Biochemistry and Molecular Biology

Research Output

Modulation of β-catenin signaling by glucagon receptor activation

Ke, J., Zhang, C., Harikumar, K. G., Zylstra-Diegel, C. R., Wang, L., Mowry, L. E., Miller, L. J., Williams, B. O. & Xu, H. E., Mar 16 2012, In : PloS one. 7, 3, e33676.

Research output: Contribution to journalArticle

13 Scopus citations

Molecular analysis of human Siglec-8 orthologs relevant to mouse eosinophils: Identification of mouse orthologs of Siglec-5 (mSiglec-F) and Siglec-10 (mSiglec-G)

Aizawa, H., Zimmermann, N., Carrigan, P. E., Lee, J. J., Rothenberg, M. E. & Bochner, B. S., Nov 1 2003, In : Genomics. 82, 5, p. 521-530 10 p.

Research output: Contribution to journalArticle

38 Scopus citations

Molecular and microenvironmental determinants of glioma stem-like cell survival and invasion

Roos, A., Ding, Z., Loftus, J. C. & Tran, N. L., Jun 16 2017, In : Frontiers in Oncology. 7, JUN, 120.

Research output: Contribution to journalReview article

50 Scopus citations

Molecular aspects of mucins

Taylor-Papadimitriou, J. & Gendler, S. J., Jan 1 1988, In : Cancer Reviews. 11-12, p. 11-24 14 p.

Research output: Contribution to journalArticle

39 Scopus citations

Molecular basis for benzodiazepine agonist action at the type 1 cholecystokinin receptor

Harikumar, K. G., Cawston, E. E., Lam, P. C. H., Patil, A., Orry, A., Henke, B. R., Abagyan, R., Christopoulos, A., Sexton, P. M. & Miller, L. J., Jul 19 2013, In : Journal of Biological Chemistry. 288, 29, p. 21082-21095 14 p.

Research output: Contribution to journalArticle

11 Scopus citations

Molecular basis for binding and subtype selectivity of 1,4-benzodiazepine antagonist ligands of the cholecystokinin receptor

Cawston, E. E., Lam, P. C. H., Harikumar, K. G., Dong, M., Ball, A. M., Augustine, M. L., Akgün, E., Portoghese, P. S., Orry, A., Abagyan, R., Sexton, P. M. & Miller, L. J., May 25 2012, In : Journal of Biological Chemistry. 287, 22, p. 18618-18635 18 p.

Research output: Contribution to journalArticle

15 Scopus citations

Molecular basis of association of receptor activity-modifying protein 3 with the family B G protein-coupled secretin receptor

Harikumar, K. G., Simms, J., Christopoulos, G., Sexton, P. M. & Miller, L. J., Dec 15 2009, In : Biochemistry. 48, 49, p. 11773-11785 13 p.

Research output: Contribution to journalArticle

39 Scopus citations

Molecular basis of metastasis [8]

Lee, J. J. & Lotze, M. T., Apr 16 2009, In : New England Journal of Medicine. 360, 16, 1 p.

Research output: Contribution to journalLetter

9 Scopus citations

Molecular characterization of the large heavily glycosylated domain glycopeptide from the rat small intestinal Muc2 mucin

Karlsson, N. G., Johansson, M. E., Asker, N., Karlsson, H., Gendler, S. J., Carlstedt, I. & Hansson, G. C., Nov 2 1996, In : Glycoconjugate Journal. 13, 5, p. 823-831 9 p.

Research output: Contribution to journalArticle

22 Scopus citations

Molecular characterization of the murine eosinophil secondary granule proteins and their potential relevance to the evolution of effector function

Larson, K. A., Horton, M. A., Olson, E. V., Gleich, G. J., Lee, N. A. & Lee, J. J., Dec 1 1996, In : FASEB Journal. 10, 6, p. A1023

Research output: Contribution to journalArticle

183 Scopus citations

Molecular cloning and chemical synthesis of a region of platelet glycoprotein IIb involved in adhesive function

Loftus, J. C., Plow, E. F., Frelinger, A. L., D'Souza, S. E., Dixon, D., Lacy, J., Sorge, J. & Ginsberg, M. H., 1987, In : Proceedings of the National Academy of Sciences of the United States of America. 84, 20, p. 7114-7118 5 p.

