Biochemistry and Molecular Biology

Research Output

Immune and anticancer responses elicited by fully synthetic aberrantly glycosylated MUC1 tripartite vaccines modified by a TLR2 or TLR9 agonist

Abdel-Aal, A. B. M., Lakshminarayanan, V., Thompson, P., Supekar, N., Bradley, J. M., Wolfert, M. A., Cohen, P. A., Gendler, S. J. & Boons, G. J., Jul 7 2014, In : ChemBioChem. 15, 10, p. 1508-1513 6 p.

Research output: Contribution to journalArticle

39 Scopus citations

Immune recognition of tumor-associated mucin MUC1 is achieved by a fully synthetic aberrantly glycosylated MUC1 tripartite vaccine

Lakshminarayanan, V., Thompson, P., Wolfert, M. A., Buskas, T., Bradley, J. M., Pathangey, L. B., Madsen, C. S., Cohen, P. A., Gendler, S. J. & Boons, G. J., Jan 3 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 1, p. 261-266 6 p.

Research output: Contribution to journalArticle

203 Scopus citations

Immunochemical and amino-terminal sequence comparison of two cytoadhesins indicates they contain similar or identical β subunits and distinct α subunits

Ginsberg, M. H., Loftus, J., Ryckwaert, J. J., Pierschbacher, M., Pytela, R., Ruoslahti, E. & Plow, E. F., Sep 15 1987, In : Journal of Biological Chemistry. 262, 12, p. 5437-5440 4 p.

Research output: Contribution to journalArticle

56 Scopus citations

Immunodetection of occult eosinophils in lung tissue biopsies may help predict survival in acute lung injury

Willetts, L., Parker, K., Wesselius, L. J., Protheroe, C. A., Jaben, E., Graziano, P., Moqbel, R., Leslie, K. O., Lee, N. A. & Lee, J. J., Aug 26 2011, In : Respiratory Research. 12, 116.

Research output: Contribution to journalArticle

19 Scopus citations

Immunoglobulin E and Eosinophil-Dependent Protective Immunity to Larval Onchocerca volvulus in Mice Immunized with Irradiated Larvae

Abraham, D., Leon, O., Schnyder-Candrian, S., Wang, C. C., Galioto, A. M., Kerepesi, L. A., Lee, J. J. & Lustigman, S., Feb 2004, In : Infection and Immunity. 72, 2, p. 810-817 8 p.

Research output: Contribution to journalArticle

58 Scopus citations

Immunological analysis of mucin molecules expressed by normal and malignant mammary epithelial cells

Griffiths, A. B., Burchell, J., Gendler, S., Lewis, A., Blight, K., Tilly, R. & Taylor‐Papadimitriou, J., Sep 15 1987, In : International Journal of Cancer. 40, 3, p. 319-327 9 p.

Research output: Contribution to journalArticle

43 Scopus citations

Immunologic relationship between platelet membrane glycoprotein GPIIb/IIIa and cell surface molecules expressed by a variety of cells

Plow, E. F., Loftus, J. C., Levin, E. G., Fair, D. S., Dixon, D., Forsyth, J. & Ginsberg, M. H., 1986, In : Proceedings of the National Academy of Sciences of the United States of America. 83, 16, p. 6002-6006 5 p.

Research output: Contribution to journalArticle

77 Scopus citations

Immunopathogenesis of Experimental Ulcerative Colitis is Mediated by Eosinophil Peroxidase

Forbes, E., Murase, T., Yang, M., Matthaei, K. I., Lee, J. J., Lee, N. A., Foster, P. S. & Hogan, S. P., May 1 2004, In : Journal of Immunology. 172, 9, p. 5664-5675 12 p.

Research output: Contribution to journalArticle

Open Access
127 Scopus citations

Immunotherapy of spontaneous mammary carcinoma with fusions of dendritic cells and mucin 1-positive carcinoma cells

Chen, D., Xia, J., Tanaka, Y., Chen, H., Koido, S., Wernet, O., Mukherjee, P., Gendler, S. J., Kufe, D. & Gong, J., Jun 1 2003, In : Immunology. 109, 2, p. 300-307 8 p.

