Biochemistry and Molecular Biology

Research Output

Characterization of the MUC1.Tg/MIN transgenic mouse as a model for studying antigen-specific immunotherapy of adenomas

Akporiaye, E. T., Bradley-Dunlop, D., Gendler, S. J., Mukherjee, P., Madsen, C. S., Hahn, T., Besselsen, D. G., Dial, S. M., Cui, H. & Trevor, K., Sep 28 2007, In : Vaccine. 25, 39-40, p. 6965-6974 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

Chemoprevention of intestinal adenomas in the Apc(Min) mouse by piroxicam: Kinetics, strain effects and resistance to chemosuppression

Ritland, S. R. & Gendler, S. J., Jan 23 1999, In : Carcinogenesis. 20, 1, p. 51-58 8 p.

Research output: Contribution to journalArticle

92 Scopus citations

Chemotherapy can induce weight normalization of morbidly obese mice despite undiminished ingestion of high fat diet

Myers, C. E., Hoelzinger, D. B., Truong, T. N., Chew, L. A., Myles, A., Chaudhuri, L., Egan, J. B., Liu, J., Gendler, S. J. & Cohen, P. A., 2017, In : Oncotarget. 8, 3, p. 5426-5438 13 p.

Research output: Contribution to journalArticle

2 Scopus citations

Chromosomal mapping of three mucin genes in the rat

Klinga-Levan, K., Gum, J. R., Gendler, S. J., Kim, Y. & Hansson, G. C., Jan 1 1996, In : Mammalian Genome. 7, 3, p. 248-250 3 p.

Research output: Contribution to journalArticle

2 Scopus citations

Chromosome 1 Charcot-Marie-Tooth disease (CMT1B) locus in the Fcγ receptor gene region

Lebo, R. V., Chance, P. F., Dyck, P. J., Redila-Flores, M. T., Lynch, E. D., Golbus, M. S., Bird, T. D., King, M. C., Anderson, L. A., Hall, J., Wiegant, J., Jiang, Z., Dazin, P. F., Punnett, H. H., Schonberg, S. A., Moore, K., Shull, M. M., Gendler, S., Hurko, O., Lovelace, R. E. & 3 others, Latov, N., Trofatter, J. & Conneally, P. M., Nov 1 1991, In : Human genetics. 88, 1, p. 1-12 12 p.

Research output: Contribution to journalArticle

67 Scopus citations

Chromosome 1 Charcot-Marie-Tooth disease (CMT1B) locus in the Fcγ receptor gene region

Lebo, R. V., Chance, P. F., Dyck, P. J., Redila-Flores, M. T., Lynch, E. D., Golbus, M. S., Bird, T. D., King, M. C., Anderson, L. A., Hall, J., Wiegant, J., Jiang, Z., Dazin, P. F., Punnett, H. H., Schonberg, S. A., Moore, K., Shull, M. M., Gendler, S., Hurko, O., Lovelace, R. E. & 3 others, Latov, N., Trofatter, J. & Conneally, P. M., Apr 1 1993, In : Human genetics. 91, 3, 1 p.

Research output: Contribution to journalComment/debate

Chronic Phenotype Characterization of a Large-Animal Model of Hereditary Tyrosinemia Type 1

Elgilani, F., Mao, S. A., Glorioso, J. M., Yin, M., Iankov, I. D., Singh, A., Amiot, B., Rinaldo, P., Marler, R. J., Ehman, R. L., Grompe, M., Lillegard, J. B., Hickey, R. D. & Nyberg, S. L., Jan 1 2017, In : American Journal of Pathology. 187, 1, p. 33-41 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

Clonal allele loss in gastrointestinal cancers

Fey, M. F., Hesketh, C., Wainscoat, J. S., Gendler, S. & Thein, S. L., May 1989, In : British journal of cancer. 59, 5, p. 750-754 5 p.

Research output: Contribution to journalArticle

56 Scopus citations

Cloning of partial cDNA encoding differentiation and tumor-associated mucin glycoproteins expressed by human mammary epithelium

Gendler, S. J., Burchell, J. M., Duhig, T., Lamport, D., White, R., Parker, M. & Taylor-Papadimitriou, J., 1987, In : Proceedings of the National Academy of Sciences of the United States of America. 84, 17, p. 6060-6064 5 p.

