aleksandrov, L. & Riordan, J. R., Jan 1 2000, In : Journal of Physiology. 528, 2, p. 259-265 7 p.

Research output: Contribution to journalArticle

61 Scopus citations
2001

Autoantibodies to αIIbβ3 in patients with chronic immune thrombocytopenic purpura bind primarily to epitopes on αIIb

McMillan, R., Lopez-Dee, J. & Loftus, J. C., Apr 1 2001, In : Blood. 97, 7, p. 2171-2172 2 p.

Research output: Contribution to journalArticle

22 Scopus citations

Blockade of CD49d inhibits allergic airway pathologies independent of effects on leukocyte recruitment

Borchers, M. T., Crosby, J., Farmer, S., Sypek, J., Ansay, T., Lee, N. A. & Lee, J. J., Apr 2001, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 280, 4 24-4, p. L813-L821

Research output: Contribution to journalArticle

47 Scopus citations

Calogero-Moser models. V - Supersymmetry and quantum Lax pair -

Bordner, A. J., Manton, N. S. & Sasaki, R., Mar 2001, In : Progress of Theoretical Physics. 103, 3, p. 463-487 25 p.

Research output: Contribution to journalArticle

50 Scopus citations

Differential Interactions of Nucleotides at the Two Nucleotide Binding Domains of the Cystic Fibrosis Transmembrane Conductance Regulator

Aleksandrov, L., Mengos, A., Chang, X. B., Aleksandrov, A. & Riordan, J. R., Apr 20 2001, In : Journal of Biological Chemistry. 276, 16, p. 12918-12923 6 p.

Research output: Contribution to journalArticle

84 Scopus citations

Disruption of integrin function in the murine myocardium leads to perinatal lethality, fibrosis, and abnormal cardiac performance

Keller, R. S., Shai, S. Y., Babbitt, C. J., Pham, C. G., Solaro, R. J., Valencik, M. L., Loftus, J. C. & Ross, R. S., Jan 1 2001, In : American Journal of Pathology. 158, 3, p. 1079-1090 12 p.

Research output: Contribution to journalArticle

77 Scopus citations

Early life of cystic fibrosis transmembrane conductance regulator (CFTR) in the cell

Riordan, J. R., Gentzsch, M., Hammerle, M., Chen, J. H., Mengos, A., Jensen, T. & Chang, X. B., Jan 1 2001, In : Kidney international. 60, 2, 1 p.

Research output: Contribution to journalArticle

Expression of IL-5 alters bone metabolism and induces ossification of the spleen in transgenic mice

Macias, M. P., Fitzpatrick, L. A., Brenneise, I., McGarry, M. P., Lee, J. J. & Lee, N. A., Jan 1 2001, In : Journal of Clinical Investigation. 107, 8, p. 949-959 11 p.

Research output: Contribution to journalArticle

Open Access
47 Scopus citations

Extensive eosinophil degranulation and peroxidase-mediated oxidation of airway proteins do not occur in a mouse ovalbumin-challenge model of pulmonary inflammation

Denzler, K. L., Borchers, M. T., Crosby, J. R., Cieslewicz, G., Hines, E. M., Justice, J. P., Cormier, S. A., Lindenberger, K. A., Song, W., Wu, W., Hazen, S. L., Gleich, G. J., Lee, J. J. & Lee, N. A., Aug 1 2001, In : Journal of Immunology. 167, 3, p. 1672-1682 11 p.

Research output: Contribution to journalArticle

Open Access
101 Scopus citations

Influence of organ site and tumor cell type on MUC1-specific tumor immunity

Morikane, K., Tempero, R. M., Sivinski, C. L., Kitajima, S., Gendler, S. J. & Hollingsworth, M. A., Jan 1 2001, In : International Immunology. 13, 2, p. 233-240 8 p.

Research output: Contribution to journalArticle

Open Access
16 Scopus citations

Inhibition of focal adhesion kinase expression or activity disrupts epidermal growth factor-stimulated signaling promoting the migration of invasive human carcinoma cells

Hauck, C. R., Sieg, D. J., Hsia, D. A., Loftus, J. C., Gaarde, W. A., Monia, B. P. & Schlaepfer, D. D., Oct 1 2001, In : Cancer research. 61, 19, p. 7079-7090 12 p.

Research output: Contribution to journalArticle

238 Scopus citations

Intrinsic AHR in IL-5 transgenic mice is dependent on C4+ cells and CD49d-mediated signaling

Borchers, M. T., Crosby, J., Justice, P., Farmer, S., Hines, E., Lee, J. J. & Lee, N. A., 2001, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 281, 3 25-3, p. L653-L659

Research output: Contribution to journalArticle

17 Scopus citations

Letter for Joyce

Gendler, S. J., Nov 1 2001, In : Glycoconjugate Journal. 18, 11-12, p. 839-840 2 p.

Research output: Contribution to journalLetter

Modulation of antagonist binding to serotonin1A receptors from bovine hippocampus by metal ions

Harikumar, K. G. & Chattopadhyay, A., Dec 1 2001, In : Cellular and molecular neurobiology. 21, 5, p. 453-464 12 p.

