Biochemistry and Molecular Biology

Research Output

1990

The locus of the polymorphic epithelial mucin (PEM) tumour antigen on chromosome 1q21 shows a high frequency of alteration in primary human breast tumours

Gendler, S. J., Cohen, E. P., Craston, A., Duhig, T., Johnstone, G. & Barnes, D., Mar 15 1990, In : International Journal of Cancer. 45, 3, p. 431-435 5 p.

Research output: Contribution to journalArticle

73 Scopus citations

Transgenic mice expressing a human poliovirus receptor: A new model for poliomyelitis

Ren, R., Costantini, F., Gorgacz, E. J., Lee, J. J. & Racaniello, V. R., Oct 19 1990, In : Cell. 63, 2, p. 353-362 10 p.

Research output: Contribution to journalArticle

296 Scopus citations
1991

Autoantibodies to the presumptive cytoplasmic domain of platelet glycoprotein IIIa in patients with chronic immune thrombocytopenic purpura

Fujisawa, K., O'Toole, T. E., Tani, P., Loftus, J. C., Plow, E. F., Ginsberg, M. H. & McMillan, R., 1991, In : Blood. 77, 10, p. 2207-2213 7 p.

Research output: Contribution to journalArticle

Open Access
63 Scopus citations

Chromosome 1 Charcot-Marie-Tooth disease (CMT1B) locus in the Fcγ receptor gene region

Lebo, R. V., Chance, P. F., Dyck, P. J., Redila-Flores, M. T., Lynch, E. D., Golbus, M. S., Bird, T. D., King, M. C., Anderson, L. A., Hall, J., Wiegant, J., Jiang, Z., Dazin, P. F., Punnett, H. H., Schonberg, S. A., Moore, K., Shull, M. M., Gendler, S., Hurko, O., Lovelace, R. E. & 3 others, Latov, N., Trofatter, J. & Conneally, P. M., Nov 1 1991, In : Human genetics. 88, 1, p. 1-12 12 p.

Research output: Contribution to journalArticle

67 Scopus citations

Common and ligand-specific integrin recognition mechanisms

Ginsberg, M. H., Loftus, J. C. & Plow, E. F., Jan 1 1991, In : Chemical Immunology. 50, p. 75-88 14 p.

Research output: Contribution to journalReview article

4 Scopus citations

Expression of the gene coding for a human mucin in mouse mammary tumor cells can affect their tumorigenicity

Lalani, E. N., Berdichevsky, F., Boshell, M., Shearer, M., Wilson, D., Stauss, H., Gendler, S. J. & Taylor-Papadimitrious, J., Oct 2 1991, In : Journal of Biological Chemistry. 266, 23, p. 15420-15426 7 p.

Research output: Contribution to journalArticle

62 Scopus citations

Hβ58, and insertional mutation affecting early postimplantation development of the mouse embryo

Radice, G., Lee, J. J. & Costantini, F., Apr 4 1991, In : Development. 111, 3, p. 801-811 11 p.

Research output: Contribution to journalArticle

49 Scopus citations

Ligand bridging mediates integrin αIIbβ3 (platelet GPIIB-IIIA) dependent homotypic and heterotypic cell-cell interactions

Gawaz, M. P., Loftus, J. C., Bajt, M. L., Frojmovic, M. M., Plow, E. F. & Ginsberg, M. H., 1991, In : Journal of Clinical Investigation. 88, 4, p. 1128-1134 7 p.

Research output: Contribution to journalArticle

Open Access
102 Scopus citations

Ligands "activate" integrin αIIbβ3 (platelet GPIIb-IIIa)

Du, X., Plow, E. F., Frelinger, A. L., O'Toole, T. E., Loftus, J. C. & Ginsberg, M. H., May 3 1991, In : Cell. 65, 3, p. 409-416 8 p.

Research output: Contribution to journalArticle

398 Scopus citations
183 Scopus citations

Phosphorylation-regulated CI- channel in CHO cells stably expressing the cystic fibrosis gene

Tabcharani, J. A., Chang, X. B., Riordan, J. R. & Hanrahan, J. W., Jan 1 1991, In : Nature. 352, 6336, p. 628-631 4 p.

Research output: Contribution to journalArticle

437 Scopus citations

Platelet glycoprotein II(b)-III(a) (α(IIb)β3 integrin) confers fibrinogen- and activation-dependent aggregation on heterologous cells

Frojmovic, M. M., O'Toole, T. E., Plow, E. F., Loftus, J. C. & Ginsberg, M. H., Jan 1 1991, In : Blood. 78, 2, p. 369-376 8 p.

Research output: Contribution to journalArticle

32 Scopus citations

Purification and characterization of a membrane-bound and a secreted mucin-type glycoprotein carrying the carcinoma-associated sialyl-Lea epitope on distinct core proteins

Baeckstrom, D., Hansson, G. C., Nilsson, O., Johansson, C., Gendler, S. J. & Lindholm, L., Jan 1 1991, In : Journal of Biological Chemistry. 266, 32, p. 21537-21547 11 p.

