Biochemistry and Molecular Biology

Research Output

Lack of muc1-regulated β-catenin stability results in aberrant expansion of cd11b +gr1 + Myeloid-derived suppressor cells from the bone marrow

Poh, T. W., Bradley, J. M., Mukherjee, P. & Gendler, S. J., Apr 15 2009, In : Cancer research. 69, 8, p. 3554-3562 9 p.

Research output: Contribution to journalArticle

25 Scopus citations

Lack of the intestinal Muc1 mucin impairs cholesterol uptake and absorption but not fatty acid uptake in Muc1-/- mice

Wang, H. H., Afdhal, N. H., Gendler, S. J. & Wang, D. Q. H., Sep 1 2004, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 287, 3 50-3, p. G547-G554

Research output: Contribution to journalArticle

20 Scopus citations

Lactam constraints provide insights into the receptor-bound conformation of secretin and stabilize a receptor antagonist

Dong, M., Te, J. A., Xu, X., Wang, J., Pinon, D. I., Storjohann, L., Bordner, A. J. & Miller, L. J., Sep 27 2011, In : Biochemistry. 50, 38, p. 8181-8192 12 p.

Research output: Contribution to journalArticle

16 Scopus citations

Large-scale prediction of protein geometry and stability changes for arbitrary single point mutations

Bordner, A. J. & Abagyan, R. A., Nov 1 2004, In : Proteins: Structure, Function and Genetics. 57, 2, p. 400-413 14 p.

Research output: Contribution to journalArticle

89 Scopus citations

Letter for Joyce

Gendler, S. J., Nov 1 2001, In : Glycoconjugate Journal. 18, 11-12, p. 839-840 2 p.

Research output: Contribution to journalLetter

Ligand binding and activation of the secretin receptor, a prototypic family B G protein-coupled receptor

Miller, L. J., Dong, M. & Harikumar, K. G., May 2012, In : British Journal of Pharmacology. 166, 1, p. 18-26 9 p.

Research output: Contribution to journalReview article

12 Scopus citations

Ligand binding and affinity modulation of integrins

Tozer, E. C., Hughes, P. E. & Loftus, J. C., Jan 1 1996, In : Biochemistry and Cell Biology. 74, 6, p. 785-798 14 p.

Research output: Contribution to journalArticle

35 Scopus citations

Ligand binding characteristics of the human serotonin 1A receptor heterologously expressed in CHO cells

Kalipatnapu, S., Pucadyil, T. J., Harikumar, K. G. & Chattopadhyay, A., Apr 1 2004, In : Bioscience reports. 24, 2, p. 101-115 15 p.

Research output: Contribution to journalArticle

32 Scopus citations

Ligand binding to integrins: Dynamic regulation and common mechanisms

Ginsberg, M. H., O'Toole, T. E., Loftus, J. C. & Plow, E. F., 1992, In : Cold Spring Harbor Symposia on Quantitative Biology. 57, p. 221-232 12 p.

Research output: Contribution to journalArticle

27 Scopus citations

Ligand binding to integrins

Plow, E. F., Haas, T. A., Zhang, L., Loftus, J. & Smith, J. W., Jul 21 2000, In : Journal of Biological Chemistry. 275, 29, p. 21785-21788 4 p.

Research output: Contribution to journalShort survey

1016 Scopus citations

Ligand binding to integrins: Common and ligand specific recognition mechanisms

Ginsberg, M. H., Loftus, J. C., D'Souza, S. & Plow, E. F., Dec 11 1990, In : Cell Differentiation and Development. 32, 3, p. 203-213 11 p.

Research output: Contribution to journalArticle

17 Scopus citations

Ligand binding to integrin α(IIb)β3 is dependent on a MIDAS-like domain in the β3 subunit

Tozer, E. C., Liddington, R. C., Sutcliffe, M. J., Smeeton, A. H. & Loftus, J. C., Sep 25 1996, In : Journal of Biological Chemistry. 271, 36, p. 21978-21984 7 p.

Research output: Contribution to journalArticle

158 Scopus citations

Ligand bridging mediates integrin αIIbβ3 (platelet GPIIB-IIIA) dependent homotypic and heterotypic cell-cell interactions

Gawaz, M. P., Loftus, J. C., Bajt, M. L., Frojmovic, M. M., Plow, E. F. & Ginsberg, M. H., 1991, In : Journal of Clinical Investigation. 88, 4, p. 1128-1134 7 p.