Research output: Contribution to journalArticle

15 Scopus citations

Mouse eosinophil-associated ribonucleases: A unique subfamily expressed during hematopoiesis

Cormier, S. A., Larson, K. A., Yuan, S., Mitchell, T. L., Lindenberger, K., Carrigan, P., Lee, N. A. & Lee, J. J., May 22 2001, In : Mammalian Genome. 12, 5, p. 352-361 10 p.

Research output: Contribution to journalArticle

36 Scopus citations

MUC1, The renaissance molecule

Gendler, S. J., Jul 1 2001, In : Journal of mammary gland biology and neoplasia. 6, 3, p. 339-353 15 p.

Research output: Contribution to journalReview article

407 Scopus citations

MUC1-specific CTLs are non-functional within a pancreatic tumor microenvironment

Mukherjee, P., Ginardi, A. R., Madsen, C. S., Tinder, T. L., Jacobs, F., Parker, J., Agrawal, B., Longenecker, B. M. & Gendler, S. J., Nov 1 2001, In : Glycoconjugate Journal. 18, 11-12, p. 931-942 12 p.

Research output: Contribution to journalArticle

49 Scopus citations

MUC1-specific cytotoxic T lymphocytes eradicate tumors when adoptively transferred in vivo

Mukherjee, P., Ginardi, A. R., Tinder, T. L., Sterner, C. J. & Gendler, S. J., Mar 1 2001, In : Clinical Cancer Research. 7, 11 SUPPL., p. 848s-855s

Research output: Contribution to journalArticle

45 Scopus citations

Mutations of the Walker B motif in the first nucleotide binding domain of multidrug resistance protein MRP1 prevent conformational maturation

Cui, L., Hou, Y. X., Riordan, J. R. & Chang, X. B., Aug 1 2001, In : Archives of Biochemistry and Biophysics. 392, 1, p. 153-161 9 p.

Research output: Contribution to journalArticle

24 Scopus citations

Nucleotide-induced conformational changes in the human multidrug resistance protein MRP1 are related to the capacity of chemotherapeutic drugs to accumulate or not in resistant cells

Manciu, L., Chang, X. B., Riordan, J. R., Buyse, F. & Ruysschaert, J. M., Mar 23 2001, In : FEBS Letters. 493, 1, p. 31-35 5 p.

Research output: Contribution to journalArticle

19 Scopus citations

Pulmonary T cells and eosinophils: Coconspirators or independent triggers of allergic respiratory pathology?

Lee, N. A., Gelfand, E. W. & Lee, J. J., Jan 1 2001, In : Journal of Allergy and Clinical Immunology. 107, 6, p. 945-957 13 p.

Research output: Contribution to journalArticle

111 Scopus citations

Spontaneous adenocarcinoma mouse models for immunotherapy

Gendler, S. J. & Mukherjee, P., Jan 1 2001, In : Trends in Molecular Medicine. 7, 10, p. 471-475 5 p.

Research output: Contribution to journalReview article

21 Scopus citations

Strain dependence of airway hyperresponsiveness reflects differences in eosinophil localization in the lung

Takeda, K., Haczku, A., Lee, J. J., Irvin, C. G. & Gelfand, E. W., Jan 1 2001, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 281, 2 25-2, p. L394-L402

Research output: Contribution to journalArticle

117 Scopus citations

Temporal association between airway hyperresponsiveness and airway eosinophilia in ovalbumin-sensitized mice

Tomkinson, A., Cieslewicz, G., Duez, C., Larson, K. A., Lee, J. J. & Gelfand, E. W., Jan 1 2001, In : American journal of respiratory and critical care medicine. 163, 3 I, p. 721-730 10 p.

Research output: Contribution to journalArticle

143 Scopus citations

Transgenic MUC1 Interacts with Epidermal Growth Factor Receptor and Correlates with Mitogen-activated Protein Kinase Activation in the Mouse Mammary Gland

Schroeder, J. A., Thompson, M. C., Gardner, M. M. & Gendler, S. J., Apr 20 2001, In : Journal of Biological Chemistry. 276, 16, p. 13057-13064 8 p.

Research output: Contribution to journalArticle

270 Scopus citations

Vaccination with allogeneic dendritic cells fused to carcinoma cells induces antitumor immunity in MUC1 transgenic mice

Tanaka, Y., Koido, S., Chen, D., Gendler, S. J., Kufe, D. & Gong, J., Jan 1 2001, In : Clinical Immunology. 101, 2, p. 192-200 9 p.

Research output: Contribution to journalArticle

57 Scopus citations
2002

Accurate transferable model for water, n-octanol, and n-hexadecane solvation free energies

Bordner, A. J., Cavasotto, C. N. & Abagyan, R. A., Oct 24 2002, In : Journal of Physical Chemistry B. 106, 42, p. 11009-11015 7 p.

Research output: Contribution to journalArticle

46 Scopus citations

A lethal perinatal cardiac phenotype resulting from altered integrin function in cardiomyocytes

Valencik, M. L., Keller, R. S., Loftus, J. C. & McDonald, J. A., Aug 2002, In : Journal of Cardiac Failure. 8, 4, p. 262-272 11 p.

Research output: Contribution to journalArticle

18 Scopus citations

Applications of fluorescence in the characterization of the ligand-binding domain and activation of the cholecystokinin receptor

Harikumar, K. G. & Miller, L. J., Dec 1 2002, In : Pharmacology and Toxicology. 91, 6, p. 286-289 4 p.

Research output: Contribution to journalArticle

4 Scopus citations