Biochemistry and Molecular Biology

Research Output

Article

Distinct molecular mechanisms for agonist peptide binding to types A and B cholecystokinin receptors demonstrated using fluorescence spectroscopy

Harikumar, K. G., Clain, J., Pinon, D. I., Bong, M. & Miller, L. J., Jan 14 2005, In : Journal of Biological Chemistry. 280, 2, p. 1044-1050 7 p.

Research output: Contribution to journalArticle

30 Scopus citations

Domain Interdependence in the Biosynthetic Assembly of CFTR

Cui, L., Aleksandrov, L., Chang, X. B., Hou, Y. X., He, L., Hegedus, T., Gentzsch, M., Aleksandrov, A., Balch, W. E. & Riordan, J. R., Jan 26 2007, In : Journal of Molecular Biology. 365, 4, p. 981-994 14 p.

Research output: Contribution to journalArticle

154 Scopus citations

Downregulation of hematopoietic MUC1 during Experimental colitis increases tumor-promoting myeloid-derived suppressor cells

Poh, T. W., Madsen, C. S., Gorman, J. E., Marler, R. J., Leighton, J. A., Cohen, P. A. & Gendler, S. J., Sep 15 2013, In : Clinical Cancer Research. 19, 18, p. 5039-5052 14 p.

Research output: Contribution to journalArticle

9 Scopus citations

Downregulation of Muc1 in MMTV-c-Neu tumors

Adriance, M. C. & Gendler, S. J., Jan 22 2004, In : Oncogene. 23, 3, p. 697-705 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Dual proinflammatory and antiviral properties of pulmonary eosinophils in respiratory syncytial virus vaccine-enhanced disease

Su, Y. C., Townsend, D., Herrero, L. J., Zaid, A., Rolph, M. S., Gahan, M. E., Nelson, M. A., Rudd, P. A., Matthaei, K. I., Foster, P. S., Dent, L., Tripp, R. A., Lee, J., Simson, L. & Mahalingam, S., Jan 1 2015, In : Journal of virology. 89, 3, p. 1564-1578 15 p.

Research output: Contribution to journalArticle

16 Scopus citations

Early life of cystic fibrosis transmembrane conductance regulator (CFTR) in the cell

Riordan, J. R., Gentzsch, M., Hammerle, M., Chen, J. H., Mengos, A., Jensen, T. & Chang, X. B., Jan 1 2001, In : Kidney international. 60, 2, 1 p.

Research output: Contribution to journalArticle

Early phase bronchoconstriction in the mouse requires allergen-specific IgG

Crosby, J. R., Cieslewicz, G., Borchers, M., Hines, E., Carrigan, P., Lee, J. J. & Lee, N. A., Apr 15 2002, In : Journal of Immunology. 168, 8, p. 4050-4054 5 p.

Research output: Contribution to journalArticle

Open Access
26 Scopus citations

Ectopic expression of IL-5 identifies an additional CD4+ T cell mechanism of airway eosinophil recruitment

Crosby, J. R., Shen, H. H., Borchers, M. T., Justice, J. P., Ansay, T., Lee, J. J. & Lee, N. A., Jun 29 2002, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 282, 1 26-1, p. L99-L108

Research output: Contribution to journalArticle

16 Scopus citations

Effect of alcohols on G-protein coupling of serotonin(1A) receptors from bovine hippocampus

Harikumar, K. G. & Chattopadhyay, A., Aug 1 2000, In : Brain Research Bulletin. 52, 6, p. 597-601 5 p.

Research output: Contribution to journalArticle

17 Scopus citations

Effect of proton pump inhibitor on esophageal eosinophilia

Schroeder, S., Capocelli, K. E., Masterson, J. C., Harris, R., Protheroe, C., Lee, J. J. & Furuta, G. T., Feb 1 2013, In : Journal of pediatric gastroenterology and nutrition. 56, 2, p. 166-172 7 p.

Research output: Contribution to journalArticle

53 Scopus citations

Effects of cholecystokinin-58 on type 1 cholecystokinin receptor function and regulation

Wu, S. V., Harikumar, K. G., Burgess, R. J., Reeve, J. R. & Miller, L. J., Sep 2008, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 295, 3, p. G641-G647

Research output: Contribution to journalArticle

10 Scopus citations

Effects of putative catalytic base mutation E211Q on ABCG2-mediated methotrexate transport

Hou, Y. X., Li, C. Z., Palaniyandi, K., Magtibay, P. M., Homolya, L., Sarkadi, B. & Chang, X. B., Oct 14 2009, In : Biochemistry. 48, 38, p. 9122-9131 10 p.

