Biochemistry and Molecular Biology

Research Output

2006

Adenovirus-mediated and targeted expression of the sodium-iodide symporter permits in vivo radioiodide imaging and therapy of pancreatic tumors

Dwyer, R. M., Bergert, E. R., O'Connor, M. K., Gendler, S. J. & Morris, J. C., Jun 2006, In : Human gene therapy. 17, 6, p. 661-668 8 p.

Research output: Contribution to journalArticle

53 Scopus citations

Bringing molecular biology to bear on adhesion prevention: Postsurgical adhesion reduction using intraperitoneal inoculation of hyaluronic acid-inducing adenoviral vector in a murine model

Hammer, R. A., Morse, A. N., Cornella, J. L., Keller, R. S., Hentz, J., McDonald, J. A. & Loftus, J. C., Mar 2006, In : Journal of Gynecologic Surgery. 22, 1, p. 7-18 12 p.

Research output: Contribution to journalArticle

CD69 expression on airway eosinophils and airway inflammation in a murine model of asthma

Wang, H. Y., Shen, H. H., Lee, J. J. & Lee, N. A., Dec 5 2006, In : Chinese medical journal. 119, 23, p. 1983-1990 8 p.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Computational challenges for modeling and simulating biomacromolecular assemblies

Uberbacher, E., LoCascio, P., Passovets, S., Ghattyvenkatakrishna, P., Agarwal, P., Arnold, N., Bordner, A. & Gorin, A., Oct 1 2006, In : Journal of Physics: Conference Series. 46, 1, p. 311-315 5 p., 043.

Research output: Contribution to journalArticle

1 Scopus citations

Constitutive formation of oligomeric complexes between family B G protein-coupled vasoactive intestinal polypeptide and secretin receptors

Harikumar, K. G., Morfis, M. M., Lisenbee, C. S., Sexton, P. M. & Miller, L. J., Jan 2006, In : Molecular pharmacology. 69, 1, p. 363-373 11 p.

Research output: Contribution to journalArticle

54 Scopus citations

Critical role of the FERM domain in Pyk2 stimulated glioma cell migration

Lipinski, C. A., Tran, N. L., Dooley, A., Pang, Y. P., Rohl, C., Kloss, J., Yang, Z., McDonough, W., Craig, D., Berens, M. E. & Loftus, J. C., Oct 27 2006, In : Biochemical and Biophysical Research Communications. 349, 3, p. 939-947 9 p.

Research output: Contribution to journalArticle

20 Scopus citations

Cutting edge: Enhanced pulmonary clearance of Pseudomonas aeruginosa by Muc1 knockout mice

Lu, W., Hisatsune, A., Koga, T., Kato, K., Kuwahara, I., Lillehoj, E. P., Chen, W., Cross, A. S., Gendler, S. J., Gewirtz, A. T. & Kim, K. C., Apr 1 2006, In : Journal of Immunology. 176, 7, p. 3890-3894 5 p.

Research output: Contribution to journalArticle

Open Access
101 Scopus citations

Eosinophils can function as antigen-presenting cells to induce primary and secondary immune responses to Strongyloides stercoralis

Padigel, U. M., Lee, J. J., Nolan, T. J., Schad, G. A. & Abraham, D., Jun 2006, In : Infection and Immunity. 74, 6, p. 3232-3238 7 p.

Research output: Contribution to journalArticle

116 Scopus citations

Evidence That Gallbladder Epithelial Mucin Enhances Cholesterol Cholelithogenesis in MUC1 Transgenic Mice

Wang, H. H., Afdhal, N. H., Gendler, S. J. & Wang, D. Q. H., Jul 2006, In : Gastroenterology. 131, 1, p. 210-222 13 p.

Research output: Contribution to journalArticle

24 Scopus citations

F508del CFTR with two altered RXR motifs escapes from ER quality control but its channel activity is thermally sensitive

Hegedus, T., Aleksandrov, A., Cui, L., Gentzsch, M., Chang, X. B. & Riordan, J. R., May 2006, In : Biochimica et Biophysica Acta - Biomembranes. 1758, 5, p. 565-572 8 p.