Research output: Contribution to journalArticle

62 Scopus citations
7 Scopus citations

Importance and regulation of the colonic mucus barrier in a mouse model of colitis

Petersson, J., Schreiber, O., Hansson, G. C., Gendler, S. J., Velcich, A., Lundberg, J. O., Roos, S., Holm, L. & Phillipson, M., Feb 2011, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 300, 2, p. G327-G333

Research output: Contribution to journalArticle

182 Scopus citations

Importance of each residue within secretin for receptor binding and biological activity

Dong, M., Le, A., Te, J. A., Pinon, D. I., Bordner, A. J. & Miller, L. J., Apr 12 2011, In : Biochemistry. 50, 14, p. 2983-2993 11 p.

Research output: Contribution to journalArticle

21 Scopus citations

Importance of lipid-exposed residues in transmembrane segment four for family B calcitonin receptor homo-dimerization

Harikumar, K. G., Ball, A. M., Sexton, P. M. & Miller, L. J., Sep 2010, In : Regulatory Peptides. 164, 2-3, p. 113-119 7 p.

Research output: Contribution to journalArticle

22 Scopus citations

Inactivation of the transcription factor GLI1 accelerates pancreatic cancer progression

Mills, L. D., Zhang, L., Marler, R., Svingen, P., Fernandez-Barrena, M. G., Dave, M., Bamlet, W., McWilliams, R. R., Petersen, G. M., Faubion, W. & Fernandez-Zapico, M. E., Jun 6 2014, In : Journal of Biological Chemistry. 289, 23, p. 16516-16525 10 p.

Research output: Contribution to journalArticle

12 Scopus citations

Incidence of a split α2-glycoprotein band in the electrophoretic pattern for serum of adenocarcinoma patients

Dermer, G. B., Silverman, L. M., Gendler, S. J. & Tokes, Z. A., Jan 1 1980, In : Clinical chemistry. 26, 3, p. 392-395 4 p.

Research output: Contribution to journalArticle

2 Scopus citations

Increased fibroblast growth factor-inducible 14 expression levels promote glioma cell invasion via Rac1 and nuclear factor-κB and correlate with poor patient outcome

Tran, N. L., McDonough, W. S., Savitch, B. A., Fortin, S. P., Winkles, J. A., Symons, M., Nakada, M., Cunliffe, H. E., Hostetter, G., Hoelzinger, D. B., Rennert, J. L., Michaelson, J. S., Burkly, L. C., Lipinski, C. A., Loftus, J. C., Mariani, L. & Berens, M. E., Oct 1 2006, In : Cancer research. 66, 19, p. 9535-9542 8 p.

Research output: Contribution to journalArticle

140 Scopus citations

Increased GATA-3 and T-bet expression in eosinophilic esophagitis versus gastroesophageal reflux disease

Wright, B. L., Nguyen, N., Shim, K. P., Masterson, J. C., Jacobsen, E. A., Ochkur, S. I., Lee, J. J. & Furuta, G. T., May 2018, In : Journal of Allergy and Clinical Immunology. 141, 5, p. 1919-1921.e5

Research output: Contribution to journalArticle

2 Scopus citations

Increased levels of mucins in the cystic fibrosis mouse small intestine, and modulator effects of the Muc1 mucin expression

Malmberg, E. K., Noaksson, K. A., Phillipson, M., Johansson, M. E. V., Hinojosa-Kurtzberg, M., Holm, L., Gendler, S. J. & Hansson, G. C., Jul 14 2006, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 291, 2, p. G203-G210

Research output: Contribution to journalArticle

41 Scopus citations

Induced association of μ opioid (MOP) and type 2 cholecystokinin (CCK 2) receptors by novel bivalent ligands

Zheng, Y., Akgiin, E., Harikumar, K. G., Hopson, J., Powers, M. D., Lunzer, M. M., Miller, L. J. & Portoghese, P. S., Jan 22 2009, In : Journal of Medicinal Chemistry. 52, 2, p. 247-258 12 p.