Research output: Contribution to journalArticle

Open Access
61 Scopus citations
107 Scopus citations

Molecular cloning and expression of human tumor-associated polymorphic epithelial mucin

Gendler, S. J., Lancaster, C. A., Taylor-Papadimitriou, J., Duhig, T., Peat, N., Burchell, J., Pemberton, L., Lalani, E. N. & Wilson, D., Sep 28 1990, In : Journal of Biological Chemistry. 265, 25, p. 15286-15293 8 p.

Research output: Contribution to journalArticle

814 Scopus citations

Molecular cloning and preliminary characterization of a novel cytoplasmic antigen recognized by myasthenia gravis sera

Gordon, T., Grove, B., Loftus, J. C., O'Toole, T., McMillan, R., Lindstrom, J. & Ginsberg, M. H., 1992, In : Journal of Clinical Investigation. 90, 3, p. 992-999 8 p.

Research output: Contribution to journalArticle

Open Access
80 Scopus citations

Molecular mechanism of ATP-dependent solute transport by multidrug resistance-associated protein 1.

Chang, X. B., 2010, In : Methods in molecular biology (Clifton, N.J.). 596, p. 223-249 27 p.

Research output: Contribution to journalReview article

24 Scopus citations

Monitoring the state of cholecystokinin receptor oligomerization after ligand binding using decay of time-resolved fluorescence anisotropy

Harikumar, K. G. & Miller, L. J., Nov 2008, Neural Signaling Opportunities for Novel Diagnostic Approaches and Therapies. Blackwell Publishing Inc., p. 21-27 7 p. (Annals of the New York Academy of Sciences; vol. 1144).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Mouse eosinophil-associated ribonucleases: A unique subfamily expressed during hematopoiesis

Cormier, S. A., Larson, K. A., Yuan, S., Mitchell, T. L., Lindenberger, K., Carrigan, P., Lee, N. A. & Lee, J. J., May 22 2001, In : Mammalian Genome. 12, 5, p. 352-361 10 p.

Research output: Contribution to journalArticle

36 Scopus citations

Mouse eosinophils possess potent antibacterial properties in vivo

Linch, S. N., Kelly, A. M., Danielson, E. T., Pero, R., Lee, J. J. & Gold, J. A., Nov 2009, In : Infection and Immunity. 77, 11, p. 4976-4982 7 p.

Research output: Contribution to journalArticle

55 Scopus citations

Mouse monoclonal antibodies generated from full length human cereblon: Detection of cereblon protein in patients with multiple myeloma

Chang, X., Xu, Q., Hou, Y., Li, C., Xu, Y. & Stewart, A. K., Sep 17 2017, In : International journal of molecular sciences. 18, 9, 1999.

Research output: Contribution to journalArticle

3 Scopus citations

Mouse Mucin 1 (MUC1) defined by monoclonal antibodies

Xing, P. X., Lees, C., Lodding, J., Prenzoska, J., Poulos, G., Sandrin, M., Gendler, S. & Mckenzie, I. F. C., Jun 10 1998, In : International Journal of Cancer. 76, 6, p. 875-883 9 p.

Research output: Contribution to journalArticle

15 Scopus citations

MUC1, The renaissance molecule

Gendler, S. J., Jul 1 2001, In : Journal of mammary gland biology and neoplasia. 6, 3, p. 339-353 15 p.

Research output: Contribution to journalReview article

409 Scopus citations

MUC1/episialin: A critical barrier in the female reproductive tract

Desouza, M. M., Surveyor, G. A., Price, R. E., Julian, J., Kardon, R., Zhou, X., Gendler, S., Hilkens, J. & Carson, D. D., Jan 1 2000, In : Journal of Reproductive Immunology. 45, 2, p. 127-158 32 p.

