Biochemistry and Molecular Biology

Research Output

Anti-CD86 (B7.2) Treatment abolishes allergic airway hyperresponsiveness in mice

Haczku, A., Takeda, K., Redai, I., Hamelmann, E., Cieslewicz, G., Joetham, A., Loader, J., Lee, J. J., Irvin, C. & Gelfand, E. W., Jan 1 1999, In : American journal of respiratory and critical care medicine. 159, 5 I, p. 1638-1643 6 p.

Research output: Contribution to journalArticle

94 Scopus citations

Antiinterleukin-5 antibody prevents airway hyperresponsiveness in a murine model airway sensitization

Hamelmann, E., Oshiba, A., Loader, J., Larsen, C. L., Gleich, C., Lee, J. & Gelfand, E. W., Jan 1 1997, In : American journal of respiratory and critical care medicine. 155, 3, p. 819-825 7 p.

Research output: Contribution to journalArticle

242 Scopus citations
2 Scopus citations

Applications of fluorescence in the characterization of the ligand-binding domain and activation of the cholecystokinin receptor

Harikumar, K. G. & Miller, L. J., Dec 1 2002, In : Pharmacology and Toxicology. 91, 6, p. 286-289 4 p.

Research output: Contribution to journalArticle

4 Scopus citations

A preclinical large animal model of adenovirus-mediated expression of the sodium-iodide symporter for radioiodide imaging and therapy of locally recurrent prostate cancer

Dwyer, R. M., Schatz, S. M., Bergert, E. R., Myers, R. M., Harvey, M. E., Classic, K. L., Blanco, M. C., Frisk, C. S., Marler, R. J., Davis, B. J., O'Connor, M. K., Russell, S. J. & Morris, J. C., Nov 2005, In : Molecular Therapy. 12, 5, p. 835-841 7 p.

Research output: Contribution to journalArticle

49 Scopus citations

A review of epithelial muc1n genes and gene products

Gendler, S. J., Dec 1 1997, In : Investigative Ophthalmology and Visual Science. 38, 4, p. S471

Research output: Contribution to journalArticle

A sensitive high throughput ELISA for human eosinophil peroxidase: A specific assay to quantify eosinophil degranulation from patient-derived sources

Ochkur, S. I., Kim, J. D., Protheroe, C. A., Colbert, D., Condjella, R. M., Bersoux, S., Helmers, R. A., Moqbel, R., Lacy, P., Kelly, E. A., Jarjour, N. N., Kern, R., Peters, A., Schleimer, R. P., Furuta, G. T., Nair, P., Lee, J. J. & Lee, N. A., Oct 31 2012, In : Journal of Immunological Methods. 384, 1-2, p. 10-20 11 p.

Research output: Contribution to journalArticle

19 Scopus citations

A short sequence, within the amino acid tandem repeat of a cancer‐associated mucin, contains immunodominant epitopes

Burchell, J., Taylor‐Papadimitriou, J., Boshell, M., Gendler, S. & Duhig, T., Oct 15 1989, In : International Journal of Cancer. 44, 4, p. 691-696 6 p.

Research output: Contribution to journalArticle

211 Scopus citations

A spontaneous mutation of integrin α(IIb)β3 (platelet glycoprotein IIb- IIIa) helps define a ligand binding site

Bajt, M. L., Ginsberg, M. H., Frelinger, A. L., Berndt, M. C. & Loftus, J. C., Jan 1 1992, In : Journal of Biological Chemistry. 267, 6, p. 3789-3794 6 p.

Research output: Contribution to journalArticle

129 Scopus citations

Assembly and glycosylation of gel forming mucins: Implications for cystic fibrosis

Hansson, G. C., Axelsson, M. A. B., Asker, N., Johansson, M. E. V., Steel, D. M., Thomsson, K. A., Lindgren, K. A. S., Axelsson, K. A., Hinojosa-Kutzberg, M., Gendler, S. J., Nilsson, T. & Karlsson, N. G., Sep 1 1999, In : Pediatric pulmonology. 28, SUPPL. 19, p. 142-143 2 p.

Research output: Contribution to journalArticle

14 Scopus citations

Asthma: Does IL-5 Have a More Provocative Role?

Lee, N. A. & Lee, J. J., Jan 1 1997, In : American journal of respiratory cell and molecular biology. 16, 5, p. 497-500 4 p.

