Biochemistry and Molecular Biology

Research Output

2017

Secretin receptor dimerization. Prototypic of class B GPCR behavior

Harikumar, K. G. & Miller, L. J., Jan 1 2017, Receptors. Humana Press Inc., p. 273-287 15 p. (Receptors; vol. 33).

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

SiglecF+Gr1hi eosinophils are a distinct subpopulation within the lungs of allergen-challenged mice

Percopo, C. M., Brenner, T. A., Ma, M., Kraemer, L. S., Hakeem, R. M. A., Lee, J. J. & Rosenberg, H. F., Jan 2017, In : Journal of Leukocyte Biology. 101, 1, p. 321-328 8 p.

Research output: Contribution to journalArticle

34 Scopus citations

Skeletal and uterotrophic effects of endoxifen in female rats

Gingery, A., Iwaniec, U. T., Subramaniam, M., Turner, R. T., Pitel, K. S., McGovern, R. M., Reid, J. M., Marler, R. J., Ingle, J. N., Goetz, M. P. & Hawse, J. R., Oct 1 2017, In : Endocrinology. 158, 10, p. 3354-3368 15 p.

Research output: Contribution to journalArticle

1 Scopus citations

Spatial intensity distribution analysis quantifies the extent and regulation of homodimerization of the secretin receptor

Ward, R. J., Pediani, J. D., Harikumar, K. G., Miller, L. J. & Milligan, G., Jun 1 2017, In : Biochemical Journal. 474, 11, p. 1879-1895 17 p.

Research output: Contribution to journalArticle

13 Scopus citations

Sputum autoantibodies in patients with severe eosinophilic asthma

Mukherjee, M., Bulir, D. C., Radford, K., Kjarsgaard, M., Huang, C. M., Jacobsen, E., Ochkur, S. I., Catuneanu, A., Lamothe-Kipnes, H., Mahony, J., Lee, J. J., Lacy, P. & Nair, P. K., Jan 1 2017, (Accepted/In press) In : Journal of Allergy and Clinical Immunology.

Research output: Contribution to journalArticle

26 Scopus citations

Surrogate in vitro activation of innate immunity synergizes with interleukin-7 to unleash rapid antigen-driven outgrowth of CD4+ and CD8+ human peripheral blood T-cells naturally recognizing MUC1, HER2/neu and other tumor-associated antigens

Pathangey, L. B., McCurry, D. B., Gendler, S. J., Dominguez, A. L., Gorman, J. E., Pathangey, G., Mihalik, L. A., Dang, Y., Disis, M. L. & Cohen, P. A., 2017, In : Oncotarget. 8, 7, p. 10785-10808 24 p.

Research output: Contribution to journalArticle

5 Scopus citations

Targeting granulocyte-macrophage colony-stimulating factor in epithelial and vascular remodeling in experimental eosinophilic esophagitis

McNamee, E. N., Biette, K. A., Hammer, J., Harris, R., Miyazawa, H., Lee, J. J., Furuta, G. T. & Masterson, J. C., Aug 2017, In : Allergy: European Journal of Allergy and Clinical Immunology. 72, 8, p. 1232-1242 11 p.

Research output: Contribution to journalArticle

3 Scopus citations

Throat-derived eosinophil peroxidase is not a reliable biomarker of pediatric eosinophilic esophagitis

Schroeder, S., Ochkur, S. I., Shim, K. P., Galvin, K. M., Bauer, C. S., Lee, J. J. & Wright, B. L., Nov 2017, In : Journal of Allergy and Clinical Immunology: In Practice. 5, 6, p. 1804-1805 2 p.

Research output: Contribution to journalLetter

3 Scopus citations

Wnt5a promotes Frizzled-4 signalosome assembly by stabilizing cysteine-rich domain dimerization

DeBruine, Z. J., Ke, J., Harikumar, K. G., Gu, X., Borowsky, P., Williams, B. O., Xu, W., Miller, L. J., Xu, H. E. & Melcher, K., 2017, In : Genes and Development. 31, 9, p. 916-926 11 p.

Research output: Contribution to journalArticle

23 Scopus citations
2018

A Novel Signaling Complex between TROY and EGFR Mediates Glioblastoma Cell Invasion

Ding, Z., Roos, A., Kloss, J., Dhruv, H., Peng, S., Pirrotte, P., Eschbacher, J. M., Tran, N. L. & Loftus, J. C., Feb 1 2018, In : Molecular Cancer Research. 16, 2, p. 322-332 11 p.

Research output: Contribution to journalArticle

6 Scopus citations

EGFRvIII–Stat5 signaling enhances glioblastoma cell migration and survival

Roos, A., Dhruv, H. D., Peng, S., Inge, L. J., Tuncali, S., Pineda, M., Millard, N., Mayo, Z., Eschbacher, J. M., Loftus, J. C., Winkles, J. A. & Tran, N. L., Jul 2018, In : Molecular Cancer Research. 16, 7, p. 1185-1195 11 p.