Research output: Contribution to journalArticle

127 Scopus citations

MUC1 (CD227) interacts with lck tyrosine kinase in Jurkat lymphoma cells and normal T cells

Mukherjee, P., Tinder, T. L., Basu, G. D. & Gendler, S. J., Jan 1 2005, In : Journal of Leukocyte Biology. 77, 1, p. 90-99 10 p.

Research output: Contribution to journalArticle

47 Scopus citations

Muc1 affects c-Src signaling in PyV MT-induced mammary tumorigenesis

Al Masri, A. & Gendler, S. J., Sep 1 2005, In : Oncogene. 24, 38, p. 5799-5808 10 p.

Research output: Contribution to journalArticle

37 Scopus citations

MUC1 alters oncogenic events and transcription in human breast cancer cells

Hattrup, C. L. & Gendler, S. J., Jul 17 2006, In : Breast Cancer Research. 8, 4, R37.

Research output: Contribution to journalArticle

66 Scopus citations

MUC1 alters β-catenin-dependent tumor formation and promotes cellular invasion

Schroeder, J. A., Adriance, M. C., Thompson, M. C., Camenisch, T. D. & Gendler, S. J., Mar 6 2003, In : Oncogene. 22, 9, p. 1324-1332 9 p.

Research output: Contribution to journalArticle

137 Scopus citations

MUC1 can interact with adenomatous polyposis coli in breast cancer

Hattrup, C. L., Fernandez-Rodriguez, J., Schroeder, J. A., Hansson, G. C. & Gendler, S. J., Apr 2 2004, In : Biochemical and Biophysical Research Communications. 316, 2, p. 364-369 6 p.

Research output: Contribution to journalArticle

20 Scopus citations

MUC1 cell surface mucin is a critical element of the mucosal barrier to infection

McAuley, J. L., Linden, S. K., Chin, W. P., King, R. M., Pennington, H. L., Gendler, S. J., Florin, T. H., Hill, G. R., Korolik, V. & McGuckin, M. A., Aug 1 2007, In : Journal of Clinical Investigation. 117, 8, p. 2313-2324 12 p.

Research output: Contribution to journalArticle

245 Scopus citations

MUC1 cytoplasmic tail detection using CT33 polyclonal and CT2 monoclonal antibodies in breast and colorectal tissue

Croce, M. V., Isla-Larrain, M., Remes-Lenicov, F., Colussi, A. G., Lacunza, E., Kim, K. C., Gendler, S. J. & Segal-Eiras, A., Jul 1 2006, In : Histology and Histopathology. 21, 7-9, p. 849-855 7 p.

Research output: Contribution to journalArticle

23 Scopus citations

MUC1 enhances invasiveness of pancreatic cancer cells by inducing epithelial to mesenchymal transition

Roy, L. D., Sahraei, M., Subramani, D. B., Besmer, D., Nath, S., Tinder, T. L., Bajaj, E., Shanmugam, K., Lee, Y. Y., Hwang, S. I. L., Gendler, S. J. & Mukherjee, P., Mar 24 2011, In : Oncogene. 30, 12, p. 1449-1459 11 p.

Research output: Contribution to journalArticle

160 Scopus citations

Muc1 enhances the β-catenin protective pathway during ischemia-reperfusion injury

Al-Bataineh, M. M., Kinlough, C. L., Poland, P. A., Pastor-Soler, N. M., Sutton, T. A., Mang, H. E., Bastacky, S. I., Gendler, S. J., Madsen, C. S., Singh, S., Monga, S. P. & Hughey, R. P., Mar 15 2016, In : American Journal of Physiology - Renal Physiology. 310, 6, p. F569-F579

Research output: Contribution to journalArticle

18 Scopus citations

MUC1 epithelial mucin (CD227) is expressed by activated dendritic cells

Wykes, M., MacDonald, K. P. A., Tran, M., Quin, R. J., Xing, P. X., Gendler, S. J., Hart, D. N. J. & McGuckin, M. A., Oct 1 2002, In : Journal of Leukocyte Biology. 72, 4, p. 692-701 10 p.