Research output: Contribution to journalArticle

47 Scopus citations

Fluorescence characteristics of hydrophobic partial agonist probes of the cholecystokinin receptor

Harikumar, K. G., Pinon, D. I. & Miller, L. J., Apr 1 2006, In : Bioscience reports. 26, 2, p. 89-100 12 p.

Research output: Contribution to journalArticle

3 Scopus citations
19 Scopus citations

Increased fibroblast growth factor-inducible 14 expression levels promote glioma cell invasion via Rac1 and nuclear factor-κB and correlate with poor patient outcome

Tran, N. L., McDonough, W. S., Savitch, B. A., Fortin, S. P., Winkles, J. A., Symons, M., Nakada, M., Cunliffe, H. E., Hostetter, G., Hoelzinger, D. B., Rennert, J. L., Michaelson, J. S., Burkly, L. C., Lipinski, C. A., Loftus, J. C., Mariani, L. & Berens, M. E., Oct 1 2006, In : Cancer research. 66, 19, p. 9535-9542 8 p.

Research output: Contribution to journalArticle

141 Scopus citations

Increased levels of mucins in the cystic fibrosis mouse small intestine, and modulator effects of the Muc1 mucin expression

Malmberg, E. K., Noaksson, K. A., Phillipson, M., Johansson, M. E. V., Hinojosa-Kurtzberg, M., Holm, L., Gendler, S. J. & Hansson, G. C., Jul 14 2006, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 291, 2, p. G203-G210

Research output: Contribution to journalArticle

42 Scopus citations

Lack of eosinophil peroxidase or major basic protein impairs defense against murine filarial infection

Specht, S., Saeftel, M., Arndt, M., Endl, E., Dubben, B., Lee, N. A., Lee, J. J. & Hoerauf, A., Sep 2006, In : Infection and Immunity. 74, 9, p. 5236-5243 8 p.

Research output: Contribution to journalArticle

67 Scopus citations

MUC1 alters oncogenic events and transcription in human breast cancer cells

Hattrup, C. L. & Gendler, S. J., Jul 17 2006, In : Breast Cancer Research. 8, 4, R37.

Research output: Contribution to journalArticle

66 Scopus citations

MUC1 cytoplasmic tail detection using CT33 polyclonal and CT2 monoclonal antibodies in breast and colorectal tissue

Croce, M. V., Isla-Larrain, M., Remes-Lenicov, F., Colussi, A. G., Lacunza, E., Kim, K. C., Gendler, S. J. & Segal-Eiras, A., Jul 1 2006, In : Histology and Histopathology. 21, 7-9, p. 849-855 7 p.

Research output: Contribution to journalArticle

23 Scopus citations

Novel approach to inhibit asthma-mediated lung inflammation using Anti-CD147 intervention

Gwinn, W. M., Damsker, J. M., Falahati, R., Okwumabua, I., Kelly-Welch, A., Keegan, A. D., Vanpouille, C., Lee, J. J., Dent, L. A., Leitenberg, D., Bukrinsky, M. I. & Constant, S. L., Oct 1 2006, In : Journal of Immunology. 177, 7, p. 4870-4879 10 p.

Research output: Contribution to journalArticle

Open Access
98 Scopus citations

Pivotal Advance: Eosinophil infiltration of solid tumors is an early and persistent inflammatory host response

Cormier, S. A., Taranova, A. G., Bedient, C., Nguyen, T., Protheroe, C., Pero, R., Dimina, D., Ochkur, S. I., O'Neill, K., Colbert, D., Lombari, T. R., Constant, S., McGarry, M. P., Lee, J. J. & Lee, N. A., Jun 2006, In : Journal of Leukocyte Biology. 79, 6, p. 1131-1139 9 p.

