Biochemistry and Molecular Biology

Research Output

2007

Platelet-derived growth factor receptor β-mediated phosphorylation of MUC1 enhances invasiveness in pancreatic adenocarcinoma cells

Singh, P. K., Wen, Y., Swanson, B. J., Shanmugam, K., Kazlauskas, A., Cerny, R. L., Gendler, S. J. & Hollingsworth, M. A., Jun 1 2007, In : Cancer research. 67, 11, p. 5201-5210 10 p.

Research output: Contribution to journalArticle

89 Scopus citations

Protein docking using surface matching and supervised machine learning

Bordner, A. J. & Gorin, A. A., Aug 1 2007, In : Proteins: Structure, Function and Genetics. 68, 2, p. 488-502 15 p.

Research output: Contribution to journalArticle

20 Scopus citations

Signaling through Gαi2 protein is required for recruitment of neutrophils for antibody-mediated elimination of larval Strongyloides stercoralis in mice

Padigel, U. M., Stein, L., Redding, K., Lee, J. J., Nolan, T. J., Schad, G. A., Birnbaumer, L. & Abraham, D., Apr 1 2007, In : Journal of Leukocyte Biology. 81, 4, p. 1120-1126 7 p.

Research output: Contribution to journalArticle

16 Scopus citations

Structural basis of natural ligand binding and activation of the Class II G-protein-coupled secretin receptor

Miller, L. J., Dong, M., Harikumar, K. G. & Gao, F., Aug 2007, In : Biochemical Society Transactions. 35, 4, p. 709-712 4 p.

Research output: Contribution to journalArticle

24 Scopus citations

Submucosal endoscopy with mucosal flap safety valve

Sumiyama, K., Gostout, C. J., Rajan, E., Bakken, T. A., Knipschield, M. A. & Marler, R. J., Apr 1 2007, In : Gastrointestinal endoscopy. 65, 4, p. 688-694 7 p.

Research output: Contribution to journalArticle

154 Scopus citations

Summary of the first international gastrointestinal eosinophil research symposium

Liacouras, C. A., Bonis, P., Putnam, P. E., Straumann, A., Ruchelli, E., Gupta, S. K., Lee, J. J., Hogan, S. P., Wershil, B. K., Rothenberg, M. E., Ackerman, S. J., Gomes, I., Murch, S., Mishra, A. & Furuta, G. T., Sep 2007, In : Journal of pediatric gastroenterology and nutrition. 45, 3, p. 370-391 22 p.

Research output: Contribution to journalArticle

32 Scopus citations

Transmembrane segment IV contributes a functionally important interface for oligomerization of the class II G protein-coupled secretin receptor

Harikumar, K. G., Pinon, D. I. & Miller, L. J., Oct 19 2007, In : Journal of Biological Chemistry. 282, 42, p. 30363-30372 10 p.

Research output: Contribution to journalArticle

74 Scopus citations
2008

A3 adenosine receptor signaling influences pulmonary inflammation and fibrosis

Morschl, E., Molina, J. G., Volmer, J. B., Mohsenin, A., Pero, R. S., Hong, J. S., Kheradmand, F., Lee, J. J. & Blackburn, M. R., Dec 1 2008, In : American journal of respiratory cell and molecular biology. 39, 6, p. 697-705 9 p.

Research output: Contribution to journalArticle

39 Scopus citations

Absence of histologic retinal toxicity of intravitreal nanogold in a rabbit model

Bakri, S. J., Pulido, J. S., Mukherjee, P., Marler, R. J. & Mukhopadhyay, D., Jan 1 2008, In : Retina. 28, 1, p. 147-149 3 p.

Research output: Contribution to journalArticle

44 Scopus citations

Allergic pulmonary inflammation in mice is dependent on eosinophil-induced recruitment of effector T cells

Jacobsen, E. A., Ochkur, S. I., Pero, R. S., Taranova, A. G., Protheroe, C. A., Colbert, D. C., Lee, N. A. & Lee, J. J., Mar 17 2008, In : Journal of Experimental Medicine. 205, 3, p. 699-710 12 p.

