Biochemistry and Molecular Biology

Research Output

1994

Phosphatase inhibitors activate normal and defective CFTR chloride channels

Becq, F., Jensen, T. J., Chang, X. B., Savoia, A., Rommens, J. M., Tsui, L. C., Buchwald, M., Riordan, J. R. & Hanrahan, J. W., Sep 13 1994, In : Proceedings of the National Academy of Sciences of the United States of America. 91, 19, p. 9160-9164 5 p.

Research output: Contribution to journalArticle

139 Scopus citations

Transcriptional regulation of the MUC1 mucin gene in colon carcinoma cells by a soluble factor. Identification of a regulatory element

Shirotani, K., Taylor-Papadimitriou, J., Gendler, S. J. & Irimura, T., Jan 1 1994, In : Journal of Biological Chemistry. 269, 21, p. 15030-15035 6 p.

Research output: Contribution to journalArticle

27 Scopus citations
1995

Analysis of mammalian MUC1 genes reveals potential functionally important domains

Spicer, A. P., Duhig, T., Chilton, B. S. & Gendler, S. J., Dec 1 1995, In : Mammalian Genome. 6, 12, p. 885-888 4 p.

Research output: Contribution to journalArticle

58 Scopus citations

A tightly organized, conserved gene cluster on mouse Chromosome 3 (E3-F1)

Vos, H. L., Mockensturm-Wilson, M., Rood, P. M. L., Mass, A. M. C. E., Duhig, T., Gendler, S. J. & Bornstein, P., Nov 1 1995, In : Mammalian Genome. 6, 11, p. 820-822 3 p.

Research output: Contribution to journalArticle

9 Scopus citations

cAMP-dependent protein kinase-mediated phosphorylation of cystic fibrosis transmembrane conductance regulator residue Ser-753 and its role in channel activation

Seibert, F. S., Tabcharani, J. A., Chang, X. B., Dulhanty, A. M., Mathews, C., Hanrahan, J. W. & Riordan, J. R., Jan 1 1995, In : Journal of Biological Chemistry. 270, 5, p. 2158-2162 5 p.

Research output: Contribution to journalArticle

71 Scopus citations

Delayed mammary tumor progression in Muc-1 null mice

Spicer, A. P., Rowse, G. J., Lidner, T. K. & Gendler, S. J., Dec 15 1995, In : Journal of Biological Chemistry. 270, 50, p. 30093-30101 9 p.

Research output: Contribution to journalArticle

211 Scopus citations

Epithelial mucin genes

Gendler, S. J. & Spicer, A. P., Jan 1 1995, In : Annual Review of Physiology. 57, p. 607-634 28 p.

Research output: Contribution to journalReview article

815 Scopus citations

Expression and steroid hormonal control of muc-1 in the mouse uterus

Surveyor, G. A., Gendler, S. J., Pemberton, L., Das, S. K., Chakraborty, I., Julian, J., Pimental, R. A., Wegner, C. C., Dey, S. K. & Carson, D. D., Aug 1995, In : Endocrinology. 136, 8, p. 3639-3647 9 p.

Research output: Contribution to journalArticle

232 Scopus citations

Function and dysfunction of the CFTR chloride channel

Hanrahan, J. W., Tabcharani, J. A., Becq, F., Mathews, C. J., Augustinas, O., Jensen, T. J., Chang, X. B. & Riordan, J. R., Jul 26 1995, In : Journal of General Physiology. 48 TH ANN. SYMP., p. 125-137 13 p.

Research output: Contribution to journalArticle

34 Scopus citations

Genetic mapping of the tumor-associated mucin 1 gene on mouse Chromosome 3

Kingsmore, S. F., Spicer, A. P., Gendler, S. J. & Seldin, M. F., May 1 1995, In : Mammalian Genome. 6, 5, p. 378-379 2 p.

Research output: Contribution to journalArticle

3 Scopus citations
107 Scopus citations

Phenotypic and molecular analysis of a transgenic insertional allele of the mouse fused locus

Perry, W. L., Vasicek, T. J., Lee, J. J., Rossi, J. M., Zeng, L., Zhang, T., Tilghman, S. M. & Costantini, F., Jan 1 1995, In : Genetics. 141, 1, p. 321-332 12 p.

Research output: Contribution to journalArticle

78 Scopus citations

Platelet adhesion receptors

Williams, M. J., Du, X., Loftus, J. C. & Ginsberg, M. H., 1995, In : Seminars in Cell and Developmental Biology. 6, 5, p. 305-314 10 p.

