Biochemistry and Molecular Biology

Research Output

Multi-parametric MRI and texture analysis to visualize spatial histologic heterogeneity and tumor extent in glioblastoma

Hu, L. S., Ning, S., Eschbacher, J. M., Gaw, N., Dueck, A. C., Smith, K. A., Nakaji, P., Plasencia, J., Ranjbar, S., Price, S. J., Tran, N., Loftus, J., Jenkins, R., O'Neill, B. P., Elmquist, W., Baxter, L. C., Gao, F., Frakes, D., Karis, J. P., Zwart, C. & 5 others, Swanson, K. R., Sarkaria, J., Wu, T., Mitchell, J. R. & Li, J., Nov 1 2015, In : PloS one. 10, 11, e0141506.

Research output: Contribution to journalArticle

57 Scopus citations

Multiple flavonoid-binding sites within multidrug resistance protein MRP1

Trompier, D., Baubichon-Cortay, H., Chang, X. B., Maitrejean, M., Barron, D., Riordan, J. R. & Di Pietro, A., Oct 1 2003, In : Cellular and Molecular Life Sciences. 60, 10, p. 2164-2177 14 p.

Research output: Contribution to journalArticle

63 Scopus citations

MultiRTA: A simple yet reliable method for predicting peptide binding affinities for multiple class II MHC allotypes

Bordner, A. J. & Mittelmann, H. D., Sep 24 2010, In : BMC bioinformatics. 11, 482.

Research output: Contribution to journalArticle

31 Scopus citations

Murine lung eosinophil activation and chemokine production in allergic airway inflammation

Rose, C. E., Lannigan, J. A., Kim, P., Lee, J. J., Fu, S. M. & Sung, S. S. J., 2010, In : Cellular and Molecular Immunology. 7, 5, p. 361-374 14 p.

Research output: Contribution to journalArticle

42 Scopus citations

Muscle development and lineage-specific expression of CiMDF, the MyoD-family gene of Ciona intestinalis

Meedel, T. H., Lee, J. J. & Whittaker, J. R., Jan 15 2002, In : Developmental Biology. 241, 2, p. 238-246 9 p.

Research output: Contribution to journalArticle

21 Scopus citations
139 Scopus citations

Mutation of the aromatic amino acid interacting with adenine moiety of ATP to a polar residue alters the properties of multidrug resistance protein 1

Zhao, Q. & Chang, X. B., Nov 19 2004, In : Journal of Biological Chemistry. 279, 47, p. 48505-48512 8 p.

Research output: Contribution to journalArticle

23 Scopus citations

Mutations of the Walker B motif in the first nucleotide binding domain of multidrug resistance protein MRP1 prevent conformational maturation

Cui, L., Hou, Y. X., Riordan, J. R. & Chang, X. B., Aug 1 2001, In : Archives of Biochemistry and Biophysics. 392, 1, p. 153-161 9 p.

Research output: Contribution to journalArticle

24 Scopus citations

Myeloid-derived suppressor cells adhere to physiologic STAT3-vs STAT5-dependent hematopoietic programming, establishing diverse tumor-mediated mechanisms of immunologic escape

Cohen, P. A., Ko, J. S., Storkus, W. J., Spencer, C. D., Bradley, J. M., Gorman, J. E., McCurry, D. B., Zorro-Manrique, S., Dominguez, A. L., Pathangey, L. B., Rayman, P. A., Rini, B. I., Gendler, S. J. & Finke, J. H., Aug 2012, In : Immunological Investigations. 41, 6-7, p. 680-710 31 p.

Research output: Contribution to journalArticle

30 Scopus citations

Nasal and pharyngeal eosinophil peroxidase levels in adults with poorly controlled asthma correlate with sputum eosinophilia

Rank, M. A., Ochkur, S. I., Lewis, J. C., Teaford, H. G., Wesselius, L. J., Helmers, R. A., Lee, N. A., Nair, P. & Lee, J. J., Apr 1 2016, In : Allergy: European Journal of Allergy and Clinical Immunology. 71, 4, p. 567-570 4 p.