Research output: Contribution to journalArticle

180 Scopus citations

Allergic pulmonary inflammation promotes the recruitment of circulating tumor cells to the lung

Taranova, A. G., Maldonado, D., Vachon, C. M., Jacobsen, E. A., Abdala-Valencia, H., McGarry, M. P., Ochkur, S. I., Protheroe, C. A., Doyle, A., Grant, C. S., Cook-Mills, J., Birnbaumer, L., Lee, N. A. & Lee, J. J., Oct 15 2008, In : Cancer research. 68, 20, p. 8582-8589 8 p.

Research output: Contribution to journalArticle

38 Scopus citations

Catapult-like release of mitochondrial DNA by eosinophils contributes to antibacterial defense

Yousefi, S., Gold, J. A., Andina, N., Lee, J. J., Kelly, A. M., Kozlowski, E., Schmid, I., Straumann, A., Reichenbach, J., Gleich, G. J. & Simon, H. U., Sep 1 2008, In : Nature Medicine. 14, 9, p. 949-953 5 p.

Research output: Contribution to journalArticle

521 Scopus citations

Comprehensive inventory of protein complexes in the Protein Data Bank from consistent classification of interfaces

Bordner, A. J. & Gorin, A. A., May 12 2008, In : BMC bioinformatics. 9, 234.

Research output: Contribution to journalArticle

24 Scopus citations

Corrigendum to "Multidrug resistance protein 1 is not associated to detergent-resistant membranes" [Biochem. Biophys. Res. Commun. 355 (2007) 1025-1030] (DOI:10.1016/j.bbrc.2007.02.075)

Cerf, E., Gasper, R., Belani, J. D., Rychnovsky, S., Chang, X. B., Buyse, F. & Ruysschaert, J. M., Feb 8 2008, In : Biochemical and Biophysical Research Communications. 366, 2, 1 p.

Research output: Contribution to journalComment/debate

Dimerization in the absence of higher-order oligomerization of the G protein-coupled secretin receptor

Harikumar, K. G., Happs, R. M. & Miller, L. J., Nov 2008, In : Biochimica et Biophysica Acta - Biomembranes. 1778, 11, p. 2555-2563 9 p.

Research output: Contribution to journalArticle

35 Scopus citations

Distinct binding modes specify the recognition of methylated histones H3K4 and H4K20 by JMJD2A-tudor

Lee, J., Thompson, J. R., Botuyan, M. V. & Mer, G., Jan 1 2008, In : Nature Structural and Molecular Biology. 15, 1, p. 109-111 3 p.

Research output: Contribution to journalArticle

146 Scopus citations

Effects of cholecystokinin-58 on type 1 cholecystokinin receptor function and regulation

Wu, S. V., Harikumar, K. G., Burgess, R. J., Reeve, J. R. & Miller, L. J., Sep 2008, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 295, 3, p. G641-G647

Research output: Contribution to journalArticle

10 Scopus citations

Extended survival of Pyk2 or FAK deficient orthotopic glioma xenografts

Lipinski, C. A., Tran, N. L., Viso, C., Kloss, J., Yang, Z., Berens, M. E. & Loftus, J. C., 2008, In : Journal of neuro-oncology. 90, 2, p. 181-189 9 p.

Research output: Contribution to journalArticle

18 Scopus citations

Extensive exploration of conformational space improves Rosetta results for short protein domains.