Research output: Contribution to journalArticle

126 Scopus citations

Pro-oxidative diesel exhaust particle chemicals inhibit LPS-induced dendritic cell responses involved in T-helper differentiation

Chan, R. C. F., Wang, M., Li, N., Yanagawa, Y., Onoé, K., Lee, J. J. & Nel, A. E., Aug 1 2006, In : Journal of Allergy and Clinical Immunology. 118, 2, p. 455-465 11 p.

Research output: Contribution to journalArticle

91 Scopus citations

Regulation of mucin genes in chronic inflammatory airway diseases

Voynow, J. A., Gendler, S. J. & Rose, M. C., Jun 1 2006, In : American journal of respiratory cell and molecular biology. 34, 6, p. 661-665 5 p.

Research output: Contribution to journalReview article

150 Scopus citations

Regulatory role of CD8+ T lymphocytes in bone marrow eosinophilopoiesis

Rådinger, M., Sergejeva, S., Johansson, A. K., Malmhäll, C., Bossios, A., Sjöstrand, M., Lee, J. J. & Lötvall, J., Jan 6 2006, In : Respiratory Research. 7, 83.

Research output: Contribution to journalArticle

9 Scopus citations

Replacement of the positively charged Walker A lysine residue with a hydrophobic leucine residue and conformational alterations caused by this mutation in MRP1 impair ATP binding and hydrolysis

Buyse, F., Hou, Y. X., Vigano, C., Zhao, Q., Ruysschaert, J. M. & Chang, X. B., Jul 1 2006, In : Biochemical Journal. 397, 1, p. 121-130 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

Role of eosinophils and neutrophils in innate and adaptive protective immunity to larval Strongyloides stercoralis in mice

Galioto, A. M., Hess, J. A., Nolan, T. J., Schad, G. A., Lee, J. J. & Abraham, D., Oct 2006, In : Infection and Immunity. 74, 10, p. 5730-5738 9 p.

Research output: Contribution to journalArticle

90 Scopus citations

Schistosoma mansoni infection in eosinophil lineage-ablated mice

Swartz, J. M., Dyer, K. D., Cheever, A. W., Ramalingam, T., Pesnicak, L., Domachowske, J. B., Lee, J. J., Lee, N. A., Foster, P. S., Wynn, T. A. & Rosenberg, H. F., Oct 1 2006, In : Blood. 108, 7, p. 2420-2427 8 p.

Research output: Contribution to journalArticle

129 Scopus citations

Sodium iodide symporter-mediated radioiodide imaging and therapy of ovarian tumor xenografts in mice

Dwyer, R. M., Bergert, E. R., O'Connor, M. K., Gendler, S. J. & Morris, J. C., Jan 2006, In : Gene Therapy. 13, 1, p. 60-66 7 p.

Research output: Contribution to journalArticle

61 Scopus citations

Structural Basis for the Methylation State-Specific Recognition of Histone H4-K20 by 53BP1 and Crb2 in DNA Repair

Botuyan, M. V., Lee, J., Ward, I. M., Kim, J. E., Thompson, J. R., Chen, J. & Mer, G., Dec 29 2006, In : Cell. 127, 7, p. 1361-1373 13 p.

Research output: Contribution to journalArticle

667 Scopus citations

Transmembrane segment peptides can disrupt cholecystokinin receptor oligomerization without affecting receptor function

Harikumar, K. G., Dong, M., Cheng, Z., Pinon, D. I., Lybrand, T. P. & Miller, L. J., Dec 12 2006, In : Biochemistry. 45, 49, p. 14706-14716 11 p.

Research output: Contribution to journalArticle

29 Scopus citations

Tyrosines in the MUC1 cytoplasmic tail modulate transcription via the extracellular signal-regulated kinase 1/2 and nuclear factor-κB pathways

Thompson, E. J., Shanmugam, K., Hattrup, C. L., Kotlarczyk, K. L., Gutierrez, A., Bradley, J. M., Mukherjee, P. & Gendler, S. J., Jul 2006, In : Molecular Cancer Research. 4, 7, p. 489-497 9 p.