Research output: Contribution to journalArticle

22 Scopus citations

New insights into integrin-ligand interaction

Loftus, J. C. & Liddington, R. C., Dec 1 1997, In : Journal of Clinical Investigation. 100, 11 SUPPL., p. S77-S81

Research output: Contribution to journalReview article

30 Scopus citations

New insights into integrin-ligand interaction

Loftus, J. C. & Liddington, R. C., May 15 1997, In : Journal of Clinical Investigation. 99, 10, p. 2302-2306 5 p.

Research output: Contribution to journalReview article

Open Access
103 Scopus citations

Normalized serum eosinophil peroxidase levels are inversely correlated with esophageal eosinophilia in eosinophilic esophagitis

Wright, B. L., Ochkur, S. I., Olson, N. S., Shim, K. P., Jacobsen, E. A., Rank, M. A., Dellon, E. S. & Lee, J. J., Feb 1 2018, In : Diseases of the Esophagus. 31, 2, p. 1-9 9 p., dox139.

Research output: Contribution to journalReview article

9 Scopus citations

Novel approach to inhibit asthma-mediated lung inflammation using Anti-CD147 intervention

Gwinn, W. M., Damsker, J. M., Falahati, R., Okwumabua, I., Kelly-Welch, A., Keegan, A. D., Vanpouille, C., Lee, J. J., Dent, L. A., Leitenberg, D., Bukrinsky, M. I. & Constant, S. L., Oct 1 2006, In : Journal of Immunology. 177, 7, p. 4870-4879 10 p.

Research output: Contribution to journalArticle

Open Access
98 Scopus citations

Novel model of TH2-polarized chronic ileitis: The SAMPl mouse

McNamee, E. N., Wermers, J. D., Masterson, J. C., Collins, C. B., Matthew, D. P., Lebsack, B. A., Fillon, S., Robinson, Z. D., Grenawalt, J., Lee, J. J., Jedlicka, P., Furuta, G. T. & Rivera-Nieves, J., 2010, In : Inflammatory bowel diseases. 16, 5, p. 743-752 10 p.

Research output: Contribution to journalArticle

26 Scopus citations

Novel MUC1 splice variants contribute to mucin overexpression in CFTR-deficient mice

Hinojosa-Kurtzberg, A. M., Johansson, M. E. V., Madsen, C. S., Hansson, G. C. & Gendler, S. J., May 1 2003, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 284, 5 47-5, p. G853-G862

Research output: Contribution to journalArticle

23 Scopus citations

Nucleotide dissociation from NBD1 promotes solute transport by MRP1

Yang, R., McBride, A., Hou, Y. X., Goldberg, A. & Chang, X. B., Mar 1 2005, In : Biochimica et Biophysica Acta - Biomembranes. 1668, 2, p. 248-261 14 p.

Research output: Contribution to journalArticle

17 Scopus citations

Nucleotide-induced conformational changes in the human multidrug resistance protein MRP1 are related to the capacity of chemotherapeutic drugs to accumulate or not in resistant cells

Manciu, L., Chang, X. B., Riordan, J. R., Buyse, F. & Ruysschaert, J. M., Mar 23 2001, In : FEBS Letters. 493, 1, p. 31-35 5 p.

Research output: Contribution to journalArticle

19 Scopus citations

Obese asthmatic patients have decreased surfactant protein A levels: Mechanisms and implications

Lugogo, N., Francisco, D., Addison, K. J., Manne, A., Pederson, W., Ingram, J. L., Green, C. L., Suratt, B. T., Lee, J. J., Sunday, M. E., Kraft, M. & Ledford, J. G., Mar 2018, In : Journal of Allergy and Clinical Immunology. 141, 3, p. 918-926.e3

Research output: Contribution to journalArticle

9 Scopus citations

Occupancy of an adhesive glycoprotein receptor modulates expression of an antigenic site involved in cell adhesion

Frelinger, A. L., Lam, S. C. T., Plow, E. F., Smith, M. A., Loftus, J. C. & Ginsberg, M. H., Dec 1 1988, In : Journal of Biological Chemistry. 263, 25, p. 12397-12402 6 p.