Research output: Contribution to journalArticle

36 Scopus citations

Platelet integrins

Ginsberg, M. H., Du, X., O'Toole, T. E. & Loftus, J. C., 1995, In : Thrombosis and Haemostasis. 74, 1, p. 352-359 8 p.

Research output: Contribution to journalArticle

63 Scopus citations

The epithelial mucin, MUC1, of milk, mammary gland and other tissues

Patton, S., Gendler, S. J. & Spicer, A. P., Dec 20 1995, In : BBA - Reviews on Biomembranes. 1241, 3, p. 407-423 17 p.

Research output: Contribution to journalArticle

225 Scopus citations

The identification and cloning of a murine major basic protein gene expressed in eosinophils

Larson, K. A., Horton, M. A., Madden, B. J., Gleich, G. J., Lee, N. A. & Lee, J. J., Jan 1 1995, In : Journal of Immunology. 155, 6, p. 3002-3012 11 p.

Research output: Contribution to journalArticle

43 Scopus citations
1996

A molecular basis for affinity modulation of Fab ligand binding to integrin α(IIb)β3

Kunicki, T. J., Annis, D. S., Deng, Y. J., Loftus, J. C. & Shattil, S. J., Sep 5 1996, In : Journal of Biological Chemistry. 271, 34, p. 20315-20321 7 p.

Research output: Contribution to journalArticle

24 Scopus citations

cAMP- and Ca2+-independent activation of cystic fibrosis transmembrane conductance regulator channels by phenylimidazothiazole drugs

Becq, F., Verrier, B., Chang, X. B., Riordan, J. R. & Hanrahan, J. W., Jan 1 1996, In : Journal of Biological Chemistry. 271, 27, p. 16171-16179 9 p.

Research output: Contribution to journalArticle

44 Scopus citations

Chromosomal mapping of three mucin genes in the rat

Klinga-Levan, K., Gum, J. R., Gendler, S. J., Kim, Y. & Hansson, G. C., Jan 1 1996, In : Mammalian Genome. 7, 3, p. 248-250 3 p.

Research output: Contribution to journalArticle

2 Scopus citations

Cloning of the murine eosinophil peroxidase gene (mEPO): Characterization of a conserved subgroup of mammalian hematopoietic peroxidases

Horton, M. A., Larson, K. A., Lee, J. J. & Lee, N. A., Aug 1996, In : Journal of Leukocyte Biology. 60, 2, p. 285-294 10 p.

Research output: Contribution to journalArticle

51 Scopus citations

Dependence of critical micelle concentration of a zwitterionic detergent on ionic strength: Implications in receptor solubilization

Chattopadhyay, A. & Harikumar, K. G., Aug 5 1996, In : FEBS Letters. 391, 1-2, p. 199-202 4 p.

Research output: Contribution to journalArticle

99 Scopus citations

Ligand binding and affinity modulation of integrins

Tozer, E. C., Hughes, P. E. & Loftus, J. C., Jan 1 1996, In : Biochemistry and Cell Biology. 74, 6, p. 785-798 14 p.

Research output: Contribution to journalArticle

35 Scopus citations

Ligand binding to integrin α(IIb)β3 is dependent on a MIDAS-like domain in the β3 subunit

Tozer, E. C., Liddington, R. C., Sutcliffe, M. J., Smeeton, A. H. & Loftus, J. C., Sep 25 1996, In : Journal of Biological Chemistry. 271, 36, p. 21978-21984 7 p.

Research output: Contribution to journalArticle

158 Scopus citations

Molecular characterization of the large heavily glycosylated domain glycopeptide from the rat small intestinal Muc2 mucin

Karlsson, N. G., Johansson, M. E., Asker, N., Karlsson, H., Gendler, S. J., Carlstedt, I. & Hansson, G. C., Nov 2 1996, In : Glycoconjugate Journal. 13, 5, p. 823-831 9 p.

Research output: Contribution to journalArticle

22 Scopus citations

Molecular characterization of the murine eosinophil secondary granule proteins and their potential relevance to the evolution of effector function

Larson, K. A., Horton, M. A., Olson, E. V., Gleich, G. J., Lee, N. A. & Lee, J. J., Dec 1 1996, In : FASEB Journal. 10, 6, p. A1023

Research output: Contribution to journalArticle

Regulation of the CFTR chloride channel from humans and sharks

Hanrahan, J. W., Mathews, C. J., Grygorczyk, R., Tabcharani, J. A., Grzelczak, Z., Chang, X. B. & Riordan, J. R., Jul 1 1996, In : Journal of Experimental Zoology. 275, 4, p. 283-291 9 p.