Research output: Contribution to journalArticle

Open Access
245 Scopus citations

Cloning of the murine eosinophil peroxidase gene (mEPO): Characterization of a conserved subgroup of mammalian hematopoietic peroxidases

Horton, M. A., Larson, K. A., Lee, J. J. & Lee, N. A., Aug 1996, In : Journal of Leukocyte Biology. 60, 2, p. 285-294 10 p.

Research output: Contribution to journalArticle

51 Scopus citations

Close linkage of PUM and SPTA within chromosome band 1q21

MIDDLETON‐PRICE, H., GENDLER, S. & MALCOLM, S., Jul 1988, In : Annals of Human Genetics. 52, 4, p. 273-278 6 p.

Research output: Contribution to journalArticle

20 Scopus citations

Co-amplification of two cDNAs in RT-PCR can alter the yield of both products

Braga, V. M. M. & Gendler, S. J., Jan 1 1994, In : BioTechniques. 17, 2, p. 228+230

Research output: Contribution to journalArticle

11 Scopus citations

Coexpressed class B G protein-coupled secretin and GLP-1 receptors self-and cross-associate: Impact on pancreatic islets

Harikumar, K. G., Lau, S., Sexton, P. M., Wootten, D. & Miller, L. J., Jun 1 2017, In : Endocrinology. 158, 6, p. 1685-1700 16 p.

Research output: Contribution to journalArticle

6 Scopus citations

Coexpression of IL-5 and eotaxin-2 in mice creates an eosinophil-dependent model of respiratory inflammation with characteristics of severe asthma

Ochkur, S. I., Jacobsen, E. A., Protheroe, C. A., Biechele, T. L., Pero, R. S., McGarry, M. P., Wang, H., O'Neill, K. R., Colbert, D. C., Colby, T. V., Shen, H., Blackburn, M. R., Irvin, C. C., Lee, J. J. & Lee, N. A., Jun 15 2007, In : Journal of Immunology. 178, 12, p. 7879-7889 11 p.

Research output: Contribution to journalArticle

Open Access
117 Scopus citations

Common and ligand-specific integrin recognition mechanisms

Ginsberg, M. H., Loftus, J. C. & Plow, E. F., Jan 1 1991, In : Chemical Immunology. 50, p. 75-88 14 p.

Research output: Contribution to journalReview article

4 Scopus citations

Commuting charges of the quantum Korteweg-De Vries and Boussinesq theories from the reduction of W and W1+∞ algebras

Bordner, A. J., Mar 7 1998, In : Modern Physics Letters A. 13, 7, p. 541-552 12 p.

Research output: Contribution to journalArticle

Comparison of Filler DNA at immune, nonimmune, and oncogenic rearrangements suggests multiple mechanisms of formation

Roth, D. B., Chang, X. B. & Wilson, J. H., 1989, In : Molecular and cellular biology. 9, 7, p. 3049-3057 9 p.

Research output: Contribution to journalArticle

106 Scopus citations

Comparison of three staining methods to identify eosinophils in formalin-fixed canine skin

Gomes, P., Torres, S. M. F., Plager, D. A., Jessen, C. R. & Lee, J. J., Jun 1 2013, In : Veterinary Dermatology. 24, 3, p. 323-e72

Research output: Contribution to journalArticle

14 Scopus citations

Comprehensive inventory of protein complexes in the Protein Data Bank from consistent classification of interfaces

Bordner, A. J. & Gorin, A. A., May 12 2008, In : BMC bioinformatics. 9, 234.

Research output: Contribution to journalArticle

24 Scopus citations

Computational challenges for modeling and simulating biomacromolecular assemblies

Uberbacher, E., LoCascio, P., Passovets, S., Ghattyvenkatakrishna, P., Agarwal, P., Arnold, N., Bordner, A. & Gorin, A., Oct 1 2006, In : Journal of Physics: Conference Series. 46, 1, p. 311-315 5 p., 043.

Research output: Contribution to journalArticle

1 Scopus citations

Conformational maturation of CFTR but not its mutant counterpart (ΔF508) occurs in the endoplasmic reticulum and requires ATP

Lukacs, G. L., Mohamed, A., Kartner, N., Chang, X. B., Riordan, J. R. & Grinstein, S., Dec 1 1994, In : EMBO Journal. 13, 24, p. 6076-6086 11 p.

Research output: Contribution to journalArticle

319 Scopus citations

Constitutive formation of oligomeric complexes between family B G protein-coupled vasoactive intestinal polypeptide and secretin receptors

Harikumar, K. G., Morfis, M. M., Lisenbee, C. S., Sexton, P. M. & Miller, L. J., Jan 2006, In : Molecular pharmacology. 69, 1, p. 363-373 11 p.