Research output: Contribution to journalArticle

Open Access
102 Scopus citations

Ligand-induced internalization of the type 1 cholecystokinin receptor independent of recognized signaling activity

Cawston, E. E., Harikumar, K. G. & Miller, L. J., Feb 2012, In : American Journal of Physiology - Cell Physiology. 302, 3, p. C615-C627

Research output: Contribution to journalArticle

2 Scopus citations

Ligands "activate" integrin αIIbβ3 (platelet GPIIb-IIIa)

Du, X., Plow, E. F., Frelinger, A. L., O'Toole, T. E., Loftus, J. C. & Ginsberg, M. H., May 3 1991, In : Cell. 65, 3, p. 409-416 8 p.

Research output: Contribution to journalArticle

398 Scopus citations

Linear canonical transformations in quantum mechanics

Bordner, A. J., Jul 1997, In : Journal of Mathematical Physics. 38, 7, p. 3427-3434 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

Linear synthesis and immunological properties of a fully synthetic vaccine candidate containing a sialylated MUC1 glycopeptide

Thompson, P., Lakshminarayanan, V., Supekar, N. T., Bradley, J. M., Cohen, P. A., Wolfert, M. A., Gendler, S. J. & Boons, G. J., May 28 2015, In : Chemical Communications. 51, 50, p. 10214-10217 4 p.

Research output: Contribution to journalArticle

28 Scopus citations

Local hypersensitivity reaction in transgenic mice with squamous epithelial IL-5 overexpression provides a novel model of eosinophilic oesophagitis

Masterson, J. C., McNamee, E. N., Hosford, L., Capocelli, K. E., Ruybal, J., Fillon, S. A., Doyle, A. D., Eltzschig, H. K., Rustgi, A. K., Protheroe, C. A., Lee, N. A., Lee, J. J. & Furuta, G. T., Jan 1 2014, In : Gut. 63, 1, p. 43-53 11 p.

Research output: Contribution to journalArticle

24 Scopus citations

Local proliferation and mobilization of CCR3+ CD34+ eosinophil-lineage-committed cells in the lung

Rådinger, M., Bossios, A., Sjöstrand, M., Lu, Y., Malmhäll, C., Dahlborn, A. K., Lee, J. J. & Lötvall, J., Jan 1 2011, In : Immunology. 132, 1, p. 144-154 11 p.

Research output: Contribution to journalArticle

24 Scopus citations

Longevity and age-related pathology of mice deficient in pregnancy-associated plasma protein-a

Conover, C. A., Bale, L. K., Mader, J. R., Mason, M. A., Keenan, K. P. & Marler, R. J., Jun 2010, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 65 A, 6, p. 590-599 10 p.

Research output: Contribution to journalArticle

59 Scopus citations

Loss of heterozygosity analysis in primary mammary tumors and lung metastases of MMTV-MTAg and MMTV-neu transgenic mice

Ritland, S. R., Rowse, G. J., Chang, Y. & Gendler, S. J., Aug 15 1997, In : Cancer research. 57, 16, p. 3520-3525 6 p.

Research output: Contribution to journalArticle

40 Scopus citations

Loss of the transcription factor GLI1 identifies a signaling network in the tumor microenvironment mediating KRAS oncogene-induced transformation

Mills, L. D., Zhang, Y., Marler, R. J., Herreros-Villanueva, M., Zhang, L., Almada, L. L., Couch, F., Wetmore, C., Di Magliano, M. P. & Fernandez-Zapico, M. E., Apr 26 2013, In : Journal of Biological Chemistry. 288, 17, p. 11786-11794 9 p.

Research output: Contribution to journalArticle

68 Scopus citations

Low-Dose Gamma Irradiation of Decellularized Heart Valves Results in Tissue Injury In Vitro and In Vivo

Helder, M. R. K., Hennessy, R. S., Spoon, D. B., Tefft, B. J., Witt, T. A., Marler, R. J., Pislaru, S. V., Simari, R. D., Stulak, J. M. & Lerman, A., Feb 1 2016, In : Annals of Thoracic Surgery. 101, 2, p. 667-674 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Lung pathologies in a chronic inflammation mouse model are independent of eosinophil degranulation

Jacobsen, E. A., Ochkur, S. I., Doyle, A. D., LeSuer, W. E., Li, W., Protheroe, C. A., Colbert, D., Zellner, K. R., Shen, H. H., Irvin, C. G., Lee, J. J. & Lee, N. A., May 15 2017, In : American journal of respiratory and critical care medicine. 195, 10, p. 1321-1332 12 p.

Research output: Contribution to journalArticle

11 Scopus citations

Major basic protein-1 promotes fibrosis of dystrophic muscle and attenuates the cellular immune response in muscular dystrophy

Wehling-henricks, M., Sokolow, S., Lee, J. J., Myung, K. H., Villalta, S. A. & Tidball, J. G., Aug 2008, In : Human molecular genetics. 17, 15, p. 2280-2292 13 p.