Research output: Contribution to journalArticle

8 Scopus citations

Effects of raloxifene hydrochloride on endometrial cancer cells in vitro

Hibner, M., Magrina, J. F., Lefler, S. R., Cornella, J. L., Pizarro, A. R. & Loftus, J. C., Jun 1 2004, In : Gynecologic oncology. 93, 3, p. 642-646 5 p.

Research output: Contribution to journalArticle

13 Scopus citations

Efficient molecular mechanics simulations of the folding, orientation, and assembly of peptides in lipid bilayers using an implicit atomic solvation model

Bordner, A. J., Zorman, B. & Abagyan, R., Oct 1 2011, In : Journal of Computer-Aided Molecular Design. 25, 10, p. 895-911 17 p.

Research output: Contribution to journalArticle

3 Scopus citations

Efficient surface expression of platelet GPIIb-IIIa requires both subunits

O'Toole, T. E., Loftus, J. C., Plow, E. F., Glass, A. A., Harper, J. R. & Ginsberg, M. H., 1989, In : Blood. 74, 1, p. 14-18 5 p.

Research output: Contribution to journalArticle

Open Access
116 Scopus citations

EGFRvIII–Stat5 signaling enhances glioblastoma cell migration and survival

Roos, A., Dhruv, H. D., Peng, S., Inge, L. J., Tuncali, S., Pineda, M., Millard, N., Mayo, Z., Eschbacher, J. M., Loftus, J. C., Winkles, J. A. & Tran, N., Jul 1 2018, In : Molecular Cancer Research. 16, 7, p. 1185-1195 11 p.

Research output: Contribution to journalArticle

6 Scopus citations

Elevated expression of Fn14 in non-small cell lung cancer correlates with activated EGFR and promotes tumor cell migration and invasion

Whitsett, T. G., Cheng, E., Inge, L., Asrani, K., Jameson, N. M., Hostetter, G., Weiss, G. J., Kingsley, C. B., Loftus, J. C., Bremner, R., Tran, N. L. & Winkles, J. A., Jul 1 2012, In : American Journal of Pathology. 181, 1, p. 111-120 10 p.

Research output: Contribution to journalArticle

36 Scopus citations

Elucidation of the active conformation of the amino terminus of receptor-bound secretin using intramolecular disulfide bond constraints

Dong, M., Pinon, D. I., Bordner, A. J. & Miller, L. J., Oct 1 2010, In : Bioorganic and Medicinal Chemistry Letters. 20, 20, p. 6040-6044 5 p.

Research output: Contribution to journalArticle

5 Scopus citations

Encephalitis in a confined coyote.

Marler, R. J., Kruckenberg, S. M., Cook, J. E. & O'Keefe, C. M., Nov 1 1976, In : Journal of the American Veterinary Medical Association. 169, 9, p. 964-965 2 p.

Research output: Contribution to journalArticle

1 Scopus citations

Endocytic trafficking routes of wild type and ΔF508 cystic fibrosis transmembrane conductance regulator

Gentzsch, M., Chang, X. B., Cui, L., Wu, Y., Ozols, V. V., Choudhury, A., Pagano, R. E. & Riordan, J. R., Jun 2004, In : Molecular biology of the cell. 15, 6, p. 2684-2696 13 p.

Research output: Contribution to journalArticle

169 Scopus citations

Endoscopic band ligation for closure of GI perforations in a porcine animal model (with video)

Law, R., Deters, J. L., Miller, C. A., Marler, R. J. & Baron, T. H., Oct 1 2014, In : Gastrointestinal endoscopy. 80, 4, p. 717-722 6 p.

Research output: Contribution to journalArticle

3 Scopus citations

Environment and mobility of a series of fluorescent reporters at the amino terminus of structurally related peptide agonists and antagonists bound to the cholecystokinin receptor

Harikumar, K. G., Pinon, D. I., Wessels, W. S., Prendergast, F. G. & Miller, L. J., May 24 2002, In : Journal of Biological Chemistry. 277, 21, p. 18552-18560 9 p.