Research output: Contribution to journalArticle

66 Scopus citations

Muc1 is protective during kidney ischemia - Reperfusion injury

Pastor-Soler, N. M., Sutton, T. A., Mang, H. E., Kinlough, C. L., Gendler, S. J., Madsen, C. S., Bastacky, S. I., Ho, J., Al-Bataineh, M. M., Hallows, K. R., Singh, S., Monga, S. P., Kobayashi, H., Haase, V. H. & Hughey, R. P., Jun 15 2015, In : American Journal of Physiology - Renal Physiology. 308, 12, p. F1452-F1462

Research output: Contribution to journalArticle

22 Scopus citations

MUC1 mucin is a negative regulator of toll-like receptor signaling

Ueno, K., Koga, T., Kato, K., Golenbock, D. T., Gendler, S. J., Kai, H. & Kim, K. C., Mar 1 2008, In : American journal of respiratory cell and molecular biology. 38, 3, p. 263-268 6 p.

Research output: Contribution to journalArticle

112 Scopus citations

MUC1 overexpression results in mammary gland tumorigenesis and prolonged alveolar differentiation

Schroeder, J. A., Al Masri, A., Adriance, M. C., Tessier, J. C., Kotlarczyk, K. L., Thompson, M. C. & Gendler, S. J., Jul 29 2004, In : Oncogene. 23, 34, p. 5739-5747 9 p.

Research output: Contribution to journalArticle

110 Scopus citations

MUC1 regulates PDGFA expression during pancreatic cancer progression

Sahraei, M., Roy, L. D., Curry, J. M., Teresa, T. L., Nath, S., Besmer, D., Kidiyoor, A., Dalia, R., Gendler, S. J. & Mukherjee, P., Nov 22 2012, In : Oncogene. 31, 47, p. 4935-4945 11 p.

Research output: Contribution to journalArticle

37 Scopus citations

MUC1-specific CTLs are non-functional within a pancreatic tumor microenvironment

Mukherjee, P., Ginardi, A. R., Madsen, C. S., Tinder, T. L., Jacobs, F., Parker, J., Agrawal, B., Longenecker, B. M. & Gendler, S. J., Nov 1 2001, In : Glycoconjugate Journal. 18, 11-12, p. 931-942 12 p.

Research output: Contribution to journalArticle

49 Scopus citations

MUC1-specific cytotoxic T lymphocytes eradicate tumors when adoptively transferred in vivo

Mukherjee, P., Ginardi, A. R., Tinder, T. L., Sterner, C. J. & Gendler, S. J., Mar 1 2001, In : Clinical Cancer Research. 7, 11 SUPPL., p. 848s-855s

Research output: Contribution to journalArticle

45 Scopus citations

MUC1-specific immune therapy generates a strong anti-tumor response in a MUC1-tolerant colon cancer model

Mukherjee, P., Pathangey, L. B., Bradley, J. B., Tinder, T. L., Basu, G. D., Akporiaye, E. T. & Gendler, S. J., Feb 19 2007, In : Vaccine. 25, 9, p. 1607-1618 12 p.

Research output: Contribution to journalArticle

52 Scopus citations

MUC1 vaccines, comprised of glycosylated or non-glycosylated peptides or tumor-derived MUC1, can circumvent immunoediting to control tumor growth in MUC1 transgenic mice

Lakshminarayanan, V., Supekar, N. T., Wei, J., McCurry, D. B., Dueck, A. C., Kosiorek, H. E., Trivedi, P. P., Bradley, J. M., Madsen, C. S., Pathangey, L. B., Hoelzinger, D. B., Wolfert, M. A., Boons, G. J., Cohen, P. A. & Gendler, S. J., Jan 1 2016, In : PloS one. 11, 1, e0145920.