Research output: Contribution to journalArticle

204 Scopus citations

Operator transformations between exactly solvable potentials and their Lie group generators

Bordner, A. J., Jun 7 1997, In : Journal of Physics A: Mathematical and General. 30, 11, p. 3927-3936 10 p.

Research output: Contribution to journalArticle

Orientation-dependent backbone-only residue pair scoring functions for fixed backbone protein design

Bordner, A. J., Apr 16 2010, In : BMC bioinformatics. 11, 192.

Research output: Contribution to journalArticle

5 Scopus citations

Pancreatic cancer pain and its correlation with changes in tumor vasculature, macrophage infiltration, neuronal innervation, body weight and disease progression

Lindsay, T. H., Jonas, B. M., Sevcik, M. A., Kubota, K., Halvorson, K. G., Ghilardi, J. R., Kuskowski, M. A., Stelow, E. B., Mukherjee, P., Gendler, S. J., Wong, G. Y. & Mantyh, P. W., Dec 15 2005, In : Pain. 119, 1-3, p. 233-246 14 p.

Research output: Contribution to journalArticle

74 Scopus citations

Pancreatic ductal adenocarcinoma mice lacking mucin 1 have a profound defect in tumor growth and metastasis

Besmer, D. M., Curry, J. M., Roy, L. D., Tinder, T. L., Sahraei, M., Schettini, J., Hwang, S. I., Lee, Y. Y., Gendler, S. J. & Mukherjee, P., Jul 1 2011, In : Cancer research. 71, 13, p. 4432-4442 11 p.

Research output: Contribution to journalArticle

80 Scopus citations

Partial structure, chromosome localization, and expression of the mouse Girk4 gene

Wickman, K., Seldin, M. F., Gendler, S. J. & Clapham, D. E., Mar 15 1997, In : Genomics. 40, 3, p. 395-401 7 p.

Research output: Contribution to journalArticle

18 Scopus citations

Partial structure, chromosome localization, and expression of the mouse Icln gene

Wickman, K., Seldin, M. F., James, M. R., Gendler, S. J. & Clapham, D. E., Mar 15 1997, In : Genomics. 40, 3, p. 402-408 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

Passively transferred anti-MUC1 antibodies cause neither autoimmune disorders nor immunity against transplanted tumors in MUC1 transgenic mice

Tempero, R. M., Rowse, G. J., Gendler, S. J. & Hollingsworth, M. A., Feb 4 1999, In : International Journal of Cancer. 80, 4, p. 595-599 5 p.

Research output: Contribution to journalArticle

19 Scopus citations

Pathology in practice

Gades, N. M. & Marier, R. J., Jun 15 2009, In : Journal of the American Veterinary Medical Association. 234, 12, p. 1535-1537 3 p.

Research output: Contribution to journalArticle

3 Scopus citations

Pattern of intra-family hetero-oligomerization involving the G-protein-coupled secretin receptor

Harikumar, K. G., Morfis, M. M., Sexton, P. M. & Miller, L. J., Nov 2008, In : Journal of Molecular Neuroscience. 36, 1-3, p. 279-285 7 p.

Research output: Contribution to journalArticle

42 Scopus citations

Patterns of MUC1 tissue expression defined by an Anti-MUC1 cytoplasmic tail monoclonal antibody in breast cancer

Croce, M. V., Isla-Larrain, M. T., Rua, C. E., Rabassa, M. E., Gendler, S. J. & Segal-Eiras, A., Jun 1 2003, In : Journal of Histochemistry and Cytochemistry. 51, 6, p. 781-788 8 p.

Research output: Contribution to journalArticle

Open Access
48 Scopus citations

PDZ-RhoGEF Is a Signaling Effector for TROY-Induced Glioblastoma Cell Invasion and Survival

Ding, Z., Dhruv, H., Kwiatkowska-Piwowarczyk, A., Ruggieri, R., Kloss, J., Symons, M., Pirrotte, P., Eschbacher, J. M., Tran, N. L. & Loftus, J. C., Oct 2018, In : Neoplasia (United States). 20, 10, p. 1045-1058 14 p.