Research output: Contribution to journalReview article

15 Scopus citations

A tale of two controversies. Defining both the role of peroxidases in nitrotyrosine formation in vivo using eosinophil peroxidase and myeloperoxidase-deficient mice, and the nature of peroxidase-generated reactive nitrogen species

Brennan, M. L., Wu, W., Fu, X., Shen, Z., Song, W., Frost, H., Vadseth, C., Narine, L., Lenkiewicz, E., Borchers, M. T., Lusis, A. J., Lee, J. J., Lee, N. A., Abu-Soud, H. M., Ischiropoulos, H. & Hazen, S. L., May 17 2002, In : Journal of Biological Chemistry. 277, 20, p. 17415-17427 13 p.

Research output: Contribution to journalArticle

430 Scopus citations

A tightly organized, conserved gene cluster on mouse Chromosome 3 (E3-F1)

Vos, H. L., Mockensturm-Wilson, M., Rood, P. M. L., Mass, A. M. C. E., Duhig, T., Gendler, S. J. & Bornstein, P., Nov 1 1995, In : Mammalian Genome. 6, 11, p. 820-822 3 p.

Research output: Contribution to journalArticle

9 Scopus citations

ATPase activity of purified multidrug resistance-associated protein

Chang, X. B., Hou, Y. X. & Riordan, J. R., Dec 5 1997, In : Journal of Biological Chemistry. 272, 49, p. 30962-30968 7 p.

Research output: Contribution to journalArticle

128 Scopus citations

ATP binding, not hydrolysis, at the first nucleotide-binding domain of multidrug resistance-associated protein MRP1 enhances ADP·Vi trapping at the second domain

Hou, Y. X., Riordan, J. R. & Chang, X. B., Feb 7 2003, In : Journal of Biological Chemistry. 278, 6, p. 3599-3605 7 p.

Research output: Contribution to journalArticle

31 Scopus citations
42 Scopus citations

ATP binding to the first nucleotide-binding domain of multidrug resistance protein MRP1 increases binding and hydrolysis of ATP and trapping of ADP at the second domain

Hou, Y. X., Cui, L., Riordan, J. R. & Chang, X. B., Feb 15 2002, In : Journal of Biological Chemistry. 277, 7, p. 5110-5119 10 p.

Research output: Contribution to journalArticle

52 Scopus citations

Atresia ani and rectovaginal fistula in Buffalo

Marler, R. J., Baker, W., Leipold, H. W., Cook, J. E. & Kruckenberg, S. M., Dec 1 1977, In : Journal of the American Veterinary Medical Association. 171, 9, p. 988-989 2 p.

Research output: Contribution to journalArticle

A type 1 cholecystokinin receptor mutant that mimics the dysfunction observed for wild type receptor in a high cholesterol environment

Desai, A. J., Harikumar, K. G. & Miller, L. J., Jun 27 2014, In : Journal of Biological Chemistry. 289, 26, p. 18314-18326 13 p.

Research output: Contribution to journalArticle

12 Scopus citations

Autoantibodies to the presumptive cytoplasmic domain of platelet glycoprotein IIIa in patients with chronic immune thrombocytopenic purpura

Fujisawa, K., O'Toole, T. E., Tani, P., Loftus, J. C., Plow, E. F., Ginsberg, M. H. & McMillan, R., 1991, In : Blood. 77, 10, p. 2207-2213 7 p.

Research output: Contribution to journalArticle

Open Access
63 Scopus citations

Autoantibodies to αIIbβ3 in patients with chronic immune thrombocytopenic purpura bind primarily to epitopes on αIIb

McMillan, R., Lopez-Dee, J. & Loftus, J. C., Apr 1 2001, In : Blood. 97, 7, p. 2171-2172 2 p.

Research output: Contribution to journalArticle

22 Scopus citations

A β3 integrin mutation abolishes ligand binding and alters divalent cation-dependent conformation

Loftus, J. C., O'Toole, T. E., Plow, E. F., Glass, A., Frelinger, A. L. & Ginsberg, M. H., Jan 1 1990, In : Science. 249, 4971, p. 915-918 4 p.

Research output: Contribution to journalArticle

314 Scopus citations

Bacterial conjunctivitis in Muc1 null mice

Kardon, R., Price, R. E., Julian, J. A., Lagow, E., Tseng, S. C. G., Gendler, S. J. & Carson, D. D., Jun 9 1999, In : Investigative Ophthalmology and Visual Science. 40, 7, p. 1328-1335 8 p.

Research output: Contribution to journalArticle

68 Scopus citations

Biochemical and cell biological mechanisms of cholecystokinin receptor regulation

Miller, L. J., Dong, M., Harikumar, K. G. & Lisenbee, C. S., Jun 1 2007, In : Current Topics in Medicinal Chemistry. 7, 12, p. 1166-1172 7 p.