Li, Y., Bordner, A. J., Tian, Y., Tao, X. & Gorin, A. A., 2008, In : Computational systems bioinformatics / Life Sciences Society. Computational Systems Bioinformatics Conference. 7, p. 203-209 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

Identification of kinetin riboside as a repressor of CCND1 and CCND2 with preclinical antimyeloma activity

Tiedemann, R. E., Mao, X., Shi, C. X., Yuan, X. Z., Palmer, S. E., Sebag, M., Marler, R., Chesi, M., Fonseca, R., Bergsagel, P. L., Schimmer, A. D. & Stewart, A. K., May 1 2008, In : Journal of Clinical Investigation. 118, 5, p. 1750-1764 15 p.

Research output: Contribution to journalArticle

47 Scopus citations
5 Scopus citations

Intestinal macrophage/epithelial cell-derived CCL11/eotaxin-1 mediates eosinophil recruitment and function in pediatric ulcerative colitis

Ahrens, R., Waddell, A., Seidu, L., Blanchard, C., Carey, R., Forbes, E., Lampinen, M., Wilson, T., Cohen, E., Stringer, K., Ballard, E., Munitz, A., Xu, H., Lee, N., Lee, J. J., Rothenberg, M. E., Denson, L. & Hogan, S. P., Nov 15 2008, In : Journal of Immunology. 181, 10, p. 7390-7399 10 p.

Research output: Contribution to journalArticle

Open Access
105 Scopus citations

Major basic protein-1 promotes fibrosis of dystrophic muscle and attenuates the cellular immune response in muscular dystrophy

Wehling-henricks, M., Sokolow, S., Lee, J. J., Myung, K. H., Villalta, S. A. & Tidball, J. G., Aug 2008, In : Human molecular genetics. 17, 15, p. 2280-2292 13 p.

Research output: Contribution to journalArticle

51 Scopus citations

Monitoring the state of cholecystokinin receptor oligomerization after ligand binding using decay of time-resolved fluorescence anisotropy

Harikumar, K. G. & Miller, L. J., Nov 2008, Neural Signaling Opportunities for Novel Diagnostic Approaches and Therapies. Blackwell Publishing Inc., p. 21-27 7 p. (Annals of the New York Academy of Sciences; vol. 1144).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

MUC1 mucin is a negative regulator of toll-like receptor signaling

Ueno, K., Koga, T., Kato, K., Golenbock, D. T., Gendler, S. J., Kai, H. & Kim, K. C., Mar 1 2008, In : American journal of respiratory cell and molecular biology. 38, 3, p. 263-268 6 p.

Research output: Contribution to journalArticle

112 Scopus citations

Pattern of intra-family hetero-oligomerization involving the G-protein-coupled secretin receptor

Harikumar, K. G., Morfis, M. M., Sexton, P. M. & Miller, L. J., Nov 2008, In : Journal of Molecular Neuroscience. 36, 1-3, p. 279-285 7 p.

Research output: Contribution to journalArticle

42 Scopus citations

Phosphorylation of MUC1 by met modulates interaction with p53 and MMP1 expression

Singh, P. K., Behrens, M. E., Eggers, J. P., Cerny, R. L., Bailey, J. M., Shanmugam, K., Gendler, S. J., Bennett, E. P. & Hollingsworth, M. A., Oct 3 2008, In : Journal of Biological Chemistry. 283, 40, p. 26985-26995 11 p.

Research output: Contribution to journalArticle

71 Scopus citations

Post-translational tyrosine nitration of eosinophil granule toxins mediated by eosinophil peroxidase

Ulrich, M., Petre, A., Youhnovski, N., Prömm, F., Schirle, M., Schumm, M., Pero, R. S., Doyle, A., Checkel, J., Kita, H., Thiyagarajan, N., Acharya, K. R., Schmid-Grendelmeier, P., Simon, H. U., Schwarz, H., Tsutsui, M., Shimokawa, H., Bellon, G., Lee, J. J., Przybylski, M. & 1 others, Döring, G., Oct 17 2008, In : Journal of Biological Chemistry. 283, 42, p. 28629-28640 12 p.

Research output: Contribution to journalArticle

37 Scopus citations

Predicting small ligand binding sites in proteins using backbone structure

Bordner, A. J., Dec 2008, In : Bioinformatics. 24, 24, p. 2865-2871 7 p.