Research output: Contribution to journalArticle

54 Scopus citations

Core-glycosylated mucin-like repeats from MUC1 are an apical targeting signal

Kinlough, C. L., Poland, P. A., Gendler, S. J., Mattila, P. E., Mo, D., Weisz, O. A. & Hughey, R. P., Nov 11 2011, In : Journal of Biological Chemistry. 286, 45, p. 39072-39081 10 p.

Research output: Contribution to journalArticle

23 Scopus citations

Corrigendum to "Multidrug resistance protein 1 is not associated to detergent-resistant membranes" [Biochem. Biophys. Res. Commun. 355 (2007) 1025-1030] (DOI:10.1016/j.bbrc.2007.02.075)

Cerf, E., Gasper, R., Belani, J. D., Rychnovsky, S., Chang, X. B., Buyse, F. & Ruysschaert, J. M., Feb 8 2008, In : Biochemical and Biophysical Research Communications. 366, 2, 1 p.

Research output: Contribution to journalComment/debate

CRISPR/Cas9-Mediated Three Nucleotide Insertion Corrects a Deletion Mutation in MRP1/ABCC1 and Restores Its Proper Folding and Function

Xu, Q., Hou, Y. X. & Chang, X. B., Jun 1 2017, In : Molecular Therapy - Nucleic Acids. 7, p. 429-438 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

Critical role of the FERM domain in Pyk2 stimulated glioma cell migration

Lipinski, C. A., Tran, N. L., Dooley, A., Pang, Y. P., Rohl, C., Kloss, J., Yang, Z., McDonough, W., Craig, D., Berens, M. E. & Loftus, J. C., Oct 27 2006, In : Biochemical and Biophysical Research Communications. 349, 3, p. 939-947 9 p.

Research output: Contribution to journalArticle

20 Scopus citations

Curative ex vivo liver-directed gene therapy in a pig model of hereditary tyrosinemia type 1

Hickey, R. D., Mao, S. A., Glorioso, J., Elgilani, F., Amiot, B., Chen, H., Rinaldo, P., Marler, R., Jiang, H., DeGrado, T. R., Suksanpaisan, L., O'Connor, M. K., Freeman, B. L., Ibrahim, S. H., Peng, K. W., Harding, C. O., Ho, C. S., Grompe, M., Ikeda, Y., Lillegard, J. B. & 2 others, Russell, S. J. & Nyberg, S. L., Jul 27 2016, In : Science translational medicine. 8, 349, 349ra99.

Research output: Contribution to journalArticle

26 Scopus citations

Cutting edge: Enhanced pulmonary clearance of Pseudomonas aeruginosa by Muc1 knockout mice

Lu, W., Hisatsune, A., Koga, T., Kato, K., Kuwahara, I., Lillehoj, E. P., Chen, W., Cross, A. S., Gendler, S. J., Gewirtz, A. T. & Kim, K. C., Apr 1 2006, In : Journal of Immunology. 176, 7, p. 3890-3894 5 p.

Research output: Contribution to journalArticle

Open Access
101 Scopus citations

Cyclooxygenase-2 inhibitor induces apoptosis in breast cancer cells in an in vivo model of spontaneous metastatic breast cancer

Basu, G. D., Pathangey, L. B., Tinder, T. L., LaGioia, M., Gendler, S. J. & Mukherjee, P., Nov 1 2004, In : Molecular Cancer Research. 2, 11, p. 632-642 11 p.

Research output: Contribution to journalArticle

131 Scopus citations

Cys-leukotrienes promote fibrosis in a mouse model of eosinophil-mediated respiratory inflammation

Ochkur, S. I., Protheroe, C. A., Li, W., Colbert, D. C., Zellner, K. R., Shen, H. H., Luster, A. D., Irvin, C. G., Lee, J. J. & Lee, N. A., Dec 2013, In : American journal of respiratory cell and molecular biology. 49, 6, p. 1074-1084 11 p.

Research output: Contribution to journalArticle

17 Scopus citations

Cystic fibrosis mice lacking Muc1 have reduced amounts of intestinal mucus

Parmley, R. R. & Gendler, S. J., Nov 15 1998, In : Journal of Clinical Investigation. 102, 10, p. 1798-1806 9 p.