Research output: Contribution to journalArticle

4 Scopus citations

Pediatric Eosinophilic Esophagitis Symptom Scores (PEESS v2.0) identify histologic and molecular correlates of the key clinical features of disease

Martin, L. J., Franciosi, J. P., Collins, M. H., Abonia, J. P., Lee, J. J., Hommel, K. A., Varni, J. W., Grotjan, J. T., Eby, M., He, H., Marsolo, K., Putnam, P. E., Garza, J. M., Kaul, A., Wen, T. & Rothenberg, M. E., Jun 1 2015, In : Journal of Allergy and Clinical Immunology. 135, 6, p. 1519-1528.e8

Research output: Contribution to journalArticle

56 Scopus citations

Permeability of wild-type and mutant cystic fibrosis transmembrane conductance regulator chloride channels to polyatomic anions

Linsdell, P., Tabcharani, J. A., Rommens, J. M., Hou, Y. X., Chang, X. B., Tsui, L. C., Riordan, J. R. & Hanrahan, J. W., Oct 1997, In : Journal of General Physiology. 110, 4, p. 355-364 10 p.

Research output: Contribution to journalArticle

158 Scopus citations

Peroxisome proliferator-activated receptor γ controls Muc1 transcription in trophoblasts

Shalom-Barak, T., Nicholas, J. M., Wang, Y., Zhang, X., Ong, E. S., Young, T. H., Gendler, S. J., Evans, R. M. & Barak, Y., Dec 2004, In : Molecular and cellular biology. 24, 24, p. 10661-10669 9 p.

Research output: Contribution to journalArticle

64 Scopus citations

Perturbation of Hsp90 interaction with nascent CFTR prevents its maturation and accelerates its degradation by the proteasome

Loo, M. A., Jensen, T. J., Cui, L., Hou, Y. X., Chang, X. B. & Riordan, J. R., Dec 1 1998, In : EMBO Journal. 17, 23, p. 6879-6887 9 p.

Research output: Contribution to journalArticle

287 Scopus citations

Phase space reduction and vortex statistics: An anyon quantization ambiguity

Allen, T. J., Bordner, A. J. & Crossley, D. B., 1994, In : Physical Review D. 49, 12, p. 6907-6913 7 p.

Research output: Contribution to journalArticle

1 Scopus citations

Phenotypic and molecular analysis of a transgenic insertional allele of the mouse fused locus

Perry, W. L., Vasicek, T. J., Lee, J. J., Rossi, J. M., Zeng, L., Zhang, T., Tilghman, S. M. & Costantini, F., Jan 1 1995, In : Genetics. 141, 1, p. 321-332 12 p.

Research output: Contribution to journalArticle

78 Scopus citations

PHF20 is an effector protein of p53 double lysine methylation that stabilizes and activates p53

Cui, G., Park, S., Badeaux, A. I., Kim, D., Lee, J., Thompson, J. R., Yan, F., Kaneko, S., Yuan, Z., Botuyan, M. V., Bedford, M. T., Cheng, J. Q. & Mer, G., Sep 2012, In : Nature Structural and Molecular Biology. 19, 9, p. 916-924 9 p.

Research output: Contribution to journalArticle

51 Scopus citations

Phosphatase inhibitors activate normal and defective CFTR chloride channels

Becq, F., Jensen, T. J., Chang, X. B., Savoia, A., Rommens, J. M., Tsui, L. C., Buchwald, M., Riordan, J. R. & Hanrahan, J. W., Sep 13 1994, In : Proceedings of the National Academy of Sciences of the United States of America. 91, 19, p. 9160-9164 5 p.

Research output: Contribution to journalArticle

139 Scopus citations

Phosphorylation of MUC1 by met modulates interaction with p53 and MMP1 expression

Singh, P. K., Behrens, M. E., Eggers, J. P., Cerny, R. L., Bailey, J. M., Shanmugam, K., Gendler, S. J., Bennett, E. P. & Hollingsworth, M. A., Oct 3 2008, In : Journal of Biological Chemistry. 283, 40, p. 26985-26995 11 p.

