Biochemistry and Molecular Biology

Research Output

Differential sensitivity of types 1 and 2 cholecystokinin receptors to membrane cholesterol

Potter, R. M., Harikumar, K. G., Wu, S. V. & Miller, L. J., Jan 1 2012, In : Journal of Lipid Research. 53, 1, p. 137-148 12 p.

Research output: Contribution to journalArticle

29 Scopus citations

Dimeric arrangement of the parathyroid hormone receptor and a structural mechanism for ligand-induced dissociation

Pioszak, A. A., Harikumar, K. G., Parker, N. R., Miller, L. J. & Xu, H. E., Apr 16 2010, In : Journal of Biological Chemistry. 285, 16, p. 12435-12444 10 p.

Research output: Contribution to journalArticle

49 Scopus citations

Dimerization in the absence of higher-order oligomerization of the G protein-coupled secretin receptor

Harikumar, K. G., Happs, R. M. & Miller, L. J., Nov 1 2008, In : Biochimica et Biophysica Acta - Biomembranes. 1778, 11, p. 2555-2563 9 p.

Research output: Contribution to journalArticle

35 Scopus citations

Dimerization of the transmembrane domain of amyloid precursor protein is determined by residues around the γ-secretase cleavage sites

Yan, Y., Xu, T. H., Harikumar, K. G., Miller, L. J., Melcher, K. & Xu, H. E., Sep 22 2017, In : Journal of Biological Chemistry. 292, 38, p. 15826-15837 12 p.

Research output: Contribution to journalArticle

11 Scopus citations

Direct derivation of van der Waals force field parameters from quantum mechanical interaction energies

Bordner, A. J., Cavasotto, C. N. & Abagyan, R. A., Sep 4 2003, In : Journal of Physical Chemistry B. 107, 35, p. 9601-9609 9 p.

Research output: Contribution to journalArticle

19 Scopus citations

Disruption of integrin function in the murine myocardium leads to perinatal lethality, fibrosis, and abnormal cardiac performance

Keller, R. S., Shai, S. Y., Babbitt, C. J., Pham, C. G., Solaro, R. J., Valencik, M. L., Loftus, J. C. & Ross, R. S., Jan 1 2001, In : American Journal of Pathology. 158, 3, p. 1079-1090 12 p.

Research output: Contribution to journalArticle

77 Scopus citations

Distinct binding modes specify the recognition of methylated histones H3K4 and H4K20 by JMJD2A-tudor

Lee, J., Thompson, J. R., Botuyan, M. V. & Mer, G., Jan 1 2008, In : Nature Structural and Molecular Biology. 15, 1, p. 109-111 3 p.

Research output: Contribution to journalArticle

143 Scopus citations

Distinct functions of integrin α and β subunit cytoplasmic domains in cell spreading and formation of focal adhesions

Ylänne, J., Chen, Y., O'Toole, T. E., Loftus, J. C., Takada, Y. & Ginsberg, M. H., Jul 1993, In : Journal of Cell Biology. 122, 1, p. 223-233 11 p.

Research output: Contribution to journalArticle

Open Access
188 Scopus citations

Distinct molecular mechanisms for agonist peptide binding to types A and B cholecystokinin receptors demonstrated using fluorescence spectroscopy

Harikumar, K. G., Clain, J., Pinon, D. I., Bong, M. & Miller, L. J., Jan 14 2005, In : Journal of Biological Chemistry. 280, 2, p. 1044-1050 7 p.

Research output: Contribution to journalArticle

30 Scopus citations

Domain Interdependence in the Biosynthetic Assembly of CFTR

Cui, L., Aleksandrov, L., Chang, X. B., Hou, Y. X., He, L., Hegedus, T., Gentzsch, M., Aleksandrov, A., Balch, W. E. & Riordan, J. R., Jan 26 2007, In : Journal of Molecular Biology. 365, 4, p. 981-994 14 p.

Research output: Contribution to journalArticle

154 Scopus citations

Downregulation of hematopoietic MUC1 during Experimental colitis increases tumor-promoting myeloid-derived suppressor cells

Poh, T. W., Madsen, C. S., Gorman, J. E., Marler, R. J., Leighton, J. A., Cohen, P. A. & Gendler, S. J., Sep 15 2013, In : Clinical Cancer Research. 19, 18, p. 5039-5052 14 p.

