Biochemistry and Molecular Biology

Research Output

Expression of the cereblon binding protein argonaute 2 plays an important role for multiple myeloma cell growth and survival

Xu, Q., Hou, Y. X., Langlais, P., Erickson, P., Zhu, J., Shi, C. X., Luo, M., Zhu, Y., Xu, Y., Mandarino, L. J., Stewart, K. & Chang, X. B., May 3 2016, In : BMC cancer. 16, 1, 297.

Research output: Contribution to journalArticle

20 Scopus citations

Expression of the gene coding for a human mucin in mouse mammary tumor cells can affect their tumorigenicity

Lalani, E. N., Berdichevsky, F., Boshell, M., Shearer, M., Wilson, D., Stauss, H., Gendler, S. J. & Taylor-Papadimitrious, J., Oct 2 1991, In : Journal of Biological Chemistry. 266, 23, p. 15420-15426 7 p.

Research output: Contribution to journalArticle

62 Scopus citations

Expression of the secondary granule proteins major basic protein 1 (MBP-1) and eosinophil peroxidase (EPX) is required for eosinophilopoiesis in mice

Doyle, A. D., Jacobsen, E. A., Ochkur, S. I., McGarry, M. P., Shim, K. G., Nguyen, D. T. C., Protheroe, C., Colbert, D., Kloeber, J., Neely, J., Shim, K. P., Dyer, K. D., Rosenberg, H. F., Lee, J. J. & Lee, N. A., Aug 1 2013, In : Blood. 122, 5, p. 781-790 10 p.

Research output: Contribution to journalArticle

48 Scopus citations

Expression of wild-type and mutant S20G hIAPP in physiologic knock-in mouse models fails to induce islet amyloid formation, but induces mild glucose intolerance

Hiddinga, H. J., Sakagashira, S., Ishigame, M., Madde, P., Sanke, T., Nanjo, K., Kudva, Y. C., Lee, J. J., van Deursen, J. & Eberhardt, N. L., Apr 1 2012, In : Journal of Diabetes Investigation. 3, 2, p. 138-147 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

Extended survival of Pyk2 or FAK deficient orthotopic glioma xenografts

Lipinski, C. A., Tran, N. L., Viso, C., Kloss, J., Yang, Z., Berens, M. E. & Loftus, J. C., 2008, In : Journal of neuro-oncology. 90, 2, p. 181-189 9 p.

Research output: Contribution to journalArticle

18 Scopus citations

Extensive eosinophil degranulation and peroxidase-mediated oxidation of airway proteins do not occur in a mouse ovalbumin-challenge model of pulmonary inflammation

Denzler, K. L., Borchers, M. T., Crosby, J. R., Cieslewicz, G., Hines, E. M., Justice, J. P., Cormier, S. A., Lindenberger, K. A., Song, W., Wu, W., Hazen, S. L., Gleich, G. J., Lee, J. J. & Lee, N. A., Aug 1 2001, In : Journal of Immunology. 167, 3, p. 1672-1682 11 p.

Research output: Contribution to journalArticle

Open Access
101 Scopus citations

Extensive exploration of conformational space improves Rosetta results for short protein domains.

Li, Y., Bordner, A. J., Tian, Y., Tao, X. & Gorin, A. A., 2008, In : Computational systems bioinformatics / Life Sciences Society. Computational Systems Bioinformatics Conference. 7, p. 203-209 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

Extensive pulmonary arterial thrombosis without subsequent infarction.

Marler, R. J., Kennedy, G. A., Cook, J. E. & Willard, M., Feb 1 1978, In : Veterinary medicine, small animal clinician : VM, SAC. 73, 2, p. 145-147 3 p.

Research output: Contribution to journalArticle

F508del CFTR with two altered RXR motifs escapes from ER quality control but its channel activity is thermally sensitive

Hegedus, T., Aleksandrov, A., Cui, L., Gentzsch, M., Chang, X. B. & Riordan, J. R., May 2006, In : Biochimica et Biophysica Acta - Biomembranes. 1758, 5, p. 565-572 8 p.