Research output: Contribution to journalArticle

25 Scopus citations

Synthesis and intracellular trafficking of Muc-1 and mucins by polarized mouse uterine epithelial cells

Pimental, R. A., Julian, J., Gendler, S. J. & Carson, D. D., Nov 19 1996, In : Journal of Biological Chemistry. 271, 45, p. 28128-28137 10 p.

Research output: Contribution to journalArticle

46 Scopus citations

The amino-terminal one-third of αIIb defines the ligand recognition specificity of integrin αIIbβ3

Loftus, J. C., Halloran, C. E., Ginsberg, M. H., Feigen, L. P., Zablocki, J. A. & Smith, J. W., Jan 26 1996, In : Journal of Biological Chemistry. 271, 4, p. 2033-2039 7 p.

Research output: Contribution to journalArticle

Open Access
66 Scopus citations

The epithelial mucin MUC1 contains at least two discrete signals specifying membrane localization in cells

Pemberton, L. F., Rughetti, A., Taylor-Papadimitriou, J. & Gendler, S. J., Jan 26 1996, In : Journal of Biological Chemistry. 271, 4, p. 2332-2340 9 p.

Research output: Contribution to journalArticle

54 Scopus citations

Thymocyte Cell Fate Alteration by High Levels of CD8α Is Independent of CD8-lck Association

Smith, D. H., Lee, N. & Lacy, E., Aug 1 1996, In : Journal of Immunology. 157, 3, p. 1087-1095 9 p.

Research output: Contribution to journalArticle

3 Scopus citations

Tissue/Cell specific expression of IL-5 in transgenic mice induces pathophysiological changes and unique histopathologies associated with the site of expression

Lee, N. A., McGarry, M. P., Larson, K. A., Horton, M. A., Denzler, K. L., Farmer, S. C., Fredrikson, L. J., Mitchell, T. L. & Lee, J. J., Dec 1 1996, In : FASEB Journal. 10, 6, p. A1029

Research output: Contribution to journalArticle

Two highly homologous ribonuclease genes expressed in mouse eosinophils identify a larger subgroup of the mammalian ribonuclease superfamily

Larson, K. A., Olson, E. V., Madden, B. J., Gleich, G. J., Lee, N. A. & Lee, J. J., Oct 29 1996, In : Proceedings of the National Academy of Sciences of the United States of America. 93, 22, p. 12370-12375 6 p.

Research output: Contribution to journalArticle

67 Scopus citations
1997

A genetic analysis of integrin function: Glanzmann thrombasthenia in vitro

Baker, E. K., Tozer, E. C., Pfaff, M., Shattil, S. J., Loftus, J. C. & Ginsberg, M. H., Mar 4 1997, In : Proceedings of the National Academy of Sciences of the United States of America. 94, 5, p. 1973-1978 6 p.

Research output: Contribution to journalArticle

63 Scopus citations

Antiinterleukin-5 antibody prevents airway hyperresponsiveness in a murine model airway sensitization

Hamelmann, E., Oshiba, A., Loader, J., Larsen, C. L., Gleich, C., Lee, J. & Gelfand, E. W., Jan 1 1997, In : American journal of respiratory and critical care medicine. 155, 3, p. 819-825 7 p.

Research output: Contribution to journalArticle

242 Scopus citations

A review of epithelial muc1n genes and gene products

Gendler, S. J., Dec 1 1997, In : Investigative Ophthalmology and Visual Science. 38, 4, p. S471

Research output: Contribution to journalArticle

Asthma: Does IL-5 Have a More Provocative Role?

Lee, N. A. & Lee, J. J., Jan 1 1997, In : American journal of respiratory cell and molecular biology. 16, 5, p. 497-500 4 p.

Research output: Contribution to journalReview article

15 Scopus citations

ATPase activity of purified multidrug resistance-associated protein

Chang, X. B., Hou, Y. X. & Riordan, J. R., Dec 5 1997, In : Journal of Biological Chemistry. 272, 49, p. 30962-30968 7 p.