Research output: Contribution to journalArticle

9 Scopus citations

Downregulation of Muc1 in MMTV-c-Neu tumors

Adriance, M. C. & Gendler, S. J., Jan 22 2004, In : Oncogene. 23, 3, p. 697-705 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Dual proinflammatory and antiviral properties of pulmonary eosinophils in respiratory syncytial virus vaccine-enhanced disease

Su, Y. C., Townsend, D., Herrero, L. J., Zaid, A., Rolph, M. S., Gahan, M. E., Nelson, M. A., Rudd, P. A., Matthaei, K. I., Foster, P. S., Dent, L., Tripp, R. A., Lee, J., Simson, L. & Mahalingam, S., Jan 1 2015, In : Journal of virology. 89, 3, p. 1564-1578 15 p.

Research output: Contribution to journalArticle

16 Scopus citations

Early life of cystic fibrosis transmembrane conductance regulator (CFTR) in the cell

Riordan, J. R., Gentzsch, M., Hammerle, M., Chen, J. H., Mengos, A., Jensen, T. & Chang, X. B., Jan 1 2001, In : Kidney international. 60, 2, 1 p.

Research output: Contribution to journalArticle

Early phase bronchoconstriction in the mouse requires allergen-specific IgG

Crosby, J. R., Cieslewicz, G., Borchers, M., Hines, E., Carrigan, P., Lee, J. J. & Lee, N. A., Apr 15 2002, In : Journal of Immunology. 168, 8, p. 4050-4054 5 p.

Research output: Contribution to journalArticle

Open Access
26 Scopus citations

Ectopic expression of IL-5 identifies an additional CD4+ T cell mechanism of airway eosinophil recruitment

Crosby, J. R., Shen, H. H., Borchers, M. T., Justice, J. P., Ansay, T., Lee, J. J. & Lee, N. A., Jun 29 2002, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 282, 1 26-1, p. L99-L108

Research output: Contribution to journalArticle

16 Scopus citations

Effect of alcohols on G-protein coupling of serotonin(1A) receptors from bovine hippocampus

Harikumar, K. G. & Chattopadhyay, A., Aug 1 2000, In : Brain Research Bulletin. 52, 6, p. 597-601 5 p.

Research output: Contribution to journalArticle

17 Scopus citations

Effect of proton pump inhibitor on esophageal eosinophilia

Schroeder, S., Capocelli, K. E., Masterson, J. C., Harris, R., Protheroe, C., Lee, J. J. & Furuta, G. T., Feb 1 2013, In : Journal of pediatric gastroenterology and nutrition. 56, 2, p. 166-172 7 p.

Research output: Contribution to journalArticle

53 Scopus citations

Effects of cholecystokinin-58 on type 1 cholecystokinin receptor function and regulation

Wu, S. V., Harikumar, K. G., Burgess, R. J., Reeve, J. R. & Miller, L. J., Sep 1 2008, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 295, 3, p. G641-G647

Research output: Contribution to journalArticle

10 Scopus citations

Effects of putative catalytic base mutation E211Q on ABCG2-mediated methotrexate transport

Hou, Y. X., Li, C. Z., Palaniyandi, K., Magtibay, P. M., Homolya, L., Sarkadi, B. & Chang, X. B., Oct 14 2009, In : Biochemistry. 48, 38, p. 9122-9131 10 p.

Research output: Contribution to journalArticle

8 Scopus citations

Effects of raloxifene hydrochloride on endometrial cancer cells in vitro

Hibner, M., Magrina, J. F., Lefler, S. R., Cornella, J. L., Pizarro, A. R. & Loftus, J. C., Jun 1 2004, In : Gynecologic oncology. 93, 3, p. 642-646 5 p.

Research output: Contribution to journalArticle

13 Scopus citations

Efficient molecular mechanics simulations of the folding, orientation, and assembly of peptides in lipid bilayers using an implicit atomic solvation model

Bordner, A. J., Zorman, B. & Abagyan, R., Oct 1 2011, In : Journal of Computer-Aided Molecular Design. 25, 10, p. 895-911 17 p.

Research output: Contribution to journalArticle

3 Scopus citations

Efficient surface expression of platelet GPIIb-IIIa requires both subunits

O'Toole, T. E., Loftus, J. C., Plow, E. F., Glass, A. A., Harper, J. R. & Ginsberg, M. H., Jan 1 1989, In : Blood. 74, 1, p. 14-18 5 p.