Research output: Contribution to journalArticle

47 Scopus citations

Fluorescence characteristics of hydrophobic partial agonist probes of the cholecystokinin receptor

Harikumar, K. G., Pinon, D. I. & Miller, L. J., Apr 1 2006, In : Bioscience reports. 26, 2, p. 89-100 12 p.

Research output: Contribution to journalArticle

3 Scopus citations

Fluorescence polarization screening for allosteric small molecule ligands of the cholecystokinin receptor

Harikumar, K. G., Cawston, E. E. & Miller, L. J., Aug 1 2011, In : Assay and Drug Development Technologies. 9, 4, p. 394-402 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

Fluorescence resonance energy transfer analysis of secretin docking to its receptor: Mapping distances between residues distributed throughout the ligand pharmacophore and distinct receptor residues

Harikumar, K. G., Lam, P. C. H., Dong, M., Sexton, P. M., Abagyan, R. & Miller, L. J., Nov 9 2007, In : Journal of Biological Chemistry. 282, 45, p. 32834-32843 10 p.

Research output: Contribution to journalArticle

25 Scopus citations

Fluorescence resonance energy transfer analysis of the antagonist- and partial agonist-occupied states of the cholecystokinin receptor

Harikumar, K. G. & Miller, L. J., May 13 2005, In : Journal of Biological Chemistry. 280, 19, p. 18631-18635 5 p.

Research output: Contribution to journalArticle

13 Scopus citations
19 Scopus citations

Fluorescent modified phosphatidylcholine floppase activity of reconstituted multidrug resistance-associated protein MRP1

Huang, Z., Chang, X., Riordan, J. R. & Huang, Y., Jan 28 2004, In : Biochimica et Biophysica Acta - Biomembranes. 1660, 1-2, p. 155-163 9 p.

Research output: Contribution to journalArticle

18 Scopus citations

Force fields for homology modeling

Bordner, A. J., Mar 16 2012, Homology Modeling: Methods and Protocols. Orry, A. & Abagyan, R. (eds.). p. 83-106 24 p. (Methods in Molecular Biology; vol. 857).

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Scopus citations

Formation of deletions after initiation of simian virus 40 replication: Influence of packaging limit of the capsid

Chang, X. B. & Wilson, J. H., 1986, In : Journal of virology. 58, 2, p. 393-401 9 p.

Research output: Contribution to journalArticle

Open Access
20 Scopus citations

Frontline science: Eosinophil-deficient MBP-1 and EPX double-knockout mice link pulmonary remodeling and airway dysfunction with type 2 inflammation

Ochkur, S. I., Doyle, A. D., Jacobsen, E. A., LeSuer, W. E., Li, W., Protheroe, C. A., Zellner, K. R., Colbert, D., Shen, H. H. H., Irvin, C. G., Lee, J. J. & Lee, N. A., Sep 2017, In : Journal of Leukocyte Biology. 102, 3, p. 589-599 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

Frontline Science: Characterization of a novel mouse strain expressing human Siglec-8 only on eosinophils

O'Sullivan, J. A., Wei, Y., Carroll, D. J., Moreno-Vinasco, L., Cao, Y., Zhang, F., Lee, J. J., Zhu, Z. & Bochner, B. S., Jul 2018, In : Journal of Leukocyte Biology. 104, 1, p. 11-19 9 p.

Research output: Contribution to journalArticle

10 Scopus citations

Fumarylacetoacetate hydrolase deficient pigs are a novel large animal model of metabolic liver disease

Hickey, R. D., Mao, S. A., Glorioso, J., Lillegard, J. B., Fisher, J. E., Amiot, B., Rinaldo, P., Harding, C. O., Marler, R., Finegold, M. J., Grompe, M. & Nyberg, S. L., Jul 2014, In : Stem Cell Research. 13, 1, p. 144-153 10 p.

Research output: Contribution to journalArticle

33 Scopus citations

Functional importance of a structurally distinct homodimeric complex of the family B G protein-coupled secretin receptor

Gao, F., Harikumar, K. G., Dong, M., Lam, P. C. H., Sexton, P. M., Christopoulos, A., Bordner, A., Abagyan, R. & Miller, L. J., Aug 2009, In : Molecular pharmacology. 76, 2, p. 264-274 11 p.