Research output: Contribution to journalArticle

6 Scopus citations

Eosinophil-derived CCL-6 impairs hematopoietic stem cell homeostasis

Zhang, C., Yi, W., Li, F., Du, X., Wang, H., Wu, P., Peng, C., Luo, M., Hua, W., Wong, C. C. L., Lee, J. J., Li, W., Chen, Z., Ying, S., Ju, Z. & Shen, H., Mar 1 2018, In : Cell Research. 28, 3, p. 323-335 13 p.

Research output: Contribution to journalArticle

1 Scopus citations

Eosinophils Mediate Tissue Injury in the Autoimmune Skin Disease Bullous Pemphigoid

Lin, L., Hwang, B. J., Culton, D. A., Li, N., Burette, S., Koller, B. H., Messingham, K. A., Fairley, J. A., Lee, J. J., Hall, R. P., An, L., Diaz, L. A. & Liu, Z., May 1 2018, In : Journal of Investigative Dermatology. 138, 5, p. 1032-1043 12 p.

Research output: Contribution to journalArticle

23 Scopus citations

Frontline Science: Characterization of a novel mouse strain expressing human Siglec-8 only on eosinophils

O'Sullivan, J. A., Wei, Y., Carroll, D. J., Moreno-Vinasco, L., Cao, Y., Zhang, F., Lee, J. J., Zhu, Z. & Bochner, B. S., Jul 2018, In : Journal of Leukocyte Biology. 104, 1, p. 11-19 9 p.

Research output: Contribution to journalArticle

10 Scopus citations

Increased GATA-3 and T-bet expression in eosinophilic esophagitis versus gastroesophageal reflux disease

Wright, B. L., Nguyen, N., Shim, K. P., Masterson, J. C., Jacobsen, E. A., Ochkur, S. I., Lee, J. J. & Furuta, G. T., May 2018, In : Journal of Allergy and Clinical Immunology. 141, 5, p. 1919-1921.e5

Research output: Contribution to journalArticle

2 Scopus citations

Inhibiting focal adhesion kinase (FAK) blocks IL-4 induced VCAM-1 expression and eosinophil recruitment in vitro and in vivo

Aulakh, G. K., Petri, B., Wojcik, K. M., Colarusso, P., Lee, J. J. & Patel, K. D., Jan 1 2018, (Accepted/In press) In : Journal of Leukocyte Biology.

Research output: Contribution to journalArticle

2 Scopus citations

Methylprednisolone acetate induces, and ?7-dafachronic acid suppresses, Strongyloides stercoralis hyperinfection in NSG mice

Patton, J. B., Bonne-Année, S., Deckman, J., Hess, J. A., Torigian, A., Nolan, T. J., Wang, Z., Kliewer, S. A., Durham, A. C., Lee, J. J., Eberhard, M. L., Mangelsdorf, D. J., Lok, J. B. & Abraham, D., Jan 2 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 1, p. 204-209 6 p.

Research output: Contribution to journalArticle

17 Scopus citations

Normalized serum eosinophil peroxidase levels are inversely correlated with esophageal eosinophilia in eosinophilic esophagitis

Wright, B. L., Ochkur, S. I., Olson, N. S., Shim, K. P., Jacobsen, E. A., Rank, M. A., Dellon, E. S. & Lee, J. J., Feb 1 2018, In : Diseases of the Esophagus. 31, 2, p. 1-9 9 p., dox139.

Research output: Contribution to journalReview article

9 Scopus citations

Obese asthmatic patients have decreased surfactant protein A levels: Mechanisms and implications

Lugogo, N., Francisco, D., Addison, K. J., Manne, A., Pederson, W., Ingram, J. L., Green, C. L., Suratt, B. T., Lee, J. J., Sunday, M. E., Kraft, M. & Ledford, J. G., Mar 2018, In : Journal of Allergy and Clinical Immunology. 141, 3, p. 918-926.e3

Research output: Contribution to journalArticle

6 Scopus citations

PDZ-RhoGEF Is a Signaling Effector for TROY-Induced Glioblastoma Cell Invasion and Survival

Ding, Z., Dhruv, H., Kwiatkowska-Piwowarczyk, A., Ruggieri, R., Kloss, J., Symons, M., Pirrotte, P., Eschbacher, J. M., Tran, N. L. & Loftus, J. C., Oct 2018, In : Neoplasia (United States). 20, 10, p. 1045-1058 14 p.

Research output: Contribution to journalArticle

2 Scopus citations

Shaping eosinophil identity in the tissue contexts of development, homeostasis, and disease

Abdala-Valencia, H., Coden, M. E., Chiarella, S. E., Jacobsen, E. A., Bochner, B. S., Lee, J. J. & Berdnikovs, S., Jul 2018, In : Journal of Leukocyte Biology. 104, 1, p. 95-108 14 p.