Research output: Contribution to journalArticle

131 Scopus citations

Structure and biology of a carcinoma-associated mucin, MUC1

Gendler, S. J., Spicer, A. P., Lalani, E. N., Duhig, T., Peat, N., Burchell, J., Pemberton, L., Boshell, M. & Taylor-Papadimitriou, J., 1991, In : American Review of Respiratory Disease. 144, 3 II, p. S42-S47

Research output: Contribution to journalArticle

173 Scopus citations
1992

Antibodies to the cytoplasmic domain of the MUC1 mucin show conservation throughout mammals

Pemberton, L., Taylor-Papadimitriou, J. & Gendler, S. J., May 29 1992, In : Biochemical and Biophysical Research Communications. 185, 1, p. 167-175 9 p.

Research output: Contribution to journalArticle

119 Scopus citations

A spontaneous mutation of integrin α(IIb)β3 (platelet glycoprotein IIb- IIIa) helps define a ligand binding site

Bajt, M. L., Ginsberg, M. H., Frelinger, A. L., Berndt, M. C. & Loftus, J. C., Jan 1 1992, In : Journal of Biological Chemistry. 267, 6, p. 3789-3794 6 p.

Research output: Contribution to journalArticle

129 Scopus citations

CD8 surface levels alter the fate of α/β T cell receptor-expressing thymocytes in transgenic mice

Lee, N. A., Loh, D. Y. & Lacy, E., Apr 1 1992, In : Journal of Experimental Medicine. 175, 4, p. 1013-1025 13 p.

Research output: Contribution to journalArticle

Open Access
126 Scopus citations

CFTR, a channel with the structure of a transporter

Riordan, J. R. & Chang, X. B., 1992, In : Biochimica et Biophysica Acta - Bioenergetics. 1101, 2, p. 221-222 2 p.

Research output: Contribution to journalArticle

39 Scopus citations

Characterization of a gain of function mutation of integrin α(IIb)β3 (platelet glycoprotein IIb-IIIa)

Bajt, M. L., Loftus, J. C., Gawaz, M. P. & Ginsberg, M. H., 1992, In : Journal of Biological Chemistry. 267, 31, p. 22211-22216 6 p.

Research output: Contribution to journalArticle

33 Scopus citations

Identification and characterization of a novel, evolutionarily conserved gene disrupted by the murine Hβ58 embryonic lethal transgene insertion

Lee, J. J., Radice, G., Perkins, C. P. & Costantini, F., Jan 1 1992, In : Development. 115, 1, p. 277-288 12 p.

Research output: Contribution to journalArticle

76 Scopus citations

Ligand binding to integrins: Dynamic regulation and common mechanisms

Ginsberg, M. H., O'Toole, T. E., Loftus, J. C. & Plow, E. F., 1992, In : Cold Spring Harbor Symposia on Quantitative Biology. 57, p. 221-232 12 p.

Research output: Contribution to journalArticle

27 Scopus citations

Molecular cloning and preliminary characterization of a novel cytoplasmic antigen recognized by myasthenia gravis sera

Gordon, T., Grove, B., Loftus, J. C., O'Toole, T., McMillan, R., Lindstrom, J. & Ginsberg, M. H., 1992, In : Journal of Clinical Investigation. 90, 3, p. 992-999 8 p.

Research output: Contribution to journalArticle

Open Access
80 Scopus citations

Right-angle light scattering to assay basal and regulated plasma membrane Cl- conductances

Dho, S., Chou, S., Chang, X. B., Rommens, J. M. & Foskett, J. K., 1992, In : American Journal of Physiology - Cell Physiology. 263, 2 32-2, p. C530-C534

Research output: Contribution to journalArticle

7 Scopus citations

Spatial and temporal expression of an epithelial mucin, Muc-1, during mouse development

Braga, V. M. M., Pemberton, L. F., Duhig, T. & Gendler, S. J., Jan 1 1992, In : Development. 115, 2, p. 427-437 11 p.

Research output: Contribution to journalArticle

107 Scopus citations

Studies of Muc-1 mucin expression and polarity in the mouse mammary gland demonstrate developmental regulation of Muc-1 glycosylation and establish the hormonal basis for mRNA expression

Parry, G., Li, J., Stubbs, J., Bissell, M. J., Schmidhauser, C., Spicer, A. P. & Gendler, S. J., Jan 1 1992, In : Journal of cell science. 101, 1, p. 191-199 9 p.