Research output: Contribution to journalArticle

116 Scopus citations

EGFRvIII–Stat5 signaling enhances glioblastoma cell migration and survival

Roos, A., Dhruv, H. D., Peng, S., Inge, L. J., Tuncali, S., Pineda, M., Millard, N., Mayo, Z., Eschbacher, J. M., Loftus, J. C., Winkles, J. A. & Tran, N., Jul 1 2018, In : Molecular Cancer Research. 16, 7, p. 1185-1195 11 p.

Research output: Contribution to journalArticle

6 Scopus citations

Elevated expression of Fn14 in non-small cell lung cancer correlates with activated EGFR and promotes tumor cell migration and invasion

Whitsett, T. G., Cheng, E., Inge, L., Asrani, K., Jameson, N. M., Hostetter, G., Weiss, G. J., Kingsley, C. B., Loftus, J. C., Bremner, R., Tran, N. L. & Winkles, J. A., Jul 1 2012, In : American Journal of Pathology. 181, 1, p. 111-120 10 p.

Research output: Contribution to journalArticle

36 Scopus citations

Elucidation of the active conformation of the amino terminus of receptor-bound secretin using intramolecular disulfide bond constraints

Dong, M., Pinon, D. I., Bordner, A. J. & Miller, L. J., Oct 1 2010, In : Bioorganic and Medicinal Chemistry Letters. 20, 20, p. 6040-6044 5 p.

Research output: Contribution to journalArticle

5 Scopus citations

Emerging Concepts

Lee, J. J., Ptaschinski, C., Plank, M., Mattes, J., Foster, P. S., Balla, K. M., Traver, D., Ilarraza, R., Orihara, K., Arizmendi, N., Moqbel, R., Odemuyiwa, S. O., Smith, D. E. & Comeau, M. R., Aug 29 2013, Eosinophils in Health and Disease. Elsevier Inc., p. 607-641 35 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Encephalitis in a confined coyote.

Marler, R. J., Kruckenberg, S. M., Cook, J. E. & O'Keefe, C. M., Nov 1 1976, In : Journal of the American Veterinary Medical Association. 169, 9, p. 964-965 2 p.

Research output: Contribution to journalArticle

1 Scopus citations

Endocytic trafficking routes of wild type and ΔF508 cystic fibrosis transmembrane conductance regulator

Gentzsch, M., Chang, X. B., Cui, L., Wu, Y., Ozols, V. V., Choudhury, A., Pagano, R. E. & Riordan, J. R., Jun 1 2004, In : Molecular biology of the cell. 15, 6, p. 2684-2696 13 p.

Research output: Contribution to journalArticle

169 Scopus citations

Endoscopic band ligation for closure of GI perforations in a porcine animal model (with video)

Law, R., Deters, J. L., Miller, C. A., Marler, R. J. & Baron, T. H., Oct 1 2014, In : Gastrointestinal endoscopy. 80, 4, p. 717-722 6 p.

Research output: Contribution to journalArticle

3 Scopus citations

Environment and mobility of a series of fluorescent reporters at the amino terminus of structurally related peptide agonists and antagonists bound to the cholecystokinin receptor

Harikumar, K. G., Pinon, D. I., Wessels, W. S., Prendergast, F. G. & Miller, L. J., May 24 2002, In : Journal of Biological Chemistry. 277, 21, p. 18552-18560 9 p.

Research output: Contribution to journalArticle

44 Scopus citations

Enzymatic lipid oxidation by eosinophils propagates coagulation, hemostasis, and thrombotic disease

Uderhardt, S., Ackermann, J. A., Fillep, T., Hammond, V. J., Willeit, J., Santer, P., Mayr, M., Biburger, M., Miller, M., Zellner, K. R., Stark, K., Zarbock, A., Rossaint, J., Schubert, I., Mielenz, D., Dietel, B., Raaz-Schrauder, D., Ay, C., Gremmel, T., Thaler, J. & 14 others, Heim, C., Herrmann, M., Collins, P. W., Schabbauer, G., Mackman, N., Voehringer, D., Nadler, J. L., Lee, J. J., Massberg, S., Rauh, M., Kiechl, S., Schett, G., O'Donnell, V. B. & Krönke, G., Jul 1 2017, In : Journal of Experimental Medicine. 214, 7, p. 2121-2138 18 p.