Research output: Contribution to journalArticle

Open Access
64 Scopus citations

Cytoadhesins, integrins, and platelets

Ginsberg, M. H., Loftus, J. C. & Plow, E. F., 1988, In : Thrombosis and Haemostasis. 59, 1, p. 1-6 6 p.

Research output: Contribution to journalReview article

217 Scopus citations

Cytogenetic methods for the mouse: Preparation of chromosomes, karyotyping, and in situ hybridization

Lee, J. J., Warburton, D. & Robertson, E. J., Aug 15 1990, In : Analytical Biochemistry. 189, 1, p. 1-17 17 p.

Research output: Contribution to journalReview article

31 Scopus citations

Decreased size and survival of weanling mice in litters of IL-5 -/- mice are a consequence of the IL-5 deficiency in nursing dams

Colbert, D. C., McGarry, M. P., O'Neill, K., Lee, N. A. & Lee, J. J., May 1 2005, In : Contemporary Topics in Laboratory Animal Science. 44, 3, p. 53-55 3 p.

Research output: Contribution to journalArticle

13 Scopus citations

Defective production of interleukin 1 and interleukin 2 in patients with systemic lupus erythematosus (SLE)

Linker-Israeli, M., Bakke, A. C., Kitridou, R. C., Gendler, S., Gillis, S. & Horwitz, D. A., Aug 4 1983, In : Journal of Immunology. 130, 6, p. 2651-2655 5 p.

Research output: Contribution to journalArticle

343 Scopus citations

Defining a link with asthma in mice congenitally deficient in eosinophils

Lee, J. J., Dimina, D., Macias, M. M. P., Ochkur, S. I., McGarry, M. P., O'Neill, K. R., Protheroe, C., Pero, R., Nguyen, T., Cormier, S. A., Lenkiewicz, E., Colbert, D., Rinaldi, L., Ackerman, S. J., Irvin, C. G. & Lee, N. A., Sep 17 2004, In : Science. 305, 5691, p. 1773-1776 4 p.

Research output: Contribution to journalArticle

557 Scopus citations

Definitive activation of endogenous antitumor immunity by repetitive cycles of cyclophosphamide with interspersed Tolllike receptor agonists

Manrique, S. Z., Dominguez, A. L., Mirza, N., Spencer, C. D., Bradley, J. M., Finke, J. H., Lee, J. J., Pease, L. R., Gendler, S. J. & Cohen, P. A., 2016, In : Oncotarget. 7, 28, p. 42919-42942 24 p.

Research output: Contribution to journalArticle

14 Scopus citations

Delayed mammary tumor progression in Muc-1 null mice

Spicer, A. P., Rowse, G. J., Lidner, T. K. & Gendler, S. J., Dec 15 1995, In : Journal of Biological Chemistry. 270, 50, p. 30093-30101 9 p.

Research output: Contribution to journalArticle

211 Scopus citations

Dendritic cell-tumor cell fusion and staphylococcal enterotoxin B treatment in a pancreatic tumor model

McConnell, E. J., Pathangey, L. B., Madsen, C. S., Gendler, S. J. & Mukherjee, P., Jan 1 2002, In : Journal of Surgical Research. 107, 2, p. 196-202 7 p.

Research output: Contribution to journalArticle

17 Scopus citations

Dependence of critical micelle concentration of a zwitterionic detergent on ionic strength: Implications in receptor solubilization

Chattopadhyay, A. & Harikumar, K. G., Aug 5 1996, In : FEBS Letters. 391, 1-2, p. 199-202 4 p.

Research output: Contribution to journalArticle

99 Scopus citations

Designer Glycopeptides for Cytotoxic T Cell-based Elimination of Carcinomas

Xu, Y., Gendler, S. J. & Franco, A., Mar 1 2004, In : Journal of Experimental Medicine. 199, 5, p. 707-716 10 p.