Research output: Contribution to journalArticle

41 Scopus citations

The Arg-Gly-Asp (RGD) recognition site of platelet glycoprotein IIb-IIIa on nonactivated platelets is accessible to high-affinity macromolecules

Tomiyama, Y., Tsubakio, T., Piotrowicz, R. S., Kurata, Y., Loftus, J. C. & Kunicki, T. J., 1992, In : Blood. 79, 9, p. 2303-2312 10 p.

Research output: Contribution to journalArticle

Open Access
69 Scopus citations

The cystic fibrosis transmembrane conductance regulator chloride channel. Iodide block and permeation

Tabcharani, J. A., Chang, X. B., Riordan, J. R. & Hanrahan, J. W., 1992, In : Biophysical Journal. 62, 1, p. 1-4 4 p.

Research output: Contribution to journalArticle

Open Access
51 Scopus citations

The cystic fibrosis transmembrane regulator is present and functional in endosomes. Role as a determinant of endosomal pH

Lukacs, G. L., Chang, X. B., Kartner, N., Rotstein, O. D., Riordan, J. R. & Grinstein, S., Jan 1 1992, In : Journal of Biological Chemistry. 267, 21, p. 14568-14572 5 p.

Research output: Contribution to journalArticle

98 Scopus citations

The product of the human MUC1 gene when secreted by mouse cells transfected with the full-length cDNA lacks the cytoplasmic tail

Boshell, M., Lalani, E. N., Pemberton, L., Burchell, J., Gendler, S. & Taylor-Papadimitriou, J., May 29 1992, In : Biochemical and Biophysical Research Communications. 185, 1, p. 1-8 8 p.

Research output: Contribution to journalArticle

78 Scopus citations

Tissue-specific Expression of a Human Polymorphic Epithelial Mucin (MUC1) in Transgenic Mice

Peat, N., Gendler, S. J., Lalani, E. N., Duhig, T. & Taylor-Papadimitriou, J., Apr 1992, In : Cancer research. 52, 7, p. 1954-1960 7 p.

Research output: Contribution to journalArticle

120 Scopus citations

Use of Correlative Microscopy with Colloidal Gold Labeling to Demonstrate Platelet Receptor Distribution and Movement

Albrecht, R. M., Olorundare, O. E., Simmons, S. R., Loftus, J. C. & Mosher, D. F., Jan 1 1992, In : Methods in enzymology. 215, C, p. 456-479 24 p.

Research output: Contribution to journalArticle

10 Scopus citations

Use of embryonic stem cells to study mutations affecting postimplantation development in the mouse.

Robertson, E. J., Conlon, F. L., Barth, K. S., Costantini, F. & Lee, J. J., 1992, In : Ciba Foundation symposium. 165, p. 237-250; discussion 250-255

Research output: Contribution to journalReview article

19 Scopus citations
1993

Analysis of the tissue-specific promoter of the MUC1 gene

Kovarik, A., Peat, N., Wilson, D., Gendler, S. J. & Taylor-Papadimitriou, J., Jan 1 1993, In : Journal of Biological Chemistry. 268, 13, p. 9917-9926 10 p.

Research output: Contribution to journalArticle

111 Scopus citations

Chromosome 1 Charcot-Marie-Tooth disease (CMT1B) locus in the Fcγ receptor gene region

Lebo, R. V., Chance, P. F., Dyck, P. J., Redila-Flores, M. T., Lynch, E. D., Golbus, M. S., Bird, T. D., King, M. C., Anderson, L. A., Hall, J., Wiegant, J., Jiang, Z., Dazin, P. F., Punnett, H. H., Schonberg, S. A., Moore, K., Shull, M. M., Gendler, S., Hurko, O., Lovelace, R. E. & 3 others, Latov, N., Trofatter, J. & Conneally, P. M., Apr 1 1993, In : Human genetics. 91, 3, 1 p.

Research output: Contribution to journalComment/debate

Distinct functions of integrin α and β subunit cytoplasmic domains in cell spreading and formation of focal adhesions

Ylänne, J., Chen, Y., O'Toole, T. E., Loftus, J. C., Takada, Y. & Ginsberg, M. H., Jul 1993, In : Journal of Cell Biology. 122, 1, p. 223-233 11 p.

Research output: Contribution to journalArticle

Open Access
189 Scopus citations

Erratum: Chromosome 1 Charcot-Marie-Tooth disease (CMT1B) locus in the Fcγ receptor gene region (Human Genetics (1991) 88 (1-12))

Lebo, R. V., Chance, P. F., Dyck, P. J., Redila-Flores Ma., T., Lynch, E. D., Golbus, M. S., Bird, T. D., King, M. C., Anderson, L. A., Hall, J., Wiegant, J., Jiang, Z., Dazin, P. F., Punnett, H. H., Schonberg, S. A., Moore, K., Shull, M. M., Gendler, S. & Hurko, O., Jan 1 1993, In : Human genetics. 91, 3, 1 p.