Research output: Contribution to journalArticle

43 Scopus citations

Function and dysfunction of the CFTR chloride channel

Hanrahan, J. W., Tabcharani, J. A., Becq, F., Mathews, C. J., Augustinas, O., Jensen, T. J., Chang, X. B. & Riordan, J. R., Jul 26 1995, In : Journal of General Physiology. 48 TH ANN. SYMP., p. 125-137 13 p.

Research output: Contribution to journalArticle

34 Scopus citations

G2A signaling dampens colitic inflammation via production of IFN-γ

Frasch, S. C., McNamee, E. N., Kominsky, D., Jedlicka, P., Jakubzick, C., Berry, K. Z., Mack, M., Furuta, G. T., Lee, J. J., Henson, P. M., Colgan, S. P. & Bratton, D. L., Aug 15 2016, In : Journal of Immunology. 197, 4, p. 1425-1434 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

Generalised Calogero-Moser models and universal Lax pair operators

Bordner, A. J., Corrigan, E. & Sasaki, R., Sep 1999, In : Progress of Theoretical Physics. 102, 3, p. 499-529 31 p.

Research output: Contribution to journalArticle

Open Access
56 Scopus citations

Genetic mapping of the tumor-associated mucin 1 gene on mouse Chromosome 3

Kingsmore, S. F., Spicer, A. P., Gendler, S. J. & Seldin, M. F., May 1 1995, In : Mammalian Genome. 6, 5, p. 378-379 2 p.

Research output: Contribution to journalArticle

3 Scopus citations

Genetic modulation of neu proto-oncogene-induced mammary tumorigenesis

Rowse, G. J., Ritland, S. R. & Gendler, S. J., Jun 15 1998, In : Cancer research. 58, 12, p. 2675-2679 5 p.

Research output: Contribution to journalArticle

46 Scopus citations

Glucagon-like peptide-1 receptor dimerization differentially regulates agonist signaling but does not affect small molecule allostery

Harikumar, K. G., Wootten, D., Pinon, D. I., Koole, C., Ball, A. M., Furness, S. G. B., Graham, B., Dong, M., Christopoulos, A., Miller, L. J. & Sexton, P. M., Nov 6 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 45, p. 18607-18612 6 p.

Research output: Contribution to journalArticle

44 Scopus citations

Glutamine residues in Q-loops of multidrug resistance protein MRP1 contribute to ATP binding via interaction with metal cofactor

Yang, R., Hou, Y. X., Campbell, C. A., Palaniyandi, K., Zhao, Q., Bordner, A. J. & Chang, X. B., Jul 1 2011, In : Biochimica et Biophysica Acta - Biomembranes. 1808, 7, p. 1790-1796 7 p.

Research output: Contribution to journalArticle

4 Scopus citations

Glycocalyx restricts adenoviral vector access to apical receptors expressed on respiratory epithelium in vitro and in vivo: Role for tethered mucins as barriers to lumenal infection

Stonebraker, J. R., Wagner, D., Lefensty, R. W., Burns, K., Gendler, S. J., Bergelson, J. M., Boucher, R. C., O'Neal, W. K. & Pickles, R. J., Dec 2004, In : Journal of virology. 78, 24, p. 13755-13768 14 p.

Research output: Contribution to journalArticle

59 Scopus citations

G-protein-dependent cell surface dynamics of the human serotonin 1A receptor tagged to yellow fluorescent protein

Pucadyil, T. J., Kalipatnapu, S., Harikumar, K. G., Rangaraj, N., Karnik, S. S. & Chattopadhyay, A., Dec 21 2004, In : Biochemistry. 43, 50, p. 15852-15862 11 p.

Research output: Contribution to journalArticle

58 Scopus citations

Gq signaling is required for allergen-induced pulmonary eosinophilia

Borchers, M. T., Justice, P. J., Ansay, T., Mancino, V., McGarry, M. P., Crosby, J., Simon, M. I., Lee, N. A. & Lee, J. J., Apr 1 2002, In : Journal of Immunology. 168, 7, p. 3543-3549 7 p.