Research output: Contribution to journalReview article

7 Scopus citations

Blockade of CD49d inhibits allergic airway pathologies independent of effects on leukocyte recruitment

Borchers, M. T., Crosby, J., Farmer, S., Sypek, J., Ansay, T., Lee, N. A. & Lee, J. J., Apr 2001, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 280, 4 24-4, p. L813-L821

Research output: Contribution to journalArticle

47 Scopus citations
59 Scopus citations

Breaking tolerance with engineered class I antigen-presenting molecules

Parks, C. A., Henning, K. R., Pavelko, K. D., Hansen, M. J., Van Keulen, V. P., Reed, B. K., Stone, J. D., Schrum, A. G., Gil, D., Kranz, D. M., Bordner, A. J., Barry, M. A. & Pease, L. R., Feb 19 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 8, p. 3136-3145 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

Bringing molecular biology to bear on adhesion prevention: Postsurgical adhesion reduction using intraperitoneal inoculation of hyaluronic acid-inducing adenoviral vector in a murine model

Hammer, R. A., Morse, A. N., Cornella, J. L., Keller, R. S., Hentz, J., McDonald, J. A. & Loftus, J. C., Mar 2006, In : Journal of Gynecologic Surgery. 22, 1, p. 7-18 12 p.

Research output: Contribution to journalArticle

Calogero-moser models. I - A new formulation

Bordner, A. J., Corrigan, E. & Sasaki, R., Dec 1998, In : Progress of Theoretical Physics. 100, 6, p. 1107-1129 23 p.

Research output: Contribution to journalArticle

Open Access
60 Scopus citations

Calogero-Moser models. II: Symmetries and foldings

Bordner, A. J., Sasaki, R. & Takasaki, K., Mar 1999, In : Progress of Theoretical Physics. 101, 3, p. 487-518 32 p.

Research output: Contribution to journalArticle

Open Access
33 Scopus citations

Calogero-Moser models. III: Elliptic potentials and twisting

Bordner, A. J. & Sasaki, R., Apr 1999, In : Progress of Theoretical Physics. 101, 4, p. 799-829 31 p.

Research output: Contribution to journalArticle

Open Access
30 Scopus citations

Calogero-Moser models. V - Supersymmetry and quantum Lax pair -

Bordner, A. J., Manton, N. S. & Sasaki, R., Mar 2001, In : Progress of Theoretical Physics. 103, 3, p. 463-487 25 p.

Research output: Contribution to journalArticle

50 Scopus citations

cAMP- and Ca2+-independent activation of cystic fibrosis transmembrane conductance regulator channels by phenylimidazothiazole drugs

Becq, F., Verrier, B., Chang, X. B., Riordan, J. R. & Hanrahan, J. W., Jan 1 1996, In : Journal of Biological Chemistry. 271, 27, p. 16171-16179 9 p.

Research output: Contribution to journalArticle

44 Scopus citations

cAMP-dependent protein kinase-mediated phosphorylation of cystic fibrosis transmembrane conductance regulator residue Ser-753 and its role in channel activation

Seibert, F. S., Tabcharani, J. A., Chang, X. B., Dulhanty, A. M., Mathews, C., Hanrahan, J. W. & Riordan, J. R., Jan 1 1995, In : Journal of Biological Chemistry. 270, 5, p. 2158-2162 5 p.

Research output: Contribution to journalArticle

71 Scopus citations

Cardiac myocyte-specific excision of the β1 integrin gene results in myocardial fibrosis and cardiac failure

Shai, S. Y., Harpf, A. E., Babbitt, C. J., Jordan, M. C., Fishbein, M. C., Chen, J., Omura, M., Leil, T. A., Becker, K. D., Jiang, M., Smith, D. J., Cherry, S. R., Loftus, J. C. & Ross, R. S., Mar 8 2002, In : Circulation research. 90, 4, p. 458-464 7 p.

Research output: Contribution to journalArticle

217 Scopus citations

Catapult-like release of mitochondrial DNA by eosinophils contributes to antibacterial defense

Yousefi, S., Gold, J. A., Andina, N., Lee, J. J., Kelly, A. M., Kozlowski, E., Schmid, I., Straumann, A., Reichenbach, J., Gleich, G. J. & Simon, H. U., Sep 1 2008, In : Nature Medicine. 14, 9, p. 949-953 5 p.

Research output: Contribution to journalArticle

521 Scopus citations

CCR3 blockade attenuates eosinophilic ileitis and associated remodeling

Masterson, J. C., McNamee, E. N., Jedlicka, P., Fillon, S., Ruybal, J., Hosford, L., Rivera-Nieves, J., Lee, J. J. & Furuta, G. T., Nov 2011, In : American Journal of Pathology. 179, 5, p. 2302-2314 13 p.