Research output: Contribution to journalArticle

28 Scopus citations

Eosinophil activities modulate the immune/inflammatory character of allergic respiratory responses in mice

Jacobsen, E. A., LeSuer, W. E., Willetts, L., Zellner, K. R., Mazzolini, K., Antonios, N., Beck, B., Protheroe, C., Ochkur, S. I., Colbert, D., Lacy, P., Moqbel, R., Appleton, J., Lee, N. A. & Lee, J. J., Mar 1 2014, In : Allergy: European Journal of Allergy and Clinical Immunology. 69, 3, p. 315-327 13 p.

Research output: Contribution to journalArticle

30 Scopus citations

Eosinophil-associated ribonuclease 11 is a macrophage chemoattractant

Yamada, K. J., Barker, T., Dyer, K. D., Rice, T. A., Percopo, C. M., Garcia-Crespo, K. E., Cho, S., Lee, J. J., Druey, K. M. & Rosenberg, H. F., Apr 3 2015, In : Journal of Biological Chemistry. 290, 14, p. 8863-8875 13 p.

Research output: Contribution to journalArticle

11 Scopus citations

Eosinophil Cell-Cell Communication

Prussin, C., Scott, G. D., Fryer, A. D., Schroeder, S., Masterson, J. C., Fillon, S., Furuta, G. T., Akuthota, P., Xenakis, J. J., Wang, H., Weller, P. F., Jacobsen, E. A., Teplinsky, A., Elishmereni, M., Katz, H. R., Levi-Schaffer, F., Chu, V. T., Berek, C., Sexton, D. W., Walsh, G. M. & 5 others, (Wole) Odemuyiwa, S. O., Tulic, M. K., Cravetchi, V. O., Lee, J. J. & Moqbel, R., Aug 29 2013, Eosinophils in Health and Disease. Elsevier Inc., p. 329-390 62 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Eosinophil deficiency compromises parasite survival in chronic nematode infection

Fabre, V., Beiting, D. P., Bliss, S. K., Gebreselassie, N. G., Gagliardo, L. F., Lee, N. A., Lee, J. J. & Appleton, J. A., Feb 1 2009, In : Journal of Immunology. 182, 3, p. 1577-1583 7 p.

Research output: Contribution to journalArticle

Open Access
107 Scopus citations

Eosinophil degranulation: An evolutionary vestige or a universally destructive effector function?

Lee, J. J. & Lee, N. A., Aug 1 2005, In : Clinical and Experimental Allergy. 35, 8, p. 986-994 9 p.

Research output: Contribution to journalReview article

79 Scopus citations

Eosinophil degranulation in the allergic lung of mice primarily occurs in the airway lumen

Clark, K., Simson, L., Newcombe, N., Koskinen, A. M. L., Mattes, J., Lee, N. A., Lee, J. J., Dent, L. A., Matthaei, K. I. & Foster, P. S., Jun 1 2004, In : Journal of Leukocyte Biology. 75, 6, p. 1001-1009 9 p.

Research output: Contribution to journalArticle

44 Scopus citations

Eosinophil-dependent skin innervation and itching following contact toxicant exposure in mice

Lee, J. J., Protheroe, C. A., Luo, H., Ochkur, S. I., Scott, G. D., Zellner, K. R., Raish, R. J., Dahl, M. V., Vega, M. L., Conley, O., Condjella, R. M., Kloeber, J. A., Neely, J. L., Patel, Y. S., Maizer, P., Mazzolini, A., Fryer, A. D., Jacoby, N. W., Jacoby, D. B. & Lee, N. A., Feb 1 2015, In : Journal of Allergy and Clinical Immunology. 135, 2, p. 477-487.e1

Research output: Contribution to journalArticle

15 Scopus citations

Eosinophil-derived CCL-6 impairs hematopoietic stem cell homeostasis

Zhang, C., Yi, W., Li, F., Du, X., Wang, H., Wu, P., Peng, C., Luo, M., Hua, W., Wong, C. C. L., Lee, J. J., Li, W., Chen, Z., Ying, S., Ju, Z. & Shen, H., Mar 1 2018, In : Cell Research. 28, 3, p. 323-335 13 p.

Research output: Contribution to journalArticle

1 Scopus citations

Eosinophil-derived IL-10 supports chronic nematode infection

Huang, L., Gebreselassie, N. G., Gagliardo, L. F., Ruyechan, M. C., Lee, N. A., Lee, J. J. & Appleton, J. A., Oct 15 2014, In : Journal of Immunology. 193, 8, p. 4178-4187 10 p.