Research output: Contribution to journalArticle

44 Scopus citations

Enzymatic lipid oxidation by eosinophils propagates coagulation, hemostasis, and thrombotic disease

Uderhardt, S., Ackermann, J. A., Fillep, T., Hammond, V. J., Willeit, J., Santer, P., Mayr, M., Biburger, M., Miller, M., Zellner, K. R., Stark, K., Zarbock, A., Rossaint, J., Schubert, I., Mielenz, D., Dietel, B., Raaz-Schrauder, D., Ay, C., Gremmel, T., Thaler, J. & 14 others, Heim, C., Herrmann, M., Collins, P. W., Schabbauer, G., Mackman, N., Voehringer, D., Nadler, J. L., Lee, J. J., Massberg, S., Rauh, M., Kiechl, S., Schett, G., O'Donnell, V. B. & Krönke, G., Jul 1 2017, In : Journal of Experimental Medicine. 214, 7, p. 2121-2138 18 p.

Research output: Contribution to journalArticle

28 Scopus citations

Eosinophil activities modulate the immune/inflammatory character of allergic respiratory responses in mice

Jacobsen, E. A., LeSuer, W. E., Willetts, L., Zellner, K. R., Mazzolini, K., Antonios, N., Beck, B., Protheroe, C., Ochkur, S. I., Colbert, D., Lacy, P., Moqbel, R., Appleton, J., Lee, N. A. & Lee, J. J., Mar 1 2014, In : Allergy: European Journal of Allergy and Clinical Immunology. 69, 3, p. 315-327 13 p.

Research output: Contribution to journalArticle

30 Scopus citations

Eosinophil-associated ribonuclease 11 is a macrophage chemoattractant

Yamada, K. J., Barker, T., Dyer, K. D., Rice, T. A., Percopo, C. M., Garcia-Crespo, K. E., Cho, S., Lee, J. J., Druey, K. M. & Rosenberg, H. F., Apr 3 2015, In : Journal of Biological Chemistry. 290, 14, p. 8863-8875 13 p.

Research output: Contribution to journalArticle

11 Scopus citations

Eosinophil deficiency compromises parasite survival in chronic nematode infection

Fabre, V., Beiting, D. P., Bliss, S. K., Gebreselassie, N. G., Gagliardo, L. F., Lee, N. A., Lee, J. J. & Appleton, J. A., Feb 1 2009, In : Journal of Immunology. 182, 3, p. 1577-1583 7 p.

Research output: Contribution to journalArticle

Open Access
107 Scopus citations

Eosinophil degranulation in the allergic lung of mice primarily occurs in the airway lumen

Clark, K., Simson, L., Newcombe, N., Koskinen, A. M. L., Mattes, J., Lee, N. A., Lee, J. J., Dent, L. A., Matthaei, K. I. & Foster, P. S., Jun 1 2004, In : Journal of Leukocyte Biology. 75, 6, p. 1001-1009 9 p.

Research output: Contribution to journalArticle

44 Scopus citations

Eosinophil-dependent skin innervation and itching following contact toxicant exposure in mice

Lee, J. J., Protheroe, C. A., Luo, H., Ochkur, S. I., Scott, G. D., Zellner, K. R., Raish, R. J., Dahl, M. V., Vega, M. L., Conley, O., Condjella, R. M., Kloeber, J. A., Neely, J. L., Patel, Y. S., Maizer, P., Mazzolini, A., Fryer, A. D., Jacoby, N. W., Jacoby, D. B. & Lee, N. A., Feb 1 2015, In : Journal of Allergy and Clinical Immunology. 135, 2, p. 477-487.e1

Research output: Contribution to journalArticle

15 Scopus citations

Eosinophil-derived CCL-6 impairs hematopoietic stem cell homeostasis

Zhang, C., Yi, W., Li, F., Du, X., Wang, H., Wu, P., Peng, C., Luo, M., Hua, W., Wong, C. C. L., Lee, J. J., Li, W., Chen, Z., Ying, S., Ju, Z. & Shen, H., Mar 1 2018, In : Cell Research. 28, 3, p. 323-335 13 p.

Research output: Contribution to journalArticle

1 Scopus citations

Eosinophil-derived IL-10 supports chronic nematode infection

Huang, L., Gebreselassie, N. G., Gagliardo, L. F., Ruyechan, M. C., Lee, N. A., Lee, J. J. & Appleton, J. A., Oct 15 2014, In : Journal of Immunology. 193, 8, p. 4178-4187 10 p.