Research output: Contribution to journalArticle

46 Scopus citations

Induction of airway allergic inflammation by hypothiocyanite via epithelial cells

Suzuki, S., Ogawa, M., Ohta, S., Nunomura, S., Nanri, Y., Shiraishi, H., Mitamura, Y., Yoshihara, T., Lee, J. J. & Izuhara, K., Dec 30 2016, In : Journal of Biological Chemistry. 291, 53, p. 27219-27227 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

Induction of antitumor immunity by vaccination of dendritic cells transfected with MUC1 RNA

Koido, S., Kashiwaba, M., Chen, D., Gendler, S., Kufe, D. & Gong, J., Nov 15 2000, In : Journal of Immunology. 165, 10, p. 5713-5719 7 p.

Research output: Contribution to journalArticle

Open Access
141 Scopus citations
6 Scopus citations

Influence of organ site and tumor cell type on MUC1-specific tumor immunity

Morikane, K., Tempero, R. M., Sivinski, C. L., Kitajima, S., Gendler, S. J. & Hollingsworth, M. A., Jan 1 2001, In : International Immunology. 13, 2, p. 233-240 8 p.

Research output: Contribution to journalArticle

Open Access
16 Scopus citations

Influence of phosphorylation by protein kinase A on CFTR at the cell surface and endoplasmic reticulum

Seibert, F. S., Chang, X. B., Aleksandrov, A. A., Clarke, D. M., Hanrahan, J. W. & Riordan, J. R., Dec 6 1999, In : Biochimica et Biophysica Acta - Biomembranes. 1461, 2, p. 275-283 9 p.

Research output: Contribution to journalReview article

60 Scopus citations

Inhibiting focal adhesion kinase (FAK) blocks IL-4 induced VCAM-1 expression and eosinophil recruitment in vitro and in vivo

Aulakh, G. K., Petri, B., Wojcik, K. M., Colarusso, P., Lee, J. J. & Patel, K. D., Jan 1 2018, (Accepted/In press) In : Journal of Leukocyte Biology.

Research output: Contribution to journalArticle

2 Scopus citations

Inhibition of adaptive immunity by IL9 can be disrupted to achieve rapid t-cell sensitization and rejection of progressive tumor challenges

Hoelzinger, D. B., Dominguez, A. L., Cohen, P. A. & Gendler, S. J., Dec 1 2014, In : Cancer research. 74, 23, p. 6845-6855 11 p.

Research output: Contribution to journalArticle

28 Scopus citations

Inhibition of epidermal growth factor receptor tyrosine kinase fails to suppress adenoma formation in Apc(Min) mice but induces duodenal injury

Ritland, S. R., Gendler, S. J., Burgart, L. J., Fry, D. W., Nelson, J. M., Bridges, A. J., Andress, L. & Karnes, J., Sep 1 2000, In : Cancer research. 60, 17, p. 4678-4681 4 p.

Research output: Contribution to journalArticle

16 Scopus citations

Inhibition of focal adhesion kinase expression or activity disrupts epidermal growth factor-stimulated signaling promoting the migration of invasive human carcinoma cells

Hauck, C. R., Sieg, D. J., Hsia, D. A., Loftus, J. C., Gaarde, W. A., Monia, B. P. & Schlaepfer, D. D., Oct 1 2001, In : Cancer research. 61, 19, p. 7079-7090 12 p.

Research output: Contribution to journalArticle

239 Scopus citations

Inhibition of phosphatidylinositol 3-kinase by PX-866 suppresses temozolomide-induced autophagy and promotes apoptosis in glioblastoma cells

Harder, B. G., Peng, S., Sereduk, C. P., Sodoma, A. M., Kitange, G. J., Loftus, J. C., Sarkaria, J. N. & Tran, N. L., Nov 14 2019, In : Molecular Medicine. 25, 1, 49.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Insertional Mutations in Transgenic Mice

Costantini, F., Radice, G., Lee, J. J., Perry, W. & Son, H. J., Jan 1 1989, In : Progress in Nucleic Acid Research and Molecular Biology. 36, C, p. 159-169 11 p.