Research output: Contribution to journalArticle

33 Scopus citations
19 Scopus citations
2007

(R)- and (S)-verapamil differentially modulate the multidrug-resistant protein MRP1

Perrotton, T., Trompier, D., Chang, X. B., Di Pietro, A. & Baubichon-Cortay, H., Oct 26 2007, In : Journal of Biological Chemistry. 282, 43, p. 31542-31548 7 p.

Research output: Contribution to journalArticle

50 Scopus citations

A molecular understanding of ATP-dependent solute transport by multidrug resistance-associated protein MRP1

Chang, X. B., Mar 1 2007, In : Cancer and Metastasis Reviews. 26, 1, p. 15-37 23 p.

Research output: Contribution to journalReview article

47 Scopus citations

An organizational laser safety program at Mayo Clinic in Arizona

Wesselius, L., Frederiksen, S., Walton, H., Pasquariello, T., Didehban, R., Fleeger, R., Friedman, L. & Harikumar, K., 2007, International Laser Safety Conference: The World's Leading Conference on Laser Safety, ILSC 2007. Laser Institute of America, p. 218-220 3 p. (International Laser Safety Conference: The World's Leading Conference on Laser Safety, ILSC 2007).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Biochemical and cell biological mechanisms of cholecystokinin receptor regulation

Miller, L. J., Dong, M., Harikumar, K. G. & Lisenbee, C. S., Jun 1 2007, In : Current Topics in Medicinal Chemistry. 7, 12, p. 1166-1172 7 p.

Research output: Contribution to journalReview article

7 Scopus citations

Characterization of the MUC1.Tg/MIN transgenic mouse as a model for studying antigen-specific immunotherapy of adenomas

Akporiaye, E. T., Bradley-Dunlop, D., Gendler, S. J., Mukherjee, P., Madsen, C. S., Hahn, T., Besselsen, D. G., Dial, S. M., Cui, H. & Trevor, K., Sep 28 2007, In : Vaccine. 25, 39-40, p. 6965-6974 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

Coexpression of IL-5 and eotaxin-2 in mice creates an eosinophil-dependent model of respiratory inflammation with characteristics of severe asthma

Ochkur, S. I., Jacobsen, E. A., Protheroe, C. A., Biechele, T. L., Pero, R. S., McGarry, M. P., Wang, H., O'Neill, K. R., Colbert, D. C., Colby, T. V., Shen, H., Blackburn, M. R., Irvin, C. C., Lee, J. J. & Lee, N. A., Jun 15 2007, In : Journal of Immunology. 178, 12, p. 7879-7889 11 p.

Research output: Contribution to journalArticle

Open Access
117 Scopus citations

Domain Interdependence in the Biosynthetic Assembly of CFTR

Cui, L., Aleksandrov, L., Chang, X. B., Hou, Y. X., He, L., Hegedus, T., Gentzsch, M., Aleksandrov, A., Balch, W. E. & Riordan, J. R., Jan 26 2007, In : Journal of Molecular Biology. 365, 4, p. 981-994 14 p.

Research output: Contribution to journalArticle

154 Scopus citations

Eosinophilic granulocytes and damage-associated molecular pattern molecules (DAMPs): Role in the inflammatory response within tumors

Lotfi, R., Lee, J. J. & Lotze, M. T., Jan 1 2007, In : Journal of Immunotherapy. 30, 1, p. 16-28 13 p.

Research output: Contribution to journalReview article

125 Scopus citations

Eosinophils: Singularly destructive effector cells or purveyors of immunoregulation?

Jacobsen, E. A., Taranova, A. G., Lee, N. A. & Lee, J. J., Jun 1 2007, In : Journal of Allergy and Clinical Immunology. 119, 6, p. 1313-1320 8 p.