Research output: Contribution to journalArticle

38 Scopus citations

Reprogrammed FoxP3+ T regulatory cells become IL-17+ antigen-specific autoimmune effectors in vitro and in vivo

Radhakrishnan, S., Cabrera, R., Schenk, E. L., Nava-Parada, P., Bell, M. P., Van Keulen, V. P., Marler, R. J., Felts, S. J. & Pease, L. R., Sep 1 2008, In : Journal of Immunology. 181, 5, p. 3137-3147 11 p.

Research output: Contribution to journalArticle

Open Access
98 Scopus citations

Role of N-linked oligosaccharides in the biosynthetic processing of the cystic fibrosis membrane conductance regulator

Chang, X. B., Mengos, A., Hou, Y. X., Cui, L., Jensen, T. J., Aleksandrov, A., Riordan, J. R. & Gentzsch, M., Sep 1 2008, In : Journal of cell science. 121, 17, p. 2814-2823 10 p.

Research output: Contribution to journalArticle

53 Scopus citations

Spontaneous vulvar papillomas in a colony of mice used for pancreatic cancer research

Gades, N. M., Ohashi, A., Mills, L. D., Rowley, M. A., Predmore, K. S., Marler, R. J. & Couch, F. J., Jun 1 2008, In : Comparative medicine. 58, 3, p. 271-275 5 p.

Research output: Contribution to journalArticle

8 Scopus citations

Structure and function of the cell surface (tethered) mucins

Hattrup, C. L. & Gendler, S. J., Jun 2 2008, In : Annual Review of Physiology. 70, p. 431-457 27 p.

Research output: Contribution to journalReview article

430 Scopus citations

The gastric mucus layers: Constituents and regulation of accumulation

Phillipson, M., Johansson, M. E. V., Henriksnäs, J., Petersson, J., Gendler, S. J., Sandler, S., Persson, A. E. G., Hansson, G. C. & Holm, L., Oct 1 2008, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 295, 4, p. G806-G812

Research output: Contribution to journalArticle

74 Scopus citations
6 Scopus citations

Use of multidimensional fluorescence resonance energy transfer to establish the orientation of cholecystokinin docked at the type A cholecystokinin receptor

Harikumar, K. G., Gao, F., Pinon, D. I. & Miller, L. J., Sep 9 2008, In : Biochemistry. 47, 36, p. 9574-9581 8 p.

Research output: Contribution to journalArticle

8 Scopus citations
2009

A Novel Histologic Scoring System to Evaluate Mucosal Biopsies From Patients With Eosinophilic Esophagitis

Protheroe, C., Woodruff, S. A., de Petris, G., Mukkada, V., Ochkur, S. I., Janarthanan, S., Lewis, J. C., Pasha, S., Lunsford, T., Harris, L., Sharma, V. K., McGarry, M. P., Lee, N. A., Furuta, G. T. & Lee, J. J., Jul 2009, In : Clinical Gastroenterology and Hepatology. 7, 7, p. 749-755.e11

Research output: Contribution to journalArticle

139 Scopus citations
2 Scopus citations

Differential effects of Pyk2 and FAK on the hypertrophic response of cardiac myocytes

Menashi, E. B. & Loftus, J. C., Aug 1 2009, In : Cell and Tissue Research. 337, 2, p. 243-255 13 p.

Research output: Contribution to journalArticle

7 Scopus citations

Effects of putative catalytic base mutation E211Q on ABCG2-mediated methotrexate transport

Hou, Y. X., Li, C. Z., Palaniyandi, K., Magtibay, P. M., Homolya, L., Sarkadi, B. & Chang, X. B., 2009, In : Biochemistry. 48, 38, p. 9122-9131 10 p.

