Projects per year
Personal profile
Research Interests
The laboratory-based research program of Gregory J. Gores, M.D., is focused on mechanisms of liver cell death, especially apoptosis. He employs disease-relevant models to unravel the fundamental cellular processes contributing to liver injury during cholestasis and fatty liver diseases. In addition, Dr. Gores' lab is also interested in the mechanisms by which cancer cells escape from cell death in order to undergo malignant transformation and metastases.
URL
Areas of Research
- Gastrointestinal Cancer Program
- Cholestatic Liver Diseases
- Mayo Clinic Cancer Center - Research
- Advanced Liver Diseases: Patrick S. Kamath, Vijay Shah
- Center for Clinical and Translational Science (CCaTS)
- Liver Pathobiology - Gregory J. Gores
- Center for Cell Signaling in Gastroenterology (C-SiG)
- Physiology and Biomedical Engineering
- Gastroenterology and Hepatology Research
- Transplant Research Center
- Center for Regenerative Medicine
Faculty Profile:
Clinical Profile:
Gastroenterologist, Internist
Research Interests
The laboratory-based research program of Gregory J. Gores, M.D., is focused on mechanisms of liver cell death, especially apoptosis. He employs disease-relevant models to unravel the fundamental cellular processes contributing to liver injury during cholestasis and fatty liver diseases. In addition, Dr. Gores' lab is also interested in the mechanisms by which cancer cells escape from cell death in order to undergo malignant transformation and metastases.
URL
Areas of Research
- Gastrointestinal Cancer Program
- Cholestatic Liver Diseases
- Mayo Clinic Cancer Center - Research
- Advanced Liver Diseases: Patrick S. Kamath, Vijay Shah
- Center for Clinical and Translational Science (CCaTS)
- Liver Pathobiology - Gregory J. Gores
- Center for Cell Signaling in Gastroenterology (C-SiG)
- Physiology and Biomedical Engineering
- Gastroenterology and Hepatology Research
- Transplant Research Center
- Center for Regenerative Medicine
Faculty Profile:
Clinical Profile:
Gastroenterologist, Internist
Education/Academic qualification
Fellow - Department of Internal Medicine; Division of Gastroenterology and Hepatology, Mayo Graduate School of Medicine, Mayo Clinic College of Medicine
MD, University of North Dakota
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Enrichment Program
Gores, G. J. & Gores, G. G. J.
National Institute of Diabetes and Digestive and Kidney Diseases
9/1/19 → 6/30/24
Project: Research project
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Mayo Center for Cell Signaling in Gastroenterology
La Russo, N. F., Boardman, L. A., Ekker, S. C., Ekker, S. C., Farrugia, G., Faubion, W. A., Gores, G. J., Larusso, N., Mc Niven, M. A., Mc Niven, M. A., Shah, V., Ibrahim, S. H. & Ordog, T.
National Institute of Diabetes and Digestive and Kidney Diseases
9/1/09 → 6/30/24
Project: Research project
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Multidisciplinary Training in Digestive Diseases
Gores, G. J., Shah, V. H., La Russo, N. F., Faubion, W. W. A. & Larusso, N.
National Institute of Diabetes and Digestive and Kidney Diseases
1/1/86 → 12/31/24
Project: Research project
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Cholestatic Liver Injury
National Institute of Diabetes and Digestive and Kidney Diseases
4/1/20 → 3/31/24
Project: Research project
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Mayo Clinic Hepatobiliary SPORE
Mc Niven, M. M. A., Alberts, S. R., Gores, G. J., Leof, E. B., Roberts, L. R., Mandrekar, S. J., Torbenson, M., Vile, R. G. & Yin, V.
9/10/18 → 8/31/23
Project: Research project
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Development of a Computer-aided Prediction Tool for Evaluating Brushing Samples of Biliary Strictures
The UMass-Mayo Clinic AI Cytopathology Consortium, Jan 2024, In: Clinical Gastroenterology and Hepatology. 22, 1, p. 185-187.e3Research output: Contribution to journal › Short survey › peer-review
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Efficacy and safety of biologics in primary sclerosing cholangitis with inflammatory bowel disease: A systematic review and meta-analysis
Shah, A., Jones, M. P., Callaghan, G., Fairlie, T., Ma, X., Culver, E. L., Stuart, K., De Cruz, P., O'Beirne, J., Tabibian, J. H., Dignass, A., Canbay, A., Gores, G. J. & Holtmann, G. J., Jan 2024, In: Hepatology Communications. 8, 1, p. e0347Research output: Contribution to journal › Article › peer-review
Open Access -
Phase 1 trial of navitoclax and sorafenib in patients with relapsed or refractory solid tumors with hepatocellular carcinoma expansion cohort
Emiloju, O. E., Yin, J., Koubek, E., Reid, J. M., Borad, M. J., Lou, Y., Seetharam, M., Edelman, M. J., Sausville, E. A., Jiang, Y., Kaseb, A. O., Posey, J. A., Davis, S. L., Gores, G. J., Roberts, L. R., Takebe, N., Schwartz, G. K., Hendrickson, A. E. W., Kaufmann, S. H., Adjei, A. A., & 2 others, Feb 2024, In: Investigational New Drugs. 42, 1, p. 127-135 9 p.Research output: Contribution to journal › Article › peer-review
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Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) deletion in myeloid cells augments cholestatic liver injury
Krishnan, A., Ozturk, N. B., Cutshaw, K. A., Guicciardi, M. E., Kitagataya, T., Olson, K. E., Pavelko, K. D., Sherman, W., Wixom, A. Q., Jalan-Sakrikar, N., Baez-Faria, M., Gutierrez, F. & Gores, G. J., Dec 2024, In: Scientific reports. 14, 1, 2145.Research output: Contribution to journal › Article › peer-review
Open Access -
Cholangiocarcinoma — novel biological insights and therapeutic strategies
Ilyas, S. I., Affo, S., Goyal, L., Lamarca, A., Sapisochin, G., Yang, J. D. & Gores, G. J., Jul 2023, In: Nature Reviews Clinical Oncology. 20, 7, p. 470-486 17 p.Research output: Contribution to journal › Review article › peer-review
Open Access