Research output: Contribution to journalArticle

37 Scopus citations

Integrin cytoplasmic domains mediate inside-out signal transduction

O'Toole, T. E., Katagiri, Y., Faull, R. J., Peter, K., Tamura, R., Quaranta, V., Loftus, J. C., Shattil, S. J. & Ginsberg, M. H., Mar 1994, In : Journal of Cell Biology. 124, 6, p. 1047-1059 13 p.

Research output: Contribution to journalArticle

Open Access
563 Scopus citations

Integrin-mediated cell adhesion: The extracellular face

Loftus, J. C., Smith, J. W. & Ginsberg, M. H., Jan 1 1994, In : Journal of Biological Chemistry. 269, 41, p. 25235-25238 4 p.

Research output: Contribution to journalShort survey

181 Scopus citations
5 Scopus citations

Interleukin-5 expression in the lung epithelium of transgenic mice leads to pulmonary changes pathognomonic of asthma

Lee, J. J., McGarry, M. P., Farmer, S. C., Denzler, K. L., Larson, K. A., Carrigan, P. E., Brenneise, I. E., Horton, M. A., Haczku, A., Gelfand, E. W., Leikauf, G. D. & Lee, N. A., Jun 16 1997, In : Journal of Experimental Medicine. 185, 12, p. 2143-2156 14 p.

Research output: Contribution to journalArticle

447 Scopus citations

Interleukin-5 expression in the lung epithelium of transgenic mice leads to pulmonary changes pathognomonic of asthma

Lee, J. J., McGarry, M. P., Farmer, S. C., Denzler, K. L., Larson, K. A., Carrigan, P. E., Brenneise, I. E., Horton, M. A., Haczku, A., Gelfand, E. W., Leikauf, G. D. & Lee A, N., Dec 1 1998, In : Pneumologie. 52, 3, 1 p.

Research output: Contribution to journalArticle

Interleukin 5 is protective during sepsis in an eosinophil-independent manner

Linch, S. N., Danielson, E. T., Kelly, A. M., Tamakawa, R. A., Lee, J. J. & Gold, J. A., Aug 1 2012, In : American journal of respiratory and critical care medicine. 186, 3, p. 246-254 9 p.

Research output: Contribution to journalArticle

38 Scopus citations

Intermediate structural states involved in MRP1-mediated drug transport. Role of glutathione

Manciu, L., Chang, X. B., Buyse, F., Hou, Y. X., Gustot, A., Riordani, J. R. & Ruysschaert, J. M., Jan 31 2003, In : Journal of Biological Chemistry. 278, 5, p. 3347-3356 10 p.

Research output: Contribution to journalArticle

53 Scopus citations

Intestinal macrophage/epithelial cell-derived CCL11/eotaxin-1 mediates eosinophil recruitment and function in pediatric ulcerative colitis

Ahrens, R., Waddell, A., Seidu, L., Blanchard, C., Carey, R., Forbes, E., Lampinen, M., Wilson, T., Cohen, E., Stringer, K., Ballard, E., Munitz, A., Xu, H., Lee, N., Lee, J. J., Rothenberg, M. E., Denson, L. & Hogan, S. P., Nov 15 2008, In : Journal of Immunology. 181, 10, p. 7390-7399 10 p.

Research output: Contribution to journalArticle

Open Access
105 Scopus citations

Intestinal mucins from cystic fibrosis mice show increased fucosylation due to an induced Fucα1-2 glycosyltransferase

Thomsson, K. A., Hinojosa-Kurtzberg, M., Axelsson, K. A., Domino, S. E., Lowe, J. B., Gendler, S. J. & Hansson, G. C., Nov 1 2002, In : Biochemical Journal. 367, 3, p. 609-616 8 p.

Research output: Contribution to journalArticle

41 Scopus citations

Intrahepatic Bile Duct Carcinoma with Metastasis to Bone in a Dog

Marler, R. J., Cook, J. E., Samuelson, M. L. & Kennedy, G. A., Sep 1977, In : Veterinary Pathology. 14, 5, p. 516-518 3 p.

Research output: Contribution to journalArticle

3 Scopus citations

Intraocular use of rituximab

Kitzmann, A. S., Pulido, J. S., Mohney, B. G., Baratz, K. H., Grube, T., Marler, R. J., Donaldson, M. J., O'Neill, B. P., Johnston, P. B., Johnson, K. M., Dixon, L. E., Salomao, D. R. & Cameron, J. D., Dec 2007, In : Eye. 21, 12, p. 1524-1527 4 p.

Research output: Contribution to journalArticle

68 Scopus citations

Intratumoral delivery of CpG-conjugated anti-MUC1 antibody enhances NK cell anti-tumor activity

Schettini, J., Kidiyoor, A., Besmer, D. M., Tinder, T. L., Roy, L. D., Lustgarten, J., Gendler, S. J. & Mukherjee, P., Nov 2012, In : Cancer Immunology, Immunotherapy. 61, 11, p. 2055-2065 11 p.

Research output: Contribution to journalArticle

20 Scopus citations

Intravitreal alemtuzumab penetrates full-thickness retina in rabbit eyes

Ekdawi, N. S., Pulido, J. S., Itty, S., Marler, R. J., Herman, D. C., Hardwig, P., Mohney, B. G., Valyi-Nagy, T. & Shukla, D., Nov 1 2009, In : Retina. 29, 10, p. 1532-1534 3 p.

Research output: Contribution to journalArticle

3 Scopus citations

Intrinsic AHR in IL-5 transgenic mice is dependent on C4+ cells and CD49d-mediated signaling

Borchers, M. T., Crosby, J., Justice, P., Farmer, S., Hines, E., Lee, J. J. & Lee, N. A., 2001, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 281, 3 25-3, p. L653-L659

Research output: Contribution to journalArticle

17 Scopus citations

In vitro assessment of chemokine receptor-ligand interactions mediating mouse eosinophil migration

Borchers, M. T., Ansay, T., DeSalle, R., Daugherty, B. L., Shen, H., Metzger, M., Lee, N. A. & Lee, J. J., Jun 1 2002, In : Journal of Leukocyte Biology. 71, 6, p. 1033-1041 9 p.

Research output: Contribution to journalArticle

73 Scopus citations

In vitro kinetic analysis of cellular anti-MUC1 immune responses in MUC1 transgenic mice

VanLith, M. L., Tempero, R. M., Gendler, S. J. & Hollingsworth, M. A., Mar 20 1998, In : FASEB Journal. 12, 5, p. A891

Research output: Contribution to journalArticle

In vitro selection of fibronectin gain-of-function mutations

Tani, P. H., Loftus, J. C. & Bowditch, R. D., Jul 1 2002, In : Biochemical Journal. 365, 1, p. 287-294 8 p.

Research output: Contribution to journalArticle

6 Scopus citations

In vivo radioiodide imaging and treatment of breast cancer xenografts after MUC1-driven expression of the sodium iodide symporter

Dwyer, R. M., Bergert, E. R., O'Connor, M. K., Gendler, S. J. & Morris, J. C., Feb 15 2005, In : Clinical Cancer Research. 11, 4, p. 1483-1489 7 p.

Research output: Contribution to journalArticle

74 Scopus citations

Kinetics of cellular responses to intraperitoneal Brugia pahangi infections in normal and immunodeficient mice

Ramalingam, T., Rajan, B., Lee, J. & Rajan, T. V., Aug 1 2003, In : Infection and Immunity. 71, 8, p. 4361-4367 7 p.

Research output: Contribution to journalArticle

20 Scopus citations

Lack of eosinophil peroxidase or major basic protein impairs defense against murine filarial infection

Specht, S., Saeftel, M., Arndt, M., Endl, E., Dubben, B., Lee, N. A., Lee, J. J. & Hoerauf, A., Sep 2006, In : Infection and Immunity. 74, 9, p. 5236-5243 8 p.

Research output: Contribution to journalArticle

67 Scopus citations