Research output: Contribution to journalArticle

28 Scopus citations

CD23 exhibits negative regulatory effects on allergic sensitization and airway hyperresponsiveness

Haczku, A., Takeda, K., Hamelmann, E., Loader, J., Joetham, A., Redai, I., Irvin, C. G., Lee, J. J., Kikutani, H., Conrad, D. & Gelfand, E. W., 2000, In : American journal of respiratory and critical care medicine. 161, 3 I, p. 952-960 9 p.

Research output: Contribution to journalArticle

65 Scopus citations

CD4+ lymphocytes provide MUC1-specific tumor immunity in vivo that is undetectable in vitro and is absent in MUC1 transgenic mice

Tempero, R. M., VanLith, M. L., Morikane, K., Rowse, G. J., Gendler, S. J. & Hollingsworth, M. A., Nov 15 1998, In : Journal of Immunology. 161, 10, p. 5500-5506 7 p.

Research output: Contribution to journalArticle

57 Scopus citations

CD4+ T cell-dependent airway mucus production occurs in response to IL-5 expression in lung

Paul Justice, J., Crosby, J., Borchers, M. T., Tomkinson, A., Lee, J. J. & Lee, N. A., Jun 29 2002, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 282, 5 26-5, p. L1066-L1074

Research output: Contribution to journalArticle

40 Scopus citations

CD69 expression on airway eosinophils and airway inflammation in a murine model of asthma

Wang, H. Y., Shen, H. H., Lee, J. J. & Lee, N. A., Dec 5 2006, In : Chinese medical journal. 119, 23, p. 1983-1990 8 p.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

CD8 surface levels alter the fate of α/β T cell receptor-expressing thymocytes in transgenic mice

Lee, N. A., Loh, D. Y. & Lacy, E., Apr 1 1992, In : Journal of Experimental Medicine. 175, 4, p. 1013-1025 13 p.

Research output: Contribution to journalArticle

Open Access
126 Scopus citations

Cdc42 and the guanine nucleotide exchange factors Ect2 and trio mediate Fn14-induced migration and invasion of glioblastoma cells

Fortin, S. P., Ennis, M. J., Schumacher, C. A., Zylstra-Diegel, C. R., Williams, B. O., Ross, J. T. D., Winkles, J. A., Loftus, J. C., Symons, M. H. & Tran, N. L., Jul 2012, In : Molecular Cancer Research. 10, 7, p. 958-968 11 p.

Research output: Contribution to journalArticle

60 Scopus citations

cDNA clones for human platelet GPIIb corresponding to mRNA from megakaryocytes and HEL cells: Evidence for an extensive homology to other Arg‐Gly‐Asp adhesion receptors

UZAN, G., FRACHET, P., LAJMANOVICH, A., PRANDINI, MH. H., DENARIER, E., DUPERRAY, A., LOFTUS, J., GINSBERG, M., PLOW, E. & MARGUERIE, G., Jan 1988, In : European Journal of Biochemistry. 171, 1-2, p. 87-93 7 p.

Research output: Contribution to journalArticle

18 Scopus citations

Cereblon expression is required for the antimyeloma activity of lenalidomide and pomalidomide

Zhu, Y. X., Braggio, E., Shi, C. X., Bruins, L. A., Schmidt, J. E., Van Wier, S., Chang, X. B., Bjorklund, C. C., Fonseca, R., Bergsagel, P. L., Orlowski, R. Z. & Stewart, A. K., Nov 3 2011, In : Blood. 118, 18, p. 4771-4779 9 p.

Research output: Contribution to journalArticle

376 Scopus citations

CFTR, a channel with the structure of a transporter

Riordan, J. R. & Chang, X. B., 1992, In : Biochimica et Biophysica Acta - Bioenergetics. 1101, 2, p. 221-222 2 p.

Research output: Contribution to journalArticle

39 Scopus citations

CFTR is a monomer: Biochemical and functional evidence

Chen, J. H., Chang, X. B., Aleksandrov, A. A. & Riordan, J. R., Jul 1 2002, In : Journal of Membrane Biology. 188, 1, p. 55-71 17 p.

Research output: Contribution to journalArticle

33 Scopus citations

Changing roles of eosinophils in health and disease

Furuta, G. T., Atkins, F. D., Lee, N. A. & Lee, J. J., Jul 2014, In : Annals of Allergy, Asthma and Immunology. 113, 1, p. 3-8 6 p.

Research output: Contribution to journalArticle

53 Scopus citations

Characterization of a gain of function mutation of integrin α(IIb)β3 (platelet glycoprotein IIb-IIIa)

Bajt, M. L., Loftus, J. C., Gawaz, M. P. & Ginsberg, M. H., 1992, In : Journal of Biological Chemistry. 267, 31, p. 22211-22216 6 p.

Research output: Contribution to journalArticle

33 Scopus citations