Research output: Contribution to journalArticle

71 Scopus citations

Phosphorylation of protein kinase C sites in NBD1 and the R domain control CFTR channel activation by PKA

Chappe, V., Hinkson, D. A., Zhu, T., Chang, X. B., Riordan, J. R. & Hanrahan, J. W., Apr 1 2003, In : Journal of Physiology. 548, 1, p. 39-52 14 p.

Research output: Contribution to journalReview article

62 Scopus citations

Phosphorylation-regulated CI- channel in CHO cells stably expressing the cystic fibrosis gene

Tabcharani, J. A., Chang, X. B., Riordan, J. R. & Hanrahan, J. W., Jan 1 1991, In : Nature. 352, 6336, p. 628-631 4 p.

Research output: Contribution to journalArticle

437 Scopus citations

Pivotal Advance: Eosinophil infiltration of solid tumors is an early and persistent inflammatory host response

Cormier, S. A., Taranova, A. G., Bedient, C., Nguyen, T., Protheroe, C., Pero, R., Dimina, D., Ochkur, S. I., O'Neill, K., Colbert, D., Lombari, T. R., Constant, S., McGarry, M. P., Lee, J. J. & Lee, N. A., Jun 2006, In : Journal of Leukocyte Biology. 79, 6, p. 1131-1139 9 p.

Research output: Contribution to journalArticle

126 Scopus citations

Placental protein 13 and decidual zones of necrosis: An immunologic diversion that may be linked to preeclampsia

Kliman, H. J., Sammar, M., Grimpel, Y. I., Lynch, S. K., Milano, K. M., Pick, E., Bejar, J., Arad, A., Lee, J. J., Meiri, H. & Gonen, R., Jan 1 2012, In : Reproductive Sciences. 19, 1, p. 16-30 15 p.

Research output: Contribution to journalArticle

49 Scopus citations

Platelet activation and cytoskeletal reorganization: high voltage electron microscopic examination of intact and triton-extracted whole mounts

Loftus, J. C., Choate, J. & Albrecht, R. M., 1984, In : Journal of Cell Biology. 98, 6, p. 2019-2025 7 p.

Research output: Contribution to journalArticle

Open Access
58 Scopus citations

Platelet adhesion receptors

Williams, M. J., Du, X., Loftus, J. C. & Ginsberg, M. H., 1995, In : Seminars in Cell and Developmental Biology. 6, 5, p. 305-314 10 p.

Research output: Contribution to journalArticle

36 Scopus citations

Platelet-derived growth factor receptor β-mediated phosphorylation of MUC1 enhances invasiveness in pancreatic adenocarcinoma cells

Singh, P. K., Wen, Y., Swanson, B. J., Shanmugam, K., Kazlauskas, A., Cerny, R. L., Gendler, S. J. & Hollingsworth, M. A., Jun 1 2007, In : Cancer research. 67, 11, p. 5201-5210 10 p.

Research output: Contribution to journalArticle

89 Scopus citations

Platelet glycoprotein II(b)-III(a) (α(IIb)β3 integrin) confers fibrinogen- and activation-dependent aggregation on heterologous cells

Frojmovic, M. M., O'Toole, T. E., Plow, E. F., Loftus, J. C. & Ginsberg, M. H., Jan 1 1991, In : Blood. 78, 2, p. 369-376 8 p.

Research output: Contribution to journalArticle

32 Scopus citations

Platelet integrins

Ginsberg, M. H., Du, X., O'Toole, T. E. & Loftus, J. C., 1995, In : Thrombosis and Haemostasis. 74, 1, p. 352-359 8 p.

Research output: Contribution to journalArticle

63 Scopus citations

Platelet integrins

Ginsberg, M. H., Xiaoping, D., O'Toole, T. E., Loftus, J. C. & Plow, E. F., 1993, In : Thrombosis and Haemostasis. 70, 1, p. 87-93 7 p.

Research output: Contribution to journalReview article

104 Scopus citations