Research output: Contribution to journalArticle

65 Scopus citations

Detection of Progressive Myocardial Tissue Injury by Ultrasonic Integrated Backscatter Immediately After Coronary Reperfusion

Katayama, M., Jiamsripong, P., McMahon, E. M., Lombari, T. R., Bukatina, A. E., Wu, Q., Marler, R. J. & Belohlavek, M., Sep 2012, In : Ultrasound in Medicine and Biology. 38, 9, p. 1662-1669 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Development and validation of a symptom-based activity index for adults with eosinophilic esophagitis

Schoepfer, A. M., Straumann, A., Panczak, R., Coslovsky, M., Kuehni, C. E., Maurer, E., Haas, N. A., Romero, Y., Hirano, I., Alexander, J. A., Gonsalves, N., Furuta, G. T., Dellon, E. S., Leung, J., Collins, M. H., Bussmann, C., Netzer, P., Gupta, S. K., Aceves, S. S., Chehade, M. & 46 others, Moawad, F. J., Enders, F. T., Yost, K. J., Taft, T. H., Kern, E., Zwahlen, M., Safroneeva, E., Achem, S. R., Arora, A. S., Alpan, O., Armstrong, D., Attwood, S. E., Butterfield, J. H., Crowell, M. D., De Petris, G., DeVault, K. R., Drouin, E., Enav, B., Fleischer, D. E., Foxx-Orenstein, A., Francis, D. L., Guyatt, G. H., Harris, L. A., Kagalwalla, A. F., Katzka, D. A., Kita, H., Krishna, M., Lee, J. J., Lewis, J. C., Lim, K., Locke, G. R., Murray, J. A., Nguyen, C. C., Orbelo, D. M., Pasha, S. F., Ramirez, F. C., Sheikh, J., Smyrk, T. C., Spergel, J. M., Umar, S. B., Weiler, C. R., Wo, J. M., Woosley, J. T., Wu, T. T., Yan, P. & Yang, G. Y., Dec 1 2014, In : Gastroenterology. 147, 6, p. 1255-1266.e21

Research output: Contribution to journalArticle

121 Scopus citations

Development of an endometrial ablation model in New Zealand White rabbits

AlHilli, M. M., Brost, B. C., Marler, R. J., Mariani, A., Hopkins, M. R. & Famuyide, A. O., Aug 1 2015, In : The Journal of reproductive medicine. 60, 4, p. 315-323 9 p.

Research output: Contribution to journalArticle

1 Scopus citations

Development of a Testing Funnel for Identification of Small-Molecule Modulators Targeting Secretin Receptors

Dengler, D. G., Sun, Q., Holleran, J., Pollari, S., Beutel, J., Brown, B. T., Shinoki Iwaya, A., Ardecky, R., Harikumar, K. G., Miller, L. J. & Sergienko, E. A., 2020, (Accepted/In press) In : SLAS Discovery.

Research output: Contribution to journalArticle

Dibasic protein kinase A sites regulate bursting rate and nucleotide sensitivity of the cystic fibrosis transmembrane conductance regulator chloride channel

Mathews, C. J., Tabcharani, J. A., Chang, X. B., Jensen, T. J., Riordan, J. R. & Hanrahan, J. W., Apr 15 1998, In : Journal of Physiology. 508, 2, p. 365-377 13 p.

Research output: Contribution to journalArticle

57 Scopus citations

Diesel exhaust particles exert acute effects on airway inflammation and function in murine allergen provocation models

Hao, M., Comier, S., Wang, M., Lee, J. J. & Nel, A., Nov 2003, In : Journal of Allergy and Clinical Immunology. 112, 5, p. 905-914 10 p.

Research output: Contribution to journalArticle

67 Scopus citations

Differential activation of airway eosinophils induces IL-13-mediated allergic Th2 pulmonary responses in mice

Jacobsen, E., Doyle, A. D., Colbert, D. C., Zellner, K. R., Protheroe, C. A., Lesuer, W. E., Lee, N. A. & Lee, J. J., Sep 1 2015, In : Allergy: European Journal of Allergy and Clinical Immunology. 70, 9, p. 1148-1159 12 p.

Research output: Contribution to journalArticle

29 Scopus citations

Differential discrimination of G-protein coupling of serotonin(1A) receptors from bovine hippocampus by an agonist and an antagonist

Harikumar, K. G. & Chattopadhyay, A., Sep 3 1999, In : FEBS Letters. 457, 3, p. 389-392 4 p.

Research output: Contribution to journalArticle

43 Scopus citations

Differential effects of modification of membrane cholesterol and sphingolipids on the conformation, function, and trafficking of the G protein-coupled cholecystokinin receptor

Harikumar, K. G., Puri, V., Singh, R. D., Hanada, K., Pagano, R. E. & Miller, L. J., Jan 21 2005, In : Journal of Biological Chemistry. 280, 3, p. 2176-2185 10 p.

Research output: Contribution to journalArticle

59 Scopus citations