Research output: Contribution to journalArticle

41 Scopus citations

Eosinophil differentiation in the bone marrow is promoted by protein tyrosine phosphatase SHP2

Xia, L. X., Hua, W., Jin, Y., Tian, B. P., Qiu, Z. W., Zhang, C., Che, L. Q., Zhou, H. B., Wu, Y. F., Huang, H. Q., Lan, F., Ke, Y. H., Lee, J. J., Li, W., Ying, S. M., Chen, Z. H. & Shen, H. H., Apr 7 2016, In : Cell Death and Disease. 7, e2175.

Research output: Contribution to journalArticle

14 Scopus citations

Eosinophilic esophagitis: Epithelial mesenchymal transition contributes to esophageal remodeling and reverses with treatment

Kagalwalla, A. F., Akhtar, N., Woodruff, S. A., Rea, B. A., Masterson, J. C., Mukkada, V., Parashette, K. R., Du, J., Fillon, S., Protheroe, C. A., Lee, J. J., Amsden, K., Melin-Aldana, H., Capocelli, K. E., Furuta, G. T. & Ackerman, S. J., May 2012, In : Journal of Allergy and Clinical Immunology. 129, 5, p. 1387-1396.e6

Research output: Contribution to journalArticle

123 Scopus citations

Eosinophilic Polymyositis in a Mouse

Krugner-Higby, L. A., Gendron, A., Garland, T., Carter, P. A., Swallow, J. G. & Lee, J. J., Dec 1 1998, In : Contemporary Topics in Laboratory Animal Science. 37, 6, p. 94-97 4 p.

Research output: Contribution to journalArticle

Eosinophil major basic protein-1 does not contribute to allergen-induced airway pathologies in mouse models of asthma

Denzler, K. L., Farmer, S. C., Crosby, J. R., Borchers, M., Cieslewicz, G., Larson, K. A., Cormier-Regard, S., Lee, N. A. & Lee, J. J., Nov 15 2000, In : Journal of Immunology. 165, 10, p. 5509-5517 9 p.

Research output: Contribution to journalArticle

Open Access
102 Scopus citations

Eosinophil-mediated signalling attenuates inflammatory responses in experimental colitis

Masterson, J. C., McNamee, E. N., Fillon, S. A., Hosford, L., Harris, R., Fernando, S. D., Jedlicka, P., Iwamoto, R., Jacobsen, E., Protheroe, C., Eltzschig, H. K., Colgan, S. P., Arita, M., Lee, J. J. & Furuta, G. T., Aug 1 2015, In : Gut. 64, 8, p. 1236-1247 12 p.

Research output: Contribution to journalArticle

50 Scopus citations

Eosinophil peroxidase catalyzed protein carbamylation participates in asthma

Wang, Z., DiDonato, J. A., Buffa, J., Comhair, S. A., Aronica, M. A., Dweik, R. A., Lee, N. A., Lee, J. J., Thomassen, M. J., Kavuru, M., Erzurum, S. C. & Hazen, S. L., Oct 14 2016, In : Journal of Biological Chemistry. 291, 42, p. 22118-22135 18 p.

Research output: Contribution to journalArticle

13 Scopus citations

Eosinophil peroxidase in sputum represents a unique biomarker of airway eosinophilia

Nair, P., Ochkur, S. I., Protheroe, C., Radford, K., Efthimiadis, A., Lee, N. A. & Lee, J. J., Sep 1 2013, In : Allergy: European Journal of Allergy and Clinical Immunology. 68, 9, p. 1177-1184 8 p.

Research output: Contribution to journalArticle

46 Scopus citations

Eosinophils: Singularly destructive effector cells or purveyors of immunoregulation?

Jacobsen, E. A., Taranova, A. G., Lee, N. A. & Lee, J. J., Jun 1 2007, In : Journal of Allergy and Clinical Immunology. 119, 6, p. 1313-1320 8 p.

Research output: Contribution to journalArticle

152 Scopus citations

Eosinophils act as antigen-presenting cells to induce immunity to Strongyloides stercoralis in mice

Padigel, U. M., Hess, J. A., Lee, J. J., Lok, J. B., Nolan, T. J., Schad, G. A. & Abraham, D., Dec 15 2007, In : Journal of Infectious Diseases. 196, 12, p. 1844-1851 8 p.