Research output: Contribution to journalArticle

51 Scopus citations

Major basic protein from eosinophils and myeloperoxidase from neutrophils are required for protective immunity to Strongyloides stercoralis in mice

O'Connell, A. E., Hess, J. A., Santiago, G. A., Nolan, T. J., Lok, J. B., Lee, J. J. & Abraham, D., Jul 2011, In : Infection and Immunity. 79, 7, p. 2770-2778 9 p.

Research output: Contribution to journalArticle

63 Scopus citations

Many αIIbβ3 autoepitopes in chronic immune thrombocytopenic purpura are localized to αIIb between amino acids L1 and Q459

Mcmillan, R., Wang, L., Lopez-Dee, J., Jiu, S. & Loftus, J. C., Sep 25 2002, In : British journal of haematology. 118, 4, p. 1132-1136 5 p.

Research output: Contribution to journalArticle

12 Scopus citations

Mapping of cystic fibrosis transmembrane conductance regulator membrane topology by glycosylation site insertion

Chang, X. B., Hou, Y. X., Jensen, T. J. & Riordan, J. R., Jul 15 1994, In : Journal of Biological Chemistry. 269, 28, p. 18572-18575 4 p.

Research output: Contribution to journalArticle

114 Scopus citations
4 Scopus citations

Mast cells are required for full expression of allergen/SEB-Induced skin inflammation

Ando, T., Matsumoto, K., Namiranian, S., Yamashita, H., Glatthorn, H., Kimura, M., Dolan, B. R., Lee, J. J., Galli, S. J., Kawakami, Y., Jamora, C. & Kawakami, T., Dec 2013, In : Journal of Investigative Dermatology. 133, 12, p. 2695-2705 11 p.

Research output: Contribution to journalArticle

35 Scopus citations

Measurement of Intermolecular Distances for the Natural Agonist Peptide Docked at the Cholecystokinin Receptor Expressed in Situ Using Fluorescence Resonance Energy Transfer

Harikumar, K. G., Pinon, D. I., Wessels, W. S., Dawson, E. S., Lybrand, T. P., Prendergast, F. G. & Miller, L. J., Jan 1 2004, In : Molecular pharmacology. 65, 1, p. 28-35 8 p.

Research output: Contribution to journalArticle

21 Scopus citations

Mechanism of immunomodulatory drugs' action in the treatment of multiple myeloma

Chang, X., Zhu, Y., Shi, C. & Stewart, A. K., Mar 2014, In : Acta Biochimica et Biophysica Sinica. 46, 3, p. 240-253 14 p.

Research output: Contribution to journalReview article

37 Scopus citations

Mechanisms underlying the growth inhibitory effects of the cyclo-oxygenase-2 inhibitor celecoxib in human breast cancer cells.

Basu, G. D., Pathangey, L. B., Tinder, T. L., Gendler, S. J. & Mukherjee, P., 2005, In : Breast cancer research : BCR. 7, 4, p. R422-435

Research output: Contribution to journalArticle

Open Access
117 Scopus citations

Membrane cholesterol affects stimulus-activity coupling in type 1, but not type 2, CCK receptors: Use of cell lines with elevated cholesterol

Harikumar, K. G., Potter, R. M., Patil, A., Echeveste, V. & Miller, L. J., Mar 1 2013, In : Lipids. 48, 3, p. 231-244 14 p.

Research output: Contribution to journalArticle

13 Scopus citations

Mercury induces regional and cell-specific stress protein expression in rat kidney

Goering, P. L., Fisher, B. R., Noren, B. T., Papaconstantinou, A., Rojko, J. L. & Marler, R. J., Feb 28 2000, In : Toxicological Sciences. 53, 2, p. 447-457 11 p.

Research output: Contribution to journalArticle

71 Scopus citations

Metabolic consequences of adenosine deaminase deficiency in mice are associated with defects in alveogenesis, pulmonary inflammation, and airway obstruction

Blackburn, M. R., Volmer, J. B., Thrasher, J. L., Zhong, H., Crosby, J. R., Lee, J. J. & Kellems, R. E., Jul 17 2000, In : Journal of Experimental Medicine. 192, 2, p. 159-170 12 p.

Research output: Contribution to journalArticle

185 Scopus citations

Metal ion and guanine nucleotide modulations of agonist interaction in G-protein-coupled serotonin(1A) receptors from bovine hippocampus

Harikumar, K. G. & Chattopadhyay, A., Oct 3 1998, In : Cellular and molecular neurobiology. 18, 5, p. 535-553 19 p.