Research output: Contribution to journalArticle

41 Scopus citations

Eosinophil differentiation in the bone marrow is promoted by protein tyrosine phosphatase SHP2

Xia, L. X., Hua, W., Jin, Y., Tian, B. P., Qiu, Z. W., Zhang, C., Che, L. Q., Zhou, H. B., Wu, Y. F., Huang, H. Q., Lan, F., Ke, Y. H., Lee, J. J., Li, W., Ying, S. M., Chen, Z. H. & Shen, H. H., Apr 7 2016, In : Cell Death and Disease. 7, e2175.

Research output: Contribution to journalArticle

14 Scopus citations

Eosinophilic esophagitis: Epithelial mesenchymal transition contributes to esophageal remodeling and reverses with treatment

Kagalwalla, A. F., Akhtar, N., Woodruff, S. A., Rea, B. A., Masterson, J. C., Mukkada, V., Parashette, K. R., Du, J., Fillon, S., Protheroe, C. A., Lee, J. J., Amsden, K., Melin-Aldana, H., Capocelli, K. E., Furuta, G. T. & Ackerman, S. J., May 2012, In : Journal of Allergy and Clinical Immunology. 129, 5, p. 1387-1396.e6

Research output: Contribution to journalArticle

123 Scopus citations

Eosinophilic granulocytes and damage-associated molecular pattern molecules (DAMPs): Role in the inflammatory response within tumors

Lotfi, R., Lee, J. J. & Lotze, M. T., Jan 1 2007, In : Journal of Immunotherapy. 30, 1, p. 16-28 13 p.

Research output: Contribution to journalReview article

122 Scopus citations

Eosinophilic oesophagitis in adults - A rising epidemic

Pasha, S. F., Crowell, M. D., Alexander, J. A., Harris, L. A., Achem, S. R., Farrugia, G., Lee, J. J., Thompson, D. M., Jung, K. W., Kita, H., Ravi, K., Namasivayam, V., Kim, H. J., Fleischer, D. E., Sharma, V. K. & Romero, Y., Feb 2011, In : European Gastroenterology and Hepatology Review. 7, 1, p. 14-20 7 p.

Research output: Contribution to journalReview article

1 Scopus citations

Eosinophilic Polymyositis in a Mouse

Krugner-Higby, L. A., Gendron, A., Garland, T., Carter, P. A., Swallow, J. G. & Lee, J. J., Dec 1 1998, In : Contemporary Topics in Laboratory Animal Science. 37, 6, p. 94-97 4 p.

Research output: Contribution to journalArticle

Eosinophil major basic protein-1 does not contribute to allergen-induced airway pathologies in mouse models of asthma

Denzler, K. L., Farmer, S. C., Crosby, J. R., Borchers, M., Cieslewicz, G., Larson, K. A., Cormier-Regard, S., Lee, N. A. & Lee, J. J., Nov 15 2000, In : Journal of Immunology. 165, 10, p. 5509-5517 9 p.

Research output: Contribution to journalArticle

Open Access
102 Scopus citations

Eosinophil-mediated signalling attenuates inflammatory responses in experimental colitis

Masterson, J. C., McNamee, E. N., Fillon, S. A., Hosford, L., Harris, R., Fernando, S. D., Jedlicka, P., Iwamoto, R., Jacobsen, E., Protheroe, C., Eltzschig, H. K., Colgan, S. P., Arita, M., Lee, J. J. & Furuta, G. T., Aug 1 2015, In : Gut. 64, 8, p. 1236-1247 12 p.

Research output: Contribution to journalArticle

50 Scopus citations

Eosinophilopoiesis

Maltby, S., McNagny, K. M., Ackerman, S. J., Du, J., Mori, Y., Iwasaki, H., Akashi, K., Takatsu, K., Rådinger, M., Bossios, A., Lötvall, J. & Lee, N. A., Aug 29 2013, Eosinophils in Health and Disease. Elsevier Inc., p. 73-119 47 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Eosinophil peroxidase catalyzed protein carbamylation participates in asthma

Wang, Z., DiDonato, J. A., Buffa, J., Comhair, S. A., Aronica, M. A., Dweik, R. A., Lee, N. A., Lee, J. J., Thomassen, M. J., Kavuru, M., Erzurum, S. C. & Hazen, S. L., Oct 14 2016, In : Journal of Biological Chemistry. 291, 42, p. 22118-22135 18 p.

Research output: Contribution to journalArticle

13 Scopus citations