Research output: Contribution to journalArticle

67 Scopus citations

Eosinophils alter colonic epithelial barrier function: Role for major basic protein

Furuta, G. T., Nieuwenhuis, E. E. S., Karhausen, J., Gleich, G., Blumberg, R. S., Lee, J. J. & Ackerman, S. J., Nov 1 2005, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 289, 5 52-5, p. G890-G897

Research output: Contribution to journalArticle

98 Scopus citations

Eosinophils and IL-33 Perpetuate Chronic Inflammation and Fibrosis in a Pediatric Population with Stricturing Crohn's Ileitis

Masterson, J. C., Capocelli, K. E., Hosford, L., Biette, K., McNamee, E. N., De Zoeten, E. F., Harris, R., Fernando, S. D., Jedlicka, P., Protheroe, C., Lee, J. J. & Furuta, G. T., Jul 20 2015, In : Inflammatory bowel diseases. 21, 10, p. 2429-2440 12 p.

Research output: Contribution to journalArticle

28 Scopus citations

Eosinophils and IL-4 Support Nematode Growth Coincident with an Innate Response to Tissue Injury

Huang, L., Beiting, D. P., Gebreselassie, N. G., Gagliardo, L. F., Ruyechan, M. C., Lee, N. A., Lee, J. J. & Appleton, J. A., 2015, In : PLoS pathogens. 11, 12, e1005347.

Research output: Contribution to journalArticle

24 Scopus citations

Eosinophils are cellular targets of the novel uteroplacental heparin-binding cytokine decidual/trophoblast prolactin-related protein

Wang, D., Ishimura, R., Walia, D. S., Muller, H., Dai, G., Hunt, J. S., Lee, N. A., Lee, J. J. & Soares, M. J., Jan 1 2000, In : Journal of Endocrinology. 167, 1, p. 15-28 14 p.

Research output: Contribution to journalArticle

Open Access
25 Scopus citations

Eosinophils Are Important for Protection, Immunoregulation and Pathology during Infection with Nematode Microfilariae

Cadman, E. T., Thysse, K. A., Bearder, S., Cheung, A. Y. N., Johnston, A. C., Lee, J. J. & Lawrence, R. A., Mar 2014, In : PLoS pathogens. 10, 3, e1003988.

Research output: Contribution to journalArticle

35 Scopus citations

Eosinophils are necessary for pulmonary arterial remodeling in a mouse model of eosinophilic inflammation-induced pulmonary hypertension

Weng, M., Baron, D. M., Bloch, K. D., Luster, A. D., Lee, J. J. & Medoff, B. D., Dec 2011, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 301, 6, p. L927-L936

Research output: Contribution to journalArticle

21 Scopus citations

Eosinophils are required for the maintenance of plasma cells in the bone marrow

Chu, V. T., Fröhlich, A., Steinhauser, G., Scheel, T., Roch, T., Fillatreau, S., Lee, J. J., Löhning, M. & Berek, C., Feb 1 2011, In : Nature immunology. 12, 2, p. 151-159 9 p.

Research output: Contribution to journalArticle

303 Scopus citations

Eosinophils contribute to the resolution of lung-allergic responses following repeated allergen challenge

Takeda, K., Shiraishi, Y., Ashino, S., Han, J., Jia, Y., Wang, M., Lee, N. A., Lee, J. J. & Gelfand, E. W., Feb 1 2015, In : Journal of Allergy and Clinical Immunology. 135, 2, p. 451-460.e5

Research output: Contribution to journalArticle

17 Scopus citations

Eosinophils increase neuron branching in human and murine skin and in vitro

Foster, E. L., Simpson, E. L., Fredrikson, L. J., Lee, J. J., Lee, N. A., Fryer, A. D. & Jacoby, D. B., 2011, In : PloS one. 6, 7, e22029.

Research output: Contribution to journalArticle

48 Scopus citations

Eosinophils mediate protective immunity against secondary nematode infection

Huang, L., Gebreselassie, N. G., Gagliardo, L. F., Ruyechan, M. C., Luber, K. L., Lee, N. A., Lee, J. J. & Appleton, J. A., Jan 1 2015, In : Journal of Immunology. 194, 1, p. 283-290 8 p.

Research output: Contribution to journalArticle

32 Scopus citations

Eosinophils Mediate Tissue Injury in the Autoimmune Skin Disease Bullous Pemphigoid

Lin, L., Hwang, B. J., Culton, D. A., Li, N., Burette, S., Koller, B. H., Messingham, K. A., Fairley, J. A., Lee, J. J., Hall, R. P., An, L., Diaz, L. A. & Liu, Z., May 1 2018, In : Journal of Investigative Dermatology. 138, 5, p. 1032-1043 12 p.

Research output: Contribution to journalArticle

21 Scopus citations