Research output: Contribution to journalArticle

34 Scopus citations

Methacholine-induced airway hyperresponsiveness is dependent on Gαq signaling

Borchers, M. T., Biechele, T., Justice, J. P., Ansay, T., Cormier, S., Mancino, V., Wilkie, T. M., Simon, M. I., Lee, N. A. & Lee, J. J., Jul 1 2003, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 285, 1 29-1, p. L114-L120

Research output: Contribution to journalArticle

18 Scopus citations

Methylprednisolone acetate induces, and ?7-dafachronic acid suppresses, Strongyloides stercoralis hyperinfection in NSG mice

Patton, J. B., Bonne-Année, S., Deckman, J., Hess, J. A., Torigian, A., Nolan, T. J., Wang, Z., Kliewer, S. A., Durham, A. C., Lee, J. J., Eberhard, M. L., Mangelsdorf, D. J., Lok, J. B. & Abraham, D., Jan 2 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 1, p. 204-209 6 p.

Research output: Contribution to journalArticle

17 Scopus citations

Mice deficient in PAPP-A show resistance to the development of diabetic nephropathy

Mader, J. R., Resch, Z. T., McLean, G. R., Mikkelsen, J. H., Oxvig, C., Marler, R. J. & Conover, C. A., 2013, In : Journal of Endocrinology. 219, 1, p. 51-58 8 p.

Research output: Contribution to journalArticle

18 Scopus citations

Mice with spontaneous pancreatic cancer naturally develop MUC-1-specific CTLs that eradicate tumors when adoptively transferred

Mukherjee, P., Ginardi, A. R., Madsen, C. S., Sterner, C. J., Adriance, M. C., Tevethia, M. J. & Gendler, S. J., Sep 15 2000, In : Journal of Immunology. 165, 6, p. 3451-3460 10 p.

Research output: Contribution to journalArticle

Open Access
76 Scopus citations

Mimic 1 of MUC1

Finn, O. J. & Gendler, S. J., Jan 1 1998, In : Nature biotechnology. 16, 3, p. 236-237 2 p.

Research output: Contribution to journalArticle

5 Scopus citations

MiRNA expression profiling in migrating Glioblastoma cells: Regulation of cell migration and invasion by miR-23b via targeting of Pyk2

Loftus, J. C., Ross, J. T. D., Paquette, K. M., Paulino, V. M., Nasser, S., Yang, Z., Kloss, J., Kim, S., Berens, M. E. & Tran, N. L., Jun 22 2012, In : PloS one. 7, 6, e39818.

Research output: Contribution to journalArticle

51 Scopus citations

Misassembled mutant ΔF508 CFTR in the distal secretory pathway alters cellular lipid trafficking

Gentzsch, M., Choudhury, A., Chang, X. B., Pagano, R. E. & Riordan, J. R., Feb 1 2007, In : Journal of cell science. 120, 3, p. 447-455 9 p.

Research output: Contribution to journalArticle

51 Scopus citations
Open Access
29 Scopus citations

Modification of the tumor microenvironment as a novel target of renal cell carcinoma therapeutics

Finke, J. H., Rayman, P. A., Ko, J. S., Bradley, J. M., Gendler, S. J. & Cohen, P. A., Jul 2013, In : Cancer Journal (United States). 19, 4, p. 353-364 12 p.

Research output: Contribution to journalReview article

34 Scopus citations

Modulation of agonist and antagonist interactions in serotonin 1A receptors by alcohols

Harikumar, K. G. & Chattopadhyay, A., Oct 30 1998, In : FEBS Letters. 438, 1-2, p. 96-100 5 p.

Research output: Contribution to journalArticle

22 Scopus citations

Modulation of antagonist binding to serotonin1A receptors from bovine hippocampus by metal ions

Harikumar, K. G. & Chattopadhyay, A., Dec 1 2001, In : Cellular and molecular neurobiology. 21, 5, p. 453-464 12 p.

Research output: Contribution to journalArticle

15 Scopus citations

Modulation of cell surface expression of nonactivated cholecystokinin receptors using bivalent ligand-induced internalization

Harikumar, K. G., Akgün, E., Portoghese, P. S. & Miller, L. J., Apr 8 2010, In : Journal of Medicinal Chemistry. 53, 7, p. 2836-2842 7 p.

Research output: Contribution to journalArticle

14 Scopus citations

Modulation of Muc-1 mucin expression in the mouse uterus during the estrus cycle, early pregnancy and placentation

Braga, V. M. M. & Gendler, S. J., Jan 1 1993, In : Journal of cell science. 105, 2, p. 397-405 9 p.

Research output: Contribution to journalArticle

129 Scopus citations