Research output: Contribution to journalReview article

27 Scopus citations

Synthesis and Immunological Evaluation of a Multicomponent Cancer Vaccine Candidate Containing a Long MUC1 Glycopeptide

Supekar, N. T., Lakshminarayanan, V., Capicciotti, C. J., Sirohiwal, A., Madsen, C. S., Wolfert, M. A., Cohen, P. A., Gendler, S. J. & Boons, G. J., Jan 18 2018, In : ChemBioChem. 19, 2, p. 121-125 5 p.

Research output: Contribution to journalArticle

2 Scopus citations

Vesicle-associated membrane protein 7-mediated eosinophil degranulation promotes allergic airway inflammation in mice

Willetts, L., Felix, L. C., Jacobsen, E. A., Puttagunta, L., Condjella, R. M., Zellner, K. R., Ochkur, S. I., Kim, J. D., Luo, H., Lee, N. A., Lee, J. J., Moqbel, R. & Lacy, P., Dec 1 2018, In : Communications Biology. 1, 1, 83.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations
2019

Breaking tolerance with engineered class I antigen-presenting molecules

Parks, C. A., Henning, K. R., Pavelko, K. D., Hansen, M. J., Van Keulen, V. P., Reed, B. K., Stone, J. D., Schrum, A. G., Gil, D., Kranz, D. M., Bordner, A. J., Barry, M. A. & Pease, L. R., Feb 19 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 8, p. 3136-3145 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

Eosinophil-derived IL-13 promotes emphysema

Doyle, A. D., Mukherjee, M., LeSuer, W. E., Bittner, T. B., Pasha, S. M., Frere, J. J., Neely, J. L., Kloeber, J. A., Shim, K. P., Ochkur, S. I., Ho, T., Svenningsen, S., Wright, B. L., Rank, M. A., Lee, J. J., Nair, P. & Jacobsen, E. A., May 1 2019, In : The European respiratory journal. 53, 5

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Eosinophil peroxidase, GATA3, and T-bet as tissue biomarkers in chronic rhinosinusitis

Lal, D., Wright, B. L., Shim, K. P., Zarka, M. A., Lee, J. J., Chang, Y. H., Ochkur, S. I., Divekar, R., Doyle, A. D., Jacobsen, E. A., Kita, H. & Rank, M. A., Jun 2019, In : Journal of Allergy and Clinical Immunology. 143, 6, p. 2284-2287.e6

Research output: Contribution to journalArticle

1 Scopus citations

Inhibition of phosphatidylinositol 3-kinase by PX-866 suppresses temozolomide-induced autophagy and promotes apoptosis in glioblastoma cells

Harder, B. G., Peng, S., Sereduk, C. P., Sodoma, A. M., Kitange, G. J., Loftus, J. C., Sarkaria, J. N. & Tran, N. L., Nov 14 2019, In : Molecular Medicine. 25, 1, 49.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Variation in Endoscopic Activity Assessment and Endoscopy Score Validation in Adults With Eosinophilic Esophagitis

International EEsAI Study Group, Jul 2019, In : Clinical Gastroenterology and Hepatology. 17, 8, p. 1477-1488.e10

Research output: Contribution to journalArticle

2 Scopus citations
2020

Development of a Testing Funnel for Identification of Small-Molecule Modulators Targeting Secretin Receptors

Dengler, D. G., Sun, Q., Holleran, J., Pollari, S., Beutel, J., Brown, B. T., Shinoki Iwaya, A., Ardecky, R., Harikumar, K. G., Miller, L. J. & Sergienko, E. A., 2020, (Accepted/In press) In : SLAS Discovery.

Research output: Contribution to journalArticle

Rational development of a high-affinity secretin receptor antagonist

Dong, M., Harikumar, K. G., Raval, S. R., Milburn, J. E., Clark, C., Alcala-Torano, R., Mobarec, J. C., Reynolds, C. A., Ghirlanda, G., Christopoulos, A., Wootten, D., Sexton, P. M. & Miller, L. J., Jul 2020, In : Biochemical Pharmacology. 177, 113929.

Research output: Contribution to journalArticle

1 Scopus citations

Structure and dynamics of the active Gs-coupled human secretin receptor

Dong, M., Deganutti, G., Piper, S. J., Liang, Y. L., Khoshouei, M., Belousoff, M. J., Harikumar, K. G., Reynolds, C. A., Glukhova, A., Furness, S. G. B., Christopoulos, A., Danev, R., Wootten, D., Sexton, P. M. & Miller, L. J., Dec 1 2020, In : Nature communications. 11, 1, 4137.

Research output: Contribution to journalArticle

Open Access

TROY signals through JAK1-STAT3 to promote glioblastoma cell migration and resistance

Ding, Z., Kloss, J. M., Tuncali, S., Tran, N. L. & Loftus, J. C., Sep 2020, In : Neoplasia (United States). 22, 9, p. 352-364 13 p.

Research output: Contribution to journalArticle

Open Access