Research output: Contribution to journalComment/debate

Modulation of Muc-1 mucin expression in the mouse uterus during the estrus cycle, early pregnancy and placentation

Braga, V. M. M. & Gendler, S. J., Jan 1 1993, In : Journal of cell science. 105, 2, p. 397-405 9 p.

Research output: Contribution to journalArticle

129 Scopus citations

Multi-ion pore behaviour in the CFTR chloride channel

Tabcharani, J. A., Rommens, J. M., Hou, Y. X., Chang, X. B., Tsui, L. C., Riordan, J. R. & Hanrahan, J. W., Jan 1 1993, In : Nature. 366, 6450, p. 79-82 4 p.

Research output: Contribution to journalArticle

197 Scopus citations

Platelet integrins

Ginsberg, M. H., Xiaoping, D., O'Toole, T. E., Loftus, J. C. & Plow, E. F., 1993, In : Thrombosis and Haemostasis. 70, 1, p. 87-93 7 p.

Research output: Contribution to journalReview article

104 Scopus citations

Protein kinase A (PKA) still activates CFTR chloride channel after mutagenesis of all 10 PKA consensus phosphorylation sites

Chang, X. B., Tabcharani, J. A., Hou, Y. X., Jensen, T. J., Kartner, N., Alon, N., Hanrahan, J. W. & Riordan, J. R., Jun 11 1993, In : Journal of Biological Chemistry. 268, 15, p. 11304-11311 8 p.

Research output: Contribution to journalArticle

247 Scopus citations

Sequential neuropathology of dogs treated with vigabatrin, a GABA- transaminase inhibitor

Yarrington, J. T., Gibson, J. P., Dillberger, J. E., Hurst, G., Lippert, B., Sussman, N. M., Heydorn, W. E. & Marler, R. J., Jan 1 1993, In : Toxicologic Pathology. 21, 5, p. 480-489 10 p.

Research output: Contribution to journalArticle

23 Scopus citations

The cystic fibrosis mutation (ΔF508) does not influence the chloride channel activity of CFTR

Li, C., Ramjeesingh, M., Reyes, E., Jensen, T., Chang, X., Rommens, J. M. & Bear, C. E., Apr 1993, In : Nature Genetics. 3, 4, p. 311-316 6 p.

Research output: Contribution to journalArticle

150 Scopus citations

The ΔF508 mutation decreases the stability of cystic fibrosis transmembrane conductance regulator in the plasma membrane. Determination of functional half-lives on transfected cells

Lukacs, G. L., Chang, X. B., Bear, C., Kartner, N., Mohamed, A., Riordan, J. R. & Grinstein, S., Jan 1 1993, In : Journal of Biological Chemistry. 268, 29, p. 21592-21598 7 p.

Research output: Contribution to journalArticle

290 Scopus citations
1994

Co-amplification of two cDNAs in RT-PCR can alter the yield of both products

Braga, V. M. M. & Gendler, S. J., Jan 1 1994, In : BioTechniques. 17, 2, p. 228+230

Research output: Contribution to journalArticle

11 Scopus citations

Conformational maturation of CFTR but not its mutant counterpart (ΔF508) occurs in the endoplasmic reticulum and requires ATP

Lukacs, G. L., Mohamed, A., Kartner, N., Chang, X. B., Riordan, J. R. & Grinstein, S., Dec 1 1994, In : EMBO Journal. 13, 24, p. 6076-6086 11 p.

Research output: Contribution to journalArticle

319 Scopus citations

Integrin cytoplasmic domains mediate inside-out signal transduction

O'Toole, T. E., Katagiri, Y., Faull, R. J., Peter, K., Tamura, R., Quaranta, V., Loftus, J. C., Shattil, S. J. & Ginsberg, M. H., Mar 1994, In : Journal of Cell Biology. 124, 6, p. 1047-1059 13 p.

Research output: Contribution to journalArticle

Open Access
563 Scopus citations

Integrin-mediated cell adhesion: The extracellular face

Loftus, J. C., Smith, J. W. & Ginsberg, M. H., Jan 1 1994, In : Journal of Biological Chemistry. 269, 41, p. 25235-25238 4 p.

Research output: Contribution to journalShort survey

181 Scopus citations

Mapping of cystic fibrosis transmembrane conductance regulator membrane topology by glycosylation site insertion

Chang, X. B., Hou, Y. X., Jensen, T. J. & Riordan, J. R., Jul 15 1994, In : Journal of Biological Chemistry. 269, 28, p. 18572-18575 4 p.

Research output: Contribution to journalArticle

114 Scopus citations
139 Scopus citations

Phase space reduction and vortex statistics: An anyon quantization ambiguity

Allen, T. J., Bordner, A. J. & Crossley, D. B., 1994, In : Physical Review D. 49, 12, p. 6907-6913 7 p.

Research output: Contribution to journalArticle

1 Scopus citations