Research output: Contribution to journalArticle

128 Scopus citations

Erratum: Integrin-ligand binding properties govern cell migration speed through cell-substratum adhesiveness (Nature (1997) 385 (537-540))

Palecek, S. P., Loftus, J. C., Ginsberg, M. H., Lauffenburger, D. A. & Horwitz, A. F., 1997, In : Nature. 388, 6638, 1 p.

Research output: Contribution to journalComment/debate

Open Access
7 Scopus citations

Expression of IL-5 in Thymocytes/T Cells Leads to the Development of a Massive Eosinophilia, Extramedullary Eosinophilopoiesis, and Unique Histopathologies

Lee, N. A., McGarry, M. P., Larson, K. A., Horton, M. A., Kristensen, A. B. & Lee, J. J., Feb 1 1997, In : Journal of Immunology. 158, 3, p. 1332-1344 13 p.

Research output: Contribution to journalArticle

182 Scopus citations

Histological studies of gene-ablated mice support important functional roles for natural killer cells in the uterus during pregnancy

Croy, B. A., Ashkar, A. A., Foster, R. A., DiSanto, J. P., Magram, J., Carson, D., Gendler, S. J., Grusby, M. J., Wagner, N., Muller, W. & Guimond, M. J., Nov 15 1997, In : Journal of Reproductive Immunology. 35, 2, p. 111-133 23 p.

Research output: Contribution to journalArticle

63 Scopus citations

Interleukin-5 expression in the lung epithelium of transgenic mice leads to pulmonary changes pathognomonic of asthma

Lee, J. J., McGarry, M. P., Farmer, S. C., Denzler, K. L., Larson, K. A., Carrigan, P. E., Brenneise, I. E., Horton, M. A., Haczku, A., Gelfand, E. W., Leikauf, G. D. & Lee, N. A., Jun 16 1997, In : Journal of Experimental Medicine. 185, 12, p. 2143-2156 14 p.

Research output: Contribution to journalArticle

447 Scopus citations

Linear canonical transformations in quantum mechanics

Bordner, A. J., Jul 1997, In : Journal of Mathematical Physics. 38, 7, p. 3427-3434 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

Loss of heterozygosity analysis in primary mammary tumors and lung metastases of MMTV-MTAg and MMTV-neu transgenic mice

Ritland, S. R., Rowse, G. J., Chang, Y. & Gendler, S. J., Aug 15 1997, In : Cancer research. 57, 16, p. 3520-3525 6 p.

Research output: Contribution to journalArticle

40 Scopus citations

New insights into integrin-ligand interaction

Loftus, J. C. & Liddington, R. C., Dec 1 1997, In : Journal of Clinical Investigation. 100, 11 SUPPL., p. S77-S81

Research output: Contribution to journalReview article

30 Scopus citations

New insights into integrin-ligand interaction

Loftus, J. C. & Liddington, R. C., May 15 1997, In : Journal of Clinical Investigation. 99, 10, p. 2302-2306 5 p.

Research output: Contribution to journalReview article

Open Access
103 Scopus citations

Operator transformations between exactly solvable potentials and their Lie group generators

Bordner, A. J., Jun 7 1997, In : Journal of Physics A: Mathematical and General. 30, 11, p. 3927-3936 10 p.

Research output: Contribution to journalArticle

Partial structure, chromosome localization, and expression of the mouse Girk4 gene

Wickman, K., Seldin, M. F., Gendler, S. J. & Clapham, D. E., Mar 15 1997, In : Genomics. 40, 3, p. 395-401 7 p.

Research output: Contribution to journalArticle

18 Scopus citations

Partial structure, chromosome localization, and expression of the mouse Icln gene

Wickman, K., Seldin, M. F., James, M. R., Gendler, S. J. & Clapham, D. E., Mar 15 1997, In : Genomics. 40, 3, p. 402-408 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

Permeability of wild-type and mutant cystic fibrosis transmembrane conductance regulator chloride channels to polyatomic anions

Linsdell, P., Tabcharani, J. A., Rommens, J. M., Hou, Y. X., Chang, X. B., Tsui, L. C., Riordan, J. R. & Hanrahan, J. W., Oct 1997, In : Journal of General Physiology. 110, 4, p. 355-364 10 p.

Research output: Contribution to journalArticle

157 Scopus citations

Smooth bosonization as a quantum canonical transformation

Bordner, A. J., 1997, In : Physical Review D - Particles, Fields, Gravitation and Cosmology. 55, 12, p. 7739-7748 10 p.

Research output: Contribution to journalArticle

1 Scopus citations