Research output: Contribution to journalArticle

153 Scopus citations

Eosinophils act as antigen-presenting cells to induce immunity to Strongyloides stercoralis in mice

Padigel, U. M., Hess, J. A., Lee, J. J., Lok, J. B., Nolan, T. J., Schad, G. A. & Abraham, D., Dec 15 2007, In : Journal of Infectious Diseases. 196, 12, p. 1844-1851 8 p.

Research output: Contribution to journalArticle

68 Scopus citations

Eosinophils and asthma

Jacobsen, E. A., Ochkur, S. I., Lee, N. A. & Lee, J. J., Apr 1 2007, In : Current Allergy and Asthma Reports. 7, 1, p. 18-26 9 p.

Research output: Contribution to journalReview article

55 Scopus citations

Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells

Valadi, H., Ekström, K., Bossios, A., Sjöstrand, M., Lee, J. J. & Lötvall, J. O., Jun 1 2007, In : Nature Cell Biology. 9, 6, p. 654-659 6 p.

Research output: Contribution to journalArticle

6326 Scopus citations

Fluorescence resonance energy transfer analysis of secretin docking to its receptor: Mapping distances between residues distributed throughout the ligand pharmacophore and distinct receptor residues

Harikumar, K. G., Lam, P. C. H., Dong, M., Sexton, P. M., Abagyan, R. & Miller, L. J., Nov 9 2007, In : Journal of Biological Chemistry. 282, 45, p. 32834-32843 10 p.

Research output: Contribution to journalArticle

25 Scopus citations

i2-mediated signaling events in the endothelium are involved in controlling leukocyte extravasation

Pero, R. S., Borchers, M. T., Spicher, K., Ochkur, S. I., Sikora, L., Rao, S. P., Abdala-Valencia, H., O'Neill, K. R., Shen, H., McGarry, M. P., Lee, N. A., Cook-Mills, J. M., Sriramarao, P., Simon, M. I., Birnbaumer, L. & Lee, J. J., Mar 13 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 11, p. 4371-4376 6 p.

Research output: Contribution to journalArticle

47 Scopus citations
8 Scopus citations

Identification of an alternative Gαq-dependent chemokine receptor signal transduction pathway in dendritic cells and granulocytes

Shi, G., Partida-Sánchez, S., Misra, R. S., Tighe, M., Borchers, M. T., Lee, J. J., Simon, M. I. & Lund, F. E., Oct 29 2007, In : Journal of Experimental Medicine. 204, 11, p. 2705-2718 14 p.

Research output: Contribution to journalArticle

62 Scopus citations

Intraocular use of rituximab

Kitzmann, A. S., Pulido, J. S., Mohney, B. G., Baratz, K. H., Grube, T., Marler, R. J., Donaldson, M. J., O'Neill, B. P., Johnston, P. B., Johnson, K. M., Dixon, L. E., Salomao, D. R. & Cameron, J. D., Dec 2007, In : Eye. 21, 12, p. 1524-1527 4 p.

Research output: Contribution to journalArticle

68 Scopus citations
4 Scopus citations

Misassembled mutant ΔF508 CFTR in the distal secretory pathway alters cellular lipid trafficking

Gentzsch, M., Choudhury, A., Chang, X. B., Pagano, R. E. & Riordan, J. R., Feb 1 2007, In : Journal of cell science. 120, 3, p. 447-455 9 p.

Research output: Contribution to journalArticle

51 Scopus citations

MUC1 cell surface mucin is a critical element of the mucosal barrier to infection

McAuley, J. L., Linden, S. K., Chin, W. P., King, R. M., Pennington, H. L., Gendler, S. J., Florin, T. H., Hill, G. R., Korolik, V. & McGuckin, M. A., Aug 1 2007, In : Journal of Clinical Investigation. 117, 8, p. 2313-2324 12 p.

Research output: Contribution to journalArticle

246 Scopus citations