Research output: Contribution to journalArticle

8 Scopus citations

Eosinophil deficiency compromises parasite survival in chronic nematode infection

Fabre, V., Beiting, D. P., Bliss, S. K., Gebreselassie, N. G., Gagliardo, L. F., Lee, N. A., Lee, J. J. & Appleton, J. A., Feb 1 2009, In : Journal of Immunology. 182, 3, p. 1577-1583 7 p.

Research output: Contribution to journalArticle

Open Access
108 Scopus citations

Eosinophils oxidize damage-associated molecular pattern molecules derived from stressed cells

Lotfi, R., Herzog, G. I., DeMarco, R. A., Beer-Stolz, D., Lee, J. J., Rubartelli, A., Schrezenmeier, H. & Lotze, M. T., Oct 15 2009, In : Journal of Immunology. 183, 8, p. 5023-5031 9 p.

Research output: Contribution to journalArticle

70 Scopus citations

Eosinophils utilize multiple chemokine receptors for chemotaxis to the parasitic nematode strongyloides stercoralis

Stein, L. H., Redding, K. M., Lee, J. J., Nolan, T. J., Schad, G. A., Lok, J. B. & Abraham, D., Oct 1 2009, In : Journal of Innate Immunity. 1, 6, p. 618-630 13 p.

Research output: Contribution to journalArticle

24 Scopus citations

Expression of human MUC1 during early pregnancy in the human MUC1 transgenic mouse model

Dharmaraj, N., Gendler, S. J. & Carson, D. D., 2009, In : Biology of Reproduction. 81, 6, p. 1182-1188 7 p.

Research output: Contribution to journalArticle

20 Scopus citations

Functional importance of a structurally distinct homodimeric complex of the family B G protein-coupled secretin receptor

Gao, F., Harikumar, K. G., Dong, M., Lam, P. C. H., Sexton, P. M., Christopoulos, A., Bordner, A., Abagyan, R. & Miller, L. J., Aug 2009, In : Molecular pharmacology. 76, 2, p. 264-274 11 p.

Research output: Contribution to journalArticle

43 Scopus citations

Induced association of μ opioid (MOP) and type 2 cholecystokinin (CCK 2) receptors by novel bivalent ligands

Zheng, Y., Akgiin, E., Harikumar, K. G., Hopson, J., Powers, M. D., Lunzer, M. M., Miller, L. J. & Portoghese, P. S., Jan 22 2009, In : Journal of Medicinal Chemistry. 52, 2, p. 247-258 12 p.

Research output: Contribution to journalArticle

46 Scopus citations

Intravitreal alemtuzumab penetrates full-thickness retina in rabbit eyes

Ekdawi, N. S., Pulido, J. S., Itty, S., Marler, R. J., Herman, D. C., Hardwig, P., Mohney, B. G., Valyi-Nagy, T. & Shukla, D., Nov 1 2009, In : Retina. 29, 10, p. 1532-1534 3 p.

Research output: Contribution to journalArticle

3 Scopus citations

Lack of muc1-regulated β-catenin stability results in aberrant expansion of cd11b +gr1 + Myeloid-derived suppressor cells from the bone marrow

Poh, T. W., Bradley, J. M., Mukherjee, P. & Gendler, S. J., Apr 15 2009, In : Cancer research. 69, 8, p. 3554-3562 9 p.

Research output: Contribution to journalArticle

25 Scopus citations

Molecular basis of association of receptor activity-modifying protein 3 with the family B G protein-coupled secretin receptor

Harikumar, K. G., Simms, J., Christopoulos, G., Sexton, P. M. & Miller, L. J., Dec 15 2009, In : Biochemistry. 48, 49, p. 11773-11785 13 p.

Research output: Contribution to journalArticle

39 Scopus citations

Molecular basis of metastasis [8]

Lee, J. J. & Lotze, M. T., Apr 16 2009, In : New England Journal of Medicine. 360, 16, 1 p.

Research output: Contribution to journalLetter

9 Scopus citations