Research output: Contribution to journalArticle

21 Scopus citations

MUC4 mucin expression in human pancreatic tumours is affected by organ environment: The possible role of TGFβ2

Choudhury, A., Moniaux, N., Ulrich, A. B., Schmied, B. M., Standop, J., Pour, P. M., Gendler, S. J., Hollingsworth, M. A., Aubert, J. P. & Batra, S. K., Feb 9 2004, In : British journal of cancer. 90, 3, p. 657-664 8 p.

Research output: Contribution to journalArticle

23 Scopus citations

Mucin 1-specific immunotherapy in a mouse model of spontaneous breast cancer

Mukherjee, P., Madsen, C. S., Ginardi, A. R., Tinder, T. L., Jacobs, F., Parker, J., Agrawal, B., Longenecker, B. M. & Gendler, S. J., Jan 1 2003, In : Journal of Immunotherapy. 26, 1, p. 47-62 16 p.

Research output: Contribution to journalArticle

74 Scopus citations

Mucin antigens: Molecular structure and potential use in immunotherapy

Taylor-Papadimitriou, J., Lalani, E. N., Burchell, J. & Gendler, S. J., Jan 1 1990, In : Journal of Nuclear Medicine and Allied Sciences. 34, 3 SUPPL., p. 144-150 7 p.

Research output: Contribution to journalArticle

3 Scopus citations

Multidrug resistance protein 1 is not associated to detergent-resistant membranes

Cerf, E., Gasper, R., Rychnovsky, S., Chang, X. B., Buyse, F. & Ruysschaert, J. M., Apr 20 2007, In : Biochemical and Biophysical Research Communications. 355, 4, p. 1025-1030 6 p.

Research output: Contribution to journalArticle

10 Scopus citations

Multidrug resistance protein MRP1 reconstituted into lipid vesicles: Secondary structure and nucleotide-induced tertiary structure changes

Manciu, L., Chang, X. B., Riordan, J. R. & Ruysschaert, J. M., Oct 24 2000, In : Biochemistry. 39, 42, p. 13026-13033 8 p.

Research output: Contribution to journalArticle

26 Scopus citations

Multi-ion pore behaviour in the CFTR chloride channel

Tabcharani, J. A., Rommens, J. M., Hou, Y. X., Chang, X. B., Tsui, L. C., Riordan, J. R. & Hanrahan, J. W., Jan 1 1993, In : Nature. 366, 6450, p. 79-82 4 p.

Research output: Contribution to journalArticle

197 Scopus citations

Multi-parametric MRI and texture analysis to visualize spatial histologic heterogeneity and tumor extent in glioblastoma

Hu, L. S., Ning, S., Eschbacher, J. M., Gaw, N., Dueck, A. C., Smith, K. A., Nakaji, P., Plasencia, J., Ranjbar, S., Price, S. J., Tran, N., Loftus, J., Jenkins, R., O'Neill, B. P., Elmquist, W., Baxter, L. C., Gao, F., Frakes, D., Karis, J. P., Zwart, C. & 5 others, Swanson, K. R., Sarkaria, J., Wu, T., Mitchell, J. R. & Li, J., Nov 1 2015, In : PloS one. 10, 11, e0141506.

Research output: Contribution to journalArticle

56 Scopus citations

Multiple flavonoid-binding sites within multidrug resistance protein MRP1

Trompier, D., Baubichon-Cortay, H., Chang, X. B., Maitrejean, M., Barron, D., Riordan, J. R. & Di Pietro, A., Oct 1 2003, In : Cellular and Molecular Life Sciences. 60, 10, p. 2164-2177 14 p.

Research output: Contribution to journalArticle

63 Scopus citations

MultiRTA: A simple yet reliable method for predicting peptide binding affinities for multiple class II MHC allotypes

Bordner, A. J. & Mittelmann, H. D., Sep 24 2010, In : BMC bioinformatics. 11, 482.

Research output: Contribution to journalArticle

31 Scopus citations