Research output: Contribution to journalArticle

Open Access
17 Scopus citations

i2-mediated signaling events in the endothelium are involved in controlling leukocyte extravasation

Pero, R. S., Borchers, M. T., Spicher, K., Ochkur, S. I., Sikora, L., Rao, S. P., Abdala-Valencia, H., O'Neill, K. R., Shen, H., McGarry, M. P., Lee, N. A., Cook-Mills, J. M., Sriramarao, P., Simon, M. I., Birnbaumer, L. & Lee, J. J., Mar 13 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 11, p. 4371-4376 6 p.

Research output: Contribution to journalArticle

47 Scopus citations

Heterodimerization of Type A and B Cholecystokinin Receptors Enhance Signaling and Promote Cell Growth

Cheng, Z. J., Harikumar, K. G., Holicky, E. L. & Miller, L. J., Dec 26 2003, In : Journal of Biological Chemistry. 278, 52, p. 52972-52979 8 p.

Research output: Contribution to journalArticle

57 Scopus citations

Heterologous expression systems for study of cystic fibrosis transmembrane conductance regulator

Chang, X. B., Kartner, N., Seibert, F. S., Aleksandrov, A. A., Kloser, A. W., Kiser, G. L. & Riordan, J. R., Jan 1 1998, In : Methods in Enzymology. 292, p. 616-629 14 p.

Research output: Contribution to journalArticle

14 Scopus citations

Histological studies of gene-ablated mice support important functional roles for natural killer cells in the uterus during pregnancy

Croy, B. A., Ashkar, A. A., Foster, R. A., DiSanto, J. P., Magram, J., Carson, D., Gendler, S. J., Grusby, M. J., Wagner, N., Muller, W. & Guimond, M. J., Nov 15 1997, In : Journal of Reproductive Immunology. 35, 2, p. 111-133 23 p.

Research output: Contribution to journalArticle

63 Scopus citations

Homologous recombination into the eosinophil peroxidase locus generates a strain of mice expressing Cre recombinase exclusively in eosinophils

Doyle, A. D., Jacobsen, E. A., Ochkur, S. I., Willetts, L., Shim, K., Neely, J., Kloeber, J., LeSuer, W. E., Pero, R. S., Lacy, P., Moqbel, R., Lee, N. A. & Lee, J. J., Jul 2013, In : Journal of Leukocyte Biology. 94, 1, p. 17-24 8 p.

Research output: Contribution to journalArticle

47 Scopus citations

Human and mouse eosinophils have antiviral activity against parainfluenza virus

Drake, M. G., Bivins-Smith, E. R., Proskocil, B. J., Nie, Z., Scott, G. D., Lee, J. J., Lee, N. A., Fryer, A. D. & Jacoby, D. B., Sep 2016, In : American journal of respiratory cell and molecular biology. 55, 3, p. 387-394 8 p.

Research output: Contribution to journalArticle

27 Scopus citations
13 Scopus citations

Human versus mouse eosinophils: "That which we call an eosinophil, by any other name would stain as red"

Lee, J. J., Jacobsen, E. A., Ochkur, S. I., McGarry, M. P., Condjella, R. M., Doyle, A. D., Luo, H., Zellner, K. R., Protheroe, C. A., Willetts, L., Lesuer, W. E., Colbert, D. C., Helmers, R. A., Lacy, P., Moqbel, R. & Lee, N. A., Sep 2012, In : Journal of Allergy and Clinical Immunology. 130, 3, p. 572-584 13 p.

Research output: Contribution to journalReview article

99 Scopus citations
8 Scopus citations

Hβ58, and insertional mutation affecting early postimplantation development of the mouse embryo

Radice, G., Lee, J. J. & Costantini, F., Apr 4 1991, In : Development. 111, 3, p. 801-811 11 p.

Research output: Contribution to journalArticle

49 Scopus citations

Identification and characterization of a novel, evolutionarily conserved gene disrupted by the murine Hβ58 embryonic lethal transgene insertion

Lee, J. J., Radice, G., Perkins, C. P. & Costantini, F., Jan 1 1992, In : Development. 115, 1, p. 277-288 12 p.

Research output: Contribution to journalArticle

76 Scopus citations

Identification and characterization of high molecular-mass mucin-like glycoproteins in the plasma membrane of airway epithelial cells

Paul, E., Lee, D. I., Hyun, S. W., Gendler, S. & Kim, K. C., Jan 1 1998, In : American journal of respiratory cell and molecular biology. 19, 4, p. 681-690 10 p.

Research output: Contribution to journalArticle

16 Scopus citations

Identification of an alternative Gαq-dependent chemokine receptor signal transduction pathway in dendritic cells and granulocytes

Shi, G., Partida-Sánchez, S., Misra, R. S., Tighe, M., Borchers, M. T., Lee, J. J., Simon, M. I. & Lund, F. E., Oct 29 2007, In : Journal of Experimental Medicine. 204, 11, p. 2705-2718 14 p.

Research output: Contribution to journalArticle

61 Scopus citations

Identification of a new murine eosinophil major basic protein (mMBP) gene: Cloning and characterization of mMBP-2

Macias, M. P., Welch, K. C., Denzler, K. L., Larson, K. A., Lee, N. A. & Lee, J. J., Jan 1 2000, In : Journal of Leukocyte Biology. 67, 4, p. 567-576 10 p.

Research output: Contribution to journalArticle

24 Scopus citations

Identification of aurintricarboxylic acid as a selective inhibitor of the TWEAK-Fn14 signaling pathway in glioblastoma cells

Roos, A., Dhruv, H. D., Mathews, I. T., Inge, L. J., Tuncali, S., Hartman, L. K., Chow, D., Millard, N., Yin, H. H., Kloss, J., Loftus, J. C., Winkles, J. A., Berens, M. E. & Tran, N. L., 2017, In : Oncotarget. 8, 7, p. 12234-12246 13 p.

Research output: Contribution to journalArticle

12 Scopus citations

Identification of cereblon-binding proteins and relationship with response and survival after IMiDs in multiple myeloma

Zhu, Y. X., Braggio, E., Shi, C. X., Kortuem, K. M., Bruins, L. A., Schmidt, J. E., Chang, X. B., Langlais, P., Luo, M., Jedlowski, P., LaPlant, B., Laumann, K., Fonseca, R., Bergsagel, P. L., Mikhael, J., Lacy, M., Champion, M. D. & Stewart, A. K., Jul 24 2014, In : Blood. 124, 4, p. 536-545 10 p.

Research output: Contribution to journalArticle

102 Scopus citations

Identification of kinetin riboside as a repressor of CCND1 and CCND2 with preclinical antimyeloma activity

Tiedemann, R. E., Mao, X., Shi, C. X., Yuan, X. Z., Palmer, S. E., Sebag, M., Marler, R., Chesi, M., Fonseca, R., Bergsagel, P. L., Schimmer, A. D. & Stewart, A. K., May 1 2008, In : Journal of Clinical Investigation. 118, 5, p. 1750-1764 15 p.

Research output: Contribution to journalArticle

47 Scopus citations

IL-33 drives eosinophil infiltration and pathogenic type 2 helper T-cell immune responses leading to chronic experimental ileitis

De Salvo, C., Wang, X. M., Pastorelli, L., Mattioli, B., Omenetti, S., Buela, K. A., Chowdhry, S., Garg, R. R., Goodman, W. A., Rodriguez-Palacios, A., Smith, D. E., Abbott, D. W., Cominelli, F., Bamias, G., Xin, W., Lee, J. J., Vecchi, M. & Pizarro, T. T., Apr 1 2016, In : American Journal of Pathology. 186, 4, p. 885-898 14 p.

Research output: Contribution to journalArticle

31 Scopus citations

Immobilization of silver ions onto paramagnetic particles for binding and release of a biotin-labeled oligonucleotide

Ramírez-Vick, J. E., García, A. A. & Lee, J., Feb 16 2000, In : Reactive and Functional Polymers. 43, 1, p. 53-62 10 p.

Research output: Contribution to